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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Atf7_E4f1

Z-value: 0.95

Motif logo

Transcription factors associated with Atf7_E4f1

Gene Symbol Gene ID Gene Info
ENSRNOG00000015269 activating transcription factor 7
ENSRNOG00000009224 E4F transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4f1rn6_v1_chr10_-_13826945_13826945-0.132.4e-02Click!
Atf7rn6_v1_chr7_-_144223429_144223429-0.072.3e-01Click!

Activity profile of Atf7_E4f1 motif

Sorted Z-values of Atf7_E4f1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_65424802 56.11 ENSRNOT00000018468
Tnf receptor associated factor 4
chr2_+_189629297 55.29 ENSRNOT00000049810
DENN domain containing 4B
chr4_+_70572942 45.39 ENSRNOT00000051964

chr4_-_57625147 39.21 ENSRNOT00000074649
ENSRNOT00000078961
ubiquitin-conjugating enzyme E2H
chr17_+_43617247 37.15 ENSRNOT00000075065
histone cluster 1, H2ao
chr18_-_77322690 33.81 ENSRNOT00000058382
nuclear factor of activated T-cells 1
chr12_+_37984790 33.34 ENSRNOT00000001445
VPS37B, ESCRT-I subunit
chr10_+_11724032 31.18 ENSRNOT00000008966
TNF receptor-associated protein 1
chr17_-_43821536 29.89 ENSRNOT00000072286
histone H4 variant H4-v.1
chr13_-_50916982 25.37 ENSRNOT00000004408
BTG anti-proliferation factor 2
chr2_-_123282214 24.98 ENSRNOT00000021156
cyclin A2
chr10_+_70884531 24.26 ENSRNOT00000015199
C-C motif chemokine ligand 4
chr1_+_196996581 22.96 ENSRNOT00000021690
interleukin 21 receptor
chr4_-_67520356 22.63 ENSRNOT00000014604
B-Raf proto-oncogene, serine/threonine kinase
chr17_-_1797732 22.16 ENSRNOT00000033017
ENSRNOT00000079742
cell division cycle 14B
chr10_-_88163712 21.81 ENSRNOT00000005382
ENSRNOT00000084493
keratin 17
chr1_+_86938138 21.64 ENSRNOT00000075601
coiled-coil glutamate-rich protein 2
chr6_+_132702448 21.52 ENSRNOT00000005743
YY1 transcription factor
chr2_-_123281856 21.09 ENSRNOT00000079745
cyclin A2
chr9_+_20765296 20.84 ENSRNOT00000016291
CD2-associated protein
chr8_+_81766041 20.47 ENSRNOT00000032280
one cut homeobox 1
chr1_-_80544825 20.17 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
RELB proto-oncogene, NF-kB subunit
chr5_+_148320438 19.65 ENSRNOT00000018742
penta-EF hand domain containing 1
chr10_+_16970626 19.51 ENSRNOT00000005383
dual specificity phosphatase 1
chr4_+_99239115 18.70 ENSRNOT00000009515
CD8a molecule
chr17_+_10463303 18.06 ENSRNOT00000060822
ring finger protein 44
chr1_-_64090017 17.64 ENSRNOT00000086622
ENSRNOT00000091654
ribosomal protein S9
chr5_-_152464850 17.23 ENSRNOT00000021937
zinc finger protein 593
chr1_-_64021321 17.21 ENSRNOT00000090819
ribosomal protein S9
chr3_+_100366168 17.18 ENSRNOT00000006689
kinesin family member 18A
chr6_-_91456696 16.96 ENSRNOT00000005577
ribosomal protein S29
chr4_+_69435703 16.90 ENSRNOT00000065485
uncharacterized LOC100911271
chr15_+_57290849 16.61 ENSRNOT00000014909
carboxypeptidase B2
chr7_-_2941122 16.61 ENSRNOT00000082107
extended synaptotagmin 1
chr20_-_4070721 16.50 ENSRNOT00000000523
RT1 class II, locus Ba
chr4_-_170740274 16.35 ENSRNOT00000012212
guanylate cyclase 2C
chr2_+_240396152 16.09 ENSRNOT00000034565
centromere protein E
chrX_-_156399760 16.04 ENSRNOT00000086921
family with sequence similarity 50, member A
chr7_-_54778848 15.90 ENSRNOT00000005399
GLI pathogenesis-related 1
chr6_-_7741414 15.84 ENSRNOT00000038246
THADA, armadillo repeat containing
chr20_-_10680283 15.44 ENSRNOT00000001579
salt-inducible kinase 1
chr8_-_21995806 15.30 ENSRNOT00000028034
sphingosine-1-phosphate receptor 2
chr9_+_9970209 15.17 ENSRNOT00000075215
DENN/MADD domain containing 1C
chr3_+_161212156 15.06 ENSRNOT00000020280
ENSRNOT00000083553
deoxynucleotidyltransferase, terminal, interacting protein 1
chr4_-_51946715 14.42 ENSRNOT00000079130
protection of telomeres 1
chr10_-_64398294 13.92 ENSRNOT00000010386
glyoxalase domain containing 4
chr12_+_52072188 13.52 ENSRNOT00000056725
nucleolar complex associated 4 homolog
chr1_-_156296161 13.37 ENSRNOT00000025653
CREB/ATF bZIP transcription factor
chr11_-_62451149 13.13 ENSRNOT00000093686
ENSRNOT00000081443
zinc finger and BTB domain containing 20
chr9_+_82370924 12.91 ENSRNOT00000025219
zinc finger AN1-type containing 2B
chr10_+_45559578 12.87 ENSRNOT00000004011
similar to RIKEN cDNA 2310033P09
chr9_-_78969013 12.85 ENSRNOT00000019772
ENSRNOT00000057585
fibronectin 1
chr1_-_178218761 12.66 ENSRNOT00000019199
parathyroid hormone
chr6_+_126623015 12.62 ENSRNOT00000010672
transmembrane protein 251
chr10_+_13000090 12.20 ENSRNOT00000004845
claudin 6
chr10_-_74724472 11.87 ENSRNOT00000008846
RAD51 paralog C
chr14_+_2613406 11.85 ENSRNOT00000000083
transmembrane p24 trafficking protein 5
chr19_-_15733412 11.83 ENSRNOT00000014831
iroquois homeobox 6
chr20_+_10844266 11.63 ENSRNOT00000001583
ribosomal RNA processing 1B
chr4_+_84854386 11.62 ENSRNOT00000013620
maturin, neural progenitor differentiation regulator homolog
chr11_+_80255790 11.13 ENSRNOT00000002522
B-cell CLL/lymphoma 6
chr8_+_50310405 11.11 ENSRNOT00000073507
SIK family kinase 3
chr9_+_78968814 11.10 ENSRNOT00000057584

chr1_+_103172987 11.10 ENSRNOT00000018688
transmembrane protein 86A
chr7_+_120580743 10.92 ENSRNOT00000017181
MAF bZIP transcription factor F
chr19_-_34105610 10.74 ENSRNOT00000017347
protein arginine methyltransferase 9
chr10_+_31324512 10.70 ENSRNOT00000008559
fibronectin type III domain containing 9
chr12_+_13102019 10.60 ENSRNOT00000092628
ras-related C3 botulinum toxin substrate 1
chr5_+_159845774 10.50 ENSRNOT00000012328
Eph receptor A2
chr19_+_27404712 10.49 ENSRNOT00000023657
myosin light chain kinase 3
chr7_+_25919867 10.31 ENSRNOT00000009625
ENSRNOT00000090153
RIC8 guanine nucleotide exchange factor B
chr3_-_161212188 10.29 ENSRNOT00000065751
WAP four-disulfide core domain 3
chr7_+_61236037 10.27 ENSRNOT00000009776
interleukin 22
chr4_-_120840111 10.24 ENSRNOT00000022231
minichromosome maintenance complex component 2
chr2_-_66608324 10.24 ENSRNOT00000077597
ceroid-lipofuscinosis, neuronal 5
chr15_-_70399924 10.22 ENSRNOT00000087940
diaphanous-related formin 3
chr7_-_142180997 10.20 ENSRNOT00000087632
transcription factor CP2
chr19_+_37600148 10.11 ENSRNOT00000023853
CCCTC-binding factor
chr8_+_114866768 9.97 ENSRNOT00000076731
WD repeat domain 82
chr7_+_63922879 9.85 ENSRNOT00000043581
similar to Hypothetical protein LOC270802
chrX_+_1321315 9.83 ENSRNOT00000014250
synapsin I
chr19_+_37990374 9.63 ENSRNOT00000026827
dihydrouridine synthase 2
chr7_+_140758615 9.58 ENSRNOT00000089448
trophinin associated protein
chr9_-_99651813 9.58 ENSRNOT00000022089
NADH:ubiquinone oxidoreductase subunit A10
chrX_+_45420596 9.51 ENSRNOT00000051897
steroid sulfatase (microsomal), isozyme S
chr12_-_13668515 9.49 ENSRNOT00000086847
fascin actin-bundling protein 1
chrX_-_54303729 9.39 ENSRNOT00000087919
ENSRNOT00000064340
ENSRNOT00000051249
ENSRNOT00000087547
glycerol kinase
chr20_-_3815834 9.38 ENSRNOT00000000543
ring finger protein 1
chr4_-_80333326 9.30 ENSRNOT00000014058
cytochrome c, somatic-like
chr3_-_15463881 9.29 ENSRNOT00000009706
RNA binding motif protein 18
chr10_+_94407559 9.27 ENSRNOT00000013046
DEAD-box helicase 42
chr5_-_141430659 9.27 ENSRNOT00000034944
akirin 1
chr11_+_70034139 9.17 ENSRNOT00000002450
uridine monophosphate synthetase
chr10_-_88842233 9.14 ENSRNOT00000026760
signal transducer and activator of transcription 3
chrX_+_134940615 9.04 ENSRNOT00000005604
X-prolyl aminopeptidase 2
chr7_-_142180794 9.00 ENSRNOT00000037447
transcription factor CP2
chr20_-_3299580 8.95 ENSRNOT00000050373
G protein nucleolar 1
chr19_-_54245855 8.81 ENSRNOT00000023855
ER membrane protein complex subunit 8
chr6_+_137210052 8.80 ENSRNOT00000031788
ENSRNOT00000065213
SIVA1, apoptosis-inducing factor
chr2_+_188784222 8.72 ENSRNOT00000028095
phosphomevalonate kinase
chr4_+_25635765 8.68 ENSRNOT00000009340
GTP binding protein 10
chr9_+_45672157 8.64 ENSRNOT00000017882
phosducin-like 3
chr18_+_62174670 8.34 ENSRNOT00000025362
phorbol-12-myristate-13-acetate-induced protein 1
chr19_-_37990353 8.32 ENSRNOT00000026817
DEAD-box helicase 28
chr10_+_64398339 8.30 ENSRNOT00000056278
mitochondrial rRNA methyltransferase 3
chr2_-_30340103 8.19 ENSRNOT00000024023
ENSRNOT00000067722
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr4_+_157452607 8.19 ENSRNOT00000022467
myeloid leukemia factor 2
chr3_+_8802852 8.13 ENSRNOT00000033934
leucine rich repeat containing 8 family, member A
chr16_-_29936307 7.89 ENSRNOT00000088707
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr9_+_17817721 7.73 ENSRNOT00000086986
ENSRNOT00000026920
heat shock protein 90 alpha family class B member 1
chr19_-_43841795 7.71 ENSRNOT00000079539
lactate dehydrogenase D
chr1_-_167308827 7.64 ENSRNOT00000027590
ENSRNOT00000027575
nucleoporin 98
chr6_-_96171629 7.55 ENSRNOT00000010546
ENSRNOT00000078190
tRNA methyltransferase 5
chrX_-_158978995 7.53 ENSRNOT00000001179
membrane magnesium transporter 1
chr19_+_55917736 7.39 ENSRNOT00000020635
ribosomal protein L13
chr3_+_15463953 7.33 ENSRNOT00000033047
mitochondrial ribosome recycling factor
chr20_+_2088533 7.20 ENSRNOT00000001012
ENSRNOT00000079021
zinc ribbon domain containing 1
chr10_+_29165577 7.16 ENSRNOT00000078415
cyclin J-like
chr20_+_22728208 6.97 ENSRNOT00000000794
nuclear receptor-binding factor 2-like
chr4_+_157453069 6.97 ENSRNOT00000088622
myeloid leukemia factor 2
chrX_-_45522665 6.93 ENSRNOT00000030771
similar to GS2 gene
chr14_-_80355420 6.92 ENSRNOT00000049798
acyl-CoA oxidase 3, pristanoyl
chr1_+_102900286 6.83 ENSRNOT00000017468
lactate dehydrogenase A
chr12_-_18531161 6.74 ENSRNOT00000037829
A-kinase anchoring protein 17A
chr19_+_14523554 6.70 ENSRNOT00000084271
ENSRNOT00000064731
minichromosome maintenance complex component 5
chr1_+_81395841 6.69 ENSRNOT00000072750
immunity-related GTPase Q
chr10_+_104019888 6.68 ENSRNOT00000032016
solute carrier family 16 member 5
chr1_-_101118825 6.63 ENSRNOT00000066328
ribosomal protein S11
chr14_-_81254637 6.63 ENSRNOT00000058166
huntingtin
chr1_+_162768156 6.63 ENSRNOT00000049321
p21 (RAC1) activated kinase 1
chr1_+_280423079 6.53 ENSRNOT00000011983
solute carrier family 18 member A2
chr5_-_169200109 6.53 ENSRNOT00000012745
zinc finger and BTB domain containing 48
chr1_+_167538263 6.46 ENSRNOT00000074058
ribonucleotide reductase catalytic subunit M1
chr4_+_157554794 6.45 ENSRNOT00000024116
inhibitor of growth family, member 4
chr8_+_114867062 6.45 ENSRNOT00000074771
WD repeat domain 82
chr8_+_69127708 6.42 ENSRNOT00000013490
small nuclear RNA activating complex, polypeptide 5
chr2_-_152824547 6.41 ENSRNOT00000019824
DEAH-box helicase 36
chr20_+_3299730 6.35 ENSRNOT00000078538
proline rich 3
chr10_-_56531483 6.31 ENSRNOT00000022343
eukaryotic translation initiation factor 5A
chr12_-_52072106 6.30 ENSRNOT00000088306
ENSRNOT00000068621
DEAD-box helicase 51
chr9_-_49902943 6.23 ENSRNOT00000037094
transforming growth factor, beta receptor associated protein 1
chr10_+_55492404 6.21 ENSRNOT00000005588
ENSRNOT00000078038
ribosomal protein L26
chr2_-_104133985 6.20 ENSRNOT00000088167
ENSRNOT00000067725
phosphodiesterase 7A
chr11_-_64752544 6.14 ENSRNOT00000048738
transmembrane protein 39a
chr19_-_25955371 6.14 ENSRNOT00000004042
ENSRNOT00000084123
RAD23 homolog A, nucleotide excision repair protein
chr14_-_86706626 6.08 ENSRNOT00000082893
H2A histone family, member V
chr5_-_140162642 5.96 ENSRNOT00000046906
rearranged L-myc fusion
chr7_-_75597087 5.92 ENSRNOT00000080676
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr6_+_108032856 5.91 ENSRNOT00000014738
zinc finger protein 410
chr1_-_89124132 5.91 ENSRNOT00000031044
HAUS augmin-like complex, subunit 5
chr20_-_10407554 5.88 ENSRNOT00000074081
U2 small nuclear RNA auxiliary factor 1
chr12_+_47920743 5.87 ENSRNOT00000072511
methylmalonic aciduria (cobalamin deficiency) cblB type
chr8_+_116826680 5.85 ENSRNOT00000026854
GDP-mannose pyrophosphorylase B
chr4_-_168517177 5.85 ENSRNOT00000009151
dual specificity phosphatase 16
chr10_-_66602987 5.83 ENSRNOT00000017949
WD repeat and SOCS box-containing 1
chr3_-_110964452 5.78 ENSRNOT00000016356
regulator of microtubule dynamics 3
chr10_-_94406949 5.77 ENSRNOT00000012533
coiled-coil domain containing 47
chr2_+_264786242 5.75 ENSRNOT00000015170
ankyrin repeat domain 13C
chr19_+_31867981 5.71 ENSRNOT00000024753
ATP binding cassette subfamily E member 1
chr5_+_155935554 5.70 ENSRNOT00000031855
ubiquitin carboxyl-terminal hydrolase 48-like
chr4_+_8256611 5.69 ENSRNOT00000061894

chr14_+_107767392 5.68 ENSRNOT00000012847
chaperonin containing TCP1 subunit 4
chr5_-_150653172 5.65 ENSRNOT00000072028
mediator complex subunit 18
chr19_+_56272162 5.57 ENSRNOT00000030399
AFG3(ATPase family gene 3)-like 1 (S. cerevisiae)
chr1_+_100473643 5.56 ENSRNOT00000026379
Josephin domain containing 2
chr5_+_150001281 5.48 ENSRNOT00000034057
mitochondrial trans-2-enoyl-CoA reductase
chr4_+_67378188 5.46 ENSRNOT00000030892
NADH:ubiquinone oxidoreductase subunit B2
chr7_+_125034764 5.45 ENSRNOT00000015767
patatin-like phospholipase domain containing 3
chr7_-_2588686 5.42 ENSRNOT00000048848
RNA binding motif, single stranded interacting protein 2
chr10_-_85574889 5.37 ENSRNOT00000072274
hypothetical protein LOC691153
chr1_-_134867001 5.36 ENSRNOT00000090149
chromodomain helicase DNA binding protein 2
chr1_+_100755682 5.31 ENSRNOT00000035748
vaccinia related kinase 3
chr4_+_3043231 5.30 ENSRNOT00000013732
interleukin 6
chr13_+_111890894 5.29 ENSRNOT00000007341
hypothetical protein LOC100125367
chr9_+_38799881 5.26 ENSRNOT00000083847

chr17_+_6840463 5.26 ENSRNOT00000061233
ubiquilin 1
chr11_+_82373870 5.24 ENSRNOT00000002429
transformer 2 beta homolog (Drosophila)
chr1_+_177495782 5.22 ENSRNOT00000021020
TEA domain transcription factor 1
chr2_-_115891097 5.19 ENSRNOT00000013191
SKI-like proto-oncogene
chr20_-_7397448 5.17 ENSRNOT00000059426
similar to chromosome 6 open reading frame 106 isoform a
chr13_-_110257367 5.12 ENSRNOT00000005576
denticleless E3 ubiquitin protein ligase homolog
chr11_-_67647818 5.12 ENSRNOT00000003068
WD repeat domain 5B
chr7_-_70355619 5.11 ENSRNOT00000031272
tetraspanin 31
chr6_-_41870046 4.99 ENSRNOT00000005863
lipin 1
chr3_+_152933771 4.98 ENSRNOT00000027539
similar to RIKEN cDNA 1110008F13
chr6_+_137184820 4.93 ENSRNOT00000073796
adenylosuccinate synthase like 1
chr1_-_37863756 4.92 ENSRNOT00000077781
zinc finger protein 874b
chr15_+_34234193 4.92 ENSRNOT00000077584
DDB1 and CUL4 associated factor 11
chr7_+_120923274 4.89 ENSRNOT00000049247
GTP binding protein 1
chr9_+_10428853 4.84 ENSRNOT00000074253
lon peptidase 1, mitochondrial
chr12_-_16002788 4.83 ENSRNOT00000090318
archaelysin family metallopeptidase 1
chr2_-_187909394 4.80 ENSRNOT00000032355
RAB25, member RAS oncogene family
chr14_+_86414949 4.80 ENSRNOT00000083394
ENSRNOT00000057199
2-oxoglutarate dehydrogenase, mitochondrial-like
chr8_-_25904564 4.77 ENSRNOT00000082744
ENSRNOT00000064783
T-box 20
chr16_+_82184387 4.76 ENSRNOT00000089329
ENSRNOT00000068416
tubulin, gamma complex associated protein 3
chr3_+_94530586 4.67 ENSRNOT00000067860
cleavage stimulation factor subunit 3
chr1_+_261415191 4.66 ENSRNOT00000083287
ENSRNOT00000040740
zinc finger FYVE-type containing 27
chr4_+_21872856 4.64 ENSRNOT00000044810
cyclin D binding myb-like transcription factor 1
chr12_+_504007 4.57 ENSRNOT00000001475
BRCA2, DNA repair associated
chr15_-_43733182 4.54 ENSRNOT00000015318
protein phosphatase 2, regulatory subunit B, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf7_E4f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.1 33.3 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
10.4 31.2 GO:1901856 negative regulation of cellular respiration(GO:1901856)
8.7 34.9 GO:0045903 positive regulation of translational fidelity(GO:0045903)
8.5 33.8 GO:0002337 B-1a B cell differentiation(GO:0002337)
7.9 55.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
7.7 46.2 GO:0071314 cellular response to cocaine(GO:0071314)
6.5 19.6 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
6.2 18.7 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
5.5 16.6 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
5.4 21.5 GO:0034696 response to prostaglandin F(GO:0034696)
5.2 20.8 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
5.1 56.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
4.8 14.4 GO:0060383 positive regulation of DNA strand elongation(GO:0060383)
4.5 22.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
4.3 12.9 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
4.0 24.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
4.0 11.9 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
3.9 67.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
3.7 11.0 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
3.2 12.9 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
3.2 22.2 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
3.2 12.7 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
3.1 9.4 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
3.1 15.4 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
3.0 9.1 GO:1904685 positive regulation of metalloendopeptidase activity(GO:1904685)
2.9 8.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
2.8 11.1 GO:0048294 regulation of mast cell cytokine production(GO:0032763) negative regulation of isotype switching to IgE isotypes(GO:0048294)
2.8 8.3 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
2.7 16.1 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
2.6 10.5 GO:0048319 notochord formation(GO:0014028) axial mesoderm morphogenesis(GO:0048319) negative regulation of lymphangiogenesis(GO:1901491)
2.6 10.5 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
2.6 7.7 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
2.6 10.2 GO:1904426 positive regulation of GTP binding(GO:1904426)
2.6 15.3 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
2.5 7.5 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
2.3 6.9 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
2.2 6.6 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244) positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
2.2 17.2 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
2.1 10.6 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
2.1 25.4 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
2.1 8.3 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
2.1 6.2 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
2.0 21.8 GO:0051798 positive regulation of hair follicle development(GO:0051798)
1.8 19.5 GO:0090231 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
1.8 5.3 GO:2000660 negative regulation of chemokine biosynthetic process(GO:0045079) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
1.8 5.3 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
1.7 5.2 GO:0090669 telomerase RNA stabilization(GO:0090669)
1.7 6.6 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
1.6 4.9 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
1.6 9.6 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
1.6 4.8 GO:0021524 visceral motor neuron differentiation(GO:0021524)
1.5 4.6 GO:0090172 meiotic metaphase I plate congression(GO:0043060) microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
1.5 10.6 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
1.5 10.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.5 4.4 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
1.4 5.7 GO:0060702 negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702)
1.4 5.7 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
1.4 4.2 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
1.4 37.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
1.4 9.5 GO:0071460 microspike assembly(GO:0030035) cellular response to cell-matrix adhesion(GO:0071460)
1.3 20.2 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
1.3 4.0 GO:0021569 rhombomere 3 development(GO:0021569)
1.3 9.2 GO:0006621 protein retention in ER lumen(GO:0006621)
1.3 9.2 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
1.3 10.1 GO:0016584 maintenance of DNA methylation(GO:0010216) nucleosome positioning(GO:0016584)
1.3 8.8 GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
1.2 5.9 GO:0090168 Golgi reassembly(GO:0090168)
1.2 9.3 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
1.1 6.8 GO:0006113 fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
1.1 3.3 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
1.1 6.5 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
1.1 8.6 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
1.1 7.5 GO:0006824 cobalt ion transport(GO:0006824)
1.1 11.8 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
1.1 6.3 GO:0045901 regulation of translational termination(GO:0006449) positive regulation of translational elongation(GO:0045901)
1.0 3.1 GO:1903860 negative regulation of neuron maturation(GO:0014043) negative regulation of dendrite extension(GO:1903860)
1.0 6.0 GO:0015074 DNA integration(GO:0015074)
1.0 16.4 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
1.0 4.8 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.9 3.8 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.9 16.5 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.9 3.6 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.9 8.1 GO:0002329 pre-B cell differentiation(GO:0002329)
0.9 13.5 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.9 1.8 GO:0032202 telomere assembly(GO:0032202)
0.9 2.7 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.9 2.6 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.9 2.6 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.8 5.0 GO:0006642 triglyceride mobilization(GO:0006642)
0.8 2.5 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.8 7.3 GO:0032790 ribosome disassembly(GO:0032790)
0.8 4.8 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.8 3.9 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.8 0.8 GO:0018307 enzyme active site formation(GO:0018307)
0.8 3.8 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.7 5.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.7 3.0 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.7 5.8 GO:0006983 ER overload response(GO:0006983)
0.7 3.5 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.7 6.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.7 13.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.7 3.4 GO:0060112 generation of ovulation cycle rhythm(GO:0060112)
0.7 4.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.7 17.2 GO:0072520 seminiferous tubule development(GO:0072520)
0.7 2.0 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.6 9.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.6 9.8 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.6 4.3 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.6 3.6 GO:1904424 regulation of GTP binding(GO:1904424)
0.6 3.6 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.6 3.5 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.6 6.5 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.6 7.4 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.5 2.2 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.5 3.2 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.5 4.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.5 1.6 GO:0036451 cap mRNA methylation(GO:0036451)
0.5 5.2 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.5 5.6 GO:0034982 mitochondrial protein processing(GO:0034982)
0.5 5.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.5 2.0 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.5 1.0 GO:0019042 viral latency(GO:0019042) release from viral latency(GO:0019046)
0.5 20.5 GO:0031018 endocrine pancreas development(GO:0031018)
0.5 2.8 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.5 1.4 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.5 1.4 GO:0044375 regulation of peroxisome size(GO:0044375)
0.5 1.4 GO:1905245 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.5 4.6 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.5 4.5 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.4 13.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 3.5 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578)
0.4 5.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.4 4.8 GO:0010044 response to aluminum ion(GO:0010044)
0.4 4.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.4 2.4 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.4 1.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.4 4.9 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.4 11.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.4 7.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4 5.1 GO:0019985 translesion synthesis(GO:0019985)
0.4 9.9 GO:0006379 mRNA cleavage(GO:0006379)
0.4 3.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 3.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.3 12.4 GO:0019433 triglyceride catabolic process(GO:0019433)
0.3 3.0 GO:0051382 kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.3 16.3 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.3 3.3 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.3 1.3 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.3 3.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.3 13.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 0.9 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.3 4.8 GO:0031268 pseudopodium organization(GO:0031268)
0.3 3.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.3 3.8 GO:0034508 centromere complex assembly(GO:0034508)
0.3 5.4 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.3 2.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 2.7 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.3 3.7 GO:0031167 rRNA methylation(GO:0031167)
0.3 1.8 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.3 8.4 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.3 5.3 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.2 0.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 1.5 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.2 10.9 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.2 2.0 GO:0060017 parathyroid gland development(GO:0060017)
0.2 0.2 GO:1903210 glomerular visceral epithelial cell apoptotic process(GO:1903210)
0.2 8.3 GO:0001510 RNA methylation(GO:0001510)
0.2 1.0 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.2 6.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.2 8.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 2.3 GO:0007020 microtubule nucleation(GO:0007020)
0.2 19.4 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
0.2 0.7 GO:0048696 regulation of collateral sprouting in absence of injury(GO:0048696)
0.2 3.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.2 0.4 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.2 4.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 0.4 GO:2000384 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.2 1.4 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.2 2.6 GO:0006071 glycerol metabolic process(GO:0006071)
0.2 6.7 GO:0032508 DNA duplex unwinding(GO:0032508)
0.2 1.2 GO:0006102 isocitrate metabolic process(GO:0006102)
0.2 2.4 GO:0015693 magnesium ion transport(GO:0015693)
0.2 1.8 GO:0030953 astral microtubule organization(GO:0030953)
0.2 4.1 GO:0035641 locomotory exploration behavior(GO:0035641)
0.2 3.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 4.0 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.2 4.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 0.3 GO:1990646 cellular response to prolactin(GO:1990646)
0.2 13.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 8.5 GO:0009268 response to pH(GO:0009268)
0.2 7.2 GO:0097421 liver regeneration(GO:0097421)
0.1 2.0 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.4 GO:0031989 bombesin receptor signaling pathway(GO:0031989)
0.1 0.5 GO:0051958 methotrexate transport(GO:0051958)
0.1 4.4 GO:0031648 protein destabilization(GO:0031648)
0.1 8.0 GO:0051225 spindle assembly(GO:0051225)
0.1 4.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 6.7 GO:0010833 telomere maintenance via telomere lengthening(GO:0010833)
0.1 3.1 GO:0034204 lipid translocation(GO:0034204)
0.1 10.9 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 4.2 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 3.8 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 1.9 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.1 0.4 GO:0002877 regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877) regulation of heart rate by chemical signal(GO:0003062)
0.1 10.3 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 0.9 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.1 5.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 1.4 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 4.4 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 1.9 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 0.6 GO:0035308 negative regulation of protein dephosphorylation(GO:0035308)
0.1 3.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 3.8 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.1 24.5 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.1 0.6 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 2.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 0.8 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.1 1.1 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487) sebaceous gland development(GO:0048733)
0.1 1.7 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
0.1 4.0 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749)
0.1 0.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.1 7.4 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.1 1.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 10.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 30.3 GO:0006412 translation(GO:0006412)
0.1 4.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 5.5 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 2.3 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 1.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.4 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 1.3 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 2.0 GO:0032259 methylation(GO:0032259)
0.0 0.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 4.7 GO:0006869 lipid transport(GO:0006869)
0.0 0.2 GO:1901976 regulation of cell cycle checkpoint(GO:1901976)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.5 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.6 GO:0032570 response to progesterone(GO:0032570)
0.0 7.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.3 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.5 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
15.4 46.1 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
3.7 33.3 GO:0000813 ESCRT I complex(GO:0000813)
2.7 13.5 GO:0030689 Noc complex(GO:0030689)
2.4 9.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.4 67.0 GO:0000788 nuclear nucleosome(GO:0000788)
2.4 11.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
2.4 9.5 GO:0044393 microspike(GO:0044393)
2.2 20.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
2.2 33.3 GO:1990023 mitotic spindle midzone(GO:1990023)
1.9 5.6 GO:0005745 m-AAA complex(GO:0005745)
1.8 5.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.7 5.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
1.6 16.2 GO:0070187 telosome(GO:0070187)
1.6 12.9 GO:0005577 fibrinogen complex(GO:0005577)
1.6 4.8 GO:0008275 gamma-tubulin small complex(GO:0008275)
1.5 7.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
1.5 16.9 GO:0042555 MCM complex(GO:0042555)
1.5 7.6 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
1.5 13.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
1.4 19.6 GO:0030127 COPII vesicle coat(GO:0030127)
1.3 9.4 GO:0001739 sex chromatin(GO:0001739)
1.3 21.5 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
1.3 16.4 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
1.3 6.3 GO:0005642 annulate lamellae(GO:0005642)
1.2 16.6 GO:0044232 organelle membrane contact site(GO:0044232)
1.1 12.3 GO:0072546 ER membrane protein complex(GO:0072546)
1.0 16.5 GO:0042613 MHC class II protein complex(GO:0042613)
1.0 5.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.0 5.9 GO:0089701 U2AF(GO:0089701)
0.9 6.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.9 3.5 GO:0035363 histone locus body(GO:0035363)
0.8 4.2 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.8 2.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.8 59.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.8 7.6 GO:0070652 HAUS complex(GO:0070652)
0.8 10.6 GO:0060091 kinocilium(GO:0060091)
0.7 2.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.7 17.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.7 6.2 GO:0033263 CORVET complex(GO:0033263)
0.7 11.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.7 16.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 4.7 GO:0032584 growth cone membrane(GO:0032584)
0.6 43.0 GO:0005811 lipid particle(GO:0005811)
0.5 3.6 GO:0000322 storage vacuole(GO:0000322)
0.5 4.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.5 2.6 GO:0098536 deuterosome(GO:0098536)
0.5 11.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.5 4.2 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.5 10.2 GO:0005775 vacuolar lumen(GO:0005775)
0.5 4.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.5 3.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 6.6 GO:0071437 invadopodium(GO:0071437)
0.4 18.4 GO:0031941 filamentous actin(GO:0031941)
0.4 5.7 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.4 3.9 GO:0016461 unconventional myosin complex(GO:0016461)
0.4 3.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.4 4.9 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.4 3.2 GO:0000974 Prp19 complex(GO:0000974)
0.4 8.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 4.8 GO:0031143 pseudopodium(GO:0031143)
0.3 1.9 GO:0070847 core mediator complex(GO:0070847)
0.3 5.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.3 1.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.3 21.8 GO:0045095 keratin filament(GO:0045095)
0.3 14.4 GO:0000795 synaptonemal complex(GO:0000795)
0.3 4.5 GO:0032039 integrator complex(GO:0032039)
0.3 1.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 12.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 23.8 GO:0070469 respiratory chain(GO:0070469)
0.2 5.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 13.2 GO:0072686 mitotic spindle(GO:0072686)
0.2 16.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 3.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 1.6 GO:0000796 condensin complex(GO:0000796)
0.2 1.5 GO:0005869 dynactin complex(GO:0005869)
0.2 18.0 GO:0022626 cytosolic ribosome(GO:0022626)
0.2 1.4 GO:0097418 neurofibrillary tangle(GO:0097418)
0.2 17.9 GO:0000793 condensed chromosome(GO:0000793)
0.2 5.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 2.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 46.1 GO:0000790 nuclear chromatin(GO:0000790)
0.2 9.0 GO:0005657 replication fork(GO:0005657)
0.1 2.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 5.6 GO:0016592 mediator complex(GO:0016592)
0.1 6.0 GO:0016235 aggresome(GO:0016235)
0.1 3.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 1.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 9.7 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 19.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 8.5 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.1 3.3 GO:0000786 nucleosome(GO:0000786)
0.1 29.8 GO:0016607 nuclear speck(GO:0016607)
0.1 0.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.9 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.3 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 5.0 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 1.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 3.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 4.1 GO:0000922 spindle pole(GO:0000922)
0.1 1.9 GO:0005876 spindle microtubule(GO:0005876)
0.1 10.5 GO:0030027 lamellipodium(GO:0030027)
0.1 4.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 6.5 GO:0043195 terminal bouton(GO:0043195)
0.1 18.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 14.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 10.5 GO:0005813 centrosome(GO:0005813)
0.0 13.2 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.4 GO:0005840 ribosome(GO:0005840)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 53.4 GO:0005739 mitochondrion(GO:0005739)
0.0 4.7 GO:0005681 spliceosomal complex(GO:0005681)
0.0 3.1 GO:0045177 apical part of cell(GO:0045177)
0.0 8.1 GO:0034702 ion channel complex(GO:0034702)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.5 GO:0055037 recycling endosome(GO:0055037)
0.0 0.4 GO:0046930 pore complex(GO:0046930)
0.0 2.0 GO:0034399 nuclear periphery(GO:0034399)
0.0 32.5 GO:0005794 Golgi apparatus(GO:0005794)
0.0 2.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 4.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.1 GO:0000785 chromatin(GO:0000785)
0.0 35.3 GO:0005654 nucleoplasm(GO:0005654)
0.0 27.9 GO:0005615 extracellular space(GO:0005615)
0.0 8.1 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 33.8 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
7.0 34.9 GO:1990932 5.8S rRNA binding(GO:1990932)
6.0 18.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
5.7 17.2 GO:0031177 phosphopantetheine binding(GO:0031177)
4.0 24.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
3.6 21.8 GO:0042289 MHC class II protein binding(GO:0042289)
3.6 14.4 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
3.2 66.7 GO:0031996 thioesterase binding(GO:0031996)
3.1 9.4 GO:0004370 glycerol kinase activity(GO:0004370)
2.6 10.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.6 7.7 GO:0002134 UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
2.5 29.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
2.3 6.9 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
2.2 11.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
2.2 6.5 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
2.0 8.2 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
2.0 11.9 GO:0000150 recombinase activity(GO:0000150)
1.9 7.5 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
1.8 12.9 GO:0045340 mercury ion binding(GO:0045340)
1.8 21.5 GO:0000400 four-way junction DNA binding(GO:0000400)
1.8 16.1 GO:0043515 kinetochore binding(GO:0043515)
1.7 15.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
1.7 6.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
1.6 9.7 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.6 9.6 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
1.6 71.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.5 4.6 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
1.5 7.5 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
1.5 46.1 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
1.4 14.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.4 5.7 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.4 6.9 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
1.4 5.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
1.4 4.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
1.3 34.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
1.2 3.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
1.2 3.6 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
1.2 5.9 GO:0050733 RS domain binding(GO:0050733)
1.2 15.3 GO:0003688 DNA replication origin binding(GO:0003688)
1.1 20.3 GO:0051010 microtubule plus-end binding(GO:0051010)
1.1 37.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.0 9.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.0 3.0 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.9 11.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.9 3.6 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.9 16.3 GO:0015643 toxic substance binding(GO:0015643)
0.8 8.3 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.8 6.6 GO:0034452 dynactin binding(GO:0034452)
0.8 19.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.8 2.4 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.8 6.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.8 5.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.8 3.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.7 7.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.7 3.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.7 9.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.7 2.7 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.7 2.0 GO:0032564 dATP binding(GO:0032564)
0.7 16.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.7 6.5 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.6 12.7 GO:0048018 receptor agonist activity(GO:0048018)
0.6 8.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.6 1.9 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.6 16.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 6.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.6 2.9 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.6 28.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.5 41.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 1.6 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.5 10.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.5 23.1 GO:0031491 nucleosome binding(GO:0031491)
0.5 8.8 GO:0001618 virus receptor activity(GO:0001618)
0.5 2.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.5 9.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 4.8 GO:0051011 microtubule minus-end binding(GO:0051011)
0.4 4.7 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.4 16.5 GO:0042605 peptide antigen binding(GO:0042605)
0.4 9.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 78.5 GO:0042393 histone binding(GO:0042393)
0.4 1.2 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.4 2.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.4 3.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 6.1 GO:0005537 mannose binding(GO:0005537)
0.3 49.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 3.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 3.4 GO:0035497 cAMP response element binding(GO:0035497)
0.3 5.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 1.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.3 4.5 GO:0048156 tau protein binding(GO:0048156)
0.3 8.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 6.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 5.2 GO:0070717 poly-purine tract binding(GO:0070717)
0.3 2.5 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.3 4.5 GO:0097602 cullin family protein binding(GO:0097602)
0.3 5.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 17.2 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.3 2.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.3 7.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 0.8 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.3 3.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 4.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 23.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 23.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 3.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 13.2 GO:0009055 electron carrier activity(GO:0009055)
0.2 9.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 8.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 1.7 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 3.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 10.9 GO:0051018 protein kinase A binding(GO:0051018)
0.2 7.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 16.8 GO:0051082 unfolded protein binding(GO:0051082)
0.2 7.2 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.2 3.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 4.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.2 2.4 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.4 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 3.8 GO:0031489 myosin V binding(GO:0031489)
0.2 2.2 GO:0019841 retinol binding(GO:0019841)
0.2 25.4 GO:0001047 core promoter binding(GO:0001047)
0.2 41.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 2.6 GO:0004659 prenyltransferase activity(GO:0004659)
0.2 4.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 48.3 GO:0045296 cadherin binding(GO:0045296)
0.1 0.4 GO:0004946 bombesin receptor activity(GO:0004946)
0.1 5.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 4.3 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 0.5 GO:0015350 methotrexate transporter activity(GO:0015350)
0.1 6.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 2.5 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 2.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 6.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 2.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 7.7 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 2.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 5.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 1.3 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 3.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.9 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 19.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 0.6 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 4.7 GO:0043621 protein self-association(GO:0043621)
0.1 2.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 4.9 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.1 96.6 GO:0003723 RNA binding(GO:0003723)
0.1 9.4 GO:0008168 methyltransferase activity(GO:0008168)
0.1 0.4 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 11.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 1.8 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.1 7.6 GO:0008083 growth factor activity(GO:0008083)
0.1 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 7.0 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 1.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 10.3 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 3.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 1.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.9 GO:0008483 transaminase activity(GO:0008483)
0.0 1.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 16.2 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.3 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 5.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 46.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
2.0 5.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
1.4 22.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
1.3 32.5 PID S1P S1P2 PATHWAY S1P2 pathway
1.2 68.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
1.1 42.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.0 72.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.8 21.2 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.8 25.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.7 12.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.7 31.0 PID PLK1 PATHWAY PLK1 signaling events
0.6 26.3 PID MTOR 4PATHWAY mTOR signaling pathway
0.6 31.0 PID LKB1 PATHWAY LKB1 signaling events
0.6 20.5 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.4 47.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.4 6.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 19.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.3 17.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.3 4.4 PID IL23 PATHWAY IL23-mediated signaling events
0.3 5.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.3 10.2 PID ATR PATHWAY ATR signaling pathway
0.3 19.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.3 12.9 PID E2F PATHWAY E2F transcription factor network
0.3 18.7 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.2 3.0 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.2 3.6 PID AURORA A PATHWAY Aurora A signaling
0.2 7.7 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 2.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 8.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.7 ST GA12 PATHWAY G alpha 12 Pathway
0.1 4.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 5.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 1.9 PID ARF 3PATHWAY Arf1 pathway
0.1 5.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 0.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.3 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 33.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
2.9 46.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.6 18.9 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
1.5 16.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.2 14.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
1.1 25.0 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
1.1 59.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.1 16.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
1.0 9.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.8 20.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.8 12.9 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.8 19.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.5 21.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.5 19.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.5 4.8 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.5 11.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.5 9.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.5 14.8 REACTOME KINESINS Genes involved in Kinesins
0.5 6.3 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.4 4.9 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.4 8.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.4 5.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.4 4.5 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.4 18.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4 15.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.4 5.0 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.3 9.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.3 6.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.3 10.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 4.1 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 18.1 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.2 6.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 5.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 11.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 6.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 26.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.2 14.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 3.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.2 9.4 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.2 10.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 48.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 3.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.2 3.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 4.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 3.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 10.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 13.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 15.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 3.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 3.8 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 1.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 4.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 1.4 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein