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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Bcl6b

Z-value: 0.73

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Transcription factors associated with Bcl6b

Gene Symbol Gene ID Gene Info
Bcl6b
ENSRNOG00000059956 B-cell CLL/lymphoma 6B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bcl6brn6_v1_chr10_-_56839437_56839437-0.172.7e-03Click!

Activity profile of Bcl6b motif

Sorted Z-values of Bcl6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_11585078 24.79 ENSRNOT00000088878
Robo2
roundabout guidance receptor 2
chrX_+_20423401 18.14 ENSRNOT00000093162
Wnk3
WNK lysine deficient protein kinase 3
chr11_-_11585765 17.07 ENSRNOT00000066439
Robo2
roundabout guidance receptor 2
chr2_-_211322719 16.52 ENSRNOT00000027493
RGD1310209
similar to KIAA1324 protein
chr12_-_38782010 16.16 ENSRNOT00000001813
Wdr66
WD repeat domain 66
chr4_-_17594598 16.00 ENSRNOT00000008936
Sema3e
semaphorin 3E
chr2_+_208749996 14.77 ENSRNOT00000086321
Chia
chitinase, acidic
chr5_-_79874671 14.63 ENSRNOT00000084563
Tnc
tenascin C
chr2_+_208750356 14.29 ENSRNOT00000041562
Chia
chitinase, acidic
chr16_-_18766174 14.28 ENSRNOT00000084813
Sftpd
surfactant protein D
chr4_+_70252366 14.01 ENSRNOT00000073039
Chl1
cell adhesion molecule L1-like
chr14_+_17534412 13.11 ENSRNOT00000079304
ENSRNOT00000046771
Cdkl2
cyclin dependent kinase like 2
chr13_+_100045343 12.26 ENSRNOT00000075792
LOC690288
similar to Dynein heavy chain at 16F CG7092-PA
chr16_+_39145230 12.17 ENSRNOT00000092942
Adam21
ADAM metallopeptidase domain 21
chr13_+_112031594 12.03 ENSRNOT00000008440
Lamb3
laminin subunit beta 3
chr2_+_54660722 11.88 ENSRNOT00000060376
Mroh2b
maestro heat-like repeat family member 2B
chr3_-_60611924 11.32 ENSRNOT00000068745
Chn1
chimerin 1
chr16_+_6078122 10.91 ENSRNOT00000021407
Chdh
choline dehydrogenase
chr8_-_13513337 10.34 ENSRNOT00000071532
LOC108348070
lysine-specific demethylase 4D
chr16_+_39353283 9.63 ENSRNOT00000080125
LOC108348202
disintegrin and metalloproteinase domain-containing protein 21-like
chr13_-_36101411 8.52 ENSRNOT00000074471
Tmem37
transmembrane protein 37
chr8_+_28454962 8.12 ENSRNOT00000051573
Spata19
spermatogenesis associated 19
chr10_+_4951557 7.45 ENSRNOT00000003451
Prm3
protamine 3
chr3_-_104502471 7.36 ENSRNOT00000040306
Ryr3
ryanodine receptor 3
chr8_+_115213471 7.18 ENSRNOT00000017570
Iqcf5
IQ motif containing F5
chrX_+_159505344 6.91 ENSRNOT00000001164
Brs3
bombesin receptor subtype 3
chr9_-_54484533 6.70 ENSRNOT00000083514
Stat1
signal transducer and activator of transcription 1
chr19_+_41482728 6.57 ENSRNOT00000022943
Calb2
calbindin 2
chr1_-_13341952 6.53 ENSRNOT00000079531
NEWGENE_2319083
epithelial cell transforming 2 like
chr2_+_182006242 6.32 ENSRNOT00000064091
Fga
fibrinogen alpha chain
chr16_+_74886719 6.30 ENSRNOT00000089265
Atp7b
ATPase copper transporting beta
chr1_-_213921208 6.21 ENSRNOT00000044393
Ano9
anoctamin 9
chr18_+_30527705 6.02 ENSRNOT00000027168
Pcdhb14
protocadherin beta 14
chr1_+_99532568 5.86 ENSRNOT00000077073
Zfp819
zinc finger protein 819
chr16_+_10267482 5.71 ENSRNOT00000085255
Gdf2
growth differentiation factor 2
chr9_+_64898459 5.70 ENSRNOT00000029526
Sgo2
shugoshin 2
chr2_+_211546560 5.49 ENSRNOT00000033443
Aknad1
AKNA domain containing 1
chr7_+_27248115 5.47 ENSRNOT00000031946
ENSRNOT00000059545
LOC362863
first gene upstream of Nt5dc3
chr8_+_59900651 4.96 ENSRNOT00000020410
Tmem266
transmembrane protein 266
chr3_+_149261333 4.93 ENSRNOT00000038684
AABR07054352.1

chr2_-_165600748 4.81 ENSRNOT00000013216
Ift80
intraflagellar transport 80
chr2_-_116372226 4.55 ENSRNOT00000011932
Lrriq4
leucine-rich repeats and IQ motif containing 4
chr1_+_225037737 4.53 ENSRNOT00000077959
Bscl2
BSCL2, seipin lipid droplet biogenesis associated
chr9_+_116652530 4.50 ENSRNOT00000029210
L3mbtl4
l(3)mbt-like 4 (Drosophila)
chr9_+_43834310 4.40 ENSRNOT00000085720
Cnga3
cyclic nucleotide gated channel alpha 3
chr16_-_6077978 4.02 ENSRNOT00000020823
Il17rb
interleukin 17 receptor B
chr9_-_4327679 3.91 ENSRNOT00000073468
LOC100910235
sulfotransferase 1C1-like
chr2_+_144646308 3.57 ENSRNOT00000078337
ENSRNOT00000093407
Dclk1
doublecortin-like kinase 1
chr7_-_15364203 3.52 ENSRNOT00000036473
RGD1310212
similar to KIAA1111-like protein
chr8_-_38154344 3.45 ENSRNOT00000068043
LOC100360095
urinary protein 1-like
chr4_+_136512201 3.32 ENSRNOT00000051645
Cntn6
contactin 6
chr7_-_94563001 3.29 ENSRNOT00000051139
ENSRNOT00000005561
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr14_+_80403001 3.24 ENSRNOT00000012109
Cpz
carboxypeptidase Z
chr12_-_24578761 3.17 ENSRNOT00000076209
Tbl2
transducin (beta)-like 2
chr2_+_244058186 3.14 ENSRNOT00000021381
Tspan5
tetraspanin 5
chr9_+_92565366 3.04 ENSRNOT00000023184
Csprs
component of Sp100-rs
chr10_-_11935382 3.03 ENSRNOT00000010059
Zfp174
zinc finger protein 174
chr14_-_70098021 3.03 ENSRNOT00000004912
Med28
mediator complex subunit 28
chr1_-_81412251 2.99 ENSRNOT00000026946
Pinlyp
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr9_+_84410972 2.62 ENSRNOT00000019724
Mogat1
monoacylglycerol O-acyltransferase 1
chr3_+_134440195 2.47 ENSRNOT00000072928
AABR07054000.1

chr11_+_69739384 2.45 ENSRNOT00000016340
Kalrn
kalirin, RhoGEF kinase
chr1_-_16687817 2.43 ENSRNOT00000091376
ENSRNOT00000081620
Myb
MYB proto-oncogene, transcription factor
chr9_+_81518584 2.33 ENSRNOT00000084309
Arpc2
actin related protein 2/3 complex, subunit 2
chr10_-_13515448 2.25 ENSRNOT00000067660
Pdpk1
3-phosphoinositide dependent protein kinase-1
chr8_-_38549268 2.25 ENSRNOT00000088001
LOC100912026
urinary protein 3-like
chr2_+_34374158 2.17 ENSRNOT00000016997
Adamts6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr1_+_64506735 2.15 ENSRNOT00000086331
Nlrp12
NLR family, pyrin domain containing 12
chr10_+_106991935 2.07 ENSRNOT00000004007
Pgs1
phosphatidylglycerophosphate synthase 1
chr2_+_189413966 2.02 ENSRNOT00000056603
RGD1564171
RGD1564171
chr1_+_42169501 2.01 ENSRNOT00000025477
ENSRNOT00000092791
Vip
vasoactive intestinal peptide
chr10_-_103685844 1.97 ENSRNOT00000064284
Cd300lf
Cd300 molecule-like family member F
chr6_-_94980004 1.97 ENSRNOT00000006373
Rtn1
reticulon 1
chr4_+_45120576 1.96 ENSRNOT00000077961
ST7
suppression of tumorigenicity 7
chrX_-_70835089 1.95 ENSRNOT00000076351
Tex11
testis expressed 11
chr9_+_115916907 1.83 ENSRNOT00000023226
Lama1
laminin subunit alpha 1
chr6_+_36941596 1.74 ENSRNOT00000083383
Smc6
structural maintenance of chromosomes 6
chr18_-_60002529 1.65 ENSRNOT00000081014
ENSRNOT00000024264
ENSRNOT00000059162
Nars
asparaginyl-tRNA synthetase
chr2_+_115739813 1.65 ENSRNOT00000085452
Slc7a14
solute carrier family 7, member 14
chr10_+_66732390 1.59 ENSRNOT00000089538
Nf1
neurofibromin 1
chr19_-_37528011 1.56 ENSRNOT00000059628
Agrp
agouti related neuropeptide
chrX_+_156210002 1.51 ENSRNOT00000077744
Olr1768
olfactory receptor 1768
chr10_+_14240219 1.47 ENSRNOT00000020233
Igfals
insulin-like growth factor binding protein, acid labile subunit
chr20_+_10981998 1.25 ENSRNOT00000001597
Rrp1
ribosomal RNA processing 1
chr18_+_30869628 1.25 ENSRNOT00000060470
Pcdhgb4
protocadherin gamma subfamily B, 4
chr2_+_165601007 1.19 ENSRNOT00000013931
Smc4
structural maintenance of chromosomes 4
chr1_+_64740487 1.18 ENSRNOT00000081213
LOC103691005
zinc finger protein 679-like
chr1_-_214067657 1.12 ENSRNOT00000044390
LOC100911881
chitinase domain-containing protein 1-like
chr10_+_72147816 1.09 ENSRNOT00000090085
LOC102553386
SUMO-conjugating enzyme UBC9-like
chr5_-_75910805 1.08 ENSRNOT00000019099
Olr854
olfactory receptor 854
chr12_-_650376 1.03 ENSRNOT00000001468
N4bp2l2
NEDD4 binding protein 2-like 2
chr10_-_59883839 0.99 ENSRNOT00000093579
Aspa
aspartoacylase
chr8_-_85840818 0.98 ENSRNOT00000013608
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr7_-_134722215 0.92 ENSRNOT00000036750
Prickle1
prickle planar cell polarity protein 1
chr5_-_113532878 0.85 ENSRNOT00000010173
Caap1
caspase activity and apoptosis inhibitor 1
chr1_+_171188133 0.81 ENSRNOT00000026511
Olr231
olfactory receptor 231
chr9_-_60672246 0.74 ENSRNOT00000017761
Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr8_-_37026142 0.74 ENSRNOT00000060446
LOC100361828
rCG22807-like
chrX_-_64908682 0.67 ENSRNOT00000084107
Zc4h2
zinc finger C4H2-type containing
chr17_-_32953641 0.64 ENSRNOT00000023332
Wrnip1
Werner helicase interacting protein 1
chr7_-_4293352 0.56 ENSRNOT00000047489
Olr984
olfactory receptor 984
chr12_+_25411207 0.51 ENSRNOT00000077189
ENSRNOT00000040356
Gtf2i
general transcription factor II I
chr2_-_29029176 0.51 ENSRNOT00000020692
Fcho2
FCH domain only 2
chr2_+_200397967 0.49 ENSRNOT00000025821
Reg4
regenerating family member 4
chr1_-_168456252 0.48 ENSRNOT00000021169
Olr92
olfactory receptor 92
chr1_+_150797084 0.47 ENSRNOT00000018990
Nox4
NADPH oxidase 4
chr15_+_37171052 0.43 ENSRNOT00000011684
Zmym2
zinc finger MYM-type containing 2
chr1_-_149603272 0.42 ENSRNOT00000045582
Olr13
olfactory receptor 13
chr16_-_71237118 0.42 ENSRNOT00000066974
Nsd3
nuclear receptor binding SET domain protein 3
chr7_+_42269784 0.40 ENSRNOT00000008471
ENSRNOT00000007231
Kitlg
KIT ligand
chr1_-_168015148 0.37 ENSRNOT00000020691
Olr50
olfactory receptor 50
chr16_+_49293243 0.30 ENSRNOT00000049830
AC130162.1

chr7_-_92882068 0.29 ENSRNOT00000037809
Ext1
exostosin glycosyltransferase 1
chr7_-_7311272 0.25 ENSRNOT00000040812
Olr1020
olfactory receptor 1020
chr1_-_149914606 0.24 ENSRNOT00000044773
Olr19
olfactory receptor 19
chr1_-_214504569 0.23 ENSRNOT00000082221
Chid1
chitinase domain containing 1
chr6_-_127886540 0.17 ENSRNOT00000057298
LOC299277
similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B
chr1_-_65863037 0.10 ENSRNOT00000075269
AABR07002068.1

chr1_+_254530121 0.10 ENSRNOT00000089627
AC080157.1

chr1_-_149683357 0.09 ENSRNOT00000077975
Olr17
olfactory receptor 17
chr2_-_211235440 0.08 ENSRNOT00000033015
ENSRNOT00000091896
Sars
seryl-tRNA synthetase
chr17_+_21984325 0.07 ENSRNOT00000088725
AABR07027267.1

chr6_-_139973811 0.01 ENSRNOT00000082875
Ighv5-2
immunoglobulin heavy variable 5-2

Network of associatons between targets according to the STRING database.

First level regulatory network of Bcl6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 41.9 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
6.0 18.1 GO:2000688 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
5.8 29.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
3.7 14.6 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
2.9 14.3 GO:0050828 regulation of liquid surface tension(GO:0050828)
2.3 6.9 GO:0031989 bombesin receptor signaling pathway(GO:0031989)
2.1 6.3 GO:0015680 intracellular copper ion transport(GO:0015680)
2.1 6.2 GO:1903796 negative regulation of inorganic anion transmembrane transport(GO:1903796) negative regulation of chloride transport(GO:2001226)
1.9 5.7 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
1.7 6.7 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
1.4 16.5 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
1.4 10.9 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578)
1.3 6.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.1 3.3 GO:1903165 response to polycyclic arene(GO:1903165)
0.9 2.6 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.8 2.4 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
0.8 4.0 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664)
0.7 2.2 GO:0008592 release of cytoplasmic sequestered NF-kappaB(GO:0008588) regulation of Toll signaling pathway(GO:0008592) negative regulation of Toll signaling pathway(GO:0045751)
0.7 2.0 GO:2000426 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426)
0.6 2.3 GO:2000814 positive regulation of barbed-end actin filament capping(GO:2000814)
0.5 1.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.5 4.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.5 2.4 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.5 3.9 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.5 17.6 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.4 1.9 GO:0006311 meiotic gene conversion(GO:0006311) gene conversion(GO:0035822)
0.4 4.4 GO:0046549 retinal cone cell development(GO:0046549)
0.3 1.0 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.3 5.7 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.3 4.5 GO:0034389 lipid particle organization(GO:0034389)
0.3 14.0 GO:0035640 exploration behavior(GO:0035640)
0.3 11.9 GO:0010737 protein kinase A signaling(GO:0010737)
0.3 11.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.3 1.8 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.3 1.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.3 2.0 GO:0070459 prolactin secretion(GO:0070459)
0.2 8.6 GO:0030261 chromosome condensation(GO:0030261)
0.2 12.0 GO:0035987 endodermal cell differentiation(GO:0035987)
0.2 3.0 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.2 6.7 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.2 2.1 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.2 2.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 6.5 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 1.7 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.9 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
0.1 11.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 3.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 0.6 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.4 GO:0033026 negative regulation of mast cell apoptotic process(GO:0033026) mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 3.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 1.0 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.1 7.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.2 GO:0060976 coronary vasculature development(GO:0060976)
0.0 1.0 GO:1903427 negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.0 0.2 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.5 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 4.6 GO:0044070 regulation of anion transport(GO:0044070)
0.0 1.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.7 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071)
0.0 6.9 GO:0007283 spermatogenesis(GO:0007283)
0.0 5.7 GO:0016569 covalent chromatin modification(GO:0016569)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 12.0 GO:0005610 laminin-5 complex(GO:0005610)
1.2 41.9 GO:0030673 axolemma(GO:0030673)
0.9 1.8 GO:0005608 laminin-3 complex(GO:0005608)
0.8 7.4 GO:0030314 junctional membrane complex(GO:0030314)
0.8 6.3 GO:0005577 fibrinogen complex(GO:0005577)
0.7 14.6 GO:0005614 interstitial matrix(GO:0005614)
0.5 11.9 GO:0097225 sperm midpiece(GO:0097225)
0.4 5.7 GO:0008278 cohesin complex(GO:0008278)
0.4 4.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.4 2.3 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.4 1.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.3 1.7 GO:0035061 interchromatin granule(GO:0035061)
0.3 14.3 GO:0005771 multivesicular body(GO:0005771)
0.2 4.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 6.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 6.6 GO:0005921 gap junction(GO:0005921)
0.2 0.5 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.1 1.9 GO:0000801 central element(GO:0000801)
0.1 1.2 GO:0000796 condensin complex(GO:0000796)
0.1 1.6 GO:0005796 Golgi lumen(GO:0005796)
0.1 18.1 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 16.8 GO:0005770 late endosome(GO:0005770)
0.1 1.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 7.4 GO:0000786 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.1 3.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 3.0 GO:0016592 mediator complex(GO:0016592)
0.1 2.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 8.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 44.5 GO:0036477 somatodendritic compartment(GO:0036477)
0.0 3.6 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 13.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 13.1 GO:0005813 centrosome(GO:0005813)
0.0 4.6 GO:0034702 ion channel complex(GO:0034702)
0.0 1.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 29.1 GO:0004568 chitinase activity(GO:0004568)
3.8 11.3 GO:0001565 phorbol ester receptor activity(GO:0001565)
3.5 41.9 GO:0008046 axon guidance receptor activity(GO:0008046)
2.3 16.2 GO:0045545 syndecan binding(GO:0045545)
2.3 6.9 GO:0004946 bombesin receptor activity(GO:0004946)
1.8 7.4 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
1.5 18.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.3 16.0 GO:0030215 semaphorin receptor binding(GO:0030215)
1.3 6.3 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
1.1 3.3 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.6 14.3 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.6 3.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.6 6.7 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.5 4.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.5 2.0 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.5 2.4 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.5 13.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.4 2.6 GO:0004144 2-acylglycerol O-acyltransferase activity(GO:0003846) diacylglycerol O-acyltransferase activity(GO:0004144)
0.4 2.3 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.4 4.4 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.4 4.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.3 3.0 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.3 1.0 GO:0019807 aspartoacylase activity(GO:0019807)
0.3 6.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.3 2.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 2.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.2 1.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.2 1.4 GO:0008061 chitin binding(GO:0008061)
0.2 24.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 3.3 GO:0005112 Notch binding(GO:0005112)
0.1 10.3 GO:0051213 dioxygenase activity(GO:0051213)
0.1 3.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 10.9 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 2.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 5.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 14.0 GO:0002020 protease binding(GO:0002020)
0.1 3.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 0.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 1.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 6.1 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 7.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.7 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 1.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 2.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 1.6 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 9.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.0 GO:0003779 actin binding(GO:0003779)
0.0 1.8 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 12.0 GO:0032403 protein complex binding(GO:0032403)
0.0 1.2 GO:0003697 single-stranded DNA binding(GO:0003697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 13.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 6.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.5 14.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 13.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.3 14.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 6.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 5.7 PID ALK1 PATHWAY ALK1 signaling events
0.2 4.4 PID CONE PATHWAY Visual signal transduction: Cones
0.1 2.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 16.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 2.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 3.3 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.2 PID AURORA B PATHWAY Aurora B signaling
0.0 2.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 16.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.8 41.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.5 6.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.4 6.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 18.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 6.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 9.5 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 12.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.0 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 6.9 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 2.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.1 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis