ISMARA results: Atf7

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Atf7_E4f1

Z-value: 0.95

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Transcription factors associated with Atf7_E4f1

Gene Symbol	Gene ID	Gene Info
Atf7 NCBI RGD Ensembl	ENSRNOG00000015269	activating transcription factor 7
E4f1 NCBI RGD Ensembl	ENSRNOG00000009224	E4F transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E4f1	rn6_v1_chr10_-_13826945_13826945	-0.13	2.4e-02	Click!
Atf7	rn6_v1_chr7_-_144223429_144223429	-0.07	2.3e-01	Click!

Activity profile of Atf7_E4f1 motif

Sorted Z-values of Atf7_E4f1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_65424802 Show fit	56.11	ENSRNOT00000018468	Traf4 NCBI RGD Ensembl Show fit	Tnf receptor associated factor 4
chr2_+_189629297 Show fit	55.29	ENSRNOT00000049810	Dennd4b NCBI RGD Ensembl Show fit	DENN domain containing 4B
chr4_+_70572942 Show fit	45.39	ENSRNOT00000051964	AC142181.1 NCBI RGD Ensembl Show fit
chr4_-_57625147 Show fit	39.21	ENSRNOT00000074649 ENSRNOT00000078961	Ube2h NCBI RGD Ensembl Show fit	ubiquitin-conjugating enzyme E2H
chr17_+_43617247 Show fit	37.15	ENSRNOT00000075065	Hist1h2ao NCBI RGD Ensembl Show fit	histone cluster 1, H2ao
chr18_-_77322690 Show fit	33.81	ENSRNOT00000058382	Nfatc1 NCBI RGD Ensembl Show fit	nuclear factor of activated T-cells 1
chr12_+_37984790 Show fit	33.34	ENSRNOT00000001445	Vps37b NCBI RGD Ensembl Show fit	VPS37B, ESCRT-I subunit
chr10_+_11724032 Show fit	31.18	ENSRNOT00000008966	Trap1 NCBI RGD Ensembl Show fit	TNF receptor-associated protein 1
chr17_-_43821536 Show fit	29.89	ENSRNOT00000072286	RGD1562378 NCBI RGD Ensembl Show fit	histone H4 variant H4-v.1
chr13_-_50916982 Show fit	25.37	ENSRNOT00000004408	Btg2 NCBI RGD Ensembl Show fit	BTG anti-proliferation factor 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf7_E4f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.9	67.0	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
5.1	56.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
7.9	55.3	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
7.7	46.2	GO:0071314	cellular response to cocaine(GO:0071314)
1.4	37.4	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
8.7	34.9	GO:0045903	positive regulation of translational fidelity(GO:0045903)
8.5	33.8	GO:0002337	B-1a B cell differentiation(GO:0002337)
11.1	33.3	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
10.4	31.2	GO:1901856	negative regulation of cellular respiration(GO:1901856)
0.1	30.3	GO:0006412	translation(GO:0006412)

Showing 1 to 10 of 244 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	67.0	GO:0000788	nuclear nucleosome(GO:0000788)
0.8	59.2	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	53.4	GO:0005739	mitochondrion(GO:0005739)
15.4	46.1	GO:0097124	cyclin A2-CDK2 complex(GO:0097124)
0.2	46.1	GO:0000790	nuclear chromatin(GO:0000790)
0.6	43.0	GO:0005811	lipid particle(GO:0005811)
0.0	35.3	GO:0005654	nucleoplasm(GO:0005654)
3.7	33.3	GO:0000813	ESCRT I complex(GO:0000813)
2.2	33.3	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	32.5	GO:0005794	Golgi apparatus(GO:0005794)

Showing 1 to 10 of 127 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	96.6	GO:0003723	RNA binding(GO:0003723)
0.4	78.5	GO:0042393	histone binding(GO:0042393)
1.6	71.4	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
3.2	66.7	GO:0031996	thioesterase binding(GO:0031996)
0.3	49.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	48.3	GO:0045296	cadherin binding(GO:0045296)
1.5	46.1	GO:0097472	cyclin-dependent protein kinase activity(GO:0097472)
0.2	41.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.5	41.0	GO:0048306	calcium-dependent protein binding(GO:0048306)
1.1	37.1	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)

Showing 1 to 10 of 167 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	72.3	PID IL12 2PATHWAY	IL12-mediated signaling events
1.2	68.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.4	47.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
2.7	46.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.1	42.2	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.3	32.5	PID S1P S1P2 PATHWAY	S1P2 pathway
0.7	31.0	PID PLK1 PATHWAY	PLK1 signaling events
0.6	31.0	PID LKB1 PATHWAY	LKB1 signaling events
0.6	26.3	PID MTOR 4PATHWAY	mTOR signaling pathway
0.8	25.0	PID FOXM1 PATHWAY	FOXM1 transcription factor network

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	59.2	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	48.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
2.9	46.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
3.7	33.3	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.2	26.8	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
1.1	25.0	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.5	21.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.8	20.8	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.5	19.7	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.8	19.5	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends

Showing 1 to 10 of 63 entries

Results for Atf7_E4f1

Z-value: 0.95

Motif logo

Transcription factors associated with Atf7_E4f1

Activity-expression correlation:

Activity profile of Atf7_E4f1 motif

Sorted Z-values of Atf7_E4f1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf7_E4f1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: