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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for E2f3

Z-value: 0.82

Motif logo

Transcription factors associated with E2f3

Gene Symbol Gene ID Gene Info
ENSRNOG00000029273 E2F transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f3rn6_v1_chr17_+_36334147_363341470.523.0e-23Click!

Activity profile of E2f3 motif

Sorted Z-values of E2f3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_121302740 18.72 ENSRNOT00000067032
ribosomal protein L3
chr13_-_45068077 18.56 ENSRNOT00000004969
minichromosome maintenance complex component 6
chr3_+_100366168 14.44 ENSRNOT00000006689
kinesin family member 18A
chr12_-_51877624 14.28 ENSRNOT00000056800
checkpoint kinase 2
chr8_-_13262729 14.01 ENSRNOT00000012176
fucosyltransferase 4
chr6_-_92760018 13.68 ENSRNOT00000009560
tripartite motif-containing 9
chr14_+_91783514 13.59 ENSRNOT00000080753
IKAROS family zinc finger 1
chr10_-_108196217 13.07 ENSRNOT00000075440
chromobox 4
chr10_-_89454681 13.03 ENSRNOT00000028109
BRCA1, DNA repair associated
chr3_+_146695344 13.00 ENSRNOT00000010955
GINS complex subunit 1
chr2_+_49682754 12.94 ENSRNOT00000079907
ENSRNOT00000085576
embigin
chr19_+_55381565 12.85 ENSRNOT00000018923
chromatin licensing and DNA replication factor 1
chr6_-_91518996 12.84 ENSRNOT00000005835
DNA polymerase epsilon 2, accessory subunit
chr2_-_198412350 12.19 ENSRNOT00000040210
histone H4-like
chr2_+_149214265 11.90 ENSRNOT00000084020
mediator complex subunit 12-like
chr4_+_56981283 11.87 ENSRNOT00000010989
tetraspanin 33
chr2_-_157759819 11.52 ENSRNOT00000015763
ENSRNOT00000016016
cyclin-L1-like
chr10_+_59765258 11.17 ENSRNOT00000026351
sedoheptulokinase
chr11_+_61321459 10.95 ENSRNOT00000002759
SID1 transmembrane family, member 1
chr18_-_11858744 10.68 ENSRNOT00000061417
ENSRNOT00000082891
desmocollin 2
chr13_-_110257367 10.06 ENSRNOT00000005576
denticleless E3 ubiquitin protein ligase homolog
chrX_+_156963870 9.94 ENSRNOT00000077109
PDZ domain containing 4
chr3_-_170040953 9.83 ENSRNOT00000005866
cerebellin 4 precursor
chr3_+_138715570 9.49 ENSRNOT00000064723
Sec23 homolog B, coat complex II component
chr8_-_21968415 9.25 ENSRNOT00000067325
ENSRNOT00000064932
DNA methyltransferase 1
chr1_-_42467586 8.77 ENSRNOT00000029416
F-box protein 5
chr9_+_10471742 8.74 ENSRNOT00000072276
scaffold attachment factor B2
chrX_-_62903530 8.56 ENSRNOT00000076652
ENSRNOT00000017370
pyruvate dehydrogenase kinase 3
chr19_+_52521809 8.40 ENSRNOT00000081019
kelch-like family member 36
chr9_+_112293388 8.25 ENSRNOT00000020767
mannosidase, alpha, class 2A, member 1
chr7_-_124491004 8.03 ENSRNOT00000037710
tubulin tyrosine ligase like 12
chr5_+_79179417 7.78 ENSRNOT00000010454
orosomucoid 1
chr1_-_261051498 7.67 ENSRNOT00000071417
Rho GTPase activating protein 19
chr3_-_23474170 7.64 ENSRNOT00000039410
suppressor of cancer cell invasion
chr8_+_118378059 7.59 ENSRNOT00000043247

chr8_-_118378460 7.23 ENSRNOT00000047247
similar to ribosomal protein S23
chr2_-_23256158 7.15 ENSRNOT00000015336
betaine-homocysteine S-methyltransferase
chr4_-_71227872 7.12 ENSRNOT00000050392
TRPM8 channel-associated factor 2
chr4_-_62438958 6.86 ENSRNOT00000014010
WD repeat domain 91
chr1_-_141188031 6.85 ENSRNOT00000044567
DNA polymerase gamma, catalytic subunit
chr10_+_4578469 6.72 ENSRNOT00000003332
thioredoxin domain containing 11
chr7_+_80351774 6.70 ENSRNOT00000081948
oxidation resistance 1
chrX_+_71324365 6.61 ENSRNOT00000004911
non-POU domain containing, octamer-binding
chr10_-_53037816 6.61 ENSRNOT00000057509
shisa family member 6
chr17_-_9837293 6.46 ENSRNOT00000091320
ENSRNOT00000022134
PRELI domain containing 1
chr1_+_31835000 6.39 ENSRNOT00000020780
centrosomal protein 72
chr9_-_103207190 6.26 ENSRNOT00000026010
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr2_+_182006242 6.19 ENSRNOT00000064091
fibrinogen alpha chain
chr11_-_51202703 6.10 ENSRNOT00000002719
ENSRNOT00000077220
Cbl proto-oncogene B
chr17_-_20364714 5.99 ENSRNOT00000070962
jumonji and AT-rich interaction domain containing 2
chr3_-_150603082 5.97 ENSRNOT00000024310
adenosylhomocysteinase
chr19_+_24329544 5.94 ENSRNOT00000080934
TBC1 domain family member 9
chr18_+_3163214 5.86 ENSRNOT00000017291
RB binding protein 8, endonuclease
chr3_-_10161989 5.59 ENSRNOT00000012312
exosome component 2
chr7_+_143754892 5.59 ENSRNOT00000085896
sterol O-acyltransferase 2
chr20_-_6864571 5.54 ENSRNOT00000093253
peptidylprolyl isomerase like 1
chr12_+_43940929 5.47 ENSRNOT00000001486
ring finger protein, transmembrane 2
chr8_+_122197027 5.46 ENSRNOT00000013050
upstream binding protein 1 (LBP-1a)
chr8_-_115621394 5.40 ENSRNOT00000018995
RNA binding motif protein 15B
chr2_+_4942775 5.35 ENSRNOT00000093548
ENSRNOT00000093741
family with sequence similarity 172, member A
chr3_-_94657377 5.34 ENSRNOT00000077484
t-complex 11 like 1
chr12_+_22434814 5.31 ENSRNOT00000076829
solute carrier family 12, member 9
chr9_-_1984654 5.19 ENSRNOT00000018146
phospholipase C-like 2
chr15_+_45422010 5.12 ENSRNOT00000012231
ribonuclease H2, subunit B
chr2_+_95008311 5.12 ENSRNOT00000077270
tumor protein D52
chr2_+_95008477 5.09 ENSRNOT00000015327
tumor protein D52
chr12_-_47793534 5.05 ENSRNOT00000001588
family with sequence similarity 222, member A
chr7_-_34485034 5.01 ENSRNOT00000007351
small nuclear ribonucleoprotein polypeptide F
chr8_+_7128656 5.00 ENSRNOT00000038313
progesterone receptor
chr7_-_111722964 5.00 ENSRNOT00000041802
ribosomal protein S19-like 1
chr18_+_3162543 4.97 ENSRNOT00000078615
RB binding protein 8, endonuclease
chr5_-_159602251 4.96 ENSRNOT00000011394
NECAP endocytosis associated 2
chr3_+_22640545 4.81 ENSRNOT00000064507
ENSRNOT00000014452
LIM homeobox 2
chr1_-_112947399 4.79 ENSRNOT00000093306
ENSRNOT00000093259
gamma-aminobutyric acid type A receptor alpha 5 subunit
chr13_+_109713489 4.72 ENSRNOT00000004962
basic leucine zipper ATF-like transcription factor 3
chr6_-_135049728 4.69 ENSRNOT00000009556
heat shock protein 90 alpha family class A member 1
chrX_-_131343853 4.69 ENSRNOT00000038653
DDB1 and CUL4 associated factor 12-like 1
chr20_-_6864387 4.65 ENSRNOT00000068527
peptidylprolyl isomerase like 1
chr20_+_2501252 4.62 ENSRNOT00000079307
ENSRNOT00000084559
tripartite motif-containing 39
chr9_+_111327402 4.60 ENSRNOT00000045749
similar to D1Ertd622e protein
chr14_+_58877806 4.53 ENSRNOT00000051559
similar to 60S ribosomal protein L23a
chr1_-_112947162 4.53 ENSRNOT00000014573
ENSRNOT00000083894
gamma-aminobutyric acid type A receptor alpha 5 subunit
chr15_+_27739251 4.48 ENSRNOT00000011840
poly (ADP-ribose) polymerase 2
chr9_-_46309451 4.46 ENSRNOT00000018684
ring finger protein 149
chr20_+_48504264 4.46 ENSRNOT00000087740
cell division cycle 40
chr7_-_55604403 4.45 ENSRNOT00000088732
ataxin 7-like 3B
chr4_-_177331874 4.44 ENSRNOT00000065387
ENSRNOT00000091099
C2 calcium-dependent domain containing 5
chr2_+_128675814 4.44 ENSRNOT00000058366
similar to protein C33A12.3
chr13_+_74154835 4.44 ENSRNOT00000059524
ABL proto-oncogene 2, non-receptor tyrosine kinase
chr10_+_57057608 4.27 ENSRNOT00000085810
ENSRNOT00000026335
mediator complex subunit 11
chr1_-_128341240 4.16 ENSRNOT00000070864
ENSRNOT00000072915
myocyte enhancer factor 2a
chr3_-_124884570 4.16 ENSRNOT00000028887
proliferating cell nuclear antigen
chr1_-_101095594 4.15 ENSRNOT00000027944
Fc fragment of IgG receptor and transporter
chr12_-_14175945 4.12 ENSRNOT00000001469
adaptor-related protein complex 5, zeta 1 subunit
chr10_-_72142533 4.11 ENSRNOT00000030885
mitochondrial rRNA methyltransferase 1
chr18_+_35489274 4.07 ENSRNOT00000073952
ENSRNOT00000076060
decapping mRNA 2
chr10_-_15577977 4.03 ENSRNOT00000052292
hemoglobin alpha, adult chain 3
chr3_-_146690375 4.03 ENSRNOT00000010641
abhydrolase domain containing 12
chr13_-_44345735 3.99 ENSRNOT00000005006
transmembrane protein 163
chr12_+_24651314 3.98 ENSRNOT00000077016
ENSRNOT00000071569
VPS37D, ESCRT-I subunit
chr20_-_34929965 3.96 ENSRNOT00000004499
minichromosome maintenance 9 homologous recombination repair factor
chrX_+_71540895 3.90 ENSRNOT00000004692
ENSRNOT00000082967
O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_-_141111400 3.88 ENSRNOT00000022962
retinaldehyde binding protein 1
chr5_-_63192025 3.86 ENSRNOT00000008913
ALG2, alpha-1,3/1,6-mannosyltransferase
chrX_+_74200972 3.85 ENSRNOT00000076956
cysteine-rich hydrophobic domain 1
chr1_-_219863926 3.85 ENSRNOT00000026454
ENSRNOT00000066455
Ras converting CAAX endopeptidase 1
chr7_-_120780641 3.82 ENSRNOT00000076164
DEAD-box helicase 17
chr10_-_67285617 3.81 ENSRNOT00000019044
UTP6 small subunit processome component
chr1_-_84008293 3.81 ENSRNOT00000002053
small nuclear ribonucleoprotein polypeptide A
chrX_-_62698830 3.78 ENSRNOT00000076359
DNA polymerase alpha 1, catalytic subunit
chr19_-_59384297 3.77 ENSRNOT00000077516
TAR RNA binding protein 1
chr8_-_48619592 3.74 ENSRNOT00000012534
ATP binding cassette subfamily G member 4
chrX_+_74205842 3.73 ENSRNOT00000077003
cysteine-rich hydrophobic domain 1
chr1_+_165382690 3.71 ENSRNOT00000023802
C2 calcium-dependent domain containing 3
chr4_-_180505916 3.69 ENSRNOT00000086465

chr9_-_98536581 3.69 ENSRNOT00000027295
integrin-linked kinase-associated serine/threonine phosphatase
chr6_-_15191660 3.65 ENSRNOT00000092654
neurexin 1
chr18_-_38088457 3.57 ENSRNOT00000077814
janus kinase and microtubule interacting protein 2
chr13_-_73819896 3.56 ENSRNOT00000036392
family with sequence similarity 163, member A
chr7_+_73588163 3.49 ENSRNOT00000015707
potassium voltage-gated channel, modifier subfamily S, member 2
chr14_+_75852060 3.41 ENSRNOT00000075975
heparan sulfate-glucosamine 3-sulfotransferase 1
chr10_-_2037891 3.38 ENSRNOT00000004563
ERCC excision repair 4, endonuclease catalytic subunit
chr14_-_44375804 3.36 ENSRNOT00000042825
ribosomal protein P2-like
chr20_+_29831314 3.34 ENSRNOT00000000696
prosaposin
chr11_+_61748883 3.32 ENSRNOT00000093552
queuine tRNA-ribosyltransferase accessory subunit 2
chr10_-_13542077 3.29 ENSRNOT00000008736
ATPase H+ transporting V0 subunit C
chr15_-_40545824 3.27 ENSRNOT00000017204
nucleoporin 58
chrX_-_1704033 3.24 ENSRNOT00000051956
ubiquitin specific peptidase 11
chr5_+_172648950 3.23 ENSRNOT00000055361
Fanconi anemia core complex associated protein 20
chr15_-_24374753 3.22 ENSRNOT00000016274
autophagy related 14
chr20_-_10407554 3.19 ENSRNOT00000074081
U2 small nuclear RNA auxiliary factor 1
chr10_+_975697 3.09 ENSRNOT00000089404

chr1_-_72329856 3.08 ENSRNOT00000021391
U2 small nuclear RNA auxiliary factor 2
chr15_-_34338956 3.07 ENSRNOT00000026914
magnesium-dependent phosphatase 1
chr8_+_118525682 2.99 ENSRNOT00000028288
elongator acetyltransferase complex subunit 6
chr19_-_56731372 2.98 ENSRNOT00000024182
nucleoporin 133
chr2_-_30664163 2.96 ENSRNOT00000024801
RAD17 checkpoint clamp loader component
chrX_+_157150655 2.90 ENSRNOT00000090795
pregnancy up-regulated nonubiquitous CaM kinase
chr7_-_11406771 2.90 ENSRNOT00000047450
eukaryotic translation elongation factor 2
chr10_+_40553180 2.88 ENSRNOT00000087763
solute carrier family 36 member 1
chr18_+_24584900 2.85 ENSRNOT00000017075
WD repeat domain 33
chr15_-_30147793 2.84 ENSRNOT00000060399

chr1_+_220746387 2.82 ENSRNOT00000027753
eukaryotic translation initiation factor 1A domain containing
chr4_+_157438605 2.80 ENSRNOT00000079988

chr17_-_17947777 2.73 ENSRNOT00000036876
ring finger protein 144B
chr10_-_71441389 2.73 ENSRNOT00000003699
transcriptional adaptor 2A
chr5_+_47853818 2.61 ENSRNOT00000009228
ENSRNOT00000079656
caspase 8 associated protein 2
chr10_+_14122878 2.57 ENSRNOT00000052008
heparan sulfate-glucosamine 3-sulfotransferase 6
chr1_-_219450451 2.55 ENSRNOT00000025317
RAD9 checkpoint clamp component A
chr12_+_51878153 2.49 ENSRNOT00000056798
HscB mitochondrial iron-sulfur cluster co-chaperone
chr15_-_11912806 2.43 ENSRNOT00000068171
ENSRNOT00000008759
ENSRNOT00000049771
solute carrier family 4 member 7
chr2_-_203043847 2.33 ENSRNOT00000067000
mannosidase, alpha, class 1A, member 2
chr11_+_86890585 2.32 ENSRNOT00000002579
RAN binding protein 1
chr9_-_10441834 2.31 ENSRNOT00000043704
ribosomal protein L36
chr3_-_148312791 2.30 ENSRNOT00000091419
Bcl2-like 1
chr10_+_80790168 2.30 ENSRNOT00000073315
ENSRNOT00000075163
carbonic anhydrase 10
chr10_+_89352835 2.28 ENSRNOT00000028060
ribosomal protein L27
chr20_-_14282873 2.28 ENSRNOT00000001759
adenosine A2a receptor
chr9_+_42620006 2.28 ENSRNOT00000019966
heparan sulfate 6-O-sulfotransferase 1
chr9_-_46206605 2.26 ENSRNOT00000018640
TBC1 domain family, member 8
chr1_+_260153645 2.25 ENSRNOT00000054717
zinc finger protein 518A
chr1_+_88078350 2.25 ENSRNOT00000048677
RAS guanyl releasing protein 4
chr7_-_2961873 2.22 ENSRNOT00000067441
ribosomal protein S15, pseudogene 2
chr12_+_660011 2.20 ENSRNOT00000040830
PDS5 cohesin associated factor B
chr4_-_51844331 2.16 ENSRNOT00000003593
G protein-coupled receptor 37
chr1_+_274310153 2.13 ENSRNOT00000054686
structural maintenance of chromosomes 3
chr3_+_80614937 2.12 ENSRNOT00000065462
harbinger transposase derived 1
chr2_+_224851383 2.10 ENSRNOT00000015354
ALG14, UDP-N-acetylglucosaminyltransferase subunit
chr19_+_6046665 2.08 ENSRNOT00000084126
cadherin 8
chr20_-_48503898 2.06 ENSRNOT00000073091
WAS protein family, member 1
chr1_+_165724451 2.03 ENSRNOT00000025827
family with sequence similarity 168, member A
chr3_+_147422095 2.03 ENSRNOT00000006786
angiopoietin 4
chr5_+_128923934 2.02 ENSRNOT00000064145
epidermal growth factor receptor pathway substrate 15
chr11_+_31640407 2.01 ENSRNOT00000029985
ENSRNOT00000091472
interferon alpha and beta receptor subunit 1
chr13_+_36378356 1.98 ENSRNOT00000071305
complement C1q like 2
chr2_+_30664639 1.98 ENSRNOT00000076372
ENSRNOT00000076294
ENSRNOT00000076434
ENSRNOT00000076484
TATA-box binding protein associated factor 9
chr13_+_110257571 1.96 ENSRNOT00000005715
integrator complex subunit 7
chr15_-_37663584 1.95 ENSRNOT00000012093
crystallin, lambda 1
chr8_+_93439648 1.91 ENSRNOT00000043008
ribosomal protein S20-like
chr13_+_21678512 1.89 ENSRNOT00000047108
contactin associated protein-like 5B
chr4_-_78342863 1.86 ENSRNOT00000049038
GTPase, IMAP family member 6
chr11_+_73198522 1.83 ENSRNOT00000002356
xyloside xylosyltransferase 1
chr6_-_95890325 1.82 ENSRNOT00000050217
similar to 60S ribosomal protein L23a
chr15_-_18493366 1.79 ENSRNOT00000010303
potassium channel tetramerization domain containing 6
chr16_-_62239987 1.78 ENSRNOT00000020252
glutathione-disulfide reductase
chr5_+_166870011 1.78 ENSRNOT00000088299
ribosomal protein S2
chr6_-_1622196 1.77 ENSRNOT00000007492
protein kinase D3
chr16_+_20657099 1.77 ENSRNOT00000027053
KxDL motif containing 1
chr7_+_117963740 1.73 ENSRNOT00000075405
COMM domain-containing protein 5
chrX_-_63203643 1.69 ENSRNOT00000065194
ENSRNOT00000076974
zinc finger protein X-linked
chr8_-_67869019 1.65 ENSRNOT00000066009
protein inhibitor of activated STAT, 1
chr1_+_154377247 1.63 ENSRNOT00000092945
phosphatidylinositol binding clathrin assembly protein
chr1_+_169115981 1.57 ENSRNOT00000067478
olfactory receptor 135
chr7_-_97902585 1.50 ENSRNOT00000008382
similar to RIKEN cDNA 9130401M01
chr8_+_69971778 1.42 ENSRNOT00000058007
ENSRNOT00000037941
ENSRNOT00000050649
multiple EGF-like-domains 11
chr6_-_27107030 1.40 ENSRNOT00000012558
solute carrier family 35, member F6
chr15_+_34270648 1.39 ENSRNOT00000026333
ring finger protein 31
chr12_-_30106889 1.39 ENSRNOT00000065868
ENSRNOT00000001200
tyrosylprotein sulfotransferase 1
chr4_+_22081604 1.39 ENSRNOT00000067462
carnitine O-octanoyltransferase
chr8_+_22446661 1.35 ENSRNOT00000010030
queuine tRNA-ribosyltransferase catalytic subunit 1

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
4.3 13.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
4.3 12.9 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163) regulation of DNA replication origin binding(GO:1902595)
3.6 14.3 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
3.4 13.6 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
2.9 8.8 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
2.7 18.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.6 10.5 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
2.6 13.0 GO:1902969 mitotic DNA replication(GO:1902969)
2.6 12.8 GO:0042276 error-prone translesion synthesis(GO:0042276)
2.2 11.2 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
2.1 8.6 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
2.1 6.4 GO:0033566 gamma-tubulin complex localization(GO:0033566)
1.9 17.4 GO:0019985 translesion synthesis(GO:0019985)
1.9 5.6 GO:0071049 nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
1.8 11.0 GO:0033227 dsRNA transport(GO:0033227)
1.8 10.8 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
1.7 13.8 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
1.7 5.0 GO:1904700 granulosa cell apoptotic process(GO:1904700) regulation of granulosa cell apoptotic process(GO:1904708)
1.5 4.5 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
1.4 12.9 GO:0035879 plasma membrane lactate transport(GO:0035879)
1.4 6.9 GO:0006287 base-excision repair, gap-filling(GO:0006287)
1.3 10.7 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
1.3 5.2 GO:0002337 B-1a B cell differentiation(GO:0002337)
1.3 3.8 GO:0080120 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
1.3 3.8 GO:0006272 leading strand elongation(GO:0006272)
1.3 6.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
1.2 6.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.2 3.7 GO:0021997 neural plate axis specification(GO:0021997)
1.2 7.1 GO:0010360 negative regulation of anion channel activity(GO:0010360)
1.2 2.3 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
1.1 3.4 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
1.1 6.6 GO:1903377 neuron intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0036480) regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903376) negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
1.0 4.2 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
1.0 6.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
1.0 4.0 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
1.0 14.0 GO:0036065 fucosylation(GO:0036065)
1.0 3.9 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
1.0 11.6 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.9 4.7 GO:0061741 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741)
0.9 7.1 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.8 3.2 GO:0016240 autophagosome docking(GO:0016240)
0.8 2.3 GO:1905218 cellular response to astaxanthin(GO:1905218)
0.8 2.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.7 8.2 GO:0006013 mannose metabolic process(GO:0006013)
0.7 3.7 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.7 12.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.7 2.0 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.7 6.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.6 4.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.6 5.6 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.6 6.5 GO:2001140 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
0.6 4.7 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.6 2.9 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.6 2.3 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.6 20.5 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.6 3.3 GO:0046836 glycolipid transport(GO:0046836)
0.5 6.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.5 1.6 GO:1902962 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.5 13.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.5 3.7 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.5 2.6 GO:0036337 Fas signaling pathway(GO:0036337)
0.5 4.6 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.5 1.4 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.4 4.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 3.0 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.4 3.3 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.4 2.1 GO:0021747 cochlear nucleus development(GO:0021747)
0.4 3.9 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.4 4.8 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.4 4.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4 2.9 GO:0015808 L-alanine transport(GO:0015808)
0.4 2.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.4 1.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.3 1.0 GO:0044209 AMP salvage(GO:0044209)
0.3 2.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.3 1.8 GO:0089700 protein kinase D signaling(GO:0089700)
0.3 2.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.3 4.0 GO:0015671 oxygen transport(GO:0015671)
0.3 2.3 GO:1904044 response to aldosterone(GO:1904044)
0.3 5.1 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 2.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.3 2.0 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.3 1.4 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.3 3.9 GO:0000076 DNA replication checkpoint(GO:0000076)
0.3 4.1 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.3 4.1 GO:0031167 rRNA methylation(GO:0031167)
0.3 3.8 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.3 2.2 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.3 3.8 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.2 2.7 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.2 6.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 1.4 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.2 10.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 1.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 5.4 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.2 1.3 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.2 4.6 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.2 7.7 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.2 0.8 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.2 6.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 0.7 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 1.7 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.2 1.8 GO:0016266 O-glycan processing(GO:0016266)
0.2 4.7 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.2 3.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.2 2.3 GO:0006491 N-glycan processing(GO:0006491)
0.2 3.5 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.2 1.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 2.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.2 2.0 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.2 0.9 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.1 1.8 GO:0010041 response to iron(III) ion(GO:0010041)
0.1 5.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 5.9 GO:0016925 protein sumoylation(GO:0016925)
0.1 8.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 1.4 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 0.9 GO:0043686 co-translational protein modification(GO:0043686)
0.1 6.3 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 2.8 GO:0006379 mRNA cleavage(GO:0006379)
0.1 5.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 5.8 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 3.7 GO:0033344 cholesterol efflux(GO:0033344)
0.1 6.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 2.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 10.2 GO:0030183 B cell differentiation(GO:0030183)
0.1 0.9 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 3.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 1.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 3.1 GO:0006040 amino sugar metabolic process(GO:0006040)
0.1 1.7 GO:0060746 parental behavior(GO:0060746)
0.1 6.7 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.1 2.0 GO:0006284 base-excision repair(GO:0006284)
0.1 5.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 6.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 1.4 GO:0010842 retina layer formation(GO:0010842)
0.0 1.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 2.3 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 1.3 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.7 GO:0060707 dorsal/ventral axis specification(GO:0009950) trophoblast giant cell differentiation(GO:0060707)
0.0 5.7 GO:0090002 establishment of protein localization to plasma membrane(GO:0090002)
0.0 3.9 GO:0007601 visual perception(GO:0007601)
0.0 0.9 GO:0001881 receptor recycling(GO:0001881)
0.0 0.3 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 1.9 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.3 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 2.1 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0000811 GINS complex(GO:0000811)
3.3 13.0 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
2.6 12.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
2.3 6.9 GO:0005760 gamma DNA polymerase complex(GO:0005760)
2.0 22.5 GO:0042555 MCM complex(GO:0042555)
2.0 10.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.6 14.4 GO:0005828 kinetochore microtubule(GO:0005828)
1.5 11.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
1.4 4.2 GO:0070557 PCNA-p21 complex(GO:0070557)
1.3 5.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.1 3.4 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
1.1 3.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
1.0 6.3 GO:0089701 U2AF(GO:0089701)
0.9 6.6 GO:0042382 paraspeckles(GO:0042382)
0.9 13.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.9 13.1 GO:0035102 PRC1 complex(GO:0035102)
0.8 5.0 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.8 4.7 GO:0000125 PCAF complex(GO:0000125)
0.8 6.2 GO:0005577 fibrinogen complex(GO:0005577)
0.7 9.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.7 4.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.7 3.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.6 3.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.6 3.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.5 9.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.5 5.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.5 3.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.5 10.7 GO:0030057 desmosome(GO:0030057)
0.5 12.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 4.0 GO:0000813 ESCRT I complex(GO:0000813)
0.4 2.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.4 4.0 GO:0005833 hemoglobin complex(GO:0005833)
0.4 16.2 GO:0016592 mediator complex(GO:0016592)
0.3 6.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 2.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 10.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 8.6 GO:0030125 clathrin vesicle coat(GO:0030125)
0.3 10.1 GO:0034451 centriolar satellite(GO:0034451)
0.3 2.0 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.3 4.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.3 2.9 GO:0042788 polysomal ribosome(GO:0042788)
0.3 6.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 3.4 GO:0005796 Golgi lumen(GO:0005796)
0.3 1.4 GO:0071797 LUBAC complex(GO:0071797)
0.3 26.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 3.0 GO:0031080 nuclear pore outer ring(GO:0031080)
0.3 11.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 2.1 GO:0031209 SCAR complex(GO:0031209)
0.2 3.8 GO:0005685 U1 snRNP(GO:0005685)
0.2 14.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 3.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 9.4 GO:0005801 cis-Golgi network(GO:0005801)
0.2 2.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 3.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 1.3 GO:0071439 clathrin complex(GO:0071439)
0.2 4.3 GO:0001891 phagocytic cup(GO:0001891)
0.2 2.3 GO:0032279 asymmetric synapse(GO:0032279)
0.2 3.9 GO:0042588 zymogen granule(GO:0042588)
0.1 4.6 GO:0035869 ciliary transition zone(GO:0035869)
0.1 1.8 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 12.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 10.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 12.9 GO:0000776 kinetochore(GO:0000776)
0.1 15.7 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 8.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 6.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.3 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.1 3.7 GO:0044295 axonal growth cone(GO:0044295)
0.1 13.7 GO:0008021 synaptic vesicle(GO:0008021)
0.1 0.9 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 2.3 GO:1904115 axon cytoplasm(GO:1904115)
0.1 4.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.3 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 5.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.7 GO:0000803 sex chromosome(GO:0000803) XY body(GO:0001741)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 31.7 GO:0005730 nucleolus(GO:0005730)
0.0 4.7 GO:0043197 dendritic spine(GO:0043197)
0.0 3.7 GO:0072562 blood microparticle(GO:0072562)
0.0 7.5 GO:0016607 nuclear speck(GO:0016607)
0.0 0.6 GO:0043194 axon initial segment(GO:0043194)
0.0 1.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 5.8 GO:0016604 nuclear body(GO:0016604)
0.0 0.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.7 GO:0005903 brush border(GO:0005903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 14.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
2.2 11.0 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
2.2 6.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
2.1 8.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
2.1 6.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
1.9 9.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
1.7 21.6 GO:0008097 5S rRNA binding(GO:0008097)
1.6 4.7 GO:0017098 UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
1.5 6.0 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
1.4 4.2 GO:0030337 DNA polymerase processivity factor activity(GO:0030337) dinucleotide insertion or deletion binding(GO:0032139)
1.3 3.9 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
1.3 14.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.3 3.9 GO:0005502 11-cis retinal binding(GO:0005502)
1.3 3.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.2 3.7 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
1.0 5.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.0 6.0 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
1.0 18.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.0 2.9 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
1.0 3.8 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.9 14.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.9 4.5 GO:0050733 RS domain binding(GO:0050733)
0.9 7.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.9 13.0 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.9 14.5 GO:0050811 GABA receptor binding(GO:0050811)
0.8 4.1 GO:0019770 IgG receptor activity(GO:0019770)
0.8 10.6 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.8 23.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.8 14.7 GO:0019789 SUMO transferase activity(GO:0019789)
0.7 2.0 GO:0019961 interferon binding(GO:0019961)
0.6 16.7 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.6 4.7 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.6 2.9 GO:0036033 mediator complex binding(GO:0036033)
0.5 3.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 4.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.5 1.4 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.5 1.4 GO:0008458 carnitine O-octanoyltransferase activity(GO:0008458) O-octanoyltransferase activity(GO:0016414)
0.5 2.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.4 5.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.4 1.3 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.4 3.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.4 2.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.4 2.3 GO:0051434 BH3 domain binding(GO:0051434)
0.4 11.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 2.6 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 1.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.3 6.7 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.3 4.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.3 4.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 3.0 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 4.1 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 14.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 1.1 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
0.3 4.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 1.8 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.3 13.0 GO:0003684 damaged DNA binding(GO:0003684)
0.3 1.8 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.3 2.3 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.2 2.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 2.5 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.2 10.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 1.9 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.2 1.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 6.0 GO:0032452 histone demethylase activity(GO:0032452)
0.2 0.9 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 3.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 2.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 3.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 5.6 GO:0004532 exoribonuclease activity(GO:0004532)
0.1 1.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 3.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 5.4 GO:0015485 cholesterol binding(GO:0015485)
0.1 2.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.8 GO:0004697 protein kinase C activity(GO:0004697)
0.1 5.0 GO:0005496 steroid binding(GO:0005496)
0.1 2.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 5.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 4.4 GO:0030145 manganese ion binding(GO:0030145)
0.1 3.8 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 12.2 GO:0000149 SNARE binding(GO:0000149)
0.1 8.8 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 2.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 7.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 12.0 GO:0042393 histone binding(GO:0042393)
0.1 2.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 7.5 GO:0008144 drug binding(GO:0008144)
0.1 6.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.8 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.3 GO:0030276 clathrin binding(GO:0030276)
0.0 28.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 4.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 10.9 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 2.1 GO:0004518 nuclease activity(GO:0004518)
0.0 1.7 GO:0044325 ion channel binding(GO:0044325)
0.0 2.2 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.4 GO:0030515 snoRNA binding(GO:0030515)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 46.3 PID ATM PATHWAY ATM pathway
0.4 24.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4 6.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.3 23.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.3 4.9 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3 5.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 4.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 6.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 4.2 PID BARD1 PATHWAY BARD1 signaling events
0.2 8.8 PID PLK1 PATHWAY PLK1 signaling events
0.2 1.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 8.2 PID E2F PATHWAY E2F transcription factor network
0.2 7.6 PID RHOA PATHWAY RhoA signaling pathway
0.1 2.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.0 PID MYC PATHWAY C-MYC pathway
0.1 3.9 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 2.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 1.2 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 2.3 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 2.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 11.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 31.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.4 28.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.3 14.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.8 12.8 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.8 13.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.6 8.6 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.5 9.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.5 4.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 14.4 REACTOME KINESINS Genes involved in Kinesins
0.5 5.0 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.5 13.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 4.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.4 5.5 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.4 6.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.4 6.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 8.2 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.3 28.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.3 10.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.3 10.6 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.2 7.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 1.7 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.2 11.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 6.0 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 3.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.2 6.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 6.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 2.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.3 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 3.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 2.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 2.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 4.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 3.0 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 2.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 1.8 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 4.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.4 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 2.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 2.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 5.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.0 REACTOME MEIOSIS Genes involved in Meiosis
0.1 4.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.3 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases