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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Dmc1
Z-value: 1.60
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Transcription factors associated with Dmc1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dmc1 | rn6_v1_chr7_-_120839577_120839577 | -0.01 | 9.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_76722965 Show fit | 83.54 |
ENSRNOT00000052129
|
alcohol sulfotransferase-like |
|
| chr14_+_22375955 Show fit | 71.87 |
ENSRNOT00000063915
ENSRNOT00000034784 |
UDP-glucuronosyltransferase 2 family, member 37 |
|
| chr1_+_65576535 Show fit | 64.34 |
ENSRNOT00000026575
|
solute carrier family 27 member 5 |
|
| chr19_+_487723 Show fit | 60.99 |
ENSRNOT00000061734
|
carboxylesterase 2J |
|
| chr1_-_258877045 Show fit | 59.75 |
ENSRNOT00000071633
|
cytochrome P450, family 2, subfamily c, polypeptide 13 |
|
| chr4_+_154391647 Show fit | 57.97 |
ENSRNOT00000081488
ENSRNOT00000079192 |
murinoglobulin 1 |
|
| chr17_+_8489266 Show fit | 53.61 |
ENSRNOT00000016252
|
leukocyte cell-derived chemotaxin 2 |
|
| chr14_+_22937421 Show fit | 53.20 |
ENSRNOT00000065079
|
similar to Expressed sequence AI788959 |
|
| chr1_-_258766881 Show fit | 53.07 |
ENSRNOT00000015801
|
cytochrome P450, family 2, subfamily c, polypeptide 12 |
|
| chr1_-_148119857 Show fit | 52.00 |
ENSRNOT00000040325
|
Cytochrome P450, family 2, subfamily c, polypeptide 7-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of Dmc1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.7 | 369.7 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.3 | 364.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.4 | 121.9 | GO:0006637 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 9.3 | 120.6 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 1.8 | 98.5 | GO:0006953 | acute-phase response(GO:0006953) |
| 15.7 | 78.6 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 16.1 | 64.3 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 4.6 | 63.8 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 4.3 | 60.0 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 7.2 | 57.8 | GO:0006559 | L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 438.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.2 | 131.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 79.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 1.2 | 64.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.8 | 55.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.8 | 51.8 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.4 | 51.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 5.1 | 51.2 | GO:0045179 | apical cortex(GO:0045179) |
| 0.6 | 46.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 2.5 | 45.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.5 | 413.5 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) |
| 0.3 | 344.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 11.1 | 342.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.6 | 133.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 9.6 | 115.5 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.9 | 107.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 10.7 | 85.4 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
| 0.7 | 83.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 26.2 | 78.6 | GO:0004478 | methionine adenosyltransferase activity(GO:0004478) |
| 3.9 | 78.5 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 86.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 43.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.7 | 40.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 35.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.4 | 25.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 21.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 18.8 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 1.1 | 18.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.3 | 11.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 10.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.1 | 172.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 4.5 | 131.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 7.9 | 95.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 2.1 | 81.4 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 4.6 | 78.5 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.5 | 76.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 3.7 | 48.5 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 1.5 | 43.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 3.4 | 37.8 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 2.1 | 36.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |