ISMARA results: Atf6

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Atf6

Z-value: 1.29

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Transcription factors associated with Atf6

Gene Symbol	Gene ID	Gene Info
Atf6 NCBI RGD Ensembl	ENSRNOG00000024632	activating transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Atf6	rn6_v1_chr13_-_89242443_89242443	-0.28	3.5e-07	Click!

Activity profile of Atf6 motif

Sorted Z-values of Atf6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_56711049 Show fit	82.68	ENSRNOT00000027237	Flnc NCBI RGD Ensembl Show fit	filamin C
chr4_+_56711275 Show fit	80.25	ENSRNOT00000088149	Flnc NCBI RGD Ensembl Show fit	filamin C
chr16_+_26906716 Show fit	47.73	ENSRNOT00000064297	Cpe NCBI RGD Ensembl Show fit	carboxypeptidase E
chrX_+_106774980 Show fit	38.56	ENSRNOT00000046091	Tceal7 NCBI RGD Ensembl Show fit	transcription elongation factor A like 7
chr1_-_215660492 Show fit	38.51	ENSRNOT00000079442	AC132720.1 NCBI RGD Ensembl Show fit
chr5_+_1417478 Show fit	37.44	ENSRNOT00000008153 ENSRNOT00000085564	Jph1 NCBI RGD Ensembl Show fit	junctophilin 1
chr12_+_37490584 Show fit	35.26	ENSRNOT00000001401 ENSRNOT00000090831	Rilpl1 NCBI RGD Ensembl Show fit	Rab interacting lysosomal protein-like 1
chr17_-_47394231 Show fit	35.17	ENSRNOT00000079368 ENSRNOT00000079216	Sfrp4 NCBI RGD Ensembl Show fit	secreted frizzled-related protein 4
chr8_-_116361343 Show fit	31.75	ENSRNOT00000066296	Sema3b NCBI RGD Ensembl Show fit	semaphorin 3B
chr2_-_211017778 Show fit	31.20	ENSRNOT00000026883	Sypl2 NCBI RGD Ensembl Show fit	synaptophysin-like 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	157.5	GO:0048747	muscle fiber development(GO:0048747)
16.7	50.2	GO:0072209	mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
3.5	48.6	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
9.5	47.7	GO:0030070	insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173)
1.2	41.5	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
11.8	35.3	GO:1903445	protein transport from ciliary membrane to plasma membrane(GO:1903445)
11.7	35.2	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.6	31.2	GO:0021762	substantia nigra development(GO:0021762)
10.1	30.2	GO:0060577	pulmonary vein morphogenesis(GO:0060577)
1.4	27.9	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)

Showing 1 to 10 of 125 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.1	178.4	GO:0043034	costamere(GO:0043034)
0.1	72.2	GO:0005615	extracellular space(GO:0005615)
1.4	50.2	GO:0046930	pore complex(GO:0046930)
0.1	48.1	GO:0005813	centrosome(GO:0005813)
3.0	47.7	GO:0031045	dense core granule(GO:0031045)
4.6	41.5	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2	38.2	GO:0032993	protein-DNA complex(GO:0032993)
12.5	37.4	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
1.4	31.2	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2	29.6	GO:0036064	ciliary basal body(GO:0036064)

Showing 1 to 10 of 68 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	162.9	GO:0030506	ankyrin binding(GO:0030506)
0.1	55.0	GO:0005509	calcium ion binding(GO:0005509)
6.3	50.2	GO:0043199	sulfate binding(GO:0043199)
4.0	47.7	GO:0050897	cobalt ion binding(GO:0050897)
1.5	44.7	GO:0017147	Wnt-protein binding(GO:0017147)
6.9	41.5	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
3.5	35.3	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.9	30.7	GO:0008307	structural constituent of muscle(GO:0008307)
2.8	27.9	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
2.3	27.0	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Showing 1 to 10 of 83 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	152.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.5	51.7	PID CMYB PATHWAY	C-MYB transcription factor network
0.8	47.7	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.4	34.8	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.2	31.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5	21.9	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.7	18.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	17.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	16.2	SIG CHEMOTAXIS	Genes related to chemotaxis
0.3	16.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.6	162.9	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
1.0	50.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.2	41.5	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
1.6	40.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
2.1	37.0	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.3	27.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.8	26.8	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.9	15.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.8	13.9	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
1.3	10.8	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation

Showing 1 to 10 of 34 entries

Results for Atf6

Z-value: 1.29

Motif logo

Transcription factors associated with Atf6

Activity-expression correlation:

Activity profile of Atf6 motif

Sorted Z-values of Atf6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: