ISMARA results: Cebpb

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Cebpb

Z-value: 2.48

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Transcription factors associated with Cebpb

Gene Symbol	Gene ID	Gene Info
Cebpb NCBI RGD Ensembl	ENSRNOG00000057347	CCAAT/enhancer binding protein beta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Cebpb	rn6_v1_chr3_+_164424515_164424515	0.60	8.3e-33	Click!

Activity profile of Cebpb motif

Sorted Z-values of Cebpb motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_181987217 Show fit	196.04	ENSRNOT00000034521	Fgg NCBI RGD Ensembl Show fit	fibrinogen gamma chain
chr11_-_81717521 Show fit	157.82	ENSRNOT00000058422	Ahsg NCBI RGD Ensembl Show fit	alpha-2-HS-glycoprotein
chr9_+_74124016 Show fit	157.18	ENSRNOT00000019023	Cps1 NCBI RGD Ensembl Show fit	carbamoyl-phosphate synthase 1
chr15_+_28018040 Show fit	155.80	ENSRNOT00000041495	Rnase4 NCBI RGD Ensembl Show fit	ribonuclease A family member 4
chr2_+_55775274 Show fit	149.13	ENSRNOT00000018545	C9 NCBI RGD Ensembl Show fit	complement C9
chr1_-_76614279 Show fit	148.08	ENSRNOT00000041367 ENSRNOT00000089371	LOC100912485 NCBI RGD Ensembl Show fit	alcohol sulfotransferase-like
chrX_+_33443186 Show fit	137.09	ENSRNOT00000005622	S100g NCBI RGD Ensembl Show fit	S100 calcium binding protein G
chr1_-_76780230 Show fit	132.59	ENSRNOT00000002046	LOC100912485 NCBI RGD Ensembl Show fit	alcohol sulfotransferase-like
chr1_-_76722965 Show fit	127.69	ENSRNOT00000052129	LOC100912485 NCBI RGD Ensembl Show fit	alcohol sulfotransferase-like
chr2_+_182006242 Show fit	126.94	ENSRNOT00000064091	Fga NCBI RGD Ensembl Show fit	fibrinogen alpha chain

Showing 1 to 10 of 180 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
39.7	436.5	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
9.7	212.7	GO:0030502	negative regulation of bone mineralization(GO:0030502)
31.4	157.2	GO:0071400	cellular response to oleic acid(GO:0071400)
1.1	153.3	GO:0090501	RNA phosphodiester bond hydrolysis(GO:0090501)
13.6	149.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
42.1	126.2	GO:2001201	calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
15.2	121.4	GO:0015679	plasma membrane copper ion transport(GO:0015679)
0.9	109.2	GO:0031638	zymogen activation(GO:0031638)
27.3	109.1	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
34.5	103.6	GO:0046865	isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)

Showing 1 to 10 of 119 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	957.0	GO:0005615	extracellular space(GO:0005615)
56.2	449.2	GO:0005577	fibrinogen complex(GO:0005577)
2.9	338.0	GO:0072562	blood microparticle(GO:0072562)
0.8	198.3	GO:0016323	basolateral plasma membrane(GO:0016323)
3.3	168.4	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
37.3	149.1	GO:0044218	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.5	118.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
8.7	113.5	GO:0042627	chylomicron(GO:0042627)
18.2	109.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
6.9	96.9	GO:0097208	alveolar lamellar body(GO:0097208)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	318.0	GO:0030674	protein binding, bridging(GO:0030674)
0.8	178.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
39.5	157.8	GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
13.1	157.2	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
1.4	155.8	GO:0004540	ribonuclease activity(GO:0004540)
0.9	152.5	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
17.3	138.8	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
22.8	137.1	GO:0005499	vitamin D binding(GO:0005499)
18.0	126.2	GO:0045340	mercury ion binding(GO:0045340)
20.2	121.4	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)

Showing 1 to 10 of 96 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.4	323.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.3	296.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	263.5	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
2.2	161.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
2.9	157.8	PID BMP PATHWAY	BMP receptor signaling
3.5	147.7	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.7	136.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
8.4	126.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
4.2	109.1	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
6.0	108.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
25.0	449.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
6.1	270.4	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
6.1	207.9	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.0	182.1	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
12.4	123.6	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
2.5	83.9	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
1.0	74.9	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
5.7	74.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
1.7	73.9	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
6.1	73.8	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts

Showing 1 to 10 of 39 entries

Results for Cebpb

Z-value: 2.48

Motif logo

Transcription factors associated with Cebpb

Activity-expression correlation:

Activity profile of Cebpb motif

Sorted Z-values of Cebpb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: