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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Cebpd

Z-value: 0.58

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Transcription factors associated with Cebpd

Gene Symbol Gene ID Gene Info
Cebpd
ENSRNOG00000050869 CCAAT/enhancer binding protein delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cebpdrn6_v1_chr11_+_89008008_890080080.256.3e-06Click!

Activity profile of Cebpd motif

Sorted Z-values of Cebpd motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_33443186 29.79 ENSRNOT00000005622
S100g
S100 calcium binding protein G
chr9_-_78969013 27.77 ENSRNOT00000019772
ENSRNOT00000057585
Fn1
fibronectin 1
chrX_+_143097525 22.82 ENSRNOT00000004559
F9
coagulation factor IX
chr3_-_121882726 21.58 ENSRNOT00000006308
Il1b
interleukin 1 beta
chr11_-_81717521 20.60 ENSRNOT00000058422
Ahsg
alpha-2-HS-glycoprotein
chr10_-_104628676 16.78 ENSRNOT00000010466
Unc13d
unc-13 homolog D
chr1_+_168964202 15.68 ENSRNOT00000089102
LOC103694855
hemoglobin subunit beta-2-like
chr1_+_276240703 14.96 ENSRNOT00000022126
Acsl5
acyl-CoA synthetase long-chain family member 5
chr9_+_8052210 14.11 ENSRNOT00000073659
Adgre4
adhesion G protein-coupled receptor E4
chr4_-_157155609 13.87 ENSRNOT00000016330
C1s
complement C1s
chr8_-_111721303 13.36 ENSRNOT00000045628
ENSRNOT00000012725
Tf
transferrin
chr13_-_80775230 13.05 ENSRNOT00000091389
ENSRNOT00000004762
Fmo2
flavin containing monooxygenase 2
chr6_-_125723732 12.98 ENSRNOT00000084815
Fbln5
fibulin 5
chr10_-_70871066 12.97 ENSRNOT00000015139
Ccl3
C-C motif chemokine ligand 3
chr2_-_53313884 11.43 ENSRNOT00000046951
Ghr
growth hormone receptor
chr9_+_10952374 11.36 ENSRNOT00000074993
Lrg1
leucine-rich alpha-2-glycoprotein 1
chr10_-_62254287 10.29 ENSRNOT00000004313
Serpinf1
serpin family F member 1
chr1_-_16687817 9.19 ENSRNOT00000091376
ENSRNOT00000081620
Myb
MYB proto-oncogene, transcription factor
chrX_-_110232179 6.20 ENSRNOT00000014739
Serpina7
serpin family A member 7
chr12_-_48238887 4.22 ENSRNOT00000078868
Acacb
acetyl-CoA carboxylase beta
chr6_-_107678156 4.13 ENSRNOT00000014158
Elmsan1
ELM2 and Myb/SANT domain containing 1
chr1_+_85386470 3.85 ENSRNOT00000093332
ENSRNOT00000044326
Plekhg2
pleckstrin homology and RhoGEF domain containing G2
chr20_-_32133431 3.75 ENSRNOT00000000443
Srgn
serglycin
chr12_+_38160464 3.72 ENSRNOT00000032249
Hcar2
hydroxycarboxylic acid receptor 2
chr10_-_84920886 3.33 ENSRNOT00000068083
Sp2
Sp2 transcription factor
chr10_-_59112788 2.32 ENSRNOT00000041886
Spns3
SPNS sphingolipid transporter 3
chr2_-_178297172 2.28 ENSRNOT00000038543
Fnip2
folliculin interacting protein 2
chr3_-_160573978 2.28 ENSRNOT00000018386
Wfdc5
WAP four-disulfide core domain 5
chr1_-_254735548 2.09 ENSRNOT00000025258
Ankrd1
ankyrin repeat domain 1
chr7_+_23854846 1.53 ENSRNOT00000037290
Bpifc
BPI fold containing family C

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpd

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.3 27.8 GO:2001201 calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
7.2 21.6 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
5.6 16.8 GO:0002432 granuloma formation(GO:0002432)
5.0 15.0 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
3.3 13.4 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
3.3 13.1 GO:0072592 oxygen metabolic process(GO:0072592)
3.1 9.2 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
2.2 13.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.7 10.3 GO:0071279 cellular response to cobalt ion(GO:0071279)
1.3 13.0 GO:0048251 elastic fiber assembly(GO:0048251)
1.3 11.4 GO:0006549 allantoin metabolic process(GO:0000255) isoleucine metabolic process(GO:0006549) creatine metabolic process(GO:0006600) creatinine metabolic process(GO:0046449)
1.3 3.8 GO:0033364 mast cell secretory granule organization(GO:0033364)
1.1 20.6 GO:0030502 negative regulation of bone mineralization(GO:0030502)
1.1 4.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
1.0 15.7 GO:0015671 oxygen transport(GO:0015671)
1.0 13.9 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.6 6.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.5 3.7 GO:0070163 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.4 11.4 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.2 22.8 GO:0031638 zymogen activation(GO:0031638)
0.2 2.3 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.1 2.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 3.3 GO:0048144 fibroblast proliferation(GO:0048144)
0.0 3.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.3 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 27.8 GO:0005577 fibrinogen complex(GO:0005577)
3.2 13.0 GO:0071953 elastic fiber(GO:0071953)
2.8 16.8 GO:0033093 Weibel-Palade body(GO:0033093)
2.3 11.4 GO:0070195 growth hormone receptor complex(GO:0070195)
2.2 13.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
1.4 15.7 GO:0005833 hemoglobin complex(GO:0005833)
1.3 10.3 GO:0043203 axon hillock(GO:0043203)
0.3 34.5 GO:0072562 blood microparticle(GO:0072562)
0.2 21.6 GO:0005776 autophagosome(GO:0005776)
0.1 3.8 GO:0042629 mast cell granule(GO:0042629)
0.1 15.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 4.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 53.7 GO:0005615 extracellular space(GO:0005615)
0.0 8.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 14.1 GO:0009986 cell surface(GO:0009986)
0.0 2.1 GO:0031674 I band(GO:0031674)
0.0 2.3 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 20.6 GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
5.0 29.8 GO:0005499 vitamin D binding(GO:0005499)
4.3 13.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
4.0 27.8 GO:0045340 mercury ion binding(GO:0045340)
2.9 11.4 GO:0004903 growth hormone receptor activity(GO:0004903)
1.8 9.2 GO:0071987 WD40-repeat domain binding(GO:0071987)
1.7 13.4 GO:1990459 transferrin receptor binding(GO:1990459)
1.2 15.0 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
1.1 21.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
1.1 13.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.1 4.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
1.0 15.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.8 6.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.4 2.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.3 2.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 11.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 3.7 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.2 36.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.1 GO:0031432 titin binding(GO:0031432)
0.1 13.0 GO:0005178 integrin binding(GO:0005178)
0.1 16.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 8.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.8 GO:0005518 collagen binding(GO:0005518)
0.0 3.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 2.3 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 10.9 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 21.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
1.3 27.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.5 13.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 20.6 PID BMP PATHWAY BMP receptor signaling
0.3 20.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 13.0 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 36.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 24.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 29.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 22.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.5 27.8 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
1.3 13.9 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.8 15.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.5 11.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.5 21.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.5 13.4 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.3 13.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 4.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 9.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 3.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.7 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 2.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression