ISMARA results: Atf1

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation

Downloads

Results for Atf1_Creb5

Z-value: 0.87

Motif logo

Transcription factors associated with Atf1_Creb5

Gene Symbol	Gene ID	Gene Info
Atf1 NCBI RGD Ensembl	ENSRNOG00000061088	activating transcription factor 1
Creb5 NCBI RGD Ensembl	ENSRNOG00000008622	cAMP responsive element binding protein 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Atf1	rn6_v1_chr7_+_141889444_141889444	0.31	2.3e-08	Click!
Creb5	rn6_v1_chr4_+_83713666_83713666	-0.21	2.1e-04	Click!

Activity profile of Atf1_Creb5 motif

Sorted Z-values of Atf1_Creb5 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_113358526 Show fit	56.53	ENSRNOT00000065073	Txndc2 NCBI RGD Ensembl Show fit	thioredoxin domain containing 2
chr5_-_146446227 Show fit	55.22	ENSRNOT00000044868	Hmgb4 NCBI RGD Ensembl Show fit	high-mobility group box 4
chr8_-_115263484 Show fit	48.88	ENSRNOT00000039696 ENSRNOT00000081138	Iqcf3 NCBI RGD Ensembl Show fit	IQ motif containing F3
chr8_-_115274165 Show fit	47.63	ENSRNOT00000056386	LOC102550160 NCBI RGD Ensembl Show fit	IQ domain-containing protein F5-like
chr5_-_140024176 Show fit	47.36	ENSRNOT00000016492	Tmco2 NCBI RGD Ensembl Show fit	transmembrane and coiled-coil domains 2
chr8_+_115213471 Show fit	47.05	ENSRNOT00000017570	Iqcf5 NCBI RGD Ensembl Show fit	IQ motif containing F5
chr7_+_18310624 Show fit	45.95	ENSRNOT00000075258	Actl9 NCBI RGD Ensembl Show fit	actin-like 9
chr1_-_89190128 Show fit	41.74	ENSRNOT00000067813	Gapdhs NCBI RGD Ensembl Show fit	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr6_-_86223052 Show fit	41.21	ENSRNOT00000046828	Fscb NCBI RGD Ensembl Show fit	fibrous sheath CABYR binding protein
chr5_+_59452348 Show fit	40.96	ENSRNOT00000019887	Ccin NCBI RGD Ensembl Show fit	calicin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf1_Creb5

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.1	70.1	GO:0006662	glycerol ether metabolic process(GO:0006662)
0.8	65.6	GO:0030317	sperm motility(GO:0030317)
0.4	54.0	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.6	48.9	GO:0006334	nucleosome assembly(GO:0006334)
5.3	47.6	GO:2000344	positive regulation of acrosome reaction(GO:2000344)
0.4	38.4	GO:0007338	single fertilization(GO:0007338)
3.2	37.9	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
2.4	35.3	GO:0007288	sperm axoneme assembly(GO:0007288)
8.3	33.0	GO:0060474	positive regulation of sperm motility involved in capacitation(GO:0060474)
1.2	30.4	GO:0034508	centromere complex assembly(GO:0034508)

Showing 1 to 10 of 181 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	161.0	GO:0001669	acrosomal vesicle(GO:0001669)
7.1	121.5	GO:0035686	sperm fibrous sheath(GO:0035686)
3.1	56.5	GO:0001520	outer dense fiber(GO:0001520)
1.7	40.1	GO:0001673	male germ cell nucleus(GO:0001673)
0.8	38.8	GO:0000777	condensed chromosome kinetochore(GO:0000777)
7.1	35.3	GO:1990716	axonemal central apparatus(GO:1990716)
2.4	33.3	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
2.2	30.4	GO:0031045	dense core granule(GO:0031045)
2.5	27.8	GO:0042583	chromaffin granule(GO:0042583)
0.3	26.4	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)

Showing 1 to 10 of 95 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	177.5	GO:0005516	calmodulin binding(GO:0005516)
0.1	120.4	GO:0003677	DNA binding(GO:0003677)
9.1	72.7	GO:0047134	protein-disulfide reductase activity(GO:0047134)
16.4	65.6	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1	51.5	GO:0003779	actin binding(GO:0003779)
0.7	32.2	GO:0070063	RNA polymerase binding(GO:0070063)
1.1	29.4	GO:0042056	chemoattractant activity(GO:0042056)
0.2	29.1	GO:0042393	histone binding(GO:0042393)
3.2	28.8	GO:0043515	kinetochore binding(GO:0043515)
2.2	28.7	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)

Showing 1 to 10 of 124 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	52.6	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.8	42.8	PID PLK1 PATHWAY	PLK1 signaling events
0.5	18.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.9	14.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	12.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	11.8	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.3	9.0	PID ATR PATHWAY	ATR signaling pathway
0.9	8.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	8.8	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.2	7.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	54.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
1.0	43.0	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.8	28.7	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.5	26.1	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.3	21.8	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.5	19.0	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.2	18.8	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis
0.7	17.6	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.2	17.4	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
1.6	14.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins

Showing 1 to 10 of 49 entries

Results for Atf1_Creb5

Z-value: 0.87

Motif logo

Transcription factors associated with Atf1_Creb5

Activity-expression correlation:

Activity profile of Atf1_Creb5 motif

Sorted Z-values of Atf1_Creb5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf1_Creb5

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: