ISMARA results: Ctcfl

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ctcfl_Ctcf

Z-value: 1.15

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Transcription factors associated with Ctcfl_Ctcf

Gene Symbol	Gene ID	Gene Info
Ctcfl NCBI RGD Ensembl	ENSRNOG00000028661	CCCTC-binding factor like
Ctcf NCBI RGD Ensembl	ENSRNOG00000017674	CCCTC-binding factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Ctcf	rn6_v1_chr19_+_37600148_37600148	0.16	4.2e-03	Click!
Ctcfl	rn6_v1_chr3_-_171166454_171166454	-0.13	2.2e-02	Click!

Activity profile of Ctcfl_Ctcf motif

Sorted Z-values of Ctcfl_Ctcf motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_41482728 Show fit	73.62	ENSRNOT00000022943	Calb2 NCBI RGD Ensembl Show fit	calbindin 2
chr3_-_11382004 Show fit	59.90	ENSRNOT00000047921 ENSRNOT00000064039	Dnm1 NCBI RGD Ensembl Show fit	dynamin 1
chr3_-_52510507 Show fit	57.80	ENSRNOT00000091259	Scn1a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 1
chr14_+_83752393 Show fit	57.32	ENSRNOT00000081123	Selenom NCBI RGD Ensembl Show fit	selenoprotein M
chr3_+_51687809 Show fit	55.89	ENSRNOT00000087242	Scn2a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 2
chr9_-_32019205 Show fit	44.96	ENSRNOT00000016194	Adgrb3 NCBI RGD Ensembl Show fit	adhesion G protein-coupled receptor B3
chr3_-_51643140 Show fit	44.85	ENSRNOT00000006646	Scn3a NCBI RGD Ensembl Show fit	sodium voltage-gated channel alpha subunit 3
chr1_-_89483988 Show fit	44.55	ENSRNOT00000028603	Fxyd7 NCBI RGD Ensembl Show fit	FXYD domain-containing ion transport regulator 7
chr11_+_36851038 Show fit	43.86	ENSRNOT00000002221 ENSRNOT00000061047	Pcp4 NCBI RGD Ensembl Show fit	Purkinje cell protein 4
chr18_+_30004565 Show fit	43.57	ENSRNOT00000027393	Pcdha4 NCBI RGD Ensembl Show fit	protocadherin alpha 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Ctcfl_Ctcf

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	316.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	80.0	GO:0043547	positive regulation of GTPase activity(GO:0043547)
8.6	59.9	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
7.5	59.8	GO:0035934	corticosterone secretion(GO:0035934)
5.8	57.8	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
7.0	55.9	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
6.1	49.0	GO:0090258	negative regulation of mitochondrial fission(GO:0090258) regulation of cellular response to heat(GO:1900034)
9.0	45.0	GO:0061743	motor learning(GO:0061743)
4.5	44.8	GO:0046684	response to pyrethroid(GO:0046684)
0.9	44.5	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)

Showing 1 to 10 of 232 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	365.0	GO:0005887	integral component of plasma membrane(GO:0005887)
7.9	158.5	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	123.1	GO:0016021	integral component of membrane(GO:0016021)
0.5	108.1	GO:0070382	exocytic vesicle(GO:0070382)
4.1	81.4	GO:0043196	varicosity(GO:0043196)
0.3	74.0	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
2.3	73.6	GO:0005921	gap junction(GO:0005921)
12.2	49.0	GO:0045298	tubulin complex(GO:0045298)
3.0	47.8	GO:0005883	neurofilament(GO:0005883)
1.2	47.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)

Showing 1 to 10 of 123 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	385.4	GO:0005509	calcium ion binding(GO:0005509)
0.6	161.2	GO:0005096	GTPase activator activity(GO:0005096)
5.7	158.5	GO:0031402	sodium ion binding(GO:0031402)
13.6	81.5	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.3	52.4	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
12.2	49.0	GO:0099609	microtubule lateral binding(GO:0099609)
0.9	41.6	GO:0017080	sodium channel regulator activity(GO:0017080)
0.9	33.4	GO:0001540	beta-amyloid binding(GO:0001540)
0.7	30.9	GO:0008307	structural constituent of muscle(GO:0008307)
7.6	30.6	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)

Showing 1 to 10 of 153 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	70.5	PID RAS PATHWAY	Regulation of Ras family activation
3.8	49.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
1.8	47.5	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	41.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.9	30.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.4	25.7	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.9	23.2	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.4	23.2	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.5	18.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.5	17.0	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.7	59.9	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
1.7	55.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.8	52.9	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.9	44.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.2	41.3	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.6	32.1	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.9	28.0	REACTOME KINESINS	Genes involved in Kinesins
0.9	24.9	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
1.6	24.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
1.0	24.3	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor

Showing 1 to 10 of 62 entries

Results for Ctcfl_Ctcf

Z-value: 1.15

Motif logo

Transcription factors associated with Ctcfl_Ctcf

Activity-expression correlation:

Activity profile of Ctcfl_Ctcf motif

Sorted Z-values of Ctcfl_Ctcf motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ctcfl_Ctcf

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: