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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Cux1
Z-value: 1.76
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Transcription factors associated with Cux1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cux1 | rn6_v1_chr12_+_23151180_23151180 | -0.75 | 4.6e-58 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_83744238 Show fit | 73.62 |
ENSRNOT00000028249
|
cytochrome P450, family 2, subfamily a, polypeptide 1 |
|
| chr1_-_148119857 Show fit | 73.40 |
ENSRNOT00000040325
|
Cytochrome P450, family 2, subfamily c, polypeptide 7-like |
|
| chr14_+_22375955 Show fit | 64.22 |
ENSRNOT00000063915
ENSRNOT00000034784 |
UDP-glucuronosyltransferase 2 family, member 37 |
|
| chr17_+_9736786 Show fit | 63.05 |
ENSRNOT00000081920
|
coagulation factor XII |
|
| chr5_-_78985990 Show fit | 57.22 |
ENSRNOT00000009248
|
alpha-1-microglobulin/bikunin precursor |
|
| chr14_+_20266891 Show fit | 55.97 |
ENSRNOT00000004174
|
group specific component |
|
| chr1_+_83711251 Show fit | 54.26 |
ENSRNOT00000028237
ENSRNOT00000092008 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
|
| chr2_+_23289374 Show fit | 53.46 |
ENSRNOT00000090666
ENSRNOT00000032783 |
dimethylglycine dehydrogenase |
|
| chr4_-_161850875 Show fit | 53.17 |
ENSRNOT00000009467
|
pregnancy-zone protein |
|
| chr15_+_18451144 Show fit | 51.56 |
ENSRNOT00000010260
|
acyl-CoA oxidase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Cux1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 254.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 6.7 | 133.2 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 18.3 | 127.9 | GO:0009804 | coumarin metabolic process(GO:0009804) |
| 36.4 | 109.2 | GO:0002254 | kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 6.4 | 70.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.3 | 65.7 | GO:0006790 | sulfur compound metabolic process(GO:0006790) |
| 4.9 | 64.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 6.4 | 64.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 4.4 | 61.2 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 5.8 | 57.9 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 361.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 292.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 184.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.0 | 124.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 113.6 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 14.0 | 98.1 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.3 | 80.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 72.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 11.7 | 70.2 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.1 | 58.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.2 | 335.3 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) |
| 0.2 | 255.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.8 | 197.2 | GO:0017171 | serine hydrolase activity(GO:0017171) |
| 6.2 | 192.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 20.0 | 79.8 | GO:0004027 | alcohol sulfotransferase activity(GO:0004027) |
| 2.8 | 67.3 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 15.6 | 62.4 | GO:0047023 | androsterone dehydrogenase activity(GO:0047023) |
| 11.4 | 57.2 | GO:0019862 | IgA binding(GO:0019862) |
| 9.3 | 56.0 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.6 | 54.9 | GO:0005496 | steroid binding(GO:0005496) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 343.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 3.3 | 70.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.3 | 49.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 37.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 27.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.9 | 20.7 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.2 | 15.9 | PID P73PATHWAY | p73 transcription factor network |
| 0.8 | 15.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.3 | 14.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.3 | 14.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 160.8 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.9 | 151.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 7.1 | 148.1 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 4.6 | 97.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | Genes involved in Synthesis of bile acids and bile salts |
| 5.1 | 97.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.8 | 71.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 2.5 | 66.2 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.7 | 57.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 1.6 | 53.2 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 2.1 | 49.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |