ISMARA results: Bcl6

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Bcl6

Z-value: 1.01

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Transcription factors associated with Bcl6

Gene Symbol	Gene ID	Gene Info
Bcl6 NCBI RGD Ensembl	ENSRNOG00000001843	B-cell CLL/lymphoma 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Bcl6	rn6_v1_chr11_+_80255790_80255790	-0.52	2.8e-23	Click!

Activity profile of Bcl6 motif

Sorted Z-values of Bcl6 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_29538380 Show fit	61.09	ENSRNOT00000010845	Calb1 NCBI RGD Ensembl Show fit	calbindin 1
chr1_-_89360733 Show fit	35.41	ENSRNOT00000028544	Mag NCBI RGD Ensembl Show fit	myelin-associated glycoprotein
chr4_+_147037179 Show fit	33.71	ENSRNOT00000011292	Syn2 NCBI RGD Ensembl Show fit	synapsin II
chr17_-_10818835 Show fit	29.83	ENSRNOT00000091046	Cplx2 NCBI RGD Ensembl Show fit	complexin 2
chr17_+_47721977 Show fit	29.51	ENSRNOT00000080800	LOC100910792 NCBI RGD Ensembl Show fit	amphiphysin-like
chr2_-_89310946 Show fit	29.15	ENSRNOT00000015195	Ralyl NCBI RGD Ensembl Show fit	RALY RNA binding protein-like
chr8_-_80631873 Show fit	24.64	ENSRNOT00000091661 ENSRNOT00000080662	Unc13c NCBI RGD Ensembl Show fit	unc-13 homolog C
chr2_+_60920257 Show fit	24.32	ENSRNOT00000025170	C1qtnf3 NCBI RGD Ensembl Show fit	C1q and tumor necrosis factor related protein 3
chr14_+_8182383 Show fit	23.67	ENSRNOT00000092719	Mapk10 NCBI RGD Ensembl Show fit	mitogen activated protein kinase 10
chr18_-_37096132 Show fit	23.13	ENSRNOT00000041188	Ppp2r2b NCBI RGD Ensembl Show fit	protein phosphatase 2, regulatory subunit B, beta

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Bcl6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.3	61.1	GO:0035502	metanephric part of ureteric bud development(GO:0035502)
3.0	57.2	GO:0031643	positive regulation of myelination(GO:0031643)
0.5	33.7	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
3.0	29.8	GO:2000809	positive regulation of synaptic vesicle clustering(GO:2000809)
2.3	29.8	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.3	25.3	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
2.2	24.6	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
3.5	24.3	GO:0071638	negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
2.2	23.7	GO:0007258	JUN phosphorylation(GO:0007258)
1.5	23.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)

Showing 1 to 10 of 140 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	61.1	GO:0043195	terminal bouton(GO:0043195)
11.8	35.4	GO:0097453	mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.8	33.7	GO:0031201	SNARE complex(GO:0031201)
0.9	31.2	GO:0060077	inhibitory synapse(GO:0060077)
5.0	29.8	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1	28.9	GO:0060076	excitatory synapse(GO:0060076)
0.1	25.3	GO:0005813	centrosome(GO:0005813)
3.1	24.6	GO:0044305	calyx of Held(GO:0044305)
0.3	24.3	GO:0005581	collagen trimer(GO:0005581)
0.9	23.1	GO:0000159	protein phosphatase type 2A complex(GO:0000159)

Showing 1 to 10 of 79 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.3	61.1	GO:0099510	calcium ion binding involved in regulation of cytosolic calcium ion concentration(GO:0099510)
0.9	40.6	GO:0030507	spectrin binding(GO:0030507)
2.5	35.4	GO:0033691	sialic acid binding(GO:0033691)
0.5	33.7	GO:0048306	calcium-dependent protein binding(GO:0048306)
1.8	33.2	GO:0043295	glutathione binding(GO:0043295)
1.1	29.8	GO:0017075	syntaxin-1 binding(GO:0017075)
2.7	24.6	GO:0019992	diacylglycerol binding(GO:0019992)
2.4	23.7	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.4	23.1	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
1.4	22.2	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)

Showing 1 to 10 of 108 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	30.2	PID ATR PATHWAY	ATR signaling pathway
0.7	23.7	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3	20.4	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	18.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	11.0	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	11.0	PID RHOA PATHWAY	RhoA signaling pathway
0.5	10.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.4	9.6	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.2	9.3	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	8.4	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	59.8	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
3.2	47.3	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
1.4	40.9	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
1.2	35.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	19.3	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
1.2	18.6	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.1	18.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.8	18.5	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.5	17.7	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.6	16.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 10 of 40 entries

Results for Bcl6

Z-value: 1.01

Motif logo

Transcription factors associated with Bcl6

Activity-expression correlation:

Activity profile of Bcl6 motif

Sorted Z-values of Bcl6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Bcl6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: