ISMARA results: Creb3l2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Creb3l2

Z-value: 0.79

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Transcription factors associated with Creb3l2

Gene Symbol	Gene ID	Gene Info
Creb3l2 NCBI RGD Ensembl	ENSRNOG00000012826	cAMP responsive element binding protein 3-like 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Creb3l2	rn6_v1_chr4_-_64981384_64981384	0.37	7.1e-12	Click!

Activity profile of Creb3l2 motif

Sorted Z-values of Creb3l2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_73270308 Show fit	30.59	ENSRNOT00000007430	Rida NCBI RGD Ensembl Show fit	reactive intermediate imine deaminase A homolog
chr3_-_10375826 Show fit	27.81	ENSRNOT00000093365	Ass1 NCBI RGD Ensembl Show fit	argininosuccinate synthase 1
chr9_+_80118029 Show fit	27.09	ENSRNOT00000023068	Igfbp2 NCBI RGD Ensembl Show fit	insulin-like growth factor binding protein 2
chrX_-_138435391 Show fit	25.05	ENSRNOT00000043258	Mbnl3 NCBI RGD Ensembl Show fit	muscleblind-like splicing regulator 3
chr3_+_114176309 Show fit	23.23	ENSRNOT00000023350	Sord NCBI RGD Ensembl Show fit	sorbitol dehydrogenase
chr11_-_70499200 Show fit	22.86	ENSRNOT00000002439	Slc12a8 NCBI RGD Ensembl Show fit	solute carrier family 12, member 8
chr10_+_88459490 Show fit	19.22	ENSRNOT00000080231 ENSRNOT00000067559	Ttc25 NCBI RGD Ensembl Show fit	tetratricopeptide repeat domain 25
chr20_-_10386663 Show fit	17.74	ENSRNOT00000045275 ENSRNOT00000042432	Cbs NCBI RGD Ensembl Show fit	cystathionine beta synthase
chr7_+_141249044 Show fit	15.63	ENSRNOT00000084911	Aqp5 NCBI RGD Ensembl Show fit	aquaporin 5
chr1_+_15620653 Show fit	15.19	ENSRNOT00000017401	Map7 NCBI RGD Ensembl Show fit	microtubule-associated protein 7

Showing 1 to 10 of 106 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.2	33.6	GO:0006059	hexitol metabolic process(GO:0006059)
3.1	30.6	GO:0070314	G1 to G0 transition(GO:0070314)
0.2	30.1	GO:0006821	chloride transport(GO:0006821)
9.3	27.8	GO:0000053	argininosuccinate metabolic process(GO:0000053)
1.0	27.1	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.9	25.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.7	23.3	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
5.9	17.7	GO:0070814	cysteine biosynthetic process via cystathionine(GO:0019343) hydrogen sulfide biosynthetic process(GO:0070814)
2.2	15.6	GO:0015670	carbon dioxide transport(GO:0015670)
0.8	15.2	GO:0033327	Leydig cell differentiation(GO:0033327)

Showing 1 to 10 of 68 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.8	GO:0045177	apical part of cell(GO:0045177)
1.7	27.8	GO:0070852	cell body fiber(GO:0070852)
0.2	25.9	GO:0030139	endocytic vesicle(GO:0030139)
0.1	23.2	GO:0031514	motile cilium(GO:0031514)
0.1	20.9	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
1.3	17.6	GO:0030127	COPII vesicle coat(GO:0030127)
0.2	16.6	GO:0030667	secretory granule membrane(GO:0030667)
0.3	14.5	GO:0009925	basal plasma membrane(GO:0009925)
0.0	13.3	GO:0005743	mitochondrial inner membrane(GO:0005743)
1.1	12.9	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)

Showing 1 to 10 of 40 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	30.6	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
3.3	29.8	GO:0031995	insulin-like growth factor II binding(GO:0031995)
1.5	27.8	GO:0015643	toxic substance binding(GO:0015643)
0.2	25.9	GO:0030165	PDZ domain binding(GO:0030165)
1.9	22.9	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	20.9	GO:0008270	zinc ion binding(GO:0008270)
2.5	17.7	GO:1904047	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661) S-adenosyl-L-methionine binding(GO:1904047)
1.1	15.6	GO:0015250	water channel activity(GO:0015250)
0.4	14.3	GO:0031492	nucleosomal DNA binding(GO:0031492)
1.3	12.9	GO:1990239	steroid hormone binding(GO:1990239)

Showing 1 to 10 of 55 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	27.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	25.9	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.4	18.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.5	9.0	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	8.2	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	6.7	PID BMP PATHWAY	BMP receptor signaling
0.3	6.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	6.1	PID PLK1 PATHWAY	PLK1 signaling events
0.1	3.4	PID BARD1 PATHWAY	BARD1 signaling events
0.0	1.8	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	27.1	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	25.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	17.8	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.6	17.7	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
1.3	15.6	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.3	12.9	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	12.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.8	12.1	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.7	9.7	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.5	9.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Showing 1 to 10 of 25 entries

Results for Creb3l2

Z-value: 0.79

Motif logo

Transcription factors associated with Creb3l2

Activity-expression correlation:

Activity profile of Creb3l2 motif

Sorted Z-values of Creb3l2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: