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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Ddit3
Z-value: 0.86
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Transcription factors associated with Ddit3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ddit3 | rn6_v1_chr7_+_70580198_70580252 | -0.11 | 5.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_86297623 Show fit | 28.79 |
ENSRNOT00000067162
ENSRNOT00000081607 ENSRNOT00000085265 |
calcium/calmodulin-dependent protein kinase II beta |
|
| chr3_-_44086006 Show fit | 28.24 |
ENSRNOT00000034449
ENSRNOT00000082604 |
ermin |
|
| chr2_+_200793571 Show fit | 25.20 |
ENSRNOT00000091444
|
hydroxyacid oxidase 2 |
|
| chr16_-_49820235 Show fit | 23.13 |
ENSRNOT00000029628
|
sorbin and SH3 domain containing 2 |
|
| chr11_+_60073383 Show fit | 22.76 |
ENSRNOT00000087508
|
transgelin 3 |
|
| chr15_-_71779033 Show fit | 20.02 |
ENSRNOT00000017765
|
protocadherin 20 |
|
| chr10_-_83898527 Show fit | 17.96 |
ENSRNOT00000009815
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) |
|
| chrX_+_118084890 Show fit | 16.51 |
ENSRNOT00000065293
|
5-hydroxytryptamine receptor 2C |
|
| chr18_+_57654290 Show fit | 14.94 |
ENSRNOT00000025892
|
5-hydroxytryptamine receptor 4 |
|
| chr11_-_81717521 Show fit | 14.84 |
ENSRNOT00000058422
|
alpha-2-HS-glycoprotein |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ddit3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 49.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 34.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 9.6 | 28.8 | GO:0032430 | positive regulation of phospholipase A2 activity(GO:0032430) |
| 0.2 | 28.2 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 8.4 | 25.2 | GO:0018924 | mandelate metabolic process(GO:0018924) |
| 0.5 | 19.4 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.6 | 18.0 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 5.5 | 16.5 | GO:0007208 | phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) phospholipase D-activating G-protein coupled receptor signaling pathway(GO:0031583) |
| 0.6 | 14.9 | GO:0032098 | regulation of appetite(GO:0032098) |
| 0.6 | 14.8 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 117.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 51.3 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 50.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 35.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.8 | 28.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) spindle midzone(GO:0051233) |
| 4.7 | 28.2 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 27.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 19.1 | GO:0005874 | microtubule(GO:0005874) |
| 0.4 | 18.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 1.4 | 18.0 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 49.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 41.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.3 | 28.8 | GO:0043274 | phospholipase binding(GO:0043274) |
| 8.4 | 25.2 | GO:0052854 | very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854) |
| 0.1 | 18.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.9 | 18.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.1 | 16.6 | GO:0044325 | ion channel binding(GO:0044325) |
| 5.5 | 16.5 | GO:0071886 | 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886) |
| 0.9 | 14.9 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 3.7 | 14.8 | GO:0030294 | receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 28.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.3 | 14.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.3 | 13.3 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.3 | 13.2 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.3 | 12.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 9.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 5.4 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 5.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 31.5 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 1.6 | 28.8 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 1.1 | 18.0 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.5 | 13.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 2.9 | 11.5 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.6 | 11.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 10.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.5 | 9.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.2 | 9.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.4 | 9.3 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |