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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Creb1

Z-value: 1.32

Motif logo

Transcription factors associated with Creb1

Gene Symbol Gene ID Gene Info
ENSRNOG00000013412 cAMP responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Creb1rn6_v1_chr9_+_71230108_712301080.473.7e-19Click!

Activity profile of Creb1 motif

Sorted Z-values of Creb1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_132032944 30.09 ENSRNOT00000089278
kinesin family member 15
chr9_-_10757720 22.03 ENSRNOT00000083848
ubiquitin-like with PHD and ring finger domains 1
chr1_-_219863926 18.70 ENSRNOT00000026454
ENSRNOT00000066455
Ras converting CAAX endopeptidase 1
chr12_+_504007 18.37 ENSRNOT00000001475
BRCA2, DNA repair associated
chr1_+_221448661 17.92 ENSRNOT00000072493
sororin-like
chrX_+_105147153 17.49 ENSRNOT00000088172
centromere protein I
chr19_-_56731372 17.12 ENSRNOT00000024182
nucleoporin 133
chr7_-_28040510 16.95 ENSRNOT00000005674
achaete-scute family bHLH transcription factor 1
chr6_+_144156175 16.55 ENSRNOT00000006582
extended synaptotagmin 2
chr6_-_27080856 16.46 ENSRNOT00000012512
centromere protein A
chr17_+_18358712 16.06 ENSRNOT00000001979
nucleoporin 153
chr10_-_104482838 15.81 ENSRNOT00000007246
RecQ like helicase 5
chr1_+_29915443 15.09 ENSRNOT00000065677
centromere protein W
chr3_-_150073721 14.61 ENSRNOT00000022428
E2F transcription factor 1
chr1_-_219412816 14.57 ENSRNOT00000083204
ENSRNOT00000029580
ribosomal protein S6 kinase B2
chr10_-_85725429 13.25 ENSRNOT00000005471
ribosomal protein L23
chr10_-_103826448 12.82 ENSRNOT00000085636
ferredoxin reductase
chr1_+_220325352 12.18 ENSRNOT00000027258
breast cancer metastasis-suppressor 1 homolog
chr14_+_1469748 12.14 ENSRNOT00000071648
protein phosphatase 2, regulatory subunit B'', beta
chr1_-_198450688 12.02 ENSRNOT00000027392
Paxip1-associated glutamate-rich protein 1
chr15_-_24056073 11.99 ENSRNOT00000015100
WD repeat and HMG-box DNA binding protein 1
chr6_+_52751106 11.94 ENSRNOT00000014373
TWIST neighbor
chr7_-_70452675 11.52 ENSRNOT00000090498

chr7_-_24004774 11.43 ENSRNOT00000007549
PWP1 homolog, endonuclein
chr7_+_70452579 11.38 ENSRNOT00000046099
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr3_-_176791960 11.31 ENSRNOT00000018237
glucocorticoid modulatory element binding protein 2
chr14_+_44524416 10.83 ENSRNOT00000038927
ribosomal protein L9
chr15_+_34431357 10.83 ENSRNOT00000027604
NOP9 nucleolar protein
chr8_-_49271834 10.80 ENSRNOT00000085022
ubiquitination factor E4A
chr6_+_51662224 10.80 ENSRNOT00000060006
coiled-coil domain containing 71-like
chr12_-_52072106 10.74 ENSRNOT00000088306
ENSRNOT00000068621
DEAD-box helicase 51
chr2_-_30340103 10.59 ENSRNOT00000024023
ENSRNOT00000067722
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr10_+_4536180 10.40 ENSRNOT00000003309
zinc finger CCCH type containing 7 A
chr5_+_127480485 10.35 ENSRNOT00000017422
mago homolog, exon junction complex core component
chr4_+_6827429 10.26 ENSRNOT00000071737
Ras homolog enriched in brain
chr11_-_47122095 10.18 ENSRNOT00000002194
ribosomal protein L24
chr14_+_44524753 10.10 ENSRNOT00000076245
ribosomal protein L9
chr13_+_103300932 9.99 ENSRNOT00000085214
ENSRNOT00000038264
glutamyl-prolyl-tRNA synthetase
chr20_-_4390436 9.95 ENSRNOT00000000497
ENSRNOT00000077655
palmitoyl-protein thioesterase 2
chr13_-_109629482 9.81 ENSRNOT00000072452
feline leukemia virus subgroup C cellular receptor 1
chr10_-_14072230 9.68 ENSRNOT00000018405
transducin (beta)-like 3
chr7_-_117773134 9.62 ENSRNOT00000045135
RecQ like helicase 4
chr12_-_37444282 9.59 ENSRNOT00000001368
general transcription factor IIH subunit 3
chr12_+_37984790 9.32 ENSRNOT00000001445
VPS37B, ESCRT-I subunit
chr7_+_27081667 9.21 ENSRNOT00000066143
nuclear transcription factor Y subunit beta
chr19_-_54722563 9.21 ENSRNOT00000025784
solute carrier family 7 member 5
chr2_-_28370261 9.17 ENSRNOT00000022259
UTP15, small subunit processome component
chr16_-_54899347 9.16 ENSRNOT00000016321
VPS37A, ESCRT-I subunit
chr10_-_55589978 9.11 ENSRNOT00000007087
phosphoribosylformylglycinamidine synthase-like
chr17_+_6840463 8.93 ENSRNOT00000061233
ubiquilin 1
chr8_-_115621394 8.91 ENSRNOT00000018995
RNA binding motif protein 15B
chr6_+_26560601 8.83 ENSRNOT00000077481
general transcription factor IIIC subunit 2
chr3_-_2490392 8.83 ENSRNOT00000014993
SS nuclear autoantigen 1
chr9_+_17120759 8.79 ENSRNOT00000025787
RNA polymerase I subunit C
chr7_-_116872511 8.77 ENSRNOT00000010120
zinc finger CCCH type containing 3
chr1_-_227002139 8.75 ENSRNOT00000028405
coiled-coil domain containing 86
chrX_-_1786978 8.68 ENSRNOT00000011317
RNA binding motif protein 10
chr1_-_89124132 8.67 ENSRNOT00000031044
HAUS augmin-like complex, subunit 5
chr10_-_64398294 8.64 ENSRNOT00000010386
glyoxalase domain containing 4
chr17_-_13586554 8.63 ENSRNOT00000041371
SECIS binding protein 2
chr4_+_118167294 8.41 ENSRNOT00000022367
similar to small nuclear ribonucleoprotein polypeptide G
chr20_+_4967194 8.37 ENSRNOT00000070846
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr20_-_5865775 8.28 ENSRNOT00000000612
ENSRNOT00000092641
SRSF protein kinase 1
chr10_+_103703404 8.20 ENSRNOT00000086469
RAB37, member RAS oncogene family
chrX_-_62698830 8.17 ENSRNOT00000076359
DNA polymerase alpha 1, catalytic subunit
chr12_+_52072188 8.16 ENSRNOT00000056725
nucleolar complex associated 4 homolog
chr19_+_37990374 8.08 ENSRNOT00000026827
dihydrouridine synthase 2
chr10_-_85709568 8.06 ENSRNOT00000005426
CWC25 spliceosome-associated protein homolog
chr8_+_132204604 8.04 ENSRNOT00000084725
exosome component 7
chr5_+_148320438 8.01 ENSRNOT00000018742
penta-EF hand domain containing 1
chr2_+_187302192 8.00 ENSRNOT00000015471
interferon stimulated exonuclease gene 20-like 2
chr8_+_69127708 7.91 ENSRNOT00000013490
small nuclear RNA activating complex, polypeptide 5
chr4_-_144620731 7.90 ENSRNOT00000066468
RAD18 E3 ubiquitin protein ligase
chr17_+_43946130 7.88 ENSRNOT00000023649
activator of basal transcription 1
chr14_+_2789650 7.82 ENSRNOT00000030479
family with sequence similarity 69, member A
chr7_-_31872423 7.80 ENSRNOT00000012715
thymopoietin
chr16_+_54899452 7.79 ENSRNOT00000016882
CCR4-NOT transcription complex, subunit 7
chr14_+_80361294 7.78 ENSRNOT00000011824
tRNA methyltransferase 44 homolog (S. cerevisiae)
chr15_+_47211583 7.73 ENSRNOT00000016027
PIN2/TERF1 interacting, telomerase inhibitor 1
chr1_+_221420271 7.67 ENSRNOT00000028481
similar to Finkel-Biskis-Reilly murine sarcoma virusubiquitously expressed
chr13_+_99136871 7.66 ENSRNOT00000078263
ENSRNOT00000004350
SDE2 telomere maintenance homolog
chr8_-_72714664 7.47 ENSRNOT00000024286
RAB8B, member RAS oncogene family
chr15_-_34431325 7.37 ENSRNOT00000027511
dehydrogenase/reductase 1
chr4_-_51946715 7.33 ENSRNOT00000079130
protection of telomeres 1
chr19_+_49695579 7.33 ENSRNOT00000016963
gigaxonin
chr2_+_27365148 7.32 ENSRNOT00000021549
collagen type IV alpha 3 binding protein
chr3_+_7884822 7.31 ENSRNOT00000019157
mediator complex subunit 27
chr6_-_1622196 7.29 ENSRNOT00000007492
protein kinase D3
chr16_-_32439421 7.20 ENSRNOT00000043100
NIMA-related kinase 1
chr2_-_38208719 7.19 ENSRNOT00000019189
kinesin family member 2A
chr9_+_66045962 7.09 ENSRNOT00000058491
similar to 40S ribosomal protein S2
chr8_-_117811975 7.07 ENSRNOT00000028055
ATR interacting protein
chr1_+_224957517 7.06 ENSRNOT00000026033
nuclear RNA export factor 1
chr6_-_96171629 7.06 ENSRNOT00000010546
ENSRNOT00000078190
tRNA methyltransferase 5
chr19_+_55300395 7.00 ENSRNOT00000092169
cytosolic thiouridylase subunit 2
chr4_+_5841998 6.99 ENSRNOT00000010025
X-ray repair cross complementing 2
chr8_-_118436894 6.94 ENSRNOT00000073395
ATR-interacting protein-like
chr20_+_4966817 6.91 ENSRNOT00000081527
ENSRNOT00000081265
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr5_-_57632177 6.80 ENSRNOT00000080787
ENSRNOT00000092581
ubiquitin-associated protein 2
chr1_-_64162461 6.76 ENSRNOT00000091739
pre-mRNA processing factor 31
chr11_-_64752544 6.60 ENSRNOT00000048738
transmembrane protein 39a
chr5_+_117583502 6.58 ENSRNOT00000010933
ubiquitin specific peptidase 1
chr7_-_60416925 6.53 ENSRNOT00000008193
cleavage and polyadenylation specific factor 6
chr2_-_104133985 6.48 ENSRNOT00000088167
ENSRNOT00000067725
phosphodiesterase 7A
chr9_+_15393330 6.42 ENSRNOT00000075630
bystin-like
chr4_+_100209951 6.36 ENSRNOT00000015807
hypothetical protein LOC691113
chr14_+_44580216 6.18 ENSRNOT00000088674
ENSRNOT00000003907
replication factor C subunit 1
chr10_+_105861743 6.02 ENSRNOT00000064410
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr18_+_1142782 5.88 ENSRNOT00000046718
THO complex 1
chr3_-_111560556 5.73 ENSRNOT00000030532
leukocyte receptor tyrosine kinase
chr12_+_36871999 5.70 ENSRNOT00000001334
ENSRNOT00000084236
nuclear receptor co-repressor 2
chr17_+_6665659 5.62 ENSRNOT00000025980
heterogeneous nuclear ribonucleoprotein K
chr6_-_99400822 5.61 ENSRNOT00000089594
zinc finger and BTB domain containing 25
chr20_-_27308069 5.60 ENSRNOT00000056047
solute carrier family 25 member 16
chr11_+_61748883 5.59 ENSRNOT00000093552
queuine tRNA-ribosyltransferase accessory subunit 2
chr2_+_205553163 5.54 ENSRNOT00000039572
neuroblastoma RAS viral oncogene homolog
chr7_+_70328391 5.54 ENSRNOT00000075544
methyltransferase like 1
chr19_+_56272162 5.51 ENSRNOT00000030399
AFG3(ATPase family gene 3)-like 1 (S. cerevisiae)
chr7_-_126913585 5.47 ENSRNOT00000036025
cadherin, EGF LAG seven-pass G-type receptor 1
chr5_-_136023511 5.46 ENSRNOT00000081747
ribosomal protein S8
chr8_-_57830504 5.43 ENSRNOT00000017683
DEAD-box helicase 10
chr1_-_65551043 5.36 ENSRNOT00000029996
tripartite motif-containing 28
chr15_+_34520142 5.34 ENSRNOT00000074659
NYN domain and retroviral integrase containing
chr2_-_144007636 5.29 ENSRNOT00000092028
regulatory factor X-associated protein
chr7_-_137856485 5.22 ENSRNOT00000007003
similar to splicing factor, arginine/serine-rich 2, interacting protein
chr14_+_2100106 5.19 ENSRNOT00000000064
cyclin G associated kinase
chr19_-_55300403 5.15 ENSRNOT00000018591
ring finger protein 166
chr3_-_93698121 5.14 ENSRNOT00000012094
ENSRNOT00000044143
N-acetyltransferase 10
chr6_+_136150785 5.09 ENSRNOT00000078211
ENSRNOT00000015308
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
chr19_+_14346197 5.09 ENSRNOT00000043480
predicted gene, 18025
chr1_+_80028928 5.07 ENSRNOT00000012082
F-box protein 46
chr1_-_199159125 4.91 ENSRNOT00000025618
BCL tumor suppressor 7C
chr4_+_99399148 4.87 ENSRNOT00000088018
ring finger protein 103
chr10_+_104483042 4.85 ENSRNOT00000007362
SAP30 binding protein
chr3_+_138715570 4.85 ENSRNOT00000064723
Sec23 homolog B, coat complex II component
chr1_-_254671596 4.84 ENSRNOT00000025450
5-hydroxytryptamine receptor 7
chr18_+_72550219 4.84 ENSRNOT00000046847
SMAD family member 2
chr10_+_91200874 4.78 ENSRNOT00000004272
hexamethylene bis-acetamide inducible 1
chr2_+_264864351 4.77 ENSRNOT00000015434
leucine rich repeat containing 40
chr12_+_17277635 4.75 ENSRNOT00000001734
hypothetical protein LOC498154
chr12_-_46989876 4.73 ENSRNOT00000079043
ENSRNOT00000001534
TP53 regulated inhibitor of apoptosis 1
chr7_+_99677290 4.72 ENSRNOT00000086039
ENSRNOT00000005376
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
chr2_-_144217600 4.71 ENSRNOT00000000101
regulatory factor X-associated protein-like 1
chr14_+_100415668 4.69 ENSRNOT00000008057
C1D nuclear receptor co-repressor
chr1_-_89042176 4.63 ENSRNOT00000080842
lysine methyltransferase 2B
chr2_-_264864265 4.63 ENSRNOT00000044236
serine and arginine rich splicing factor 11
chr20_-_10257044 4.59 ENSRNOT00000068289
WD repeat domain 4
chr12_+_24669449 4.53 ENSRNOT00000044449
Williams Beuren syndrome chromosome region 22
chr12_-_47031498 4.52 ENSRNOT00000075320
TP53 regulated inhibitor of apoptosis 1
chr19_-_37990353 4.50 ENSRNOT00000026817
DEAD-box helicase 28
chr20_+_8325041 4.47 ENSRNOT00000000640
cap methyltransferase 1
chr1_-_242861767 4.46 ENSRNOT00000021185
COBW domain containing 1
chr17_-_10527839 4.43 ENSRNOT00000064477
ENSRNOT00000091837
Fas associated factor family member 2
chr6_+_135610743 4.39 ENSRNOT00000010906
Tnf receptor-associated factor 3
chr1_-_63293635 4.38 ENSRNOT00000090337
zinc finger protein interacting with K protein 1
chr7_-_99677268 4.27 ENSRNOT00000013315
similar to Hypothetical protein MGC31278
chr19_+_22569999 4.24 ENSRNOT00000022573
DnaJ heat shock protein family (Hsp40) member A2
chr9_-_17120677 4.12 ENSRNOT00000025769
Yip1 domain family, member 3
chr18_+_72550454 4.11 ENSRNOT00000092173
SMAD family member 2
chr2_-_27364906 4.10 ENSRNOT00000078639
DNA polymerase kappa
chr6_-_109692218 4.07 ENSRNOT00000012327
similar to HSPC288
chrX_-_45522665 3.92 ENSRNOT00000030771
similar to GS2 gene
chr3_-_110964452 3.90 ENSRNOT00000016356
regulator of microtubule dynamics 3
chr19_+_31867981 3.86 ENSRNOT00000024753
ATP binding cassette subfamily E member 1
chr9_+_82411013 3.82 ENSRNOT00000026194
serine/threonine kinase 16
chr10_+_38692211 3.71 ENSRNOT00000009440
AF4/FMR2 family, member 4
chr20_-_3299580 3.56 ENSRNOT00000050373
G protein nucleolar 1
chr12_-_2170504 3.50 ENSRNOT00000001309
XPA binding protein 2
chr19_-_31867850 3.49 ENSRNOT00000024689
anaphase promoting complex subunit 10
chr1_+_56982821 3.46 ENSRNOT00000059845
ER membrane-associated RNA degradation
chr1_-_190370499 3.44 ENSRNOT00000084389

chr3_+_58443101 3.41 ENSRNOT00000002075
integrin subunit alpha 6
chr2_+_196277978 3.41 ENSRNOT00000028625
vacuolar protein sorting 72 homolog
chr15_+_58170967 3.40 ENSRNOT00000001366
NUFIP1, FMR1 interacting protein 1
chr13_+_25778317 3.39 ENSRNOT00000021129
TNF receptor superfamily member 11A
chr20_+_28027054 3.36 ENSRNOT00000071386
ENSRNOT00000001044
RAN binding protein 2
chr8_+_114866768 3.32 ENSRNOT00000076731
WD repeat domain 82
chr2_-_211638788 3.27 ENSRNOT00000027666
syntaxin binding protein 3
chr11_+_87522971 3.25 ENSRNOT00000043545
sphingomyelin phosphodiesterase 4
chr20_-_3299420 3.14 ENSRNOT00000090999
G protein nucleolar 1
chr20_+_3299730 3.11 ENSRNOT00000078538
proline rich 3
chr11_-_86890390 3.04 ENSRNOT00000046183
tRNA methyltransferase 2 homolog A
chr19_+_43251539 3.02 ENSRNOT00000024793
DEAD-box helicase 19A
chr1_+_1897338 2.99 ENSRNOT00000021437
peptidylprolyl isomerase like 4
chrX_-_155862363 2.97 ENSRNOT00000089847
dyskerin pseudouridine synthase 1
chr20_+_6205903 2.94 ENSRNOT00000092333
ENSRNOT00000092655
potassium channel tetramerization domain containing 20
chr6_-_43493816 2.93 ENSRNOT00000077786
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chr3_+_112519808 2.90 ENSRNOT00000014129
RNA pseudouridylate synthase domain containing 2
chr5_+_144701949 2.87 ENSRNOT00000015618
proteasome subunit beta 2
chr3_-_13896838 2.87 ENSRNOT00000025399
F-box and WD repeat domain containing 2
chr10_+_55924938 2.84 ENSRNOT00000087003
ENSRNOT00000057079
trafficking protein particle complex 1
chr17_-_9695292 2.83 ENSRNOT00000036162
proline rich 7 (synaptic)
chr1_-_68269117 2.80 ENSRNOT00000072367
zinc finger protein interacting with ribonucleoprotein K-like
chr1_-_254671778 2.76 ENSRNOT00000025493
5-hydroxytryptamine receptor 7
chr7_+_117773230 2.76 ENSRNOT00000077562
leucine rich repeat containing 14
chr10_+_64398339 2.73 ENSRNOT00000056278
mitochondrial rRNA methyltransferase 3
chr3_+_111097326 2.69 ENSRNOT00000018717
VPS18 CORVET/HOPS core subunit
chr5_+_57291156 2.66 ENSRNOT00000060692
ENSRNOT00000060691
nuclear transcription factor, X-box binding 1
chr1_-_214163808 2.65 ENSRNOT00000082284
ribonuclease/angiogenin inhibitor 1
chr15_+_24056383 2.59 ENSRNOT00000015120
suppressor of cytokine signaling 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.7 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
6.1 18.4 GO:0043060 meiotic metaphase I plate congression(GO:0043060) microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
5.6 16.9 GO:0014016 neuroblast differentiation(GO:0014016) spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) medulla oblongata development(GO:0021550) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
3.3 10.0 GO:0006433 prolyl-tRNA aminoacylation(GO:0006433)
3.3 9.8 GO:0097037 heme export(GO:0097037)
3.2 15.8 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
3.1 9.3 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
3.0 8.9 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
2.9 14.6 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) lens fiber cell apoptotic process(GO:1990086)
2.9 8.6 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
2.9 31.6 GO:0051382 kinetochore assembly(GO:0051382)
2.8 22.0 GO:0010216 maintenance of DNA methylation(GO:0010216)
2.7 8.0 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
2.6 18.5 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
2.6 7.7 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
2.5 10.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
2.5 10.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
2.4 17.1 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
2.4 7.3 GO:0060383 positive regulation of DNA strand elongation(GO:0060383)
2.4 12.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
2.4 7.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
2.3 7.0 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
2.3 29.7 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
2.3 11.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
2.2 8.9 GO:1900224 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
2.2 8.8 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
2.0 8.2 GO:0006272 leading strand elongation(GO:0006272)
2.0 11.9 GO:0070827 chromatin maintenance(GO:0070827)
2.0 7.9 GO:0000966 RNA 5'-end processing(GO:0000966)
1.9 9.6 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
1.9 7.6 GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
1.9 13.3 GO:0072717 cellular response to actinomycin D(GO:0072717)
1.9 5.6 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
1.8 5.5 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
1.8 5.4 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
1.7 5.2 GO:0035622 intrahepatic bile duct development(GO:0035622)
1.6 11.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
1.6 17.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
1.5 4.5 GO:0036451 cap mRNA methylation(GO:0036451)
1.5 7.3 GO:0035627 ceramide transport(GO:0035627)
1.4 4.2 GO:0042196 chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
1.4 5.6 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.4 4.1 GO:0016129 phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129)
1.4 12.2 GO:2000210 positive regulation of anoikis(GO:2000210)
1.4 6.8 GO:0048254 snoRNA localization(GO:0048254)
1.3 8.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
1.3 5.1 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
1.3 10.3 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
1.3 12.8 GO:0070995 NADPH oxidation(GO:0070995)
1.3 3.8 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
1.2 7.5 GO:0051461 positive regulation of corticotropin secretion(GO:0051461)
1.2 9.9 GO:0098734 macromolecule depalmitoylation(GO:0098734)
1.2 7.3 GO:0089700 protein kinase D signaling(GO:0089700)
1.2 7.0 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) strand invasion(GO:0042148)
1.1 3.4 GO:0060086 circadian temperature homeostasis(GO:0060086)
1.1 4.5 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
1.0 6.1 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
1.0 2.0 GO:0036258 multivesicular body assembly(GO:0036258)
1.0 3.0 GO:0090669 telomerase RNA stabilization(GO:0090669)
1.0 2.0 GO:0010847 regulation of chromatin assembly(GO:0010847)
1.0 5.9 GO:0045829 negative regulation of isotype switching(GO:0045829) regulation of isotype switching to IgA isotypes(GO:0048296) negative regulation of DNA damage checkpoint(GO:2000002)
1.0 3.9 GO:0060701 negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702)
0.9 4.7 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.9 9.2 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.9 5.3 GO:0015074 DNA integration(GO:0015074)
0.8 8.7 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.8 29.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.7 8.2 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.7 5.6 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.7 14.6 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.7 3.4 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.7 12.9 GO:0030488 tRNA methylation(GO:0030488)
0.7 2.0 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.7 2.7 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.7 7.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.6 7.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.6 5.7 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.6 7.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.6 1.7 GO:1902953 endoplasmic reticulum membrane organization(GO:0090158) positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.5 1.6 GO:0007356 thorax and anterior abdomen determination(GO:0007356)
0.5 2.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.5 4.5 GO:2001138 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
0.5 5.5 GO:0034982 mitochondrial protein processing(GO:0034982)
0.5 4.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.5 8.0 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.5 3.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.4 5.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.4 19.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.4 7.9 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.4 16.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.4 15.0 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.4 23.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.4 6.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.4 3.4 GO:0010668 ectodermal cell differentiation(GO:0010668) nail development(GO:0035878)
0.4 3.5 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 3.5 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.3 3.8 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.3 1.3 GO:0046836 glycolipid transport(GO:0046836)
0.3 5.5 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.3 4.4 GO:0034389 lipid particle organization(GO:0034389)
0.3 5.7 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.3 2.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.3 9.9 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.3 3.3 GO:0022615 protein to membrane docking(GO:0022615) negative regulation of calcium ion-dependent exocytosis(GO:0045955)
0.3 0.8 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.3 9.1 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.3 6.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.3 4.8 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.2 8.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.2 4.7 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.2 5.2 GO:0001522 pseudouridine synthesis(GO:0001522)
0.2 4.8 GO:0001510 RNA methylation(GO:0001510)
0.2 2.1 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.2 9.2 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.2 14.0 GO:0000077 DNA damage checkpoint(GO:0000077)
0.2 2.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2 1.1 GO:0060486 Clara cell differentiation(GO:0060486)
0.2 12.1 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 3.4 GO:0043486 histone exchange(GO:0043486)
0.2 1.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.2 6.4 GO:0006378 mRNA polyadenylation(GO:0006378)
0.2 15.9 GO:0051225 spindle assembly(GO:0051225)
0.2 0.8 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.1 2.1 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 1.4 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.1 5.1 GO:0001825 blastocyst formation(GO:0001825)
0.1 3.9 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 8.3 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 1.0 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 3.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.7 GO:0032438 melanosome organization(GO:0032438) pigment granule organization(GO:0048753)
0.1 5.4 GO:0010043 response to zinc ion(GO:0010043)
0.1 4.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.3 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 3.4 GO:0006611 protein export from nucleus(GO:0006611)
0.1 2.4 GO:0048536 spleen development(GO:0048536)
0.1 8.0 GO:0042254 ribosome biogenesis(GO:0042254)
0.1 7.3 GO:0019827 stem cell population maintenance(GO:0019827)
0.1 0.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 2.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 10.6 GO:0008380 RNA splicing(GO:0008380)
0.0 2.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.3 GO:0003094 glomerular filtration(GO:0003094)
0.0 2.1 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.6 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 15.0 GO:0006974 cellular response to DNA damage stimulus(GO:0006974)
0.0 0.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 1.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.2 GO:0021762 substantia nigra development(GO:0021762)
0.0 7.0 GO:0072659 protein localization to plasma membrane(GO:0072659)
0.0 1.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.7 GO:0097421 liver regeneration(GO:0097421)
0.0 3.2 GO:0071560 cellular response to transforming growth factor beta stimulus(GO:0071560)
0.0 0.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 19.4 GO:0005642 annulate lamellae(GO:0005642)
3.2 9.6 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
3.1 15.3 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
3.0 15.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
2.4 14.6 GO:0035189 Rb-E2F complex(GO:0035189)
2.2 8.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
2.2 19.4 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
2.1 18.5 GO:0000813 ESCRT I complex(GO:0000813)
1.9 5.6 GO:0005760 gamma DNA polymerase complex(GO:0005760)
1.8 5.5 GO:0005745 m-AAA complex(GO:0005745)
1.7 17.1 GO:0031080 nuclear pore outer ring(GO:0031080)
1.7 16.5 GO:0042405 nuclear inclusion body(GO:0042405)
1.6 8.2 GO:0030689 Noc complex(GO:0030689)
1.6 9.7 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
1.5 18.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
1.4 7.0 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
1.3 9.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.3 16.5 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
1.3 15.2 GO:0005687 U4 snRNP(GO:0005687)
1.2 10.0 GO:0097452 GAIT complex(GO:0097452)
1.2 16.6 GO:0044232 organelle membrane contact site(GO:0044232)
1.0 6.2 GO:0005663 DNA replication factor C complex(GO:0005663)
1.0 8.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.9 6.5 GO:0042382 paraspeckles(GO:0042382)
0.9 12.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.9 12.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.9 18.4 GO:0000800 lateral element(GO:0000800)
0.9 8.7 GO:0070652 HAUS complex(GO:0070652)
0.8 3.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.8 3.3 GO:0005846 nuclear cap binding complex(GO:0005846)
0.7 7.3 GO:0070187 telosome(GO:0070187)
0.7 2.0 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.6 12.8 GO:0070822 Sin3-type complex(GO:0070822)
0.6 7.5 GO:0051286 cell tip(GO:0051286)
0.6 27.4 GO:0000791 euchromatin(GO:0000791)
0.6 3.0 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.6 4.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.6 5.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.6 8.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.5 4.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.5 22.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.5 44.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 7.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.4 0.4 GO:0055087 Ski complex(GO:0055087)
0.4 3.3 GO:0070820 tertiary granule(GO:0070820)
0.4 10.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.4 4.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.4 2.5 GO:0000796 condensin complex(GO:0000796)
0.3 2.0 GO:0090543 Flemming body(GO:0090543)
0.3 15.8 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.3 8.0 GO:0000178 exosome (RNase complex)(GO:0000178)
0.3 3.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.3 2.7 GO:0033263 CORVET complex(GO:0033263)
0.3 17.5 GO:0000776 kinetochore(GO:0000776)
0.3 7.2 GO:0000242 pericentriolar material(GO:0000242)
0.3 5.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 12.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.2 2.8 GO:0030008 TRAPP complex(GO:0030008)
0.2 5.1 GO:0030686 90S preribosome(GO:0030686)
0.2 4.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 7.2 GO:0097228 sperm principal piece(GO:0097228)
0.2 4.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 3.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 8.2 GO:0016592 mediator complex(GO:0016592)
0.2 3.4 GO:0030056 hemidesmosome(GO:0030056)
0.2 15.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 7.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 5.6 GO:0002102 podosome(GO:0002102)
0.1 6.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.7 GO:0005686 U2 snRNP(GO:0005686)
0.1 2.0 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 7.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 10.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 27.3 GO:0005819 spindle(GO:0005819)
0.1 9.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 2.9 GO:0005839 proteasome core complex(GO:0005839)
0.1 6.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 4.6 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 22.3 GO:0005840 ribosome(GO:0005840)
0.1 7.3 GO:0005581 collagen trimer(GO:0005581)
0.1 9.1 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 28.3 GO:0016607 nuclear speck(GO:0016607)
0.1 9.2 GO:0036064 ciliary basal body(GO:0036064)
0.1 6.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 3.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 2.3 GO:0016235 aggresome(GO:0016235)
0.1 3.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 7.8 GO:0001650 fibrillar center(GO:0001650)
0.1 10.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 7.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 3.7 GO:0005811 lipid particle(GO:0005811)
0.1 1.6 GO:0046930 pore complex(GO:0046930)
0.0 1.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 12.5 GO:0016604 nuclear body(GO:0016604)
0.0 7.3 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 17.7 GO:0005730 nucleolus(GO:0005730)
0.0 5.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 6.6 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 9.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 5.7 GO:0005925 focal adhesion(GO:0005925)
0.0 2.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.6 GO:0043204 perikaryon(GO:0043204)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.4 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
5.5 22.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
4.2 25.4 GO:0009378 four-way junction helicase activity(GO:0009378)
4.0 7.9 GO:0000403 Y-form DNA binding(GO:0000403)
3.6 14.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
3.3 10.0 GO:0004827 proline-tRNA ligase activity(GO:0004827)
2.6 10.6 GO:0001156 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIC-class transcription factor binding(GO:0001156)
2.2 8.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
2.2 13.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
2.2 15.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
2.0 18.1 GO:0001054 RNA polymerase I activity(GO:0001054)
2.0 17.6 GO:0043495 protein anchor(GO:0043495)
1.9 7.8 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
1.8 5.4 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
1.8 7.1 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
1.7 5.1 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
1.7 6.8 GO:0030622 U4atac snRNA binding(GO:0030622)
1.7 10.1 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
1.7 16.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
1.5 4.5 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
1.5 6.0 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
1.5 4.5 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
1.4 8.6 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
1.4 9.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
1.4 5.6 GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890)
1.3 8.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
1.3 3.9 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
1.2 7.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
1.2 8.2 GO:0003896 DNA primase activity(GO:0003896)
1.2 7.0 GO:0000150 recombinase activity(GO:0000150)
1.1 5.6 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
1.1 9.8 GO:0015232 heme transporter activity(GO:0015232)
1.1 6.5 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
1.0 25.8 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
1.0 10.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.9 7.5 GO:0030911 TPR domain binding(GO:0030911)
0.8 15.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.8 3.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.7 4.4 GO:0035473 lipase binding(GO:0035473)
0.7 5.6 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.7 3.4 GO:0038132 neuregulin binding(GO:0038132)
0.7 2.0 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.7 12.8 GO:0070402 NADPH binding(GO:0070402)
0.6 2.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.6 6.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.6 23.8 GO:0004532 exoribonuclease activity(GO:0004532)
0.5 3.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.5 7.6 GO:0051378 serotonin binding(GO:0051378)
0.5 8.1 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.5 16.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.5 10.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.4 25.4 GO:0019843 rRNA binding(GO:0019843)
0.4 11.4 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.4 12.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.4 7.8 GO:0005521 lamin binding(GO:0005521)
0.4 7.3 GO:0004697 protein kinase C activity(GO:0004697)
0.4 6.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.4 10.7 GO:0030515 snoRNA binding(GO:0030515)
0.4 33.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.3 8.8 GO:0070412 R-SMAD binding(GO:0070412)
0.3 13.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.3 3.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.3 5.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 8.0 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.3 16.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.3 4.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3 12.0 GO:0030331 estrogen receptor binding(GO:0030331)
0.3 6.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 18.9 GO:0003777 microtubule motor activity(GO:0003777)
0.2 9.2 GO:0042605 peptide antigen binding(GO:0042605)
0.2 5.2 GO:0030332 cyclin binding(GO:0030332)
0.2 1.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 4.4 GO:0031996 thioesterase binding(GO:0031996)
0.2 4.2 GO:0001671 ATPase activator activity(GO:0001671)
0.2 11.4 GO:0035064 methylated histone binding(GO:0035064)
0.2 12.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 4.8 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.2 9.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.2 3.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 1.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 2.5 GO:0019789 SUMO transferase activity(GO:0019789)
0.2 5.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 2.0 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 8.0 GO:0019003 GDP binding(GO:0019003)
0.1 2.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 2.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 10.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.8 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 18.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 135.4 GO:0003723 RNA binding(GO:0003723)
0.1 5.7 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 1.6 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.1 1.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 3.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.6 GO:0070888 E-box binding(GO:0070888)
0.1 6.8 GO:0030674 protein binding, bridging(GO:0030674)
0.1 7.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 2.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 6.9 GO:0001047 core promoter binding(GO:0001047)
0.0 3.3 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 4.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.3 GO:0030145 manganese ion binding(GO:0030145)
0.0 10.1 GO:0005525 GTP binding(GO:0005525)
0.0 15.4 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 2.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 2.0 GO:0042393 histone binding(GO:0042393)
0.0 5.0 GO:0045296 cadherin binding(GO:0045296)
0.0 2.1 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 25.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
1.0 7.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.9 14.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.8 34.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.5 5.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.4 22.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.3 18.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.3 15.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 3.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.3 18.6 PID P53 REGULATION PATHWAY p53 pathway
0.3 13.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 12.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 12.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 7.5 PID E2F PATHWAY E2F transcription factor network
0.2 6.2 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 4.4 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.2 10.3 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 7.2 PID PLK1 PATHWAY PLK1 signaling events
0.1 11.0 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 0.6 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 0.7 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 1.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID P73PATHWAY p73 transcription factor network
0.0 0.8 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 34.9 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
2.1 18.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
1.4 39.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
1.1 10.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
1.0 24.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
1.0 10.4 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
1.0 15.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
1.0 30.2 REACTOME KINESINS Genes involved in Kinesins
0.9 7.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.9 7.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.8 34.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.8 17.6 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.7 7.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.7 14.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.6 8.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.6 22.9 REACTOME RNA POL III TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.6 5.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.5 7.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.5 49.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.4 5.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.4 14.6 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.4 4.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.4 6.8 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.4 10.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 7.8 REACTOME DEADENYLATION DEPENDENT MRNA DECAY Genes involved in Deadenylation-dependent mRNA decay
0.3 9.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.3 4.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.3 2.5 REACTOME DEFENSINS Genes involved in Defensins
0.2 6.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 9.8 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.2 3.5 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.2 1.9 REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.2 7.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 2.0 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 8.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 3.0 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.1 17.0 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 2.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 7.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 3.3 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.1 1.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 16.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 0.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 6.5 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 2.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.7 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 3.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines