ISMARA results: Cebpa

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Cebpa_Cebpg

Z-value: 1.54

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Transcription factors associated with Cebpa_Cebpg

Gene Symbol	Gene ID	Gene Info
Cebpa NCBI RGD Ensembl	ENSRNOG00000010918	CCAAT/enhancer binding protein alpha
Cebpg NCBI RGD Ensembl	ENSRNOG00000021144	CCAAT/enhancer binding protein gamma

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Cebpa	rn6_v1_chr1_+_91363492_91363492	0.70	2.4e-48	Click!
Cebpg	rn6_v1_chr1_-_91296656_91296656	0.16	4.3e-03	Click!

Activity profile of Cebpa_Cebpg motif

Sorted Z-values of Cebpa_Cebpg motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_81717521 Show fit	159.65	ENSRNOT00000058422	Ahsg NCBI RGD Ensembl Show fit	alpha-2-HS-glycoprotein
chr11_-_81444375 Show fit	158.80	ENSRNOT00000058479 ENSRNOT00000078131 ENSRNOT00000080949 ENSRNOT00000080562 ENSRNOT00000084867	Kng1 NCBI RGD Ensembl Show fit	kininogen 1
chr9_+_9721105 Show fit	132.03	ENSRNOT00000073042 ENSRNOT00000075494	C3 NCBI RGD Ensembl Show fit	complement C3
chr2_+_104744461 Show fit	106.48	ENSRNOT00000016083 ENSRNOT00000082627	Cp NCBI RGD Ensembl Show fit	ceruloplasmin
chrX_+_143097525 Show fit	99.60	ENSRNOT00000004559	F9 NCBI RGD Ensembl Show fit	coagulation factor IX
chr10_+_96639924 Show fit	82.75	ENSRNOT00000004756	Apoh NCBI RGD Ensembl Show fit	apolipoprotein H
chr15_+_57290849 Show fit	82.49	ENSRNOT00000014909	Cpb2 NCBI RGD Ensembl Show fit	carboxypeptidase B2
chr4_+_65110746 Show fit	82.38	ENSRNOT00000017675	Akr1d1 NCBI RGD Ensembl Show fit	aldo-keto reductase family 1, member D1
chr9_+_74124016 Show fit	77.11	ENSRNOT00000019023	Cps1 NCBI RGD Ensembl Show fit	carbamoyl-phosphate synthase 1
chr8_-_111721303 Show fit	70.61	ENSRNOT00000045628 ENSRNOT00000012725	Tf NCBI RGD Ensembl Show fit	transferrin

Showing 1 to 10 of 161 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpa_Cebpg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.9	159.6	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
4.0	158.8	GO:0042311	vasodilation(GO:0042311)
44.0	132.0	GO:0001905	activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
13.3	106.5	GO:0015679	plasma membrane copper ion transport(GO:0015679)
0.7	99.0	GO:0031638	zymogen activation(GO:0031638)
20.7	82.8	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
27.5	82.5	GO:0003330	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
6.3	82.4	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
15.4	77.1	GO:0071400	cellular response to oleic acid(GO:0071400)
17.7	70.6	GO:0097460	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)

Showing 1 to 10 of 89 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.7	629.1	GO:0072562	blood microparticle(GO:0072562)
0.3	488.5	GO:0005615	extracellular space(GO:0005615)
1.4	97.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
6.4	82.8	GO:0042627	chylomicron(GO:0042627)
1.4	71.6	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
11.8	70.6	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.9	66.3	GO:0005811	lipid particle(GO:0005811)
0.0	60.9	GO:0070062	extracellular exosome(GO:0070062)
14.2	57.0	GO:0044279	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
6.6	52.6	GO:0005577	fibrinogen complex(GO:0005577)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	165.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
39.9	159.6	GO:0030294	receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294)
2.1	148.3	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
44.0	132.0	GO:0031714	C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
17.7	106.5	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.6	92.8	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
27.6	82.8	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
3.1	82.5	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
27.5	82.4	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
6.4	77.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)

Showing 1 to 10 of 72 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.4	290.8	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.8	175.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.9	154.1	PID BMP PATHWAY	BMP receptor signaling
1.4	101.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
2.7	70.6	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.3	53.8	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
3.5	52.6	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.9	27.9	PID IL1 PATHWAY	IL1-mediated signaling events
1.1	27.6	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4	24.5	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.3	258.4	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
9.4	132.0	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
4.5	130.9	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.5	107.8	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
4.0	83.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
6.9	82.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
2.6	76.5	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
3.1	52.6	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
1.0	48.6	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
1.0	24.1	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis

Showing 1 to 10 of 36 entries

Results for Cebpa_Cebpg

Z-value: 1.54

Motif logo

Transcription factors associated with Cebpa_Cebpg

Activity-expression correlation:

Activity profile of Cebpa_Cebpg motif

Sorted Z-values of Cebpa_Cebpg motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpa_Cebpg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: