ISMARA results: Creb1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Creb1

Z-value: 1.32

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Transcription factors associated with Creb1

Gene Symbol	Gene ID	Gene Info
Creb1 NCBI RGD Ensembl	ENSRNOG00000013412	cAMP responsive element binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Creb1	rn6_v1_chr9_+_71230108_71230108	0.47	3.7e-19	Click!

Activity profile of Creb1 motif

Sorted Z-values of Creb1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_132032944 Show fit	30.09	ENSRNOT00000089278	Kif15 NCBI RGD Ensembl Show fit	kinesin family member 15
chr9_-_10757720 Show fit	22.03	ENSRNOT00000083848	Uhrf1 NCBI RGD Ensembl Show fit	ubiquitin-like with PHD and ring finger domains 1
chr1_-_219863926 Show fit	18.70	ENSRNOT00000026454 ENSRNOT00000066455	Rce1 NCBI RGD Ensembl Show fit	Ras converting CAAX endopeptidase 1
chr12_+_504007 Show fit	18.37	ENSRNOT00000001475	Brca2 NCBI RGD Ensembl Show fit	BRCA2, DNA repair associated
chr1_+_221448661 Show fit	17.92	ENSRNOT00000072493	LOC100910252 NCBI RGD Ensembl Show fit	sororin-like
chrX_+_105147153 Show fit	17.49	ENSRNOT00000088172	Cenpi NCBI RGD Ensembl Show fit	centromere protein I
chr19_-_56731372 Show fit	17.12	ENSRNOT00000024182	Nup133 NCBI RGD Ensembl Show fit	nucleoporin 133
chr7_-_28040510 Show fit	16.95	ENSRNOT00000005674	Ascl1 NCBI RGD Ensembl Show fit	achaete-scute family bHLH transcription factor 1
chr6_+_144156175 Show fit	16.55	ENSRNOT00000006582	Esyt2 NCBI RGD Ensembl Show fit	extended synaptotagmin 2
chr6_-_27080856 Show fit	16.46	ENSRNOT00000012512	Cenpa NCBI RGD Ensembl Show fit	centromere protein A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	31.6	GO:0051382	kinetochore assembly(GO:0051382)
2.3	29.7	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.8	29.7	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.4	23.5	GO:0002181	cytoplasmic translation(GO:0002181)
2.8	22.0	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.4	19.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
6.2	18.7	GO:0071586	CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
2.6	18.5	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
6.1	18.4	GO:0043060	meiotic metaphase I plate congression(GO:0043060) microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
1.6	17.5	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)

Showing 1 to 10 of 156 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	44.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	28.3	GO:0016607	nuclear speck(GO:0016607)
0.6	27.4	GO:0000791	euchromatin(GO:0000791)
0.1	27.3	GO:0005819	spindle(GO:0005819)
0.5	22.8	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.1	22.3	GO:0005840	ribosome(GO:0005840)
3.2	19.4	GO:0005642	annulate lamellae(GO:0005642)
2.2	19.4	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
2.1	18.5	GO:0000813	ESCRT I complex(GO:0000813)
0.9	18.4	GO:0000800	lateral element(GO:0000800)

Showing 1 to 10 of 105 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	135.4	GO:0003723	RNA binding(GO:0003723)
0.4	33.3	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
1.0	25.8	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
4.2	25.4	GO:0009378	four-way junction helicase activity(GO:0009378)
0.4	25.4	GO:0019843	rRNA binding(GO:0019843)
0.6	23.8	GO:0004532	exoribonuclease activity(GO:0004532)
5.5	22.0	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
0.2	18.9	GO:0003777	microtubule motor activity(GO:0003777)
6.1	18.4	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.1	18.2	GO:0003713	transcription coactivator activity(GO:0003713)

Showing 1 to 10 of 112 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	34.8	PID FOXM1 PATHWAY	FOXM1 transcription factor network
1.2	25.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4	22.7	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.3	18.6	PID P53 REGULATION PATHWAY	p53 pathway
0.3	18.0	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.3	15.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.9	14.6	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3	13.7	PID FANCONI PATHWAY	Fanconi anemia pathway
0.2	12.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.3	12.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	49.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.4	39.7	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
2.1	34.9	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.8	34.0	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.0	30.2	REACTOME KINESINS	Genes involved in Kinesins
1.0	24.9	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.6	22.9	REACTOME RNA POL III TRANSCRIPTION	Genes involved in RNA Polymerase III Transcription
2.1	18.5	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.8	17.6	REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	Genes involved in Transport of Mature Transcript to Cytoplasm
0.1	17.0	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway

Showing 1 to 10 of 50 entries

Results for Creb1

Z-value: 1.32

Motif logo

Transcription factors associated with Creb1

Activity-expression correlation:

Activity profile of Creb1 motif

Sorted Z-values of Creb1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: