ISMARA results: E2f1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for E2f1

Z-value: 3.45

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Transcription factors associated with E2f1

Gene Symbol	Gene ID	Gene Info
E2f1 NCBI RGD Ensembl	ENSRNOG00000016708	E2F transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2f1	rn6_v1_chr3_-_150073721_150073721	0.73	1.1e-54	Click!

Activity profile of E2f1 motif

Sorted Z-values of E2f1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_43617247 Show fit	205.40	ENSRNOT00000075065	Hist1h2ao NCBI RGD Ensembl Show fit	histone cluster 1, H2ao
chr8_+_71514281 Show fit	146.02	ENSRNOT00000022256	Ns5atp9 NCBI RGD Ensembl Show fit	NS5A (hepatitis C virus) transactivated protein 9
chr7_+_53275676 Show fit	136.63	ENSRNOT00000031986	E2f7 NCBI RGD Ensembl Show fit	E2F transcription factor 7
chr13_-_110257367 Show fit	119.58	ENSRNOT00000005576	Dtl NCBI RGD Ensembl Show fit	denticleless E3 ubiquitin protein ligase homolog
chr3_+_159421671 Show fit	102.26	ENSRNOT00000010343	Mybl2 NCBI RGD Ensembl Show fit	myeloblastosis oncogene-like 2
chr3_+_59153280 Show fit	91.43	ENSRNOT00000002066	Cdca7 NCBI RGD Ensembl Show fit	cell division cycle associated 7
chr9_-_26932201 Show fit	90.77	ENSRNOT00000017081	Mcm3 NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 3
chr8_-_66893083 Show fit	88.23	ENSRNOT00000037028 ENSRNOT00000091755	Kif23 NCBI RGD Ensembl Show fit	kinesin family member 23
chr9_-_10757720 Show fit	84.48	ENSRNOT00000083848	Uhrf1 NCBI RGD Ensembl Show fit	ubiquitin-like with PHD and ring finger domains 1
chr8_-_33661049 Show fit	77.42	ENSRNOT00000068037	Fli1 NCBI RGD Ensembl Show fit	Fli-1 proto-oncogene, ETS transcription factor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
27.1	461.0	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
12.5	312.4	GO:0006270	DNA replication initiation(GO:0006270)
4.1	282.5	GO:0006342	chromatin silencing(GO:0006342)
27.6	220.8	GO:0010216	maintenance of DNA methylation(GO:0010216)
15.1	211.4	GO:0019985	translesion synthesis(GO:0019985)
13.1	209.6	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
2.2	193.2	GO:0051225	spindle assembly(GO:0051225)
3.1	181.9	GO:0006334	nucleosome assembly(GO:0006334)
0.7	178.7	GO:0008380	RNA splicing(GO:0008380)
16.1	145.3	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)

Showing 1 to 10 of 411 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	539.6	GO:0005694	chromosome(GO:0005694)
0.4	489.6	GO:0005654	nucleoplasm(GO:0005654)
17.1	480.1	GO:0000788	nuclear nucleosome(GO:0000788)
1.3	430.3	GO:0005667	transcription factor complex(GO:0005667)
32.9	361.7	GO:0042555	MCM complex(GO:0042555)
5.7	355.8	GO:0044815	DNA packaging complex(GO:0044815)
6.5	274.8	GO:0000791	euchromatin(GO:0000791)
1.7	191.4	GO:0000775	chromosome, centromeric region(GO:0000775)
1.9	174.8	GO:0017053	transcriptional repressor complex(GO:0017053)
43.5	173.9	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)

Showing 1 to 10 of 189 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	845.7	GO:0042393	histone binding(GO:0042393)
0.5	713.2	GO:0003677	DNA binding(GO:0003677)
6.6	290.0	GO:0003678	DNA helicase activity(GO:0003678)
0.7	185.8	GO:0003924	GTPase activity(GO:0003924)
1.3	179.9	GO:0003714	transcription corepressor activity(GO:0003714)
29.0	173.9	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
5.5	158.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
39.5	157.8	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
15.5	155.2	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.7	113.9	GO:0003697	single-stranded DNA binding(GO:0003697)

Showing 1 to 10 of 274 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.4	843.0	PID E2F PATHWAY	E2F transcription factor network
7.5	309.4	PID ATR PATHWAY	ATR signaling pathway
14.9	253.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
6.9	201.5	PID FANCONI PATHWAY	Fanconi anemia pathway
3.5	159.1	PID AURORA B PATHWAY	Aurora B signaling
1.5	156.2	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
2.2	107.6	PID ILK PATHWAY	Integrin-linked kinase signaling
1.4	102.0	PID CMYB PATHWAY	C-MYB transcription factor network
5.6	100.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
3.8	99.0	PID ATM PATHWAY	ATM pathway

Showing 1 to 10 of 66 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.5	337.7	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
13.4	320.7	REACTOME DNA STRAND ELONGATION	Genes involved in DNA strand elongation
25.3	278.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
3.3	271.8	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
6.8	170.4	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
8.2	147.0	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
6.3	144.4	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
4.4	128.7	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
6.6	125.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
3.7	117.3	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm

Showing 1 to 10 of 116 entries

Results for E2f1

Z-value: 3.45

Motif logo

Transcription factors associated with E2f1

Activity-expression correlation:

Activity profile of E2f1 motif

Sorted Z-values of E2f1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: