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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Atf6

Z-value: 1.29

Motif logo

Transcription factors associated with Atf6

Gene Symbol Gene ID Gene Info
ENSRNOG00000024632 activating transcription factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Atf6rn6_v1_chr13_-_89242443_89242443-0.283.5e-07Click!

Activity profile of Atf6 motif

Sorted Z-values of Atf6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_56711049 82.68 ENSRNOT00000027237
filamin C
chr4_+_56711275 80.25 ENSRNOT00000088149
filamin C
chr16_+_26906716 47.73 ENSRNOT00000064297
carboxypeptidase E
chrX_+_106774980 38.56 ENSRNOT00000046091
transcription elongation factor A like 7
chr1_-_215660492 38.51 ENSRNOT00000079442

chr5_+_1417478 37.44 ENSRNOT00000008153
ENSRNOT00000085564
junctophilin 1
chr12_+_37490584 35.26 ENSRNOT00000001401
ENSRNOT00000090831
Rab interacting lysosomal protein-like 1
chr17_-_47394231 35.17 ENSRNOT00000079368
ENSRNOT00000079216
secreted frizzled-related protein 4
chr8_-_116361343 31.75 ENSRNOT00000066296
semaphorin 3B
chr2_-_211017778 31.20 ENSRNOT00000026883
synaptophysin-like 2
chr4_-_82215022 30.14 ENSRNOT00000010256
homeobox A11
chr7_-_2786856 29.09 ENSRNOT00000047530
ENSRNOT00000086939
coenzyme Q10A
chr1_+_199941161 27.91 ENSRNOT00000027616
Bcl2-associated athanogene 3
chr8_+_65733400 25.85 ENSRNOT00000089126
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr8_-_53146953 25.56 ENSRNOT00000045356
zinc finger and BTB domain containing 16
chr13_+_113692131 25.55 ENSRNOT00000057160
CD34 molecule
chr13_+_113691932 24.67 ENSRNOT00000084709
CD34 molecule
chr1_-_31055453 24.45 ENSRNOT00000031083
SOGA family member 3
chr17_-_84614228 22.67 ENSRNOT00000043042

chr6_+_53401109 21.90 ENSRNOT00000014763
twist family bHLH transcription factor 1
chr11_-_34598102 21.21 ENSRNOT00000068743
phosphatidylinositol glycan anchor biosynthesis, class P
chr7_+_120749752 21.16 ENSRNOT00000087888
KDEL endoplasmic reticulum protein retention receptor 3
chr9_-_61810417 21.13 ENSRNOT00000020910
raftlin family member 2
chr4_+_82300778 20.80 ENSRNOT00000075254
homeobox A11, opposite strand
chr8_+_48422036 20.44 ENSRNOT00000036051
ubiquitin specific peptidase 2
chr11_-_34598275 20.33 ENSRNOT00000077233
phosphatidylinositol glycan anchor biosynthesis, class P
chr2_-_52282548 19.78 ENSRNOT00000033627
nicotinamide nucleotide transhydrogenase
chr1_+_78933372 19.75 ENSRNOT00000029810
coiled-coil domain containing 8
chr1_-_101085884 19.70 ENSRNOT00000085352
reticulocalbin 3
chr6_-_135412312 19.44 ENSRNOT00000010610
ankyrin repeat domain 9
chr4_-_82300503 18.44 ENSRNOT00000071568
homeobox A11
chr10_-_40764185 17.53 ENSRNOT00000017486
secreted protein acidic and cysteine rich
chr6_-_80107236 17.43 ENSRNOT00000006369
Sec23 homolog A, coat complex II component
chrX_+_156999826 17.26 ENSRNOT00000081819
isocitrate dehydrogenase 3 (NAD), gamma
chr5_-_64850427 16.71 ENSRNOT00000008883
transmembrane protein 246
chr2_+_233615739 16.23 ENSRNOT00000051009
paired-like homeodomain 2
chr3_+_112428395 15.86 ENSRNOT00000079109
ENSRNOT00000048141
StAR-related lipid transfer domain containing 9
chr2_-_231521052 15.49 ENSRNOT00000089534
ENSRNOT00000080470
ENSRNOT00000084756
ankyrin 2
chr1_-_101086198 15.13 ENSRNOT00000027917
reticulocalbin 3
chr9_-_115555261 15.04 ENSRNOT00000056366
protein tyrosine phosphatase, receptor type, M
chr13_+_80125391 14.81 ENSRNOT00000044190
microRNA 199a-2
chr7_-_58286770 14.70 ENSRNOT00000005258
RAB21, member RAS oncogene family
chr9_-_55673704 14.28 ENSRNOT00000066231
ENSRNOT00000081677
transmembrane protein with EGF-like and two follistatin-like domains 2
chr8_-_25904564 14.01 ENSRNOT00000082744
ENSRNOT00000064783
T-box 20
chr19_-_22632071 13.87 ENSRNOT00000077275
glutamic--pyruvic transaminase 2
chr8_-_116045954 13.51 ENSRNOT00000020065
mitogen-activated protein kinase-activated protein kinase 3
chr1_-_32643771 13.30 ENSRNOT00000016975
iroquois homeobox 4
chr13_-_47831110 13.27 ENSRNOT00000061070
mitogen-activated protein kinase-activated protein kinase 2
chr7_-_95310005 13.20 ENSRNOT00000005815
mitochondrial ribosomal protein L13
chr16_-_81880502 12.70 ENSRNOT00000079096
MCF.2 cell line derived transforming sequence-like
chr5_+_169452493 12.51 ENSRNOT00000014444
G protein-coupled receptor 153
chr1_-_209641123 11.96 ENSRNOT00000021702
early B-cell factor 3
chr1_+_240908483 11.79 ENSRNOT00000019367
Kruppel-like factor 9
chr11_-_83867203 11.65 ENSRNOT00000002394
chordin
chr7_+_24939498 11.62 ENSRNOT00000010601
cytoskeleton-associated protein 4
chr5_-_138222534 11.12 ENSRNOT00000009691
zinc finger protein 691
chr3_-_79892429 10.99 ENSRNOT00000016191
solute carrier family 39 member 13
chr7_+_142905758 10.92 ENSRNOT00000078663
nuclear receptor subfamily 4, group A, member 1
chr3_-_146470293 10.80 ENSRNOT00000009627
acyl-CoA synthetase short-chain family member 1
chr3_-_12944494 10.65 ENSRNOT00000023172
multivesicular body subunit 12B
chr20_-_11721838 10.37 ENSRNOT00000001636
ubiquitin-conjugating enzyme E2G 2
chr6_+_26797126 10.21 ENSRNOT00000010586
cell growth regulator with EF hand domain 1
chr6_-_55524436 10.20 ENSRNOT00000006752
tetraspanin 13
chr4_-_157486844 10.17 ENSRNOT00000038281
ENSRNOT00000022874
COP9 signalosome subunit 7A
chr5_-_147584038 10.04 ENSRNOT00000010983
zinc finger and BTB domain containing 8a
chr20_-_54517709 9.95 ENSRNOT00000076234
glutamate ionotropic receptor kainate type subunit 2
chr11_+_87677966 9.91 ENSRNOT00000068711
kelch-like family member 22
chrX_-_105622156 9.91 ENSRNOT00000029511
armadillo repeat containing, X-linked 2
chr4_+_56625561 9.73 ENSRNOT00000008356
ENSRNOT00000090808
ENSRNOT00000008972
calumenin
chr12_+_24473981 9.52 ENSRNOT00000001973
frizzled class receptor 9
chr20_-_5533600 9.36 ENSRNOT00000072319
cutA divalent cation tolerance homolog
chr20_-_5533448 9.20 ENSRNOT00000000568
cutA divalent cation tolerance homolog
chr1_+_264768105 9.09 ENSRNOT00000086766
ENSRNOT00000048843
leucine zipper tumor suppressor 2
chr11_+_87678295 8.82 ENSRNOT00000091675
kelch-like family member 22
chr1_+_198383201 8.68 ENSRNOT00000037405
seizure related 6 homolog like 2
chr5_+_21632926 8.49 ENSRNOT00000008522
RAB2A, member RAS oncogene family
chr20_-_29990111 8.32 ENSRNOT00000048029
cadherin-related 23
chr12_-_23021517 8.31 ENSRNOT00000041654
myosin light chain 10
chr1_+_255479261 8.16 ENSRNOT00000079808
tankyrase 2
chrX_+_73390903 8.14 ENSRNOT00000077002
zinc finger protein 449
chrX_-_34162827 7.96 ENSRNOT00000046759
similar to ferritin heavy polypeptide-like 17
chr12_+_45727112 7.85 ENSRNOT00000001507
serine/arginine repetitive matrix 4
chrX_+_105911925 7.73 ENSRNOT00000052422
armadillo repeat-containing X-linked protein 1
chr15_+_52241801 7.61 ENSRNOT00000082639
HR, lysine demethylase and nuclear receptor corepressor
chr3_+_113415774 7.07 ENSRNOT00000056151
small EDRK-rich factor 2
chr10_-_65805693 6.93 ENSRNOT00000012245
TNF alpha induced protein 1
chr1_+_226947105 6.80 ENSRNOT00000028373
pre-mRNA processing factor 19
chr10_+_94445877 6.78 ENSRNOT00000013997
proteasome 26S subunit, ATPase 5
chr5_+_76150840 6.62 ENSRNOT00000020702
DnaJ heat shock protein family (Hsp40) member C25
chr12_+_23463157 6.43 ENSRNOT00000044841
cut-like homeobox 1
chr16_+_6035926 6.27 ENSRNOT00000020284
selenoprotein K
chr10_-_74119009 6.13 ENSRNOT00000085712
ENSRNOT00000006926
DEAH-box helicase 40
chr8_+_22021213 6.00 ENSRNOT00000049706
mitochondrial ribosomal protein L4
chr20_-_48881119 5.92 ENSRNOT00000018892
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
chr1_+_77994203 5.83 ENSRNOT00000002044
NSF attachment protein alpha
chr1_-_100865894 5.81 ENSRNOT00000027580
prostate tumor overexpressed 1
chr8_+_5790034 5.71 ENSRNOT00000061887
matrix metallopeptidase 27
chr6_-_38453797 5.66 ENSRNOT00000009100
DEAD-box helicase 1
chr5_-_58445953 5.42 ENSRNOT00000046102
valosin-containing protein
chr4_-_147756294 5.10 ENSRNOT00000014537
methyl-CpG binding domain 4 DNA glycosylase
chr14_-_114484127 5.06 ENSRNOT00000056706
echinoderm microtubule associated protein like 6
chr20_+_48881194 5.05 ENSRNOT00000000304
reticulon 4 interacting protein 1
chr13_-_88497901 4.99 ENSRNOT00000058560
UDP-N-acetylglucosamine pyrophosphorylase 1
chr9_+_94178221 4.78 ENSRNOT00000033487
alkaline phosphatase, placental-like 2
chr1_+_174767960 4.73 ENSRNOT00000013362
WEE1 G2 checkpoint kinase
chr4_-_152380184 4.69 ENSRNOT00000091473
ELKS/RAB6-interacting/CAST family member 1
chr10_+_40247436 4.30 ENSRNOT00000079830
glutathione peroxidase 3
chr12_-_48663143 4.17 ENSRNOT00000082809
FIC domain containing
chr7_+_29282305 4.05 ENSRNOT00000007623
ADP-ribosylation factor like GTPase 1
chr5_+_128629942 4.00 ENSRNOT00000010462
ENSRNOT00000010440
nardilysin convertase
chr15_+_57891680 3.75 ENSRNOT00000001383
tumor protein, translationally-controlled 1
chr7_+_141249044 3.74 ENSRNOT00000084911
aquaporin 5
chr12_-_13210758 3.73 ENSRNOT00000001438
KDEL endoplasmic reticulum protein retention receptor 2
chr12_-_43940798 3.60 ENSRNOT00000001485
similar to hypothetical protein FLJ21415
chr1_-_239265997 3.58 ENSRNOT00000037500
similar to RIKEN cDNA 1110059E24
chr17_-_67945037 3.52 ENSRNOT00000023033
Kruppel-like factor 6
chr1_-_220265772 3.46 ENSRNOT00000027119
neuronal PAS domain protein 4
chr4_-_152380023 3.45 ENSRNOT00000012397
ELKS/RAB6-interacting/CAST family member 1
chr16_+_59077574 3.42 ENSRNOT00000090477
DLC1 Rho GTPase activating protein
chr9_-_113331319 3.41 ENSRNOT00000020681
VAMP associated protein A
chr13_+_35554964 3.29 ENSRNOT00000072632
transmembrane protein 185B
chr7_-_120559157 3.28 ENSRNOT00000090565
ENSRNOT00000016827
ENSRNOT00000017108
phospholipase A2 group VI
chrX_+_48779110 3.26 ENSRNOT00000058434
transmembrane protein 47
chrX_-_19369746 3.23 ENSRNOT00000075249
ras-related GTP-binding protein B
chr17_+_6459056 3.22 ENSRNOT00000025745
solute carrier family 28 member 3
chr5_+_59063531 3.20 ENSRNOT00000085311
ENSRNOT00000065909
cAMP responsive element binding protein 3
chr1_-_221129654 3.16 ENSRNOT00000032387
SCY1 like pseudokinase 1
chr1_-_205842428 3.13 ENSRNOT00000024655
DEAH-box helicase 32 (putative)
chr11_+_34598492 3.09 ENSRNOT00000065600
tetratricopeptide repeat domain 3
chr1_-_174588529 3.05 ENSRNOT00000017485
DENN domain containing 5A
chr1_-_229639187 3.04 ENSRNOT00000016804
zinc finger protein 91
chr10_+_43768708 3.01 ENSRNOT00000086218
SH3 binding domain protein 5 like
chr7_-_24667301 2.99 ENSRNOT00000009154
transmembrane protein 263
chr7_+_25919867 2.94 ENSRNOT00000009625
ENSRNOT00000090153
RIC8 guanine nucleotide exchange factor B
chr10_+_84135116 2.85 ENSRNOT00000031035
homeo box B7
chr6_-_86713370 2.77 ENSRNOT00000005821
kelch-like family member 28
chr2_+_207108552 2.77 ENSRNOT00000027234
solute carrier family 16 member 1
chr11_+_77239098 2.72 ENSRNOT00000058701
geminin coiled-coil domain containing
chr7_-_139254149 2.60 ENSRNOT00000078644
Rap guanine nucleotide exchange factor 3
chr6_-_26051229 2.55 ENSRNOT00000005855
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_56887987 2.52 ENSRNOT00000041288
glial cell derived neurotrophic factor
chrX_-_19134869 2.52 ENSRNOT00000004235
Ras-related GTP binding B
chr14_+_11198896 2.43 ENSRNOT00000079767
heterogeneous nuclear ribonucleoprotein D-like
chr12_+_8976585 2.38 ENSRNOT00000071796
proteasome maturation protein-like
chr1_+_173532803 2.30 ENSRNOT00000021017
eukaryotic translation initiation factor 3, subunit F
chr19_-_39257451 2.25 ENSRNOT00000066312
component of oligomeric golgi complex 8
chr12_+_50269347 2.19 ENSRNOT00000079190
aspartate beta-hydroxylase domain containing 2
chr5_-_39650894 2.15 ENSRNOT00000010421
ENSRNOT00000089522
Ufm1-specific ligase 1
chr7_-_123193761 2.13 ENSRNOT00000007164
phosphomannomutase 1
chr18_+_58325319 2.07 ENSRNOT00000065802
ENSRNOT00000077726
NSF attachment protein gamma
chr7_-_11001933 2.00 ENSRNOT00000084006
transducin-like enhancer of split 2
chr1_-_221420115 1.99 ENSRNOT00000028475
mitochondrial ribosomal protein L49
chr20_-_848229 1.93 ENSRNOT00000000974
olfactory receptor 1694
chr14_-_37108341 1.93 ENSRNOT00000002899
spermatogenesis associated 18
chr10_+_58784660 1.89 ENSRNOT00000019925
uncharacterized LOC100912483
chr7_+_70580198 1.88 ENSRNOT00000083472
ENSRNOT00000008941
DNA-damage inducible transcript 3
chr13_-_90467235 1.86 ENSRNOT00000081534
ENSRNOT00000008150
nicastrin
chr3_-_124461332 1.82 ENSRNOT00000073088
putative ERV-F(c)1 provirus ancestral Env polyprotein
chr6_+_70276227 1.82 ENSRNOT00000078958

chr7_-_130408187 1.82 ENSRNOT00000015374
choline kinase beta
chr1_+_101859346 1.78 ENSRNOT00000028627
KDEL endoplasmic reticulum protein retention receptor 1
chr20_+_33527932 1.61 ENSRNOT00000066492
nephrocan
chr10_-_56530842 1.61 ENSRNOT00000077451

chr4_+_120411991 1.59 ENSRNOT00000090875
RuvB-like AAA ATPase 1
chr16_+_20704807 1.59 ENSRNOT00000027241
kelch-like family member 26
chr4_+_108301129 1.50 ENSRNOT00000007993
leucine rich repeat transmembrane neuronal 1
chr12_-_8759599 1.43 ENSRNOT00000073155
proteasome maturation protein
chr3_+_138504214 1.33 ENSRNOT00000091529
lysine acetyltransferase 14
chr7_+_11295892 1.32 ENSRNOT00000089004
tight junction protein 3
chr9_+_61810859 1.30 ENSRNOT00000079058

chr18_-_56534415 1.29 ENSRNOT00000024374
solute carrier family 26 member 2
chr6_+_52459946 1.23 ENSRNOT00000073277
ENSRNOT00000013474
ataxin 7-like 1
chr9_+_121456623 1.21 ENSRNOT00000056255
peptidylprolyl isomerase D-like 1
chr10_-_84789832 1.17 ENSRNOT00000071719
CDK5 regulatory subunit associated protein 3
chr16_-_73670482 1.15 ENSRNOT00000024532
NK6 homeobox 3
chr2_+_144591755 1.14 ENSRNOT00000044424
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chrX_-_156999650 1.12 ENSRNOT00000083557
signal sequence receptor subunit 4
chr5_-_62001196 1.11 ENSRNOT00000012602
tRNA methyltransferase O
chr10_+_55687050 1.05 ENSRNOT00000057136
period circadian clock 1
chr18_+_27114822 1.02 ENSRNOT00000027418
signal recognition particle 19
chr6_+_72124417 1.02 ENSRNOT00000040548
sec1 family domain containing 1
chr12_-_52676608 0.94 ENSRNOT00000072507
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr4_+_176565694 0.89 ENSRNOT00000016794
pyridine nucleotide-disulphide oxidoreductase domain 1
chr10_+_88356615 0.86 ENSRNOT00000022687
kelch-like family member 10
chr2_+_178354890 0.85 ENSRNOT00000037890
peptidylprolyl isomerase D
chr13_-_91737053 0.80 ENSRNOT00000083561
Fc fragment of IgE receptor Ia
chr2_+_124149872 0.80 ENSRNOT00000023584
spermatogenesis associated 5
chr1_+_161922141 0.79 ENSRNOT00000078300
ENSRNOT00000015784
asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)
chr5_-_152227677 0.77 ENSRNOT00000020051
dehydrodolichyl diphosphate synthase subunit
chr15_+_36609296 0.77 ENSRNOT00000010795
ring finger protein 17
chr4_+_181628276 0.66 ENSRNOT00000077332

chr13_+_90467265 0.66 ENSRNOT00000008518
coatomer protein complex subunit alpha
chr7_-_64341207 0.64 ENSRNOT00000006051
transmembrane protein 5
chr1_+_47162394 0.64 ENSRNOT00000068457
transmembrane protein 181
chr1_-_263718745 0.55 ENSRNOT00000074810
dynamin binding protein
chr14_+_42007312 0.44 ENSRNOT00000063985
ATPase phospholipid transporting 8A1
chr5_-_59063592 0.44 ENSRNOT00000022400
talin 1
chr20_+_3588497 0.37 ENSRNOT00000048103
valyl-tRNA synthetase 2, mitochondrial
chr2_-_211352540 0.32 ENSRNOT00000023728
protein kish-B
chr6_-_88232252 0.30 ENSRNOT00000047597
ribosomal protein L10-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
16.7 50.2 GO:0072209 mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
11.8 35.3 GO:1903445 protein transport from ciliary membrane to plasma membrane(GO:1903445)
11.7 35.2 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
10.1 30.2 GO:0060577 pulmonary vein morphogenesis(GO:0060577)
9.5 47.7 GO:0030070 insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173)
7.3 21.9 GO:0033128 negative regulation of histone phosphorylation(GO:0033128) negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
5.1 25.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
4.4 13.3 GO:0048560 establishment of anatomical structure orientation(GO:0048560)
3.9 11.8 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
3.9 15.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
3.8 26.7 GO:0006621 protein retention in ER lumen(GO:0006621)
3.6 10.8 GO:0006083 acetate metabolic process(GO:0006083) propionate metabolic process(GO:0019541)
3.5 21.1 GO:0033227 dsRNA transport(GO:0033227)
3.5 48.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
3.0 26.8 GO:0044351 macropinocytosis(GO:0044351)
2.9 17.3 GO:0006102 isocitrate metabolic process(GO:0006102)
2.4 14.3 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
2.4 9.5 GO:1990523 bone regeneration(GO:1990523)
2.3 13.9 GO:0042851 L-alanine metabolic process(GO:0042851)
2.2 11.0 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
2.1 157.5 GO:0048747 muscle fiber development(GO:0048747)
2.0 5.9 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
1.8 10.9 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.8 5.4 GO:2000158 flavin-containing compound metabolic process(GO:0042726) positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.7 6.8 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
1.7 26.5 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
1.5 14.7 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
1.5 5.8 GO:0035494 SNARE complex disassembly(GO:0035494)
1.4 27.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.3 3.8 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
1.2 20.4 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642) positive regulation of skeletal muscle tissue development(GO:0048643)
1.2 41.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
1.1 25.9 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
1.1 17.5 GO:0033591 response to L-ascorbic acid(GO:0033591)
1.1 3.2 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
1.1 3.2 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.9 8.3 GO:0050957 equilibrioception(GO:0050957)
0.9 10.2 GO:0000338 protein deneddylation(GO:0000338)
0.8 6.8 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
0.8 2.5 GO:0072107 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
0.8 9.1 GO:0051255 spindle midzone assembly(GO:0051255)
0.8 3.3 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.8 5.7 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.7 5.0 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.6 2.6 GO:1904426 positive regulation of GTP binding(GO:1904426)
0.6 4.3 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.6 8.0 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.6 9.7 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.6 18.7 GO:0031577 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.6 15.0 GO:0010842 retina layer formation(GO:0010842)
0.6 8.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.6 31.2 GO:0021762 substantia nigra development(GO:0021762)
0.6 6.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.6 3.3 GO:0071569 protein ufmylation(GO:0071569)
0.5 3.7 GO:0015670 carbon dioxide transport(GO:0015670)
0.5 8.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.5 3.4 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.5 1.9 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.5 8.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.5 3.7 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.5 8.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.4 2.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.4 2.5 GO:1904263 positive regulation of TORC1 signaling(GO:1904263) cellular response to leucine starvation(GO:1990253)
0.4 19.8 GO:0006739 NADP metabolic process(GO:0006739)
0.4 0.8 GO:0045425 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.4 12.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.4 2.8 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.4 1.1 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.4 1.9 GO:0071500 cellular response to nitrosative stress(GO:0071500) regulation of determination of dorsal identity(GO:2000015)
0.3 22.0 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.3 10.4 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 3.5 GO:0007614 short-term memory(GO:0007614)
0.3 4.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.3 0.8 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.3 0.8 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.3 1.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.3 3.8 GO:0043248 proteasome assembly(GO:0043248)
0.3 3.0 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.3 4.0 GO:0009404 toxin metabolic process(GO:0009404)
0.2 1.5 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 3.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.2 0.4 GO:0061091 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2 0.9 GO:0048808 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.2 5.1 GO:0031572 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.2 0.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.2 4.6 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 1.9 GO:0007220 Notch receptor processing(GO:0007220)
0.2 0.4 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.2 1.8 GO:0006657 CDP-choline pathway(GO:0006657)
0.2 15.9 GO:0051225 spindle assembly(GO:0051225)
0.2 2.9 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.2 3.0 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 10.7 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.2 13.4 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
0.1 1.6 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 7.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 6.4 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.1 0.6 GO:0009405 pathogenesis(GO:0009405)
0.1 3.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 6.9 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 1.3 GO:0019532 oxalate transport(GO:0019532)
0.1 2.4 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 9.2 GO:0030308 negative regulation of cell growth(GO:0030308)
0.1 8.3 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)
0.1 3.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 2.5 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.1 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 2.8 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 9.7 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.7 GO:0030157 pancreatic juice secretion(GO:0030157)
0.0 1.1 GO:0030488 tRNA methylation(GO:0030488)
0.0 1.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 11.0 GO:0061448 connective tissue development(GO:0061448)
0.0 1.2 GO:0030857 negative regulation of epithelial cell differentiation(GO:0030857)
0.0 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 8.2 GO:0007517 muscle organ development(GO:0007517)
0.0 1.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0042746 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.0 9.7 GO:0010038 response to metal ion(GO:0010038)
0.0 2.3 GO:0016579 protein deubiquitination(GO:0016579)
0.0 1.3 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 1.6 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.5 37.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
5.8 17.3 GO:0045242 mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
5.2 25.9 GO:0043293 apoptosome(GO:0043293)
4.9 14.7 GO:0010009 cytoplasmic side of endosome membrane(GO:0010009)
4.6 41.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
4.4 17.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
4.1 178.4 GO:0043034 costamere(GO:0043034)
3.3 19.7 GO:1990393 3M complex(GO:1990393)
3.0 47.7 GO:0031045 dense core granule(GO:0031045)
2.7 18.7 GO:0005827 polar microtubule(GO:0005827)
2.4 9.7 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
2.3 6.8 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
2.0 5.9 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
1.8 5.4 GO:1990730 VCP-NSFL1C complex(GO:1990730)
1.7 10.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
1.4 31.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
1.4 50.2 GO:0046930 pore complex(GO:0046930)
1.2 10.7 GO:0000813 ESCRT I complex(GO:0000813)
1.2 5.8 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.9 3.8 GO:0045298 tubulin complex(GO:0045298)
0.9 2.6 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.8 6.8 GO:0031595 nuclear proteasome complex(GO:0031595)
0.8 5.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.7 10.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.7 5.7 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.6 8.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.6 1.9 GO:1990622 CHOP-C/EBP complex(GO:0036488) CHOP-ATF3 complex(GO:1990622)
0.6 8.3 GO:0032426 stereocilium tip(GO:0032426)
0.5 9.5 GO:0031527 filopodium membrane(GO:0031527)
0.5 2.5 GO:0070552 BRISC complex(GO:0070552)
0.5 1.9 GO:0070765 gamma-secretase complex(GO:0070765)
0.4 21.2 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 2.3 GO:0033290 eukaryotic 43S preinitiation complex(GO:0016282) eukaryotic 48S preinitiation complex(GO:0033290)
0.3 25.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 1.6 GO:0097255 R2TP complex(GO:0097255)
0.2 3.3 GO:0017119 Golgi transport complex(GO:0017119)
0.2 15.9 GO:0005871 kinesin complex(GO:0005871)
0.2 29.6 GO:0036064 ciliary basal body(GO:0036064)
0.2 1.1 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.2 3.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 12.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 38.2 GO:0032993 protein-DNA complex(GO:0032993)
0.1 6.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 6.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 26.0 GO:0030027 lamellipodium(GO:0030027)
0.1 15.1 GO:0030018 Z disc(GO:0030018)
0.1 2.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 48.1 GO:0005813 centrosome(GO:0005813)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 1.8 GO:0019028 viral capsid(GO:0019028)
0.1 6.4 GO:0005815 microtubule organizing center(GO:0005815)
0.1 2.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 3.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 3.7 GO:0005902 microvillus(GO:0005902)
0.1 3.8 GO:0000502 proteasome complex(GO:0000502)
0.1 72.2 GO:0005615 extracellular space(GO:0005615)
0.1 19.0 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 15.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 7.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.1 GO:0043209 myelin sheath(GO:0043209)
0.0 16.2 GO:0005739 mitochondrion(GO:0005739)
0.0 1.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 41.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
6.3 50.2 GO:0043199 sulfate binding(GO:0043199)
5.3 26.7 GO:0046923 ER retention sequence binding(GO:0046923)
4.6 13.9 GO:0047635 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
4.4 26.5 GO:0048039 ubiquinone binding(GO:0048039)
4.3 17.3 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
4.2 162.9 GO:0030506 ankyrin binding(GO:0030506)
4.0 47.7 GO:0050897 cobalt ion binding(GO:0050897)
3.5 35.3 GO:0051959 dynein light intermediate chain binding(GO:0051959)
2.8 27.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
2.7 10.8 GO:0003987 acetate-CoA ligase activity(GO:0003987)
2.6 7.9 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
2.3 6.8 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
2.3 27.0 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
2.0 5.9 GO:0004040 amidase activity(GO:0004040) glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
1.8 25.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
1.8 5.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.7 5.1 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
1.7 15.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.5 44.7 GO:0017147 Wnt-protein binding(GO:0017147)
1.5 11.7 GO:0045545 syndecan binding(GO:0045545)
1.2 8.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
1.1 3.2 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.9 30.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.9 3.4 GO:0033149 FFAT motif binding(GO:0033149)
0.7 21.6 GO:0030332 cyclin binding(GO:0030332)
0.6 3.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.6 7.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.6 5.0 GO:0070569 uridylyltransferase activity(GO:0070569)
0.6 4.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.6 6.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.5 4.3 GO:0008430 selenium binding(GO:0008430)
0.5 18.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.5 26.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.5 12.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 10.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 3.3 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.4 8.0 GO:0008199 ferric iron binding(GO:0008199)
0.4 1.8 GO:0004103 choline kinase activity(GO:0004103)
0.4 8.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 2.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 15.5 GO:0030507 spectrin binding(GO:0030507)
0.3 19.9 GO:0019003 GDP binding(GO:0019003)
0.3 3.9 GO:0017166 vinculin binding(GO:0017166)
0.3 2.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 1.1 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
0.3 17.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 18.6 GO:0005507 copper ion binding(GO:0005507)
0.3 3.7 GO:0015250 water channel activity(GO:0015250)
0.3 1.6 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.3 5.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 13.1 GO:0050661 NADP binding(GO:0050661)
0.2 0.8 GO:0019863 IgE binding(GO:0019863)
0.2 15.9 GO:0003777 microtubule motor activity(GO:0003777)
0.2 13.5 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2 6.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 2.1 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.2 1.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 6.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 4.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 1.0 GO:0008312 7S RNA binding(GO:0008312)
0.1 2.5 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.4 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 0.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 11.7 GO:0043130 ubiquitin binding(GO:0043130)
0.1 1.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 55.0 GO:0005509 calcium ion binding(GO:0005509)
0.1 8.1 GO:0030165 PDZ domain binding(GO:0030165)
0.1 4.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 14.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.5 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.8 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 1.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 1.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.1 GO:0070888 E-box binding(GO:0070888)
0.0 2.2 GO:0051213 dioxygenase activity(GO:0051213)
0.0 1.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.8 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 4.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 152.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
1.2 9.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.8 47.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.7 18.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.7 4.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.6 16.2 SIG CHEMOTAXIS Genes related to chemotaxis
0.6 15.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.5 21.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.5 51.7 PID CMYB PATHWAY C-MYB transcription factor network
0.5 13.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.4 10.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.4 34.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.4 5.8 ST G ALPHA S PATHWAY G alpha s Pathway
0.3 8.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.3 11.7 PID BMP PATHWAY BMP receptor signaling
0.3 10.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 16.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 3.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.2 31.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.9 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 3.8 PID PLK1 PATHWAY PLK1 signaling events
0.1 17.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.6 PID MYC PATHWAY C-MYC pathway
0.1 1.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 0.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 5.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 5.6 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 162.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
2.2 41.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
2.1 37.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.8 26.8 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
1.6 40.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
1.3 10.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.0 50.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.9 15.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.8 13.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.5 8.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.4 4.7 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 5.1 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.3 3.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 27.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 1.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 2.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 1.9 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.2 5.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 6.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 2.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 6.8 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.1 1.8 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 3.2 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 8.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.5 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.1 9.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 2.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.1 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides