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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Bcl6

Z-value: 1.01

Motif logo

Transcription factors associated with Bcl6

Gene Symbol Gene ID Gene Info
ENSRNOG00000001843 B-cell CLL/lymphoma 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bcl6rn6_v1_chr11_+_80255790_80255790-0.522.8e-23Click!

Activity profile of Bcl6 motif

Sorted Z-values of Bcl6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_29538380 61.09 ENSRNOT00000010845
calbindin 1
chr1_-_89360733 35.41 ENSRNOT00000028544
myelin-associated glycoprotein
chr4_+_147037179 33.71 ENSRNOT00000011292
synapsin II
chr17_-_10818835 29.83 ENSRNOT00000091046
complexin 2
chr17_+_47721977 29.51 ENSRNOT00000080800
amphiphysin-like
chr2_-_89310946 29.15 ENSRNOT00000015195
RALY RNA binding protein-like
chr8_-_80631873 24.64 ENSRNOT00000091661
ENSRNOT00000080662
unc-13 homolog C
chr2_+_60920257 24.32 ENSRNOT00000025170
C1q and tumor necrosis factor related protein 3
chr14_+_8182383 23.67 ENSRNOT00000092719
mitogen activated protein kinase 10
chr18_-_37096132 23.13 ENSRNOT00000041188
protein phosphatase 2, regulatory subunit B, beta
chr1_+_106998623 22.21 ENSRNOT00000022383
solute carrier family 17 member 6
chr12_-_10307265 21.75 ENSRNOT00000092627
WAS protein family, member 3
chr15_-_52317219 21.56 ENSRNOT00000016555
dematin actin binding protein
chr13_+_84474319 21.39 ENSRNOT00000031367
ENSRNOT00000072244
ENSRNOT00000072897
ENSRNOT00000064168
ENSRNOT00000074954
ENSRNOT00000073696
immunoglobulin-like domain containing receptor 2
chr2_+_200793571 20.63 ENSRNOT00000091444
hydroxyacid oxidase 2
chr11_+_66932614 20.46 ENSRNOT00000003189
solute carrier family 15 member 2
chr14_+_17534412 20.43 ENSRNOT00000079304
ENSRNOT00000046771
cyclin dependent kinase like 2
chr1_+_156552328 20.33 ENSRNOT00000055401
discs large MAGUK scaffold protein 2
chr9_-_85243001 20.29 ENSRNOT00000020219
secretogranin II
chr15_+_52767442 19.68 ENSRNOT00000014441
phytanoyl-CoA hydroxylase-interacting protein
chr4_-_55398941 18.48 ENSRNOT00000075324
glutamate metabotropic receptor 8
chr10_-_61361250 18.47 ENSRNOT00000092203
RAP1 GTPase activating protein 2
chr15_+_52148379 17.73 ENSRNOT00000074912
phytanoyl-CoA 2-hydroxylase interacting protein
chr3_+_56862691 17.72 ENSRNOT00000087712
glutamate decarboxylase 1
chr9_-_27452902 17.33 ENSRNOT00000018325
glutathione S-transferase alpha 1
chr1_+_32221636 17.18 ENSRNOT00000022346
ENSRNOT00000089941
solute carrier family 6 member 18
chr3_+_97723901 17.12 ENSRNOT00000080416
metallophosphoesterase domain containing 2
chr20_+_20378861 16.55 ENSRNOT00000091044
ankyrin 3
chr7_-_76294663 16.39 ENSRNOT00000064513
neurocalcin delta
chr4_-_11610518 16.35 ENSRNOT00000066643
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr4_+_9981958 16.08 ENSRNOT00000015322
N-acyl phosphatidylethanolamine phospholipase D
chr2_-_185303610 15.99 ENSRNOT00000093479
ENSRNOT00000046286
protease, serine 48
chr8_+_85503224 15.88 ENSRNOT00000012348
glutathione S-transferase alpha 4
chr2_+_58448917 15.10 ENSRNOT00000082562
RAN binding protein 3-like
chrX_+_28072826 15.01 ENSRNOT00000039796
FERM and PDZ domain containing 4
chr5_+_22392732 14.99 ENSRNOT00000087182
clavesin 1
chrX_-_123092217 14.88 ENSRNOT00000039710
predicted gene 14569
chr16_+_54765325 14.87 ENSRNOT00000065327
ENSRNOT00000086899
myotubularin related protein 7
chr5_-_2982603 14.40 ENSRNOT00000045460
potassium voltage-gated channel subfamily B member 2
chrX_+_20423401 14.40 ENSRNOT00000093162
WNK lysine deficient protein kinase 3
chr17_+_53231343 14.21 ENSRNOT00000021703
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr7_+_23403891 13.61 ENSRNOT00000037918
synapsin III
chr16_+_74886719 13.47 ENSRNOT00000089265
ATPase copper transporting beta
chrX_+_71199491 13.44 ENSRNOT00000076168
ENSRNOT00000005077
ENSRNOT00000005102
neuroligin 3
chr8_-_53899669 13.27 ENSRNOT00000082257
neural cell adhesion molecule 1
chr2_+_115739813 13.01 ENSRNOT00000085452
solute carrier family 7, member 14
chr6_+_95323579 12.98 ENSRNOT00000007369
pecanex homolog 4 (Drosophila)
chr4_-_117568348 12.84 ENSRNOT00000071447
N-acetyltransferase 8 (GCN5-related) family member 2
chr16_+_23553647 12.81 ENSRNOT00000041994
pleckstrin and Sec7 domain containing 3
chr5_-_75910805 12.65 ENSRNOT00000019099
olfactory receptor 854
chr3_+_177310753 12.52 ENSRNOT00000031448
myelin transcription factor 1
chr8_+_127735258 12.32 ENSRNOT00000015888
villin-like
chr11_-_11585078 12.11 ENSRNOT00000088878
roundabout guidance receptor 2
chr12_-_46493203 12.09 ENSRNOT00000057036
citron rho-interacting serine/threonine kinase
chr13_+_90723092 12.00 ENSRNOT00000010146
ATP-sensitive inward rectifier potassium channel 10
chr3_+_146546387 11.43 ENSRNOT00000009946
ectonucleoside triphosphate diphosphohydrolase 6
chr16_-_81945127 10.98 ENSRNOT00000023352
MCF.2 cell line derived transforming sequence-like
chr7_-_134722215 10.98 ENSRNOT00000036750
prickle planar cell polarity protein 1
chr10_-_59883839 10.83 ENSRNOT00000093579
aspartoacylase
chr16_+_74076812 10.69 ENSRNOT00000025675
adaptor-related protein complex 3, mu 2 subunit
chr3_-_2803574 10.00 ENSRNOT00000040995
similar to Gene model 996
chr16_+_75145401 9.99 ENSRNOT00000046821
ENSRNOT00000047761
sperm associated antigen 11b-like
chr5_+_133896141 9.87 ENSRNOT00000011434
PDZK1 interacting protein 1
chr10_-_15204143 9.70 ENSRNOT00000026971
rhomboid like 1
chr19_-_57333433 9.61 ENSRNOT00000024917
angiotensinogen
chr9_-_65790347 9.49 ENSRNOT00000028506

chr9_+_84410972 9.48 ENSRNOT00000019724
monoacylglycerol O-acyltransferase 1
chr4_-_117575154 9.46 ENSRNOT00000075813
probable N-acetyltransferase CML2-like
chr16_+_19097391 9.46 ENSRNOT00000018018
calreticulin 3
chr2_+_144646308 9.31 ENSRNOT00000078337
ENSRNOT00000093407
doublecortin-like kinase 1
chr1_-_250774105 9.29 ENSRNOT00000079227
sphingomyelin synthase 1
chr13_-_88061108 9.23 ENSRNOT00000003774
regulator of G-protein signaling 4
chr6_+_109110534 9.21 ENSRNOT00000009156
zinc finger, C2HC-type containing 1C
chr7_+_6644643 9.12 ENSRNOT00000051670
olfactory receptor 962
chr1_+_225037737 8.87 ENSRNOT00000077959
BSCL2, seipin lipid droplet biogenesis associated
chr1_+_81456984 8.70 ENSRNOT00000027075
ETHE1, persulfide dioxygenase
chr2_+_78245459 8.61 ENSRNOT00000089551
protein FAM134B
chr7_-_3342491 8.37 ENSRNOT00000081756
retinol dehydrogenase 5
chrX_+_13441558 8.24 ENSRNOT00000030170
similar to Ferritin light chain (Ferritin L subunit)
chr14_-_37294472 8.23 ENSRNOT00000081087
defective in cullin neddylation 1 domain containing 4
chr7_-_8060373 8.20 ENSRNOT00000071699
olfactory receptor 798
chr8_-_12902262 8.15 ENSRNOT00000033969
endonuclease domain containing 1
chr6_-_38228379 8.13 ENSRNOT00000084924
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr8_+_21890319 7.95 ENSRNOT00000027949
hypothetical protein LOC500956
chr10_+_90342051 7.75 ENSRNOT00000028487
RUN domain containing 3A
chr2_+_225827504 7.73 ENSRNOT00000018343
glutamate cysteine ligase, modifier subunit
chr17_+_43050961 7.61 ENSRNOT00000059510
capping protein regulator and myosin 1 linker 1
chr18_+_30017918 7.48 ENSRNOT00000079794
protocadherin alpha 4
chr3_-_117990289 7.33 ENSRNOT00000011084
SHC adaptor protein 4
chr1_+_42169501 7.16 ENSRNOT00000025477
ENSRNOT00000092791
vasoactive intestinal peptide
chr4_+_154309426 7.14 ENSRNOT00000019346
alpha-2-macroglobulin
chr4_+_78080310 7.11 ENSRNOT00000035906
SCO-spondin
chr5_+_139597731 7.00 ENSRNOT00000072427
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr7_+_132857628 6.95 ENSRNOT00000005438
leucine-rich repeat kinase 2
chr4_+_154423209 6.88 ENSRNOT00000075799
alpha-2-macroglobulin-like
chr1_-_188097530 6.84 ENSRNOT00000078825
synaptotagmin 17
chrX_+_9436707 6.79 ENSRNOT00000004187
calcium/calmodulin dependent serine protein kinase
chr16_+_2379480 6.76 ENSRNOT00000079215
dynein, axonemal, heavy chain 12
chr14_-_92495894 6.58 ENSRNOT00000064483
cordon-bleu WH2 repeat protein
chr5_+_162808646 6.56 ENSRNOT00000021155
dehydrogenase/reductase 3
chr14_+_115275894 6.52 ENSRNOT00000033437
G protein-coupled receptor 75
chr17_+_15194262 6.40 ENSRNOT00000073070

chr17_+_14469488 6.39 ENSRNOT00000060670

chr16_+_54291251 6.26 ENSRNOT00000079006
microtubule associated tumor suppressor 1
chr9_-_61134963 6.14 ENSRNOT00000017967
post-GPI attachment to proteins 1
chrX_+_159505344 6.10 ENSRNOT00000001164
bombesin receptor subtype 3
chr10_-_91699424 6.09 ENSRNOT00000004650
lysozyme-like 6
chr5_+_58855773 6.07 ENSRNOT00000072869
RUN and SH3 domain containing 2
chr7_-_94563001 6.01 ENSRNOT00000051139
ENSRNOT00000005561
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr16_+_4997461 5.99 ENSRNOT00000071042
leucine-rich repeat and transmembrane domain-containing protein 1-like
chr16_-_19996716 5.87 ENSRNOT00000024434
ENSRNOT00000080706
nucleoredoxin-like 1
chr15_+_33822730 5.86 ENSRNOT00000067607
similar to dehydrogenase/reductase member 2
chr8_-_63150753 5.73 ENSRNOT00000078666
TBC1 domain family, member 21
chr4_-_148711830 5.55 ENSRNOT00000049091
olfactory receptor 832
chr10_+_58784660 5.40 ENSRNOT00000019925
uncharacterized LOC100912483
chr2_-_200003443 5.40 ENSRNOT00000024900
ENSRNOT00000088041
phosphodiesterase 4D interacting protein
chr5_+_164845925 5.37 ENSRNOT00000011384
methylenetetrahydrofolate reductase
chr14_-_42560174 5.34 ENSRNOT00000003128
transmembrane protein 33
chr7_-_102298522 5.34 ENSRNOT00000006273
alpha-1-B glycoprotein
chr11_-_60251415 5.32 ENSRNOT00000080148
ENSRNOT00000086602
solute carrier family 9 member C1
chr1_-_188097374 5.19 ENSRNOT00000092246
synaptotagmin 17
chr15_+_89407426 5.06 ENSRNOT00000039423
Nedd4 family interacting protein 2
chr9_+_51302151 5.00 ENSRNOT00000085908
GULP, engulfment adaptor PTB domain containing 1
chr15_-_105402708 4.99 ENSRNOT00000057564
oxoglutarate receptor 1
chrX_-_106066227 4.93 ENSRNOT00000033752
nuclear RNA export factor 7
chr7_-_15163866 4.93 ENSRNOT00000042638
zinc finger protein 870
chr11_-_54344615 4.92 ENSRNOT00000090307
myosin, heavy chain 15
chr7_-_139223116 4.92 ENSRNOT00000086559
endonuclease, poly(U)-specific
chr16_-_31972507 4.89 ENSRNOT00000032199
carbonyl reductase 4
chr4_-_182600258 4.86 ENSRNOT00000067970
ERGIC and golgi 2
chr5_+_169452493 4.86 ENSRNOT00000014444
G protein-coupled receptor 153
chr1_-_149683357 4.83 ENSRNOT00000077975
olfactory receptor 17
chr4_-_150829913 4.54 ENSRNOT00000041571
calcium voltage-gated channel subunit alpha1 C
chr8_-_126390801 4.54 ENSRNOT00000089732

chr1_-_149914606 4.51 ENSRNOT00000044773
olfactory receptor 19
chr4_-_58216711 4.50 ENSRNOT00000015134
testis specific, 13
chr13_+_83721300 4.44 ENSRNOT00000082677
adenylate cyclase 10 (soluble)
chr10_+_92245442 4.42 ENSRNOT00000006808
signal peptide peptidase like 2C
chr14_+_36216002 4.40 ENSRNOT00000038506
sec1 family domain containing 2
chr9_-_63291350 4.35 ENSRNOT00000058831
heat shock transcription factor, Y linked 2
chrX_+_45637415 4.31 ENSRNOT00000050544
similar to ferritin heavy polypeptide-like 17
chr3_+_117335212 4.30 ENSRNOT00000043611
solute carrier family 24 member 5
chr2_-_165600748 4.26 ENSRNOT00000013216
intraflagellar transport 80
chr6_-_105160470 4.24 ENSRNOT00000008367
a disintegrin and metalloprotease domain 4
chr1_-_171028743 4.21 ENSRNOT00000026488
olfactory receptor 223
chr5_+_28395296 4.20 ENSRNOT00000009375
transmembrane protein 55A
chr4_-_150829741 4.17 ENSRNOT00000051846
ENSRNOT00000052017
calcium voltage-gated channel subunit alpha1 C
chr20_+_2194709 4.13 ENSRNOT00000001017
tripartite motif containing 15
chr19_+_15294248 4.10 ENSRNOT00000024622
carboxylesterase 1F
chr19_+_37282018 3.98 ENSRNOT00000021723
transmembrane protein 208
chr7_+_5655645 3.92 ENSRNOT00000043749
olfactory receptor 6C2-like
chr1_+_171188133 3.91 ENSRNOT00000026511
olfactory receptor 231
chr1_+_171274305 3.83 ENSRNOT00000051038
olfactory receptor 234
chr6_+_72891725 3.82 ENSRNOT00000038074
nucleotide binding protein-like
chr2_+_54660722 3.64 ENSRNOT00000060376
maestro heat-like repeat family member 2B
chr3_-_4405194 3.64 ENSRNOT00000072025

chr12_+_16030788 3.62 ENSRNOT00000051565
IQ motif containing E
chr2_+_182006242 3.60 ENSRNOT00000064091
fibrinogen alpha chain
chr1_+_190666149 3.59 ENSRNOT00000089361
uncharacterized LOC102547219
chr4_+_146455332 3.57 ENSRNOT00000009775
histamine receptor H 1
chr16_+_54358471 3.48 ENSRNOT00000047314
microtubule associated tumor suppressor 1
chr3_+_77414999 3.35 ENSRNOT00000047910
olfactory receptor 659
chr4_-_168656673 3.35 ENSRNOT00000009341
G protein-coupled receptor 19
chr1_-_171045419 3.29 ENSRNOT00000047239
olfactory receptor 224
chr19_-_37528011 3.28 ENSRNOT00000059628
agouti related neuropeptide
chr7_-_144109116 3.21 ENSRNOT00000020437
mitogen activated protein kinase kinase kinase 12
chr10_-_89088993 3.17 ENSRNOT00000027458
C-C motif chemokine receptor 10
chrX_+_136488691 3.13 ENSRNOT00000093432
Rho GTPase activating protein 36
chr4_-_58195143 3.10 ENSRNOT00000033706
coatomer protein complex, subunit gamma 2
chr15_+_23792931 3.08 ENSRNOT00000092091
sterile alpha motif domain containing 4A
chr20_+_1736377 3.05 ENSRNOT00000047035
olfactory receptor 1734
chr2_+_53109684 3.04 ENSRNOT00000086590
selenoprotein P
chr1_-_89369960 3.04 ENSRNOT00000028545
hepcidin antimicrobial peptide
chr14_+_17195014 3.01 ENSRNOT00000031667
C-X-C motif chemokine ligand 11
chrX_+_156854594 2.94 ENSRNOT00000083442
renin binding protein
chr3_+_149261333 2.89 ENSRNOT00000038684

chr9_+_100104000 2.87 ENSRNOT00000074160
calpain 10
chr1_+_70480941 2.84 ENSRNOT00000072404
olfactory receptor 6
chr17_+_9830332 2.82 ENSRNOT00000021946
RAB24, member RAS oncogene family
chr1_-_114371897 2.82 ENSRNOT00000018028
non imprinted in Prader-Willi/Angelman syndrome 2
chr7_+_139685573 2.77 ENSRNOT00000088376
phosphofructokinase, muscle
chr6_-_76652757 2.69 ENSRNOT00000042177
ferritin light chain 2
chr7_-_7617499 2.66 ENSRNOT00000051053
olfactory receptor 950
chr19_+_37668693 2.65 ENSRNOT00000084970
par-6 family cell polarity regulator alpha
chrX_-_71127237 2.65 ENSRNOT00000076403
ENSRNOT00000076635
ENSRNOT00000068098
sorting nexin 12
chr3_+_75379451 2.63 ENSRNOT00000071725
olfactory receptor 558
chr10_+_106991935 2.58 ENSRNOT00000004007
phosphatidylglycerophosphate synthase 1
chr1_-_149603272 2.56 ENSRNOT00000045582
olfactory receptor 13
chr8_+_22750336 2.55 ENSRNOT00000013496
low density lipoprotein receptor
chr19_-_37281933 2.52 ENSRNOT00000059663
leucine rich repeat containing 29
chr2_-_259150479 2.46 ENSRNOT00000085892

chr4_+_9821541 2.45 ENSRNOT00000015733
solute carrier family 26 member 5
chr1_+_85337805 2.44 ENSRNOT00000026839
sterile alpha motif domain containing 4B
chr7_-_6971557 2.44 ENSRNOT00000050153
olfactory receptor 960
chr5_-_164585634 2.43 ENSRNOT00000065985
mitofusin 2
chr7_-_70328148 2.41 ENSRNOT00000074645
methyltransferase like 21B
chr19_+_43220508 2.34 ENSRNOT00000091788
ENSRNOT00000084462
ENSRNOT00000087474
DEAD-box helicase 19A
chr1_-_200696928 2.33 ENSRNOT00000068183
ENSRNOT00000022253
ENSRNOT00000065448
ENSRNOT00000022331
fibroblast growth factor receptor 2
chr15_+_103344476 2.32 ENSRNOT00000013329
ENSRNOT00000077047
ENSRNOT00000078103
G protein-coupled receptor 180
chr2_-_209582627 2.29 ENSRNOT00000024351
olfactory receptor 392

Network of associatons between targets according to the STRING database.

First level regulatory network of Bcl6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.3 61.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
6.9 20.6 GO:0018924 mandelate metabolic process(GO:0018924)
5.4 21.6 GO:0070560 protein secretion by platelet(GO:0070560)
5.1 20.5 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
4.8 14.4 GO:2000682 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
4.5 13.5 GO:0015680 intracellular copper ion transport(GO:0015680)
4.4 13.3 GO:0001928 regulation of exocyst assembly(GO:0001928)
4.1 16.5 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
4.0 16.1 GO:1903999 negative regulation of eating behavior(GO:1903999)
4.0 12.0 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
3.5 17.7 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
3.5 7.0 GO:2000468 regulation of peroxidase activity(GO:2000468)
3.5 24.3 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
3.2 9.6 GO:0003331 ovarian follicle rupture(GO:0001543) angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) angiotensin-mediated drinking behavior(GO:0003051) regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) positive regulation of gap junction assembly(GO:1903598)
3.2 9.5 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
3.0 57.2 GO:0031643 positive regulation of myelination(GO:0031643)
3.0 29.8 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
2.5 7.6 GO:0051695 actin filament uncapping(GO:0051695)
2.5 22.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
2.4 12.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
2.3 29.8 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
2.2 24.6 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
2.2 8.7 GO:0070813 hydrogen sulfide metabolic process(GO:0070813)
2.2 23.7 GO:0007258 JUN phosphorylation(GO:0007258)
2.0 6.1 GO:0031989 bombesin receptor signaling pathway(GO:0031989)
2.0 6.0 GO:1903165 response to polycyclic arene(GO:1903165)
1.9 7.7 GO:0097069 cellular response to thyroxine stimulus(GO:0097069)
1.9 15.0 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
1.8 20.3 GO:0046710 GDP metabolic process(GO:0046710)
1.8 7.1 GO:1990402 embryonic liver development(GO:1990402)
1.7 8.6 GO:0061709 reticulophagy(GO:0061709)
1.7 18.5 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
1.5 23.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
1.5 8.7 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
1.4 4.1 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.3 5.3 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.3 17.3 GO:0042178 xenobiotic catabolic process(GO:0042178)
1.3 9.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
1.3 6.6 GO:0001757 somite specification(GO:0001757)
1.3 11.7 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
1.2 3.6 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
1.2 15.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
1.2 2.3 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
1.1 12.5 GO:0060539 diaphragm development(GO:0060539)
1.1 15.9 GO:0009635 response to herbicide(GO:0009635)
1.0 8.1 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
1.0 14.9 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.9 7.2 GO:0070459 prolactin secretion(GO:0070459)
0.9 5.4 GO:0070827 chromatin maintenance(GO:0070827)
0.9 6.1 GO:0015791 polyol transport(GO:0015791)
0.9 4.3 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.8 2.5 GO:0009751 response to salicylic acid(GO:0009751)
0.8 2.4 GO:0098749 cerebellar neuron development(GO:0098749)
0.8 14.9 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.8 10.8 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.8 3.0 GO:0034760 negative regulation of iron ion transmembrane transport(GO:0034760)
0.8 1.5 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.7 2.9 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.7 6.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 3.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.7 7.7 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.7 4.9 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.7 2.8 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.7 2.6 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.6 3.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.6 21.2 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.6 2.6 GO:0090118 regulation of phosphatidylcholine catabolic process(GO:0010899) receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.6 8.9 GO:0034389 lipid particle organization(GO:0034389)
0.6 4.9 GO:0030638 polyketide metabolic process(GO:0030638) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.6 4.3 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.6 2.4 GO:1990910 response to hypobaric hypoxia(GO:1990910)
0.5 7.0 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.5 10.7 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 12.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.5 2.7 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.5 12.0 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.5 1.6 GO:0030242 pexophagy(GO:0030242)
0.5 33.7 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.5 1.9 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.5 8.8 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.5 1.4 GO:1900060 negative regulation of ceramide biosynthetic process(GO:1900060)
0.4 4.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.4 3.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.4 5.3 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4 17.6 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.4 11.4 GO:0032026 response to magnesium ion(GO:0032026)
0.4 10.0 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.4 14.1 GO:0006972 hyperosmotic response(GO:0006972)
0.4 2.6 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.4 8.2 GO:0045116 protein neddylation(GO:0045116)
0.4 4.9 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.3 8.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.3 25.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.3 15.0 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.3 2.6 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.2 3.8 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 4.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.2 1.4 GO:0071569 protein ufmylation(GO:0071569)
0.2 9.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 2.8 GO:0015693 magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830)
0.2 3.0 GO:0010818 T cell chemotaxis(GO:0010818)
0.2 10.2 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2 3.0 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 4.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 4.4 GO:0003351 epithelial cilium movement(GO:0003351)
0.2 1.8 GO:0033139 regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.2 8.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 13.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.2 13.6 GO:0007269 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 2.3 GO:0019236 response to pheromone(GO:0019236)
0.1 0.8 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 4.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 3.1 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 1.6 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 3.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 16.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 5.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 1.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 2.0 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.1 3.6 GO:0010737 protein kinase A signaling(GO:0010737)
0.1 12.0 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.1 6.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 8.4 GO:0007601 visual perception(GO:0007601)
0.1 1.4 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 4.9 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 0.4 GO:0007060 meiotic gene conversion(GO:0006311) male meiosis chromosome segregation(GO:0007060) gene conversion(GO:0035822)
0.1 5.7 GO:1902017 regulation of cilium assembly(GO:1902017)
0.1 0.2 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.1 0.7 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 5.1 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.1 2.9 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 10.6 GO:0007369 gastrulation(GO:0007369)
0.0 3.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 1.1 GO:1901799 negative regulation of proteasomal protein catabolic process(GO:1901799)
0.0 0.7 GO:0001662 behavioral fear response(GO:0001662)
0.0 2.4 GO:0006457 protein folding(GO:0006457)
0.0 0.5 GO:0006695 cholesterol biosynthetic process(GO:0006695)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.8 35.4 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
7.2 21.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
5.0 29.8 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
3.1 24.6 GO:0044305 calyx of Held(GO:0044305)
2.1 16.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
1.7 7.0 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.6 16.4 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.3 20.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.3 20.3 GO:0031045 dense core granule(GO:0031045)
1.1 22.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.0 9.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.9 6.6 GO:1990357 terminal web(GO:1990357)
0.9 2.8 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.9 6.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.9 31.2 GO:0060077 inhibitory synapse(GO:0060077)
0.9 23.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.8 33.7 GO:0031201 SNARE complex(GO:0031201)
0.8 7.6 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.7 8.7 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.7 12.0 GO:0097449 astrocyte projection(GO:0097449)
0.7 17.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.6 4.4 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.6 6.8 GO:0005652 nuclear lamina(GO:0005652)
0.6 13.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.5 1.6 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.5 61.1 GO:0043195 terminal bouton(GO:0043195)
0.4 3.6 GO:0005577 fibrinogen complex(GO:0005577)
0.4 14.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 12.1 GO:0030673 axolemma(GO:0030673)
0.4 10.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.4 18.5 GO:0042734 presynaptic membrane(GO:0042734)
0.3 1.4 GO:0035339 SPOTS complex(GO:0035339)
0.3 24.3 GO:0005581 collagen trimer(GO:0005581)
0.3 2.6 GO:0097443 sorting endosome(GO:0097443)
0.3 1.6 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.3 3.0 GO:0045179 apical cortex(GO:0045179)
0.3 13.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 3.3 GO:0005796 Golgi lumen(GO:0005796)
0.2 15.0 GO:0031901 early endosome membrane(GO:0031901)
0.2 15.0 GO:0043197 dendritic spine(GO:0043197)
0.2 2.0 GO:0030314 junctional membrane complex(GO:0030314)
0.2 1.5 GO:0030137 COPI-coated vesicle(GO:0030137)
0.2 4.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 17.2 GO:0031526 brush border membrane(GO:0031526)
0.2 1.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 3.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.2 8.6 GO:0005801 cis-Golgi network(GO:0005801)
0.2 3.6 GO:0097225 sperm midpiece(GO:0097225)
0.2 12.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 12.3 GO:0031985 Golgi cisterna(GO:0031985)
0.2 2.7 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.7 GO:0035061 interchromatin granule(GO:0035061)
0.1 13.1 GO:0030426 growth cone(GO:0030426)
0.1 0.9 GO:0036128 CatSper complex(GO:0036128)
0.1 16.3 GO:0005802 trans-Golgi network(GO:0005802)
0.1 20.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 6.8 GO:0030286 dynein complex(GO:0030286)
0.1 28.9 GO:0060076 excitatory synapse(GO:0060076)
0.1 12.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 20.4 GO:0030027 lamellipodium(GO:0030027)
0.1 12.5 GO:0072562 blood microparticle(GO:0072562)
0.1 2.4 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.1 0.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 9.2 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.6 GO:0031902 late endosome membrane(GO:0031902)
0.1 7.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 25.3 GO:0005813 centrosome(GO:0005813)
0.1 5.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.6 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 2.5 GO:0005776 autophagosome(GO:0005776)
0.0 4.2 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 0.4 GO:0000801 central element(GO:0000801)
0.0 20.5 GO:0005794 Golgi apparatus(GO:0005794)
0.0 1.5 GO:0098800 inner mitochondrial membrane protein complex(GO:0098800)
0.0 1.2 GO:0031514 motile cilium(GO:0031514)
0.0 1.9 GO:0043209 myelin sheath(GO:0043209)
0.0 4.0 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 1.5 GO:0044798 nuclear transcription factor complex(GO:0044798)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
15.3 61.1 GO:0099510 calcium ion binding involved in regulation of cytosolic calcium ion concentration(GO:0099510)
6.9 20.6 GO:0052854 very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
6.8 20.5 GO:0042895 antibiotic transporter activity(GO:0042895)
4.6 18.5 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
4.1 16.4 GO:0070699 type II activin receptor binding(GO:0070699)
3.6 10.8 GO:0019807 aspartoacylase activity(GO:0019807)
3.5 17.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
3.0 12.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
2.9 11.4 GO:0045134 uridine-diphosphatase activity(GO:0045134)
2.7 24.6 GO:0019992 diacylglycerol binding(GO:0019992)
2.7 13.5 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
2.7 16.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
2.5 35.4 GO:0033691 sialic acid binding(GO:0033691)
2.4 23.7 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.3 7.0 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
2.0 20.3 GO:0004385 guanylate kinase activity(GO:0004385)
2.0 6.1 GO:0004946 bombesin receptor activity(GO:0004946)
2.0 6.0 GO:0004528 phosphodiesterase I activity(GO:0004528)
1.9 9.5 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846) diacylglycerol O-acyltransferase activity(GO:0004144)
1.9 9.3 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
1.8 33.2 GO:0043295 glutathione binding(GO:0043295)
1.8 7.1 GO:0019959 interleukin-8 binding(GO:0019959)
1.6 4.9 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
1.5 8.7 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
1.4 20.2 GO:0042043 neurexin family protein binding(GO:0042043)
1.4 22.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
1.2 14.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.1 7.7 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
1.1 29.8 GO:0017075 syntaxin-1 binding(GO:0017075)
1.0 12.1 GO:0008046 axon guidance receptor activity(GO:0008046)
1.0 9.6 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.9 40.6 GO:0030507 spectrin binding(GO:0030507)
0.9 2.6 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.8 4.2 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.7 20.3 GO:0042056 chemoattractant activity(GO:0042056)
0.7 3.6 GO:0004969 histamine receptor activity(GO:0004969)
0.7 20.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.7 2.8 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.7 14.9 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.7 17.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.6 14.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 15.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.6 1.9 GO:0004775 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.6 14.9 GO:0052866 phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.6 4.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.6 16.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.6 3.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.5 33.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 5.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.5 12.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 2.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.5 10.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 8.2 GO:0097602 cullin family protein binding(GO:0097602)
0.5 13.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.5 6.1 GO:0003796 lysozyme activity(GO:0003796)
0.4 7.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.4 3.0 GO:0008430 selenium binding(GO:0008430)
0.4 23.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 1.0 GO:0047708 biotinidase activity(GO:0047708)
0.3 12.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 9.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 4.7 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.3 2.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.3 15.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.3 5.4 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.3 5.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 2.9 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2 9.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 22.2 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.2 5.5 GO:0030371 translation repressor activity(GO:0030371)
0.2 2.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 15.8 GO:0046332 SMAD binding(GO:0046332)
0.2 1.8 GO:0005132 type I interferon receptor binding(GO:0005132)
0.2 7.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 13.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 4.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.2 0.5 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 14.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 5.1 GO:0050699 WW domain binding(GO:0050699)
0.1 2.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 3.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.8 GO:0003785 actin monomer binding(GO:0003785)
0.1 3.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 3.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 4.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 22.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 4.4 GO:0030145 manganese ion binding(GO:0030145)
0.1 10.2 GO:0005179 hormone activity(GO:0005179)
0.1 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.1 GO:0070628 proteasome binding(GO:0070628)
0.1 6.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.1 6.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 5.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 0.7 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 1.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0 6.4 GO:0016874 ligase activity(GO:0016874)
0.0 13.7 GO:0003779 actin binding(GO:0003779)
0.0 1.5 GO:0019003 GDP binding(GO:0019003)
0.0 4.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.5 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.8 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 23.7 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.6 30.2 PID ATR PATHWAY ATR signaling pathway
0.5 4.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.5 10.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 9.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 8.4 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.3 11.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.3 20.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 9.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 11.0 PID RHOA PATHWAY RhoA signaling pathway
0.2 1.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.2 8.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 5.0 PID ARF6 PATHWAY Arf6 signaling events
0.1 3.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 18.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 3.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.1 2.0 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 2.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 3.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.1 PID FGF PATHWAY FGF signaling pathway
0.0 0.5 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 47.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
1.5 16.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
1.5 17.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
1.4 40.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
1.2 35.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
1.2 59.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
1.2 18.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
1.1 18.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
1.0 16.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.8 18.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.6 16.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.6 16.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.4 12.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 7.1 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 13.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.3 7.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 13.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.3 14.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.3 12.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.3 3.6 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 7.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.2 2.6 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.2 6.1 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.2 2.3 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.2 5.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 19.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 1.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 4.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.7 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 3.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters