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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Bbx

Z-value: 0.31

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Transcription factors associated with Bbx

Gene Symbol Gene ID Gene Info
Bbx
ENSRNOG00000001971 BBX, HMG-box containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bbxrn6_v1_chr11_+_53081025_53081025-0.198.6e-04Click!

Activity profile of Bbx motif

Sorted Z-values of Bbx motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_102794168 10.80 ENSRNOT00000048400
AABR07061022.1

chr15_+_32614002 9.46 ENSRNOT00000072962
AABR07017902.1

chr14_-_5859581 8.48 ENSRNOT00000052308
AABR07014241.1

chr10_+_71047310 8.25 ENSRNOT00000042643
ENSRNOT00000088737
Wfdc21
WAP four-disulfide core domain 21
chrX_-_110230610 7.61 ENSRNOT00000093401
Serpina7
serpin family A member 7
chr14_+_2050483 6.26 ENSRNOT00000000047
Slc26a1
solute carrier family 26 member 1
chr11_+_85042348 6.07 ENSRNOT00000042220
AABR07034718.1

chr20_-_27782586 6.02 ENSRNOT00000001093
Dse
dermatan sulfate epimerase
chr16_-_25192675 5.92 ENSRNOT00000032289
March1
membrane associated ring-CH-type finger 1
chr17_-_86657473 5.24 ENSRNOT00000078827
AABR07028795.1

chr3_-_79282493 5.07 ENSRNOT00000049832
Ptprj
protein tyrosine phosphatase, receptor type, J
chr7_-_143497108 4.81 ENSRNOT00000048613
Krt76
keratin 76
chr13_+_92146586 4.31 ENSRNOT00000004659
Olr1588
olfactory receptor 1588
chr5_+_151776004 3.90 ENSRNOT00000009683
Nr0b2
nuclear receptor subfamily 0, group B, member 2
chr8_-_97647072 3.84 ENSRNOT00000030645
Tbc1d2b
TBC1 domain family, member 2B
chr18_+_40596166 3.09 ENSRNOT00000087984
Eif1a
eukaryotic translation initiation factor 1A
chr13_-_111972603 3.02 ENSRNOT00000007870
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr3_-_24601063 2.84 ENSRNOT00000037043
LOC100362366
40S ribosomal protein S17-like
chr2_+_107233054 2.82 ENSRNOT00000015573
Tbl1xr1
transducin (beta)-like 1 X-linked receptor 1
chr18_+_72571327 2.41 ENSRNOT00000089468
Smad2
SMAD family member 2
chr3_-_173166369 1.70 ENSRNOT00000090602
AABR07054887.1

chr1_-_124803363 1.68 ENSRNOT00000066380
Klf13
Kruppel-like factor 13
chr15_-_27140657 1.60 ENSRNOT00000016727
Olr1612
olfactory receptor 1612
chr12_-_6630274 1.49 ENSRNOT00000087840
AABR07035194.1

chr8_+_61659445 1.40 ENSRNOT00000023831
Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chr3_-_43119159 1.31 ENSRNOT00000041394
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chrX_-_80142902 1.19 ENSRNOT00000071650
Hmgn5
high mobility group nucleosome binding domain 5
chr3_-_167225532 1.06 ENSRNOT00000075012
LOC102553249
zinc finger protein 120-like
chr8_-_94920441 0.88 ENSRNOT00000014165
Cep162
centrosomal protein 162
chr1_+_124477164 0.73 ENSRNOT00000048744
Hmgn5b
high mobility group nucleosome binding domain 5B
chr3_-_173371835 0.58 ENSRNOT00000073650
LOC102557590
zinc finger protein 709-like
chr4_+_166911595 0.56 ENSRNOT00000030813
Tas2r124
taste receptor, type 2, member 124
chr3_-_167270512 0.41 ENSRNOT00000075542
AABR07054708.1

chr2_+_240642184 0.39 ENSRNOT00000083181
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr19_-_37528011 0.32 ENSRNOT00000059628
Agrp
agouti related neuropeptide
chr3_-_173249556 0.28 ENSRNOT00000081623
AABR07054895.1

chr6_-_26135952 0.20 ENSRNOT00000084751
Mrpl33
mitochondrial ribosomal protein L33
chrX_-_135419704 0.05 ENSRNOT00000044435
Zfp280c
zinc finger protein 280C

Network of associatons between targets according to the STRING database.

First level regulatory network of Bbx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
1.0 3.0 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.7 7.6 GO:0070327 thyroid hormone transport(GO:0070327)
0.6 2.4 GO:1900224 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.6 11.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.5 5.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.4 6.3 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.3 4.8 GO:0048733 sebaceous gland development(GO:0048733)
0.3 1.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 5.9 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 1.7 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 2.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 3.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 1.2 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 3.9 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 3.1 GO:0006413 translational initiation(GO:0006413)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 5.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.9 GO:0005879 axonemal microtubule(GO:0005879)
0.1 5.1 GO:0001772 immunological synapse(GO:0001772)
0.1 4.8 GO:0045095 keratin filament(GO:0045095)
0.0 2.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 6.3 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
1.0 3.0 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
1.0 7.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.6 2.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.4 6.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.4 5.1 GO:0070097 delta-catenin binding(GO:0070097)
0.3 3.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 5.9 GO:0042287 MHC protein binding(GO:0042287)
0.2 3.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 8.3 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 2.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 3.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 5.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 2.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 5.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.0 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 2.8 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 5.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides