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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ddit3

Z-value: 0.86

Motif logo

Transcription factors associated with Ddit3

Gene Symbol Gene ID Gene Info
ENSRNOG00000006789 DNA-damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ddit3rn6_v1_chr7_+_70580198_70580252-0.115.3e-02Click!

Activity profile of Ddit3 motif

Sorted Z-values of Ddit3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_86297623 28.79 ENSRNOT00000067162
ENSRNOT00000081607
ENSRNOT00000085265
calcium/calmodulin-dependent protein kinase II beta
chr3_-_44086006 28.24 ENSRNOT00000034449
ENSRNOT00000082604
ermin
chr2_+_200793571 25.20 ENSRNOT00000091444
hydroxyacid oxidase 2
chr16_-_49820235 23.13 ENSRNOT00000029628
sorbin and SH3 domain containing 2
chr11_+_60073383 22.76 ENSRNOT00000087508
transgelin 3
chr15_-_71779033 20.02 ENSRNOT00000017765
protocadherin 20
chr10_-_83898527 17.96 ENSRNOT00000009815
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chrX_+_118084890 16.51 ENSRNOT00000065293
5-hydroxytryptamine receptor 2C
chr18_+_57654290 14.94 ENSRNOT00000025892
5-hydroxytryptamine receptor 4
chr11_-_81717521 14.84 ENSRNOT00000058422
alpha-2-HS-glycoprotein
chrX_+_39711201 14.60 ENSRNOT00000080512
ENSRNOT00000009802
connector enhancer of kinase suppressor of Ras 2
chr19_+_50848736 13.81 ENSRNOT00000077053
cadherin 13
chr8_+_39305128 13.75 ENSRNOT00000008285
fasciculation and elongation protein zeta 1
chr3_-_158328881 13.67 ENSRNOT00000044466
protein tyrosine phosphatase, receptor type, T
chr7_+_64672722 13.59 ENSRNOT00000064448
ENSRNOT00000005539
glutamate receptor interacting protein 1
chr7_+_12433933 12.79 ENSRNOT00000060690
CACN beta subunit associated regulatory protein
chr18_+_30387937 12.61 ENSRNOT00000027210
protocadherin beta 4
chr20_-_48503898 12.44 ENSRNOT00000073091
WAS protein family, member 1
chr8_-_59139946 12.43 ENSRNOT00000078571
calcium and integrin binding family member 2
chr9_-_8632017 11.70 ENSRNOT00000043269

chr16_-_75309176 11.49 ENSRNOT00000018427
defensin beta 1
chr8_-_49106177 11.05 ENSRNOT00000067558
transmembrane protein 25
chr10_+_37215937 11.00 ENSRNOT00000006567
secretion associated, Ras related GTPase 1B
chr15_+_17834635 10.82 ENSRNOT00000085530
similar to RIKEN cDNA 4933406L09
chr12_+_32103198 10.76 ENSRNOT00000085464
transmembrane protein 132D
chr18_+_30527705 10.70 ENSRNOT00000027168
protocadherin beta 14
chr4_-_86466797 10.61 ENSRNOT00000017531
phosphodiesterase 1C
chr11_-_35098883 10.59 ENSRNOT00000079955
potassium voltage-gated channel subfamily J member 6
chr7_-_82687130 10.57 ENSRNOT00000006791
transmembrane protein 74
chr7_+_80625010 10.45 ENSRNOT00000084940
oxidation resistance 1
chr9_-_4945352 10.40 ENSRNOT00000082530
sulfotransferase family 1C member 3
chr3_+_111160205 9.95 ENSRNOT00000019392
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
chr14_-_82048251 9.83 ENSRNOT00000074734
N-acetyltransferase 8-like
chr1_-_233145924 9.81 ENSRNOT00000018763
ENSRNOT00000082442
phosphoserine aminotransferase 1
chr3_-_45210474 9.69 ENSRNOT00000091777
coiled-coil domain containing 148
chr1_-_215033460 9.64 ENSRNOT00000044565
dual specificity phosphatase 8
chr9_-_9142339 9.45 ENSRNOT00000046852
similar to RIKEN cDNA 1700001E04
chr6_-_1319541 9.35 ENSRNOT00000006527
striatin
chr2_-_53185926 9.29 ENSRNOT00000081558
growth hormone receptor
chr10_-_104748003 9.27 ENSRNOT00000042372
ENSRNOT00000046754
acyl-CoA oxidase 1
chr19_-_6031655 9.27 ENSRNOT00000092016

chr9_-_30844199 9.22 ENSRNOT00000017169
collagen type XIX alpha 1 chain
chr18_+_31444472 9.05 ENSRNOT00000075159
ring finger protein 14
chr19_+_24044103 9.04 ENSRNOT00000004621
ring finger protein 150
chr3_+_147226004 8.84 ENSRNOT00000012765
transmembrane protein 74B
chr1_+_100131449 8.69 ENSRNOT00000091964
ENSRNOT00000071416
kallikrein 1
chr12_-_2592838 8.53 ENSRNOT00000079918
ecotropic viral integration site 5-like
chr9_-_26707571 8.20 ENSRNOT00000080948

chrX_+_33884499 7.99 ENSRNOT00000090041
RALBP1 associated Eps domain containing protein 2
chr1_-_222350173 7.97 ENSRNOT00000030625
fibronectin leucine rich transmembrane protein 1
chr16_+_23668595 7.64 ENSRNOT00000067886
pleckstrin and Sec7 domain containing 3
chr4_+_34962339 7.59 ENSRNOT00000086248

chr10_+_40543288 7.18 ENSRNOT00000016755
solute carrier family 36 member 1
chr14_-_42560174 7.05 ENSRNOT00000003128
transmembrane protein 33
chr1_+_157573324 6.99 ENSRNOT00000092066
RAB30, member RAS oncogene family
chr1_+_48273611 6.94 ENSRNOT00000022254
ENSRNOT00000022068
solute carrier family 22 member 1
chr20_-_48881119 6.73 ENSRNOT00000018892
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
chr2_+_116970344 6.33 ENSRNOT00000039603
EGF-like and EMI domain containing 1
chr20_-_5123073 6.27 ENSRNOT00000001126
apolipoprotein M
chr2_-_148722263 6.27 ENSRNOT00000017868
stress-associated endoplasmic reticulum protein 1
chrM_-_14061 6.10 ENSRNOT00000051268
mitochondrially encoded NADH dehydrogenase 6
chr3_-_143899370 6.05 ENSRNOT00000049635
androgen regulated protein
chr11_-_61874327 5.96 ENSRNOT00000089057
dopamine receptor D3
chr2_-_216382244 5.89 ENSRNOT00000086695
ENSRNOT00000087259
pancreatic alpha-amylase-like
chr1_-_166943592 5.79 ENSRNOT00000026962
folate receptor 1
chr11_+_9642365 5.79 ENSRNOT00000087080
ENSRNOT00000042384
roundabout guidance receptor 1
chr4_+_120672152 5.76 ENSRNOT00000077231
monoglyceride lipase
chr9_-_99680979 5.74 ENSRNOT00000049347
olfactory receptor 1345
chr8_-_21831668 5.71 ENSRNOT00000027897
collagen type V alpha 3 chain
chr10_+_44547564 5.61 ENSRNOT00000047914
olfactory receptor 1443
chr5_+_33580944 5.51 ENSRNOT00000092054
ENSRNOT00000036050
regulator of microtubule dynamics 1
chr6_-_26241337 5.50 ENSRNOT00000006525
solute carrier family 4 member 1 adaptor protein
chr10_-_81653717 5.45 ENSRNOT00000003611
NME/NM23 nucleoside diphosphate kinase 2
chr10_+_98706960 5.36 ENSRNOT00000006217
mitogen-activated protein kinase kinase 6
chr5_+_14415841 5.36 ENSRNOT00000010682
regulator of G-protein signaling 20
chr11_-_77703255 4.89 ENSRNOT00000083319
claudin 16
chr19_+_24670699 4.86 ENSRNOT00000038213
olfactory receptor 1667
chr2_+_85377318 4.83 ENSRNOT00000016506
ENSRNOT00000085094
semaphorin 5A
chr1_+_7658890 4.76 ENSRNOT00000020946
fucosidase, alpha-L- 2, plasma
chr1_-_167588630 4.71 ENSRNOT00000050707
olfactory receptor 39
chr12_-_47793534 4.58 ENSRNOT00000001588
family with sequence similarity 222, member A
chr12_-_8156151 4.43 ENSRNOT00000064721
microtubule associated tumor suppressor candidate 2
chr8_+_116297950 4.32 ENSRNOT00000051522
NPR2-like, GATOR1 complex subunit
chr6_-_28994519 4.32 ENSRNOT00000006668
UBX domain protein 2A
chr15_+_61069581 4.29 ENSRNOT00000084333
von Willebrand factor A domain containing 8
chr2_-_216348194 4.23 ENSRNOT00000087839
pancreatic alpha-amylase-like
chr8_+_82037977 4.22 ENSRNOT00000082288
myosin VA
chr1_-_173469699 4.15 ENSRNOT00000040345
olfactory receptor 281
chr10_-_45514878 4.10 ENSRNOT00000036940
IBA57 homolog, iron-sulfur cluster assembly
chr20_+_48881194 4.00 ENSRNOT00000000304
reticulon 4 interacting protein 1
chr1_+_267618248 3.97 ENSRNOT00000017186
glutathione S-transferase omega 2
chr1_+_41590494 3.92 ENSRNOT00000089984
estrogen receptor 1
chr19_-_11057254 3.84 ENSRNOT00000025559
homocysteine inducible ER protein with ubiquitin like domain 1
chr10_-_37215899 3.68 ENSRNOT00000006356
SEC24 homolog A, COPII coat complex component
chr1_+_174655939 3.63 ENSRNOT00000014002
importin 7
chr8_+_43872728 3.48 ENSRNOT00000079702
olfactory receptor 1337
chr1_-_174379566 3.47 ENSRNOT00000067388
TMEM9 domain family, member B
chr6_+_26241672 3.45 ENSRNOT00000006543
SPT7-like STAGA complex gamma subunit
chrX_-_105568343 3.39 ENSRNOT00000029807
armadillo repeat containing, X-linked 6
chr1_-_264294630 3.36 ENSRNOT00000035758
SEC31 homolog B, COPII coat complex component
chr1_-_229804614 3.17 ENSRNOT00000049665
olfactory receptor 343
chr1_-_228524439 3.06 ENSRNOT00000028601
olfactory receptor 323
chrX_-_33722090 2.92 ENSRNOT00000059010
ribosomal protein L39
chr11_+_80319177 2.83 ENSRNOT00000036777
receptor (chemosensory) transporter protein 2
chr5_-_164927869 2.78 ENSRNOT00000012080
dorsal inhibitory axon guidance protein
chr10_-_95431312 2.77 ENSRNOT00000085552

chr2_-_122690617 2.75 ENSRNOT00000018942
methylcrotonoyl-CoA carboxylase 1
chr19_+_26194465 2.74 ENSRNOT00000087627
ENSRNOT00000065931
WD repeat domain 83 opposite strand
chr3_-_77661863 2.70 ENSRNOT00000080807
olfactory receptor 668
chr18_+_53088994 2.69 ENSRNOT00000091921

chr3_+_102925471 2.64 ENSRNOT00000040364
olfactory receptor 772
chr7_-_124367630 2.64 ENSRNOT00000055978
tubulin tyrosine ligase like 1
chr1_+_72356880 2.49 ENSRNOT00000021917
zinc finger protein 865
chr1_-_214067657 2.46 ENSRNOT00000044390
chitinase domain-containing protein 1-like
chr4_+_66276835 2.46 ENSRNOT00000007544
formation of mitochondrial complex V assembly factor 1
chr4_+_22082194 2.42 ENSRNOT00000091799
carnitine O-octanoyltransferase
chr5_+_106952082 2.41 ENSRNOT00000046931
similar to put. precursor MuIFN-alpha 5
chr14_-_10749120 2.36 ENSRNOT00000003046
COP9 signalosome subunit 4
chr5_-_137874692 2.36 ENSRNOT00000089549
olfactory receptor 867
chr14_+_104250617 2.36 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chr2_+_181987217 2.35 ENSRNOT00000034521
fibrinogen gamma chain
chr12_+_8032809 2.34 ENSRNOT00000082850
solute carrier family 7 member 1
chr3_-_143807287 2.29 ENSRNOT00000046355
ENSRNOT00000081843

chr1_-_173129038 2.25 ENSRNOT00000075693
olfactory receptor 10A3-like
chr10_-_62366044 2.21 ENSRNOT00000045673
olfactory receptor 1474
chr6_-_111131271 2.14 ENSRNOT00000081727
neuroglobin
chr7_-_140502441 2.10 ENSRNOT00000089544
lysine methyltransferase 2D
chr6_-_23581052 2.06 ENSRNOT00000006190
protein phosphatase 1 catalytic subunit beta
chr8_-_116297850 2.03 ENSRNOT00000031739
ENSRNOT00000082320
cytochrome b561 family, member D2
chr10_+_96661696 1.98 ENSRNOT00000077567

chr14_-_37361798 1.96 ENSRNOT00000002980
cell wall biogenesis 43 C-terminal homolog
chr1_-_214504569 1.90 ENSRNOT00000082221
chitinase domain containing 1
chrX_-_119162518 1.89 ENSRNOT00000073176
ubiquitin-conjugating enzyme E2 W
chr2_+_93758919 1.89 ENSRNOT00000077782
fatty acid binding protein 12
chr2_-_96032722 1.87 ENSRNOT00000015746
proteasome subunit beta type 6-like
chr15_+_33004133 1.81 ENSRNOT00000013246
OXA1L, mitochondrial inner membrane protein
chr5_+_27326762 1.69 ENSRNOT00000066191
RUNX1 translocation partner 1
chr2_-_260108897 1.68 ENSRNOT00000014106
mutS homolog 4
chr7_+_16304954 1.61 ENSRNOT00000050751
olfactory receptor 927
chr2_-_38110567 1.56 ENSRNOT00000072212
importin 11
chr4_+_174692331 1.54 ENSRNOT00000011770
pleckstrin homology domain containing A5
chr15_+_39638510 1.53 ENSRNOT00000037800
RCC1 and BTB domain containing protein 1
chr7_+_9262982 1.49 ENSRNOT00000047647
olfactory receptor 1063
chr1_-_230766515 1.44 ENSRNOT00000040049
olfactory receptor 383
chr1_+_101397828 1.42 ENSRNOT00000028189
potassium voltage-gated channel subfamily A member 7
chr12_+_17253791 1.39 ENSRNOT00000083814
zinc finger AN1-type containing 2A
chr20_+_13965121 1.37 ENSRNOT00000089005
ENSRNOT00000066773
ENSRNOT00000079996
sushi domain containing 2
chr10_+_105073077 1.32 ENSRNOT00000083022
ENSRNOT00000086382
ENSRNOT00000087084
TEN1 CST complex subunit
chr1_+_218058405 1.29 ENSRNOT00000028365
fibroblast growth factor 19
chr17_+_6684621 1.26 ENSRNOT00000089138
similar to CG9752-PA
chr9_-_99659425 1.23 ENSRNOT00000051686
olfactory receptor 1343
chr15_-_36213666 1.19 ENSRNOT00000078704
olfactory receptor 1291
chr9_-_16406338 1.18 ENSRNOT00000073079
tubulin folding cofactor C
chr20_+_1110773 1.17 ENSRNOT00000041697
olfactory receptor 1702
chr7_+_70335061 1.15 ENSRNOT00000072176
ENSRNOT00000084933
cytochrome P450, family 27, subfamily b, polypeptide 1
chr2_-_112368557 1.10 ENSRNOT00000075017

chr1_-_71173216 1.09 ENSRNOT00000020523
zinc finger protein 28
chr1_-_172943853 1.09 ENSRNOT00000047040
olfactory receptor 278
chr17_+_48436720 1.05 ENSRNOT00000074309

chr1_+_254531659 1.04 ENSRNOT00000091377

chr14_-_21771567 1.02 ENSRNOT00000038393

chr1_+_168668707 0.96 ENSRNOT00000015108

chr10_+_71536533 0.93 ENSRNOT00000088138
acetyl-CoA carboxylase alpha
chr15_+_64939527 0.88 ENSRNOT00000045865

chr3_-_72219246 0.88 ENSRNOT00000009903
smoothelin-like 1
chr5_-_39689824 0.88 ENSRNOT00000046713

chr7_-_99808612 0.87 ENSRNOT00000074953

chr13_+_106751625 0.87 ENSRNOT00000004992
usherin
chr7_-_122403667 0.82 ENSRNOT00000088814
megakaryoblastic leukemia (translocation) 1
chr5_-_137846436 0.81 ENSRNOT00000046941
olfactory receptor 866
chrX_+_137934484 0.79 ENSRNOT00000049046
hypothetical protein LOC317588
chr1_-_168869420 0.78 ENSRNOT00000021436
olfactory receptor 125
chr1_+_142679345 0.76 ENSRNOT00000034267
zinc finger and SCAN domain containing 2
chr1_-_4560789 0.75 ENSRNOT00000082415
androglobin
chr8_-_43055175 0.72 ENSRNOT00000074413
olfactory receptor 8G1-like
chrX_+_70408064 0.71 ENSRNOT00000038924
acyl-CoA wax alcohol acyltransferase 1
chr3_+_75354237 0.70 ENSRNOT00000050634
olfactory receptor 557
chr4_-_155740193 0.63 ENSRNOT00000043229
LRRGT00188
chr5_-_172078760 0.61 ENSRNOT00000016781
actin-related protein T2
chr1_+_207508414 0.60 ENSRNOT00000054896
neuropeptide S
chr4_-_166803127 0.60 ENSRNOT00000067909
LOC362451
chr1_+_169590308 0.60 ENSRNOT00000023147
olfactory receptor 155
chr1_+_79573118 0.53 ENSRNOT00000072039
IGF-like family member 3
chr10_+_59923201 0.53 ENSRNOT00000073603
ENSRNOT00000045573
olfactory receptor 1498
chr1_+_75326217 0.50 ENSRNOT00000044964
vomeronasal 1 receptor 62
chr1_+_190462327 0.50 ENSRNOT00000030732
similar to ankyrin repeat domain 26
chr1_+_170796271 0.50 ENSRNOT00000042820
olfactory receptor 210
chr3_-_76718684 0.48 ENSRNOT00000050173
olfactory receptor 631
chr8_+_82038967 0.45 ENSRNOT00000079535
myosin VA
chr6_-_125812517 0.44 ENSRNOT00000007061
thyroid hormone receptor interactor 11
chr20_+_572454 0.43 ENSRNOT00000061839
olfactory receptor 1684
chr1_+_88586837 0.42 ENSRNOT00000080555
zinc finger protein 382
chr15_-_43542939 0.42 ENSRNOT00000012996
dihydropyrimidinase-like 2
chr7_+_25919867 0.36 ENSRNOT00000009625
ENSRNOT00000090153
RIC8 guanine nucleotide exchange factor B
chr1_+_170887363 0.36 ENSRNOT00000036261
olfactory receptor 215
chr2_-_221099738 0.35 ENSRNOT00000022947
sorting nexin 7
chr11_-_87485833 0.31 ENSRNOT00000079948

chr3_+_16311578 0.27 ENSRNOT00000010341
olfactory receptor 409
chr1_-_171979933 0.24 ENSRNOT00000026744
cytochrome b5 reductase 2
chr10_+_34672726 0.17 ENSRNOT00000043058
olfactory receptor 1394

Network of associatons between targets according to the STRING database.

First level regulatory network of Ddit3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 28.8 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
8.4 25.2 GO:0018924 mandelate metabolic process(GO:0018924)
5.5 16.5 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) phospholipase D-activating G-protein coupled receptor signaling pathway(GO:0031583)
3.1 9.3 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
3.0 6.0 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
2.9 11.5 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
2.5 9.8 GO:0051586 positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
2.2 6.7 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
2.1 6.3 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
2.0 9.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.9 5.8 GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
1.8 12.4 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
1.8 7.0 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.7 13.8 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
1.4 5.8 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.2 9.9 GO:0006751 glutathione catabolic process(GO:0006751)
1.2 4.8 GO:0006004 fucose metabolic process(GO:0006004)
1.2 4.7 GO:0051643 endoplasmic reticulum localization(GO:0051643)
1.1 13.8 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
1.1 12.4 GO:0071318 cellular response to ATP(GO:0071318)
1.1 3.2 GO:0060974 cell migration involved in heart formation(GO:0060974)
1.0 10.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
1.0 9.3 GO:0046449 allantoin metabolic process(GO:0000255) isoleucine metabolic process(GO:0006549) creatine metabolic process(GO:0006600) creatinine metabolic process(GO:0046449)
1.0 3.9 GO:1990375 baculum development(GO:1990375)
1.0 10.6 GO:0071315 cellular response to morphine(GO:0071315)
0.9 2.7 GO:0006552 leucine catabolic process(GO:0006552)
0.9 7.2 GO:0015808 L-alanine transport(GO:0015808)
0.9 3.5 GO:0072709 cellular response to sorbitol(GO:0072709)
0.9 12.8 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955) negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.8 10.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.8 5.4 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.8 3.8 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.7 4.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.7 6.9 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.7 8.5 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.6 14.9 GO:0032098 regulation of appetite(GO:0032098)
0.6 18.0 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.6 14.8 GO:0030502 negative regulation of bone mineralization(GO:0030502) positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.6 4.8 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.6 1.8 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.6 1.1 GO:0010979 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369)
0.5 19.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 2.4 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.5 3.7 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.4 12.0 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.4 4.0 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.4 2.1 GO:0001555 oocyte growth(GO:0001555)
0.4 6.3 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.3 4.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.3 2.3 GO:1990822 arginine transmembrane transport(GO:1903826) basic amino acid transmembrane transport(GO:1990822)
0.3 7.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 4.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.3 9.1 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.3 0.8 GO:0032197 transposition, RNA-mediated(GO:0032197)
0.3 2.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.3 1.3 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.2 34.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 0.9 GO:0044268 multicellular organismal protein metabolic process(GO:0044268) malonyl-CoA biosynthetic process(GO:2001295)
0.2 1.6 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 6.0 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.2 3.4 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.2 2.4 GO:0000338 protein deneddylation(GO:0000338)
0.2 2.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.2 2.4 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.2 4.1 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 2.9 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 28.2 GO:0008360 regulation of cell shape(GO:0008360)
0.2 1.9 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.2 2.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.2 8.0 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 1.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 2.1 GO:0015671 oxygen transport(GO:0015671)
0.1 10.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.8 GO:0051205 protein insertion into membrane(GO:0051205)
0.1 0.9 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.6 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.1 0.8 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 6.5 GO:0042220 response to cocaine(GO:0042220)
0.1 2.8 GO:0030517 negative regulation of axon extension(GO:0030517)
0.1 1.4 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 1.3 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.1 1.7 GO:0006298 mismatch repair(GO:0006298)
0.0 9.2 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 12.1 GO:0016358 dendrite development(GO:0016358)
0.0 0.8 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 49.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 10.4 GO:0006790 sulfur compound metabolic process(GO:0006790)
0.0 0.4 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413)
0.0 4.6 GO:0016236 macroautophagy(GO:0016236)
0.0 1.4 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807)
0.0 0.9 GO:0014823 response to activity(GO:0014823)
0.0 8.6 GO:0008284 positive regulation of cell proliferation(GO:0008284)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 28.2 GO:0033269 internode region of axon(GO:0033269)
2.5 12.4 GO:0005927 muscle tendon junction(GO:0005927)
2.2 6.7 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
1.9 9.3 GO:0070195 growth hormone receptor complex(GO:0070195)
1.6 4.7 GO:0042642 actomyosin, myosin complex part(GO:0042642)
1.4 12.4 GO:0031209 SCAR complex(GO:0031209)
1.4 18.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.3 3.8 GO:1990037 Lewy body core(GO:1990037)
1.3 6.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.9 4.3 GO:1990130 Iml1 complex(GO:1990130)
0.8 28.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017) spindle midzone(GO:0051233)
0.6 1.7 GO:0005713 recombination nodule(GO:0005713) MutSalpha complex(GO:0032301)
0.4 18.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 11.5 GO:0097225 sperm midpiece(GO:0097225)
0.4 1.3 GO:1990879 CST complex(GO:1990879)
0.4 3.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 9.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 5.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.3 9.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.3 2.4 GO:0005577 fibrinogen complex(GO:0005577)
0.3 5.8 GO:0043196 varicosity(GO:0043196)
0.3 3.4 GO:0030914 STAGA complex(GO:0030914)
0.3 3.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 11.8 GO:0005801 cis-Golgi network(GO:0005801)
0.2 35.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 2.1 GO:0042587 glycogen granule(GO:0042587)
0.2 5.8 GO:0030673 axolemma(GO:0030673)
0.2 11.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 2.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 51.3 GO:0014069 postsynaptic density(GO:0014069)
0.1 0.9 GO:1990696 stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
0.1 27.6 GO:0043209 myelin sheath(GO:0043209)
0.1 7.0 GO:0005643 nuclear pore(GO:0005643)
0.1 4.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 3.4 GO:0030120 vesicle coat(GO:0030120)
0.1 16.2 GO:0005802 trans-Golgi network(GO:0005802)
0.1 8.0 GO:0005901 caveola(GO:0005901)
0.1 1.9 GO:0005839 proteasome core complex(GO:0005839)
0.1 6.1 GO:0070469 respiratory chain(GO:0070469)
0.1 8.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 19.1 GO:0005874 microtubule(GO:0005874)
0.1 1.8 GO:0098573 integral component of mitochondrial membrane(GO:0032592) intrinsic component of mitochondrial membrane(GO:0098573)
0.1 0.9 GO:0031430 M band(GO:0031430)
0.0 4.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 50.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 8.4 GO:0030141 secretory granule(GO:0030141)
0.0 2.4 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 4.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 9.0 GO:0043025 neuronal cell body(GO:0043025)
0.0 9.1 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.4 GO:0000502 proteasome complex(GO:0000502)
0.0 6.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 117.7 GO:0016021 integral component of membrane(GO:0016021)
0.0 1.7 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 25.2 GO:0052854 very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
5.5 16.5 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
3.7 14.8 GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
3.5 13.8 GO:0055100 adiponectin binding(GO:0055100)
3.4 10.1 GO:0004556 alpha-amylase activity(GO:0004556)
2.9 11.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
2.7 10.6 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
2.6 10.4 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
2.5 9.9 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
2.4 7.2 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
2.3 9.3 GO:0004903 growth hormone receptor activity(GO:0004903)
2.3 6.9 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
2.2 6.7 GO:0050567 amidase activity(GO:0004040) glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
2.1 10.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.9 9.3 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
1.4 5.8 GO:0051870 methotrexate binding(GO:0051870)
1.3 28.8 GO:0043274 phospholipase binding(GO:0043274)
1.1 13.7 GO:0070097 delta-catenin binding(GO:0070097)
1.0 4.0 GO:0045174 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.9 9.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.9 18.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.9 10.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.9 14.9 GO:0001594 trace-amine receptor activity(GO:0001594)
0.8 2.4 GO:0008458 carnitine O-octanoyltransferase activity(GO:0008458) O-octanoyltransferase activity(GO:0016414)
0.8 3.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.7 5.4 GO:0004673 protein histidine kinase activity(GO:0004673)
0.7 13.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.7 6.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.6 9.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.6 2.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.6 2.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.5 3.7 GO:0016421 CoA carboxylase activity(GO:0016421)
0.4 5.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 13.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.4 7.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 9.8 GO:0008483 transaminase activity(GO:0008483)
0.3 2.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 4.4 GO:0008061 chitin binding(GO:0008061)
0.3 3.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 7.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 2.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.3 9.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 4.7 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.2 12.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 9.1 GO:0050681 androgen receptor binding(GO:0050681)
0.2 6.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 41.0 GO:0051015 actin filament binding(GO:0051015)
0.2 4.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 2.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 1.2 GO:0003924 GTPase activity(GO:0003924)
0.1 1.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 3.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 16.6 GO:0044325 ion channel binding(GO:0044325)
0.1 10.5 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 6.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 18.6 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 12.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 4.8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 8.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 49.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.3 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 11.6 GO:0005525 GTP binding(GO:0005525)
0.0 1.8 GO:0043022 ribosome binding(GO:0043022)
0.0 2.4 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.9 GO:0017022 myosin binding(GO:0017022)
0.0 2.2 GO:0005319 lipid transporter activity(GO:0005319)
0.0 1.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.7 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 7.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.8 GO:0003727 single-stranded RNA binding(GO:0003727)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 28.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 12.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.3 13.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 14.4 PID BMP PATHWAY BMP receptor signaling
0.3 13.3 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.2 5.4 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 9.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 3.4 PID MYC PATHWAY C-MYC pathway
0.1 2.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 4.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 4.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID FGF PATHWAY FGF signaling pathway
0.0 0.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
2.2 31.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
1.6 28.8 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.1 18.0 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.8 6.9 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.6 11.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.6 6.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.5 9.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.5 7.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.5 13.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.4 9.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.4 10.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3 5.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 4.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.3 5.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 9.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 6.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 4.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 5.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 2.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 4.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 5.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 3.8 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 2.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 4.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 6.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.9 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 1.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.9 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 1.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling