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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Atf4

Z-value: 0.87

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Transcription factors associated with Atf4

Gene Symbol Gene ID Gene Info
Atf4
ENSRNOG00000017801 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Atf4rn6_v1_chr7_+_121480723_121480723-0.165.1e-03Click!

Activity profile of Atf4 motif

Sorted Z-values of Atf4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_70643169 44.36 ENSRNOT00000010106
Inhbe
inhibin beta E subunit
chr3_+_111160205 42.53 ENSRNOT00000019392
Chac1
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
chr1_-_101596822 31.00 ENSRNOT00000028490
Fgf21
fibroblast growth factor 21
chr9_+_74124016 30.01 ENSRNOT00000019023
Cps1
carbamoyl-phosphate synthase 1
chr10_-_62254287 21.53 ENSRNOT00000004313
Serpinf1
serpin family F member 1
chr5_-_137372993 19.54 ENSRNOT00000092823
Tmem125
transmembrane protein 125
chr1_-_194769524 16.74 ENSRNOT00000025988
Nupr1
nuclear protein 1, transcriptional regulator
chr1_-_198045154 15.99 ENSRNOT00000072875
Nupr1l1
nuclear protein, transcriptional regulator, 1-like 1
chr7_-_70829815 15.85 ENSRNOT00000011082
Shmt2
serine hydroxymethyltransferase 2
chr13_+_103300932 13.61 ENSRNOT00000085214
ENSRNOT00000038264
Eprs
glutamyl-prolyl-tRNA synthetase
chr5_+_136669674 13.36 ENSRNOT00000048770
Slc6a9
solute carrier family 6 member 9
chr1_-_263269762 12.89 ENSRNOT00000022309
Got1
glutamic-oxaloacetic transaminase 1
chr19_-_43215281 12.70 ENSRNOT00000025052
Aars
alanyl-tRNA synthetase
chr9_-_78969013 12.39 ENSRNOT00000019772
ENSRNOT00000057585
Fn1
fibronectin 1
chr1_-_216801656 12.14 ENSRNOT00000050721
Cars
cysteinyl-tRNA synthetase
chr19_-_43215077 12.04 ENSRNOT00000082151
Aars
alanyl-tRNA synthetase
chr7_+_130296897 12.04 ENSRNOT00000044854
Adm2
adrenomedullin 2
chr19_-_11057254 11.95 ENSRNOT00000025559
Herpud1
homocysteine inducible ER protein with ubiquitin like domain 1
chr11_-_29641551 11.84 ENSRNOT00000064103
Krtap7-1
keratin associated protein 7-1
chr14_+_22072024 11.35 ENSRNOT00000002680
ste2
estrogen sulfotransferase
chr10_-_38782419 10.92 ENSRNOT00000073964
Uqcrq
ubiquinol-cytochrome c reductase, complex III subunit VII
chr10_-_109821807 10.49 ENSRNOT00000054949
Pycr1
pyrroline-5-carboxylate reductase 1
chr5_+_147375350 10.31 ENSRNOT00000010674
Yars
tyrosyl-tRNA synthetase
chr7_+_141054494 9.96 ENSRNOT00000088176
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr13_+_49933155 9.55 ENSRNOT00000037039
Ppp1r15b
protein phosphatase 1, regulatory subunit 15B
chr8_+_22856539 9.05 ENSRNOT00000015381
Angptl8
angiopoietin-like 8
chr7_-_101140308 7.95 ENSRNOT00000006279
Fam84b
family with sequence similarity 84, member B
chr15_-_35113678 7.51 ENSRNOT00000059677
Ctsg
cathepsin G
chr14_+_89384512 6.62 ENSRNOT00000035612
Abca13
ATP binding cassette subfamily A member 13
chr1_-_91296656 5.98 ENSRNOT00000028703
Cebpg
CCAAT/enhancer binding protein gamma
chr11_+_80319177 5.83 ENSRNOT00000036777
Rtp2
receptor (chemosensory) transporter protein 2
chr4_+_85235172 5.63 ENSRNOT00000014780
Gars
glycyl-tRNA synthetase
chr20_+_5933303 5.54 ENSRNOT00000000617
Mapk14
mitogen activated protein kinase 14
chr4_-_44136815 5.46 ENSRNOT00000086810
Tfec
transcription factor EC
chr19_-_11451278 5.30 ENSRNOT00000026118
Ogfod1
2-oxoglutarate and iron-dependent oxygenase domain containing 1
chrX_-_130794673 5.24 ENSRNOT00000080612
LOC691030
similar to RIKEN cDNA 1700001F22
chr17_-_15402631 5.24 ENSRNOT00000019862
ENSRNOT00000093637
Iars
isoleucyl-tRNA synthetase
chr10_-_20622600 4.73 ENSRNOT00000020554
Fbll1
fibrillarin-like 1
chr5_+_59452348 4.71 ENSRNOT00000019887
Ccin
calicin
chr4_-_157829241 4.47 ENSRNOT00000026184
Ltbr
lymphotoxin beta receptor
chr19_+_14508616 4.46 ENSRNOT00000019192
Hmox1
heme oxygenase 1
chr2_-_189333015 4.38 ENSRNOT00000076424
ENSRNOT00000076952
Hax1
HCLS1 associated protein X-1
chr2_-_189333322 4.35 ENSRNOT00000073599
ENSRNOT00000071253
ENSRNOT00000076325
Hax1
HCLS1 associated protein X-1
chr8_-_13680870 4.33 ENSRNOT00000081616
Hephl1
hephaestin-like 1
chr10_+_84119884 4.07 ENSRNOT00000009951
Hoxb9
homeo box B9
chrX_-_144001727 3.95 ENSRNOT00000078404
RGD1560585
similar to RIKEN cDNA 1700001F22
chr10_-_75120247 3.77 ENSRNOT00000011402
Lpo
lactoperoxidase
chr12_+_48677905 3.77 ENSRNOT00000083196
1700069L16Rik
RIKEN cDNA 1700069L16 gene
chr17_-_53087274 3.62 ENSRNOT00000020794
RGD1308147
similar to expressed sequence AW209491
chr4_+_133540540 3.61 ENSRNOT00000073232
AABR07061556.1

chr8_-_48674748 3.54 ENSRNOT00000014127
Hmbs
hydroxymethylbilane synthase
chr4_-_115015965 3.54 ENSRNOT00000014603
Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr9_-_84383687 3.41 ENSRNOT00000019685
Farsb
phenylalanyl-tRNA synthetase, beta subunit
chr11_-_28842287 3.32 ENSRNOT00000061610
Krtap19-5
keratin associated protein 19-5
chr1_+_102849889 3.23 ENSRNOT00000066791
Gtf2h1
general transcription factor IIH subunit 1
chr19_+_49695579 3.13 ENSRNOT00000016963
Gan
gigaxonin
chr14_+_96300596 3.12 ENSRNOT00000071967
LOC302228
similar to Spindlin-like protein 2 (SPIN-2)
chr1_+_174655939 3.01 ENSRNOT00000014002
Ipo7
importin 7
chr18_-_36579403 2.88 ENSRNOT00000025284
Lars
leucyl-tRNA synthetase
chr12_+_11240761 2.83 ENSRNOT00000001310
Pdap1
PDGFA associated protein 1
chr15_+_30735921 2.73 ENSRNOT00000078887
AABR07017763.2

chr18_-_60002529 2.66 ENSRNOT00000081014
ENSRNOT00000024264
ENSRNOT00000059162
Nars
asparaginyl-tRNA synthetase
chr4_+_163293724 2.66 ENSRNOT00000077356
Gabarapl1
GABA type A receptor associated protein like 1
chr16_+_8207223 2.52 ENSRNOT00000026751
Oxnad1
oxidoreductase NAD-binding domain containing 1
chr18_-_67224566 2.30 ENSRNOT00000064947
Dcc
DCC netrin 1 receptor
chr3_-_77911561 2.20 ENSRNOT00000084947
Olr679
olfactory receptor 679
chr4_+_145440114 2.15 ENSRNOT00000013052
Creld1
cysteine-rich with EGF-like domains 1
chr18_+_40596166 1.99 ENSRNOT00000087984
Eif1a
eukaryotic translation initiation factor 1A
chr1_-_233145924 1.88 ENSRNOT00000018763
ENSRNOT00000082442
Psat1
phosphoserine aminotransferase 1
chr4_-_68349273 1.82 ENSRNOT00000016251
Prss37
protease, serine, 37
chr6_+_64808238 1.74 ENSRNOT00000093195
Nrcam
neuronal cell adhesion molecule
chr1_+_100473643 1.74 ENSRNOT00000026379
Josd2
Josephin domain containing 2
chr16_-_70998575 1.66 ENSRNOT00000019935
Kcnu1
potassium calcium-activated channel subfamily U member 1
chr16_-_8207464 1.45 ENSRNOT00000026742
Dph3
diphthamide biosynthesis 3
chr7_+_123381077 1.38 ENSRNOT00000082603
ENSRNOT00000056041
Srebf2
sterol regulatory element binding transcription factor 2
chr7_+_18310624 1.16 ENSRNOT00000075258
Actl9
actin-like 9
chr2_-_31753528 1.09 ENSRNOT00000075057
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
chr19_+_53629779 0.94 ENSRNOT00000051352
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
chr6_+_18821815 0.93 ENSRNOT00000062057
Mtm1
myotubularin 1
chr15_-_33527031 0.86 ENSRNOT00000019979
Homez
homeobox and leucine zipper encoding
chr19_+_37668133 0.76 ENSRNOT00000044971
Pard6a
par-6 family cell polarity regulator alpha
chr7_-_63728988 0.53 ENSRNOT00000009645
Xpot
exportin for tRNA
chr10_+_57239993 0.46 ENSRNOT00000067919
LOC687707
hypothetical protein LOC687707
chr7_-_117773134 0.22 ENSRNOT00000045135
Recql4
RecQ like helicase 4
chr19_+_37668693 0.11 ENSRNOT00000084970
Pard6a
par-6 family cell polarity regulator alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 31.0 GO:1904640 response to methionine(GO:1904640)
6.2 24.7 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
6.0 30.0 GO:0071400 cellular response to oleic acid(GO:0071400)
5.3 42.5 GO:0006751 glutathione catabolic process(GO:0006751)
4.5 13.6 GO:0006433 prolyl-tRNA aminoacylation(GO:0006433)
4.3 12.9 GO:0006532 fumarate metabolic process(GO:0006106) glycerol biosynthetic process(GO:0006114) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
4.1 12.4 GO:2001201 calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
3.6 10.9 GO:0021539 subthalamus development(GO:0021539)
3.5 17.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
3.5 10.5 GO:0055129 L-proline biosynthetic process(GO:0055129)
3.3 10.0 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
2.5 7.5 GO:0070946 neutrophil mediated killing of gram-positive bacterium(GO:0070946)
2.4 21.5 GO:0071279 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279)
2.4 12.0 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
1.9 5.6 GO:0015966 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
1.6 4.7 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
1.5 4.5 GO:0006788 heme oxidation(GO:0006788)
1.4 5.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
1.4 9.5 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
1.3 5.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
1.2 13.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
1.1 16.7 GO:2000194 regulation of female gonad development(GO:2000194)
1.0 2.9 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.9 2.7 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.9 5.3 GO:0006449 regulation of translational termination(GO:0006449)
0.8 25.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.8 44.4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.8 8.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.7 6.0 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.6 9.1 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
0.6 3.5 GO:0018065 protein-cofactor linkage(GO:0018065) cellular response to amine stimulus(GO:0071418)
0.6 2.3 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.3 1.4 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.3 9.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 3.5 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.2 0.9 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.2 1.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 13.1 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.2 0.5 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 4.5 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.2 3.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.9 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 5.5 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.9 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 1.8 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.2 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 4.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 4.7 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 2.0 GO:0006413 translational initiation(GO:0006413)
0.0 1.4 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.0 1.7 GO:0050821 protein stabilization(GO:0050821)
0.0 3.0 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.0 GO:1990037 Lewy body core(GO:1990037)
3.2 15.8 GO:0070552 BRISC complex(GO:0070552)
2.7 21.5 GO:0043203 axon hillock(GO:0043203)
2.1 26.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.5 12.4 GO:0005577 fibrinogen complex(GO:0005577)
1.1 3.4 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
1.0 10.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.7 9.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.6 4.7 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 30.0 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 1.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 1.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.4 3.2 GO:0000439 core TFIIH complex(GO:0000439)
0.3 2.3 GO:0032584 growth cone membrane(GO:0032584)
0.2 12.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 42.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 8.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 7.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.7 GO:0043194 axon initial segment(GO:0043194)
0.1 0.9 GO:0044754 autolysosome(GO:0044754)
0.1 12.9 GO:0043679 axon terminus(GO:0043679)
0.0 4.5 GO:0005901 caveola(GO:0005901)
0.0 13.4 GO:0098793 presynapse(GO:0098793)
0.0 10.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 5.5 GO:0000922 spindle pole(GO:0000922)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 54.2 GO:0005739 mitochondrion(GO:0005739)
0.0 37.2 GO:0005615 extracellular space(GO:0005615)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
10.6 42.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
6.2 24.7 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
5.3 15.8 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
4.5 13.6 GO:0004827 proline-tRNA ligase activity(GO:0004827)
4.3 12.9 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
3.5 10.5 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
2.5 30.0 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
2.5 10.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.8 12.4 GO:0045340 mercury ion binding(GO:0045340)
1.5 4.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
1.4 10.9 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.3 5.3 GO:0031544 peptidyl-proline 3-dioxygenase activity(GO:0031544)
1.3 5.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
1.2 3.5 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
1.2 5.8 GO:0031849 olfactory receptor binding(GO:0031849)
1.0 13.4 GO:0015187 sodium:amino acid symporter activity(GO:0005283) glycine transmembrane transporter activity(GO:0015187)
1.0 31.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
1.0 2.9 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.9 34.1 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.9 3.5 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.8 44.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.7 8.7 GO:0019966 interleukin-1 binding(GO:0019966)
0.7 4.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.7 5.5 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273) NFAT protein binding(GO:0051525)
0.5 2.3 GO:0005042 netrin receptor activity(GO:0005042)
0.4 1.7 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.4 4.7 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.3 2.7 GO:0030957 Tat protein binding(GO:0030957)
0.3 6.0 GO:0008301 DNA binding, bending(GO:0008301)
0.2 4.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 2.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 1.7 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 0.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 21.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 3.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 9.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 21.1 GO:0005179 hormone activity(GO:0005179)
0.1 3.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 3.8 GO:0004601 peroxidase activity(GO:0004601)
0.1 1.9 GO:0008483 transaminase activity(GO:0008483)
0.1 12.0 GO:0044325 ion channel binding(GO:0044325)
0.1 7.5 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0000405 bubble DNA binding(GO:0000405) four-way junction helicase activity(GO:0009378)
0.0 0.9 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 7.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 6.6 GO:0016887 ATPase activity(GO:0016887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 19.0 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 72.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 5.2 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.2 7.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 21.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 1.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 5.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.9 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 44.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
2.9 77.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
1.4 25.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.7 12.4 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.6 13.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 8.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.5 7.8 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.4 7.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 7.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 10.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 30.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.2 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 0.9 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 1.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 4.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.4 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression