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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Brca1

Z-value: 0.48

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Transcription factors associated with Brca1

Gene Symbol Gene ID Gene Info
Brca1
ENSRNOG00000020701 BRCA1, DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Brca1rn6_v1_chr10_-_89454681_89454681-0.091.1e-01Click!

Activity profile of Brca1 motif

Sorted Z-values of Brca1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_47397558 13.90 ENSRNOT00000085923
Epdr1
ependymin related 1
chr1_-_143392532 12.55 ENSRNOT00000026089
Fsd2
fibronectin type III and SPRY domain containing 2
chr3_-_48535909 9.49 ENSRNOT00000008148
Fap
fibroblast activation protein, alpha
chr13_-_91872954 8.77 ENSRNOT00000004613
ENSRNOT00000079263
Cadm3
cell adhesion molecule 3
chr4_+_154215250 7.76 ENSRNOT00000072465
Mug2
murinoglobulin 2
chr3_+_14467330 7.53 ENSRNOT00000078939
Gsn
gelsolin
chr14_-_19159923 7.18 ENSRNOT00000003879
Afp
alpha-fetoprotein
chr5_+_152533349 7.11 ENSRNOT00000067524
Trim63
tripartite motif containing 63
chr20_+_31102476 6.48 ENSRNOT00000078719
Lrrc20
leucine rich repeat containing 20
chr8_-_49502647 5.08 ENSRNOT00000040313
Tmprss4
transmembrane protease, serine 4
chrX_-_23139694 4.77 ENSRNOT00000033656
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr10_-_51669297 4.65 ENSRNOT00000071595
Arhgap44
Rho GTPase activating protein 44
chr13_-_83680207 4.44 ENSRNOT00000004199
Dcaf6
DDB1 and CUL4 associated factor 6
chr16_-_75637789 3.83 ENSRNOT00000058029
Defb4
defensin beta 4
chr3_-_101474890 3.73 ENSRNOT00000091869
Bbox1
gamma-butyrobetaine hydroxylase 1
chr18_+_53088994 3.33 ENSRNOT00000091921
AC104053.2

chr3_+_100787956 3.19 ENSRNOT00000073636
Bdnf
brain-derived neurotrophic factor
chr10_+_18912865 3.15 ENSRNOT00000007393
Kcnmb1
potassium calcium-activated channel subfamily M regulatory beta subunit 1
chr7_-_143167772 3.06 ENSRNOT00000011374
Krt85
keratin 85
chr14_-_86190659 2.94 ENSRNOT00000086474
Gck
glucokinase
chr10_-_89816491 2.93 ENSRNOT00000028220
Meox1
mesenchyme homeobox 1
chr2_-_147819335 2.61 ENSRNOT00000057909
Ankub1
ankyrin repeat and ubiquitin domain containing 1
chr1_-_94610854 2.60 ENSRNOT00000020383
Plekhf1
pleckstrin homology and FYVE domain containing 1
chr16_+_74408183 2.60 ENSRNOT00000036506
Smim19
small integral membrane protein 19
chr10_-_90042877 2.54 ENSRNOT00000028318
Ppy
pancreatic polypeptide
chr3_-_72895740 2.51 ENSRNOT00000012568
Fads2l1
fatty acid desaturase 2-like 1
chr16_+_54386513 2.49 ENSRNOT00000080696
AABR07025896.1

chr15_-_8183682 2.43 ENSRNOT00000011438
Nkiras1
NFKB inhibitor interacting Ras-like 1
chr11_-_15858281 2.43 ENSRNOT00000090586
AABR07033287.1

chr8_+_26432514 2.36 ENSRNOT00000081574
Sept7
septin 7
chr11_-_87485833 2.29 ENSRNOT00000079948
AABR07034751.1

chr15_-_52210746 2.21 ENSRNOT00000046054
Bmp1
bone morphogenetic protein 1
chr5_+_104362971 2.13 ENSRNOT00000058520
Adamtsl1
ADAMTS-like 1
chr14_-_92577936 2.06 ENSRNOT00000086154
Cobl
cordon-bleu WH2 repeat protein
chr6_+_28515025 2.05 ENSRNOT00000088033
ENSRNOT00000005317
ENSRNOT00000081141
Dnajc27
DnaJ heat shock protein family (Hsp40) member C27
chr19_-_55183557 2.03 ENSRNOT00000017317
Mlnr
motilin receptor
chr2_+_93803449 2.01 ENSRNOT00000014949
Fabp9
fatty acid binding protein 9
chr10_+_66099531 1.99 ENSRNOT00000056192
Lyrm9
LYR motif containing 9
chr12_-_20028097 1.96 ENSRNOT00000048430
Vom2r62
vomeronasal 2 receptor, 62
chr9_+_53626592 1.96 ENSRNOT00000031267
Mfsd6
major facilitator superfamily domain containing 6
chr1_+_264309214 1.95 ENSRNOT00000019070
Hif1an
hypoxia-inducible factor 1, alpha subunit inhibitor
chrX_+_45637415 1.95 ENSRNOT00000050544
RGD1563378
similar to ferritin heavy polypeptide-like 17
chr3_-_139735397 1.90 ENSRNOT00000088315
AABR07054088.1

chr1_+_214747625 1.86 ENSRNOT00000091110
AABR07006033.1

chr13_+_106751625 1.85 ENSRNOT00000004992
Ush2a
usherin
chr10_+_89251370 1.82 ENSRNOT00000076820
Aoc3
amine oxidase, copper containing 3
chr19_-_14945302 1.76 ENSRNOT00000079391
AABR07042936.2

chr17_+_36690249 1.71 ENSRNOT00000089476
ENSRNOT00000082140
LOC688583
similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a)
chr12_+_10255416 1.68 ENSRNOT00000092720
Gpr12
G protein-coupled receptor 12
chr20_-_47306318 1.66 ENSRNOT00000075151
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_-_243407608 1.63 ENSRNOT00000014631
Mttp
microsomal triglyceride transfer protein
chr11_-_32550539 1.62 ENSRNOT00000002715
Rcan1
regulator of calcineurin 1
chr9_+_51009116 1.59 ENSRNOT00000039313
Mettl21cl1
methyltransferase like 21C-like 1
chr13_+_63526486 1.58 ENSRNOT00000003788
Brinp3
BMP/retinoic acid inducible neural specific 3
chr16_+_69022792 1.54 ENSRNOT00000035985
Got1l1
glutamic-oxaloacetic transaminase 1-like 1
chr13_-_102790639 1.51 ENSRNOT00000003177
RGD1310587
similar to hypothetical protein FLJ14146
chr13_+_98857177 1.51 ENSRNOT00000004232
Parp1
poly (ADP-ribose) polymerase 1
chr3_-_51643140 1.50 ENSRNOT00000006646
Scn3a
sodium voltage-gated channel alpha subunit 3
chr1_-_69835185 1.48 ENSRNOT00000020757
LOC108349745
spindle assembly abnormal protein 6 homolog
chr10_+_20320878 1.45 ENSRNOT00000009714
Slit3
slit guidance ligand 3
chr1_-_178196294 1.45 ENSRNOT00000067170
Btbd10
BTB domain containing 10
chr18_-_49937522 1.42 ENSRNOT00000033254
Zfp608
zinc finger protein 608
chr12_+_22535672 1.41 ENSRNOT00000073046
AABR07035791.1

chr9_-_10734073 1.40 ENSRNOT00000071199
Kdm4b
lysine demethylase 4B
chr4_+_6330466 1.39 ENSRNOT00000089582
E130116L18Rik
RIKEN cDNA E130116L18 gene
chr18_+_35136132 1.38 ENSRNOT00000078731
Spink5
serine peptidase inhibitor, Kazal type 5
chr2_+_30664441 1.36 ENSRNOT00000061166
Ak6
adenylate kinase 6
chr4_+_109477920 1.33 ENSRNOT00000008468
Reg3a
regenerating islet-derived 3 alpha
chr15_+_32355565 1.32 ENSRNOT00000072382
AABR07017900.1

chr10_+_85646633 1.30 ENSRNOT00000086608
Psmb3
proteasome subunit beta 3
chr1_-_91296656 1.27 ENSRNOT00000028703
Cebpg
CCAAT/enhancer binding protein gamma
chr9_+_88494676 1.24 ENSRNOT00000089451
LOC102556337
mitochondrial fission factor-like
chr1_+_168196862 1.23 ENSRNOT00000021006
Olr74
olfactory receptor 74
chr13_+_90532326 1.23 ENSRNOT00000008944
Dcaf8
DDB1 and CUL4 associated factor 8
chr3_+_150574473 1.21 ENSRNOT00000023905
Asip
agouti signaling protein
chr7_-_123259636 1.19 ENSRNOT00000007424
Desi1
desumoylating isopeptidase 1
chr6_+_76174452 1.19 ENSRNOT00000084062
Psma6
proteasome subunit alpha 6
chr1_+_42170281 1.18 ENSRNOT00000092879
Vip
vasoactive intestinal peptide
chr1_+_62964901 1.16 ENSRNOT00000075013
LOC100365824
vomeronasal 2 receptor, 22-like
chr16_-_81945127 1.15 ENSRNOT00000023352
Mcf2l
MCF.2 cell line derived transforming sequence-like
chr7_+_13013541 1.13 ENSRNOT00000042792
ENSRNOT00000010549
Theg
theg spermatid protein
chr4_-_103403976 1.13 ENSRNOT00000088153
AABR07061057.3

chr3_-_78193481 1.08 ENSRNOT00000008419
Olr696
olfactory receptor 696
chr5_-_57845509 1.07 ENSRNOT00000035541
Kif24
kinesin family member 24
chr10_+_49368314 1.05 ENSRNOT00000004392
Cdrt4
CMT1A duplicated region transcript 4
chr3_+_95715193 1.01 ENSRNOT00000089525
Pax6
paired box 6
chr2_-_189602143 1.00 ENSRNOT00000032062
Creb3l4
cAMP responsive element binding protein 3-like 4
chr1_-_148847662 0.99 ENSRNOT00000090329
LOC100911376
olfactory receptor 226-like
chr2_+_30664639 0.99 ENSRNOT00000076372
ENSRNOT00000076294
ENSRNOT00000076434
ENSRNOT00000076484
Taf9
TATA-box binding protein associated factor 9
chr13_+_84588702 0.91 ENSRNOT00000058689
Tada1
transcriptional adaptor 1
chr3_+_15749691 0.87 ENSRNOT00000030984
Olr396
olfactory receptor 396
chr10_+_43768708 0.87 ENSRNOT00000086218
Sh3bp5l
SH3 binding domain protein 5 like
chr20_+_27129291 0.86 ENSRNOT00000031053
AABR07044933.1

chr1_-_78333321 0.86 ENSRNOT00000020402
Sae1
SUMO1 activating enzyme subunit 1
chr1_-_226572349 0.85 ENSRNOT00000028028
Sdhaf2
succinate dehydrogenase complex assembly factor 2
chr5_+_164950917 0.85 ENSRNOT00000083678
Mad2l2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr7_-_16036185 0.83 ENSRNOT00000047899
LOC108348036
olfactory receptor 6C2-like
chr7_+_3900228 0.81 ENSRNOT00000071350
Olr921
olfactory receptor 921
chr3_+_172195844 0.81 ENSRNOT00000034915
Npepl1
aminopeptidase-like 1
chr2_+_30664217 0.78 ENSRNOT00000076786
Ak6
adenylate kinase 6
chrX_-_152932953 0.74 ENSRNOT00000078929
Cetn2
centrin 2
chr2_-_140334912 0.73 ENSRNOT00000015067
Elf2
E74-like factor 2
chr1_-_171060011 0.72 ENSRNOT00000042829
Olr226
olfactory receptor 226
chr18_+_62852303 0.72 ENSRNOT00000087673
Gnal
G protein subunit alpha L
chr3_-_37445907 0.72 ENSRNOT00000006172
Rbm43
RNA binding motif protein 43
chr16_+_61926586 0.71 ENSRNOT00000058884
AABR07026059.1

chr3_-_73580594 0.67 ENSRNOT00000012929
Olr488
olfactory receptor 488
chr18_+_35249137 0.65 ENSRNOT00000017489
LOC100910942
serine protease inhibitor Kazal-type 6-like
chr1_-_178195948 0.60 ENSRNOT00000081767
Btbd10
BTB domain containing 10
chr6_-_91456696 0.60 ENSRNOT00000005577
Rps29
ribosomal protein S29
chr7_+_122160171 0.58 ENSRNOT00000074499
LOC100362980
CG3918-like
chr16_+_6542216 0.55 ENSRNOT00000021475
Dcp1a
decapping mRNA 1A
chr5_-_57168610 0.55 ENSRNOT00000090499
B4galt1
beta-1,4-galactosyltransferase 1
chr7_-_5818625 0.53 ENSRNOT00000051699
Olr886
olfactory receptor 886
chr14_-_2371883 0.51 ENSRNOT00000000077
Pde6b
phosphodiesterase 6B
chr9_+_67130259 0.50 ENSRNOT00000023796
Cyp20a1
cytochrome P450, family 20, subfamily a, polypeptide 1
chr1_+_144070754 0.50 ENSRNOT00000079989
Sh3gl3
SH3 domain-containing GRB2-like 3
chr3_-_73401074 0.50 ENSRNOT00000012848
Olr476
olfactory receptor 476
chr7_-_3707226 0.49 ENSRNOT00000064380
Olr879
olfactory receptor 879
chr3_+_76890792 0.49 ENSRNOT00000087552
Olr639
olfactory receptor 639
chr10_-_89084885 0.49 ENSRNOT00000027452
Plekhh3
pleckstrin homology, MyTH4 and FERM domain containing H3
chr19_-_29802083 0.48 ENSRNOT00000024755
AC123471.1

chr9_-_15393131 0.44 ENSRNOT00000018523
ENSRNOT00000088314
Med20
mediator complex subunit 20
chr10_-_98124743 0.44 ENSRNOT00000037415
RGD1559578
RGD1559578
chr3_-_21131492 0.42 ENSRNOT00000010493
Olr424
olfactory receptor 424
chr6_-_26318568 0.40 ENSRNOT00000072707
LOC102556504
titin-like
chr1_-_142759882 0.40 ENSRNOT00000015218
Sec11a
SEC11 homolog A, signal peptidase complex subunit
chr7_+_13698647 0.40 ENSRNOT00000067342
Olr1086
olfactory receptor 1086
chr16_-_19637609 0.40 ENSRNOT00000021742
Zfp709
zinc finger protein 709
chr19_-_41433346 0.39 ENSRNOT00000022952
Cmtr2
cap methyltransferase 2
chr8_-_113689681 0.34 ENSRNOT00000056435
LOC688828
similar to Nucleoside diphosphate-linked moiety X motif 16 (Nudix motif 16)
chr6_+_108796182 0.34 ENSRNOT00000006297
Fcf1
FCF1 rRNA-processing protein
chr20_-_2767240 0.33 ENSRNOT00000073990
Btnl7
butyrophilin-like 7
chr4_-_39711271 0.33 ENSRNOT00000029602
Vwde
von Willebrand factor D and EGF domains
chr1_+_169410115 0.32 ENSRNOT00000023043
Trim6
tripartite motif containing 6
chr10_+_34662186 0.32 ENSRNOT00000049754
Olr1393
olfactory receptor 1393
chr8_-_17833773 0.31 ENSRNOT00000049758
Olr1117
olfactory receptor 1117
chr14_+_45982244 0.30 ENSRNOT00000076881
ENSRNOT00000002984
Rell1
RELT-like 1
chr18_+_30895831 0.28 ENSRNOT00000026985
Pcdhga10
protocadherin gamma subfamily A, 10
chr10_-_92602082 0.28 ENSRNOT00000007963
Cdc27
cell division cycle 27
chr1_-_78968329 0.26 ENSRNOT00000023078
Ppp5c
protein phosphatase 5, catalytic subunit
chr1_-_80630038 0.25 ENSRNOT00000025281
Tomm40
translocase of outer mitochondrial membrane 40
chr1_-_217720414 0.24 ENSRNOT00000078810
Ppfia1
PTPRF interacting protein alpha 1
chr20_+_42966140 0.19 ENSRNOT00000000707
Marcks
myristoylated alanine rich protein kinase C substrate
chr20_-_11546046 0.19 ENSRNOT00000068374
LOC690386
hypothetical protein LOC690386
chr1_-_64099277 0.19 ENSRNOT00000084846
Tsen34
tRNA splicing endonuclease subunit 34
chr17_-_10559627 0.19 ENSRNOT00000023515
Higd2a
HIG1 hypoxia inducible domain family, member 2A
chr10_+_34553284 0.16 ENSRNOT00000049989
Olr1387
olfactory receptor 1387
chr13_-_70299733 0.15 ENSRNOT00000044235
Smg7
SMG7 nonsense mediated mRNA decay factor
chr4_+_106361762 0.13 ENSRNOT00000052417
AABR07061136.1

chr15_-_28721127 0.11 ENSRNOT00000017720
Mettl3
methyltransferase-like 3
chr3_-_64024205 0.10 ENSRNOT00000037015
Ccdc141
coiled-coil domain containing 141
chr15_-_28446785 0.08 ENSRNOT00000015439
Olr1638
olfactory receptor 1638
chr10_+_34564009 0.08 ENSRNOT00000041536
Olr1388
olfactory receptor 1388
chr17_-_17872573 0.06 ENSRNOT00000082733
Rnf144b
ring finger protein 144B
chr1_-_242083484 0.05 ENSRNOT00000065921
Tjp2
tight junction protein 2
chr5_+_154668179 0.05 ENSRNOT00000015971
Hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr17_-_89780691 0.05 ENSRNOT00000091830
LOC108348042
ankyrin repeat domain-containing protein 7-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Brca1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0097325 melanocyte proliferation(GO:0097325)
2.5 7.5 GO:1903923 protein processing in phagocytic vesicle(GO:1900756) regulation of establishment of T cell polarity(GO:1903903) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
1.4 7.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.2 4.7 GO:0098886 modification of dendritic spine(GO:0098886)
1.0 5.0 GO:0001757 somite specification(GO:0001757)
0.8 3.1 GO:1903413 cellular response to bile acid(GO:1903413)
0.8 2.4 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.7 2.9 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.6 3.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.6 4.8 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
0.5 1.5 GO:0006532 aspartate biosynthetic process(GO:0006532)
0.5 1.5 GO:0070212 peptidyl-serine ADP-ribosylation(GO:0018312) myofibroblast differentiation(GO:0036446) protein poly-ADP-ribosylation(GO:0070212) regulation of myofibroblast differentiation(GO:1904760) regulation of interleukin-17 secretion(GO:1905076) negative regulation of interleukin-17 secretion(GO:1905077)
0.4 7.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.4 3.2 GO:0061193 taste bud development(GO:0061193)
0.4 2.0 GO:0061428 peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.4 1.5 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.3 1.4 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.3 1.0 GO:0021917 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.3 1.2 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.3 0.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.3 1.9 GO:0048496 maintenance of organ identity(GO:0048496)
0.2 1.7 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.2 0.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 1.6 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 1.4 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.2 1.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 2.0 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 1.5 GO:0046684 response to pyrethroid(GO:0046684)
0.1 8.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.1 1.2 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244)
0.1 0.5 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.1 1.2 GO:0070459 prolactin secretion(GO:0070459)
0.1 0.4 GO:0036451 cap mRNA methylation(GO:0036451)
0.1 1.6 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 2.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 2.0 GO:0001675 acrosome assembly(GO:0001675)
0.1 1.3 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 1.8 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 0.7 GO:0009405 pathogenesis(GO:0009405)
0.1 2.5 GO:0032098 regulation of appetite(GO:0032098)
0.1 0.3 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.6 GO:1903608 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) protein localization to cytoplasmic stress granule(GO:1903608)
0.1 3.8 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 2.0 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 2.6 GO:0007032 endosome organization(GO:0007032)
0.1 2.2 GO:0007099 centriole replication(GO:0007099)
0.1 0.5 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 13.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 0.3 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 2.1 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 1.8 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.2 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.3 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 1.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.9 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 7.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.1 GO:1904690 primary miRNA processing(GO:0031053) regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0 0.5 GO:0046037 GMP metabolic process(GO:0046037)
0.0 1.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.0 2.0 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 1.1 GO:0032392 DNA geometric change(GO:0032392)
0.0 1.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.1 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 0.9 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.2 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 9.5 GO:0071438 invadopodium membrane(GO:0071438)
1.3 7.5 GO:0030478 actin cap(GO:0030478)
0.5 2.4 GO:0005940 septin ring(GO:0005940)
0.3 1.9 GO:0002142 stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
0.3 2.1 GO:1990357 terminal web(GO:1990357)
0.3 0.9 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.2 0.7 GO:0071942 XPC complex(GO:0071942)
0.2 1.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 7.1 GO:0031430 M band(GO:0031430)
0.2 5.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 3.2 GO:0030061 mitochondrial crista(GO:0030061)
0.2 2.9 GO:0045180 basal cortex(GO:0045180)
0.2 0.8 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.2 1.0 GO:0000125 PCAF complex(GO:0000125)
0.1 1.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.9 GO:0030914 STAGA complex(GO:0030914)
0.1 1.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 1.3 GO:0005839 proteasome core complex(GO:0005839)
0.1 1.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.1 1.6 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.5 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 5.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.2 GO:0045095 keratin filament(GO:0045095)
0.0 2.1 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 3.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.8 GO:0005902 microvillus(GO:0005902)
0.0 2.5 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0036396 MIS complex(GO:0036396)
0.0 9.7 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.9 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0032040 small-subunit processome(GO:0032040)
0.0 3.5 GO:0044445 cytosolic part(GO:0044445)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.5 GO:0045159 myosin II binding(GO:0045159)
1.0 3.8 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.9 9.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.7 4.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.5 1.5 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.5 7.1 GO:0031432 titin binding(GO:0031432)
0.5 2.9 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.4 2.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.4 1.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.4 3.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.3 2.0 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 1.2 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.2 1.5 GO:0048495 Roundabout binding(GO:0048495)
0.2 2.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.2 0.5 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.2 1.5 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 1.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 3.0 GO:0008301 DNA binding, bending(GO:0008301)
0.2 3.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.7 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 0.4 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 1.0 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.9 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.1 3.1 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 2.0 GO:0008199 ferric iron binding(GO:0008199)
0.1 5.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 4.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 9.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 4.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 1.7 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 3.7 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 2.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.8 GO:0008432 JUN kinase binding(GO:0008432)
0.1 1.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.2 GO:0015266 protein channel activity(GO:0015266)
0.0 1.9 GO:0017022 myosin binding(GO:0017022)
0.0 0.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 4.5 GO:0003924 GTPase activity(GO:0003924)
0.0 0.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.6 GO:0019894 kinesin binding(GO:0019894)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.5 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.2 10.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 4.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID MYC PATHWAY C-MYC pathway
0.0 1.0 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 4.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.8 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.1 4.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.0 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 2.5 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 8.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 4.6 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.8 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 2.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex