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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Atf1_Creb5

Z-value: 0.87

Motif logo

Transcription factors associated with Atf1_Creb5

Gene Symbol Gene ID Gene Info
ENSRNOG00000061088 activating transcription factor 1
ENSRNOG00000008622 cAMP responsive element binding protein 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Atf1rn6_v1_chr7_+_141889444_1418894440.312.3e-08Click!
Creb5rn6_v1_chr4_+_83713666_83713666-0.212.1e-04Click!

Activity profile of Atf1_Creb5 motif

Sorted Z-values of Atf1_Creb5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_113358526 56.53 ENSRNOT00000065073
thioredoxin domain containing 2
chr5_-_146446227 55.22 ENSRNOT00000044868
high-mobility group box 4
chr8_-_115263484 48.88 ENSRNOT00000039696
ENSRNOT00000081138
IQ motif containing F3
chr8_-_115274165 47.63 ENSRNOT00000056386
IQ domain-containing protein F5-like
chr5_-_140024176 47.36 ENSRNOT00000016492
transmembrane and coiled-coil domains 2
chr8_+_115213471 47.05 ENSRNOT00000017570
IQ motif containing F5
chr7_+_18310624 45.95 ENSRNOT00000075258
actin-like 9
chr1_-_89190128 41.74 ENSRNOT00000067813
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr6_-_86223052 41.21 ENSRNOT00000046828
fibrous sheath CABYR binding protein
chr5_+_59452348 40.96 ENSRNOT00000019887
calicin
chr5_+_73496027 40.10 ENSRNOT00000022395
actin-like 7a
chr15_-_5417570 39.91 ENSRNOT00000061525
Spetex-2F protein
chr4_-_6449949 39.53 ENSRNOT00000062026
polypeptide N-acetylgalactosaminyltransferase-like 5
chr16_-_82288022 38.38 ENSRNOT00000078609
sperm acrosome associated 7
chrX_-_144001727 37.26 ENSRNOT00000078404
similar to RIKEN cDNA 1700001F22
chr15_+_28319136 36.53 ENSRNOT00000048723
tubulin polymerization-promoting protein family member 2
chr1_-_198267093 35.72 ENSRNOT00000047477
similar to RIKEN cDNA 4930451I11
chr11_+_88424414 35.31 ENSRNOT00000022328
sperm associated antigen 6-like
chr1_-_24604400 34.13 ENSRNOT00000081175
RIKEN cDNA 1700020N01 gene
chr8_+_115193146 33.05 ENSRNOT00000056391
IQ motif containing F1
chrX_-_132424746 32.84 ENSRNOT00000087819
similar to RIKEN cDNA 1700001F22
chrX_-_139329975 32.46 ENSRNOT00000086405
high mobility group protein B4-like
chrX_-_130794673 32.06 ENSRNOT00000080612
similar to RIKEN cDNA 1700001F22
chr4_-_169036950 31.95 ENSRNOT00000011295
germ cell associated 1
chr16_+_83161880 31.92 ENSRNOT00000080793
RIKEN cDNA 1700016D06 gene
chr9_-_85243001 31.42 ENSRNOT00000020219
secretogranin II
chr6_+_28515025 31.28 ENSRNOT00000088033
ENSRNOT00000005317
ENSRNOT00000081141
DnaJ heat shock protein family (Hsp40) member C27
chrX_+_137197396 29.25 ENSRNOT00000082227
similar to RIKEN cDNA 1700001F22
chr2_+_240396152 28.79 ENSRNOT00000034565
centromere protein E
chr6_-_47848026 28.76 ENSRNOT00000011048
ENSRNOT00000090017
allantoicase
chr6_+_122603269 28.64 ENSRNOT00000005297
spermatogenesis associated 7
chr3_+_170475831 27.98 ENSRNOT00000006949
family with sequence similarity 209, member A
chr6_+_126434226 27.81 ENSRNOT00000090857
chromogranin A
chrX_-_158261717 27.48 ENSRNOT00000086804
similar to RIKEN cDNA 1700001F22
chr9_-_63291350 27.02 ENSRNOT00000058831
heat shock transcription factor, Y linked 2
chr15_-_5467047 26.40 ENSRNOT00000042743
Spetex-2F protein
chr6_+_26780352 26.07 ENSRNOT00000009916
proline rich 30
chr3_+_35014538 25.70 ENSRNOT00000006341
kinesin family member 5C
chrX_+_114929029 25.55 ENSRNOT00000006459
p21 (RAC1) activated kinase 3
chr1_-_169334093 25.19 ENSRNOT00000032587
ubiquilin 3
chr9_+_82053581 24.94 ENSRNOT00000086375
wingless-type MMTV integration site family, member 10A
chr1_+_211582077 24.64 ENSRNOT00000023619
PWWP domain containing 2B
chr15_-_47442664 24.45 ENSRNOT00000072994
protease, serine, 55
chr1_+_101603222 24.35 ENSRNOT00000033278
izumo sperm-egg fusion 1
chr4_+_159403501 24.15 ENSRNOT00000086525
A-kinase anchoring protein 3
chr14_-_9456990 24.04 ENSRNOT00000002918
CDP-diacylglycerol synthase 1
chrX_+_142344878 24.01 ENSRNOT00000056621
high mobility group protein B4-like
chr10_+_57239993 23.97 ENSRNOT00000067919
hypothetical protein LOC687707
chr4_+_70977556 23.91 ENSRNOT00000031984
hypothetical protein LOC680112
chr1_-_89194602 23.83 ENSRNOT00000028518
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr9_+_93445002 22.86 ENSRNOT00000025029
similar to hypothetical protein MGC35154
chr4_+_120156659 21.73 ENSRNOT00000050584
DnaJ heat shock protein family (Hsp40) member B8
chr10_-_56511583 21.49 ENSRNOT00000021402
similar to RIKEN cDNA 2810408A11
chr19_+_49457677 21.03 ENSRNOT00000084445
centromere protein N
chr9_+_10172832 21.00 ENSRNOT00000074555
acyl-CoA synthetase bubblegum family member 2
chr5_-_54482159 20.61 ENSRNOT00000050030
similar to RAN protein
chr2_-_44504354 20.20 ENSRNOT00000013035
DEAD-box helicase 4
chr15_+_80040842 19.98 ENSRNOT00000043065
similar to RIKEN cDNA 4921530L21
chr4_-_156945126 19.90 ENSRNOT00000064853
LOC362433
chr1_+_86938138 19.68 ENSRNOT00000075601
coiled-coil glutamate-rich protein 2
chr3_-_112371664 19.58 ENSRNOT00000079606
ENSRNOT00000012636
leucine-rich repeat-containing protein 57-like
chr5_-_73494030 19.49 ENSRNOT00000022291
actin-like 7b
chr9_+_10535340 19.46 ENSRNOT00000075408
zinc and ring finger 4
chr1_-_188245628 19.23 ENSRNOT00000022800
transmembrane channel-like 7
chr4_-_88565292 18.65 ENSRNOT00000008948
LanC like 2
chr2_-_246737997 18.02 ENSRNOT00000021719
pyruvate dehydrogenase (lipoamide) alpha 2
chrX_+_13992064 17.80 ENSRNOT00000036543
rCG42854-like
chr7_-_140951071 17.77 ENSRNOT00000082521
family with sequence similarity 186, member B
chr1_+_162768156 17.75 ENSRNOT00000049321
p21 (RAC1) activated kinase 1
chr17_+_9746485 17.65 ENSRNOT00000072298
profilin 3
chr14_+_39368530 17.33 ENSRNOT00000084367
cytochrome c oxidase subunit 7B2
chr2_+_127686925 17.20 ENSRNOT00000086653
ENSRNOT00000016946
polo-like kinase 4
chr9_-_14906410 17.19 ENSRNOT00000061674
hypothetical protein LOC680955
chr5_-_113880911 17.14 ENSRNOT00000029441
equatorin
chr2_+_104290726 17.08 ENSRNOT00000017387
DnaJ heat shock protein family (Hsp40) member C5 beta
chr4_-_184096806 16.76 ENSRNOT00000055433
mKIAA1238 protein-like
chr18_+_25962855 16.66 ENSRNOT00000078822
calcium/calmodulin-dependent protein kinase IV
chr10_-_45297385 16.55 ENSRNOT00000041187
histone cluster 3 H2B family member b
chr4_+_174181644 16.30 ENSRNOT00000011555
capping actin protein of muscle Z-line alpha subunit 3
chr17_-_9695292 16.29 ENSRNOT00000036162
proline rich 7 (synaptic)
chr5_-_75116490 16.13 ENSRNOT00000042788
thioredoxin domain containing 8
chr11_+_52828116 16.12 ENSRNOT00000035340
coiled-coil domain containing 54
chr6_+_8669722 16.11 ENSRNOT00000048550
calmodulin-lysine N-methyltransferase
chr4_-_157078130 16.10 ENSRNOT00000015570
calsyntenin 3
chr4_-_183697531 15.99 ENSRNOT00000055441
antagonist of mitotic exit network 1 homolog
chr10_+_65454658 15.82 ENSRNOT00000037048
protein interacting with cyclin A1
chr17_+_85382116 15.04 ENSRNOT00000002513
sperm associated antigen 6
chr16_+_90613870 15.03 ENSRNOT00000079334
SHC binding and spindle associated 1
chr2_+_260039651 14.93 ENSRNOT00000073873
ankyrin repeat and SOCS box-containing 17
chr10_-_36716601 14.92 ENSRNOT00000038838
similar to hypothetical protein 4930503F14
chr20_+_5262120 14.68 ENSRNOT00000000535
bromodomain containing 2
chr1_-_174411141 14.56 ENSRNOT00000065288
nuclear receptor interacting protein 3
chr11_-_32469566 14.53 ENSRNOT00000002718
similar to RIKEN cDNA 4930563D23
chr12_+_37984790 14.17 ENSRNOT00000001445
VPS37B, ESCRT-I subunit
chr5_-_141430659 14.12 ENSRNOT00000034944
akirin 1
chr1_+_17602281 14.12 ENSRNOT00000075461
jouberin-like
chr3_-_45210474 13.98 ENSRNOT00000091777
coiled-coil domain containing 148
chr3_-_112385528 13.95 ENSRNOT00000049756
leucine rich repeat containing 57
chr10_+_38104558 13.78 ENSRNOT00000067809
follistatin-like 4
chr9_+_10760113 13.67 ENSRNOT00000073054
arrestin domain containing 5
chr10_-_74724472 13.65 ENSRNOT00000008846
RAD51 paralog C
chr10_-_91699424 13.55 ENSRNOT00000004650
lysozyme-like 6
chr17_-_43821536 13.46 ENSRNOT00000072286
histone H4 variant H4-v.1
chr3_+_125428260 13.37 ENSRNOT00000028892
chromogranin B
chr19_+_55300395 13.14 ENSRNOT00000092169
cytosolic thiouridylase subunit 2
chr3_-_160922341 13.13 ENSRNOT00000029206
TP53 target 5
chr14_-_83062302 13.12 ENSRNOT00000086769
ENSRNOT00000085735
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr9_-_16095007 13.07 ENSRNOT00000073333

chr8_+_4085829 13.02 ENSRNOT00000031286
actin-like 9b
chr5_-_104920906 12.88 ENSRNOT00000071318
family with sequence similarity 154, member A
chr1_+_102849889 12.75 ENSRNOT00000066791
general transcription factor IIH subunit 1
chr7_+_123168811 12.70 ENSRNOT00000007091
cold shock domain containing C2
chr7_+_72924799 12.69 ENSRNOT00000008969
lysosomal protein transmembrane 4 beta
chr11_-_1437732 12.59 ENSRNOT00000037345
casein kinase 2, alpha prime interacting protein
chr4_-_170740274 12.52 ENSRNOT00000012212
guanylate cyclase 2C
chrX_-_79066932 12.39 ENSRNOT00000057460
similar to WASP family 1
chr5_-_39611053 12.35 ENSRNOT00000046595
four and a half LIM domains 5
chr17_+_55008265 12.09 ENSRNOT00000033827
zinc finger protein 438
chr1_+_142087208 12.05 ENSRNOT00000017532
protein regulator of cytokinesis 1
chr3_-_149356160 12.00 ENSRNOT00000037589
ENSRNOT00000081775
Sad1 and UNC84 domain containing 5
chr13_-_110257367 11.92 ENSRNOT00000005576
denticleless E3 ubiquitin protein ligase homolog
chr7_-_72328128 11.88 ENSRNOT00000008227
TSPY-like 5
chr9_-_114152716 11.75 ENSRNOT00000044153

chr2_-_137404996 11.69 ENSRNOT00000090907
similar to T-cell activation Rho GTPase-activating protein isoform b
chr9_-_114282799 11.45 ENSRNOT00000090539
uncharacterized LOC102555328
chr18_+_45023932 11.25 ENSRNOT00000039379
family with sequence similarity 170, member A
chr10_+_14519164 11.16 ENSRNOT00000079543
ENSRNOT00000046884
coiled-coil domain containing 154
chr7_+_140758615 11.12 ENSRNOT00000089448
trophinin associated protein
chr15_+_5904569 10.47 ENSRNOT00000072599
disks large homolog 5-like
chr16_+_71241335 10.40 ENSRNOT00000066144
leucine zipper and EF-hand containing transmembrane protein 2
chr1_+_211205903 10.36 ENSRNOT00000023139
protein phosphatase 2, regulatory subunit B, delta
chr5_-_58163584 10.12 ENSRNOT00000060594
C-C motif chemokine ligand 27
chr2_-_251970768 10.07 ENSRNOT00000020141
WD repeat domain 63
chr13_-_104284068 9.97 ENSRNOT00000005407
uncharacterized LOC100912365
chr4_-_11497531 9.82 ENSRNOT00000078799
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr18_-_14016713 9.78 ENSRNOT00000041125
nucleolar protein 4
chr5_+_58937615 9.77 ENSRNOT00000080909
testis-specific kinase 1
chr1_+_224938801 9.75 ENSRNOT00000073052
RIKEN cDNA 1700092M07 gene
chr10_+_49368314 9.74 ENSRNOT00000004392
CMT1A duplicated region transcript 4
chr14_+_35683442 9.65 ENSRNOT00000003085
cysteine-rich hydrophobic domain 2
chr1_-_67302751 9.62 ENSRNOT00000041518
vomeronasal 1 receptor 42
chr15_-_33527031 9.54 ENSRNOT00000019979
homeobox and leucine zipper encoding
chr9_-_100253609 9.54 ENSRNOT00000036061
kinesin family member 1A
chr6_-_126622532 9.49 ENSRNOT00000038816
modulator of apoptosis 1
chr5_+_152721940 9.48 ENSRNOT00000039322
aurora kinase A and ninein interacting protein
chr16_-_70998575 9.38 ENSRNOT00000019935
potassium calcium-activated channel subfamily U member 1
chrY_+_151937 9.35 ENSRNOT00000077988
ENSRNOT00000083382
testis specific protein, Y-linked 1
chr2_-_112802073 9.18 ENSRNOT00000093081
epithelial cell transforming 2
chr14_+_7581189 9.15 ENSRNOT00000077215
similar to hypothetical protein MGC26744
chr16_-_49522341 9.14 ENSRNOT00000081642
coiled-coil domain-containing protein 110-like
chr10_+_59893067 9.11 ENSRNOT00000056443
spermatogenesis associated 22
chr7_+_27248115 9.08 ENSRNOT00000031946
ENSRNOT00000059545
first gene upstream of Nt5dc3
chr17_-_89780691 9.07 ENSRNOT00000091830
ankyrin repeat domain-containing protein 7-like
chr7_-_120558805 9.07 ENSRNOT00000087344
phospholipase A2 group VI
chr12_+_504007 9.02 ENSRNOT00000001475
BRCA2, DNA repair associated
chr20_+_13498926 8.97 ENSRNOT00000070992
ENSRNOT00000045375
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr19_-_55300403 8.96 ENSRNOT00000018591
ring finger protein 166
chr16_-_32439421 8.83 ENSRNOT00000043100
NIMA-related kinase 1
chr9_-_82461903 8.83 ENSRNOT00000026654
protein tyrosine phosphatase, receptor type, N
chr10_+_39726507 8.66 ENSRNOT00000036822
meiotic kinetochore factor
chr1_-_47213749 8.65 ENSRNOT00000024656
dynein light chain Tctex-type 1
chr12_-_13067341 8.62 ENSRNOT00000029692
family with sequence similarity 220, member A
chrX_+_16337102 8.60 ENSRNOT00000003954
cyclin B3
chr7_-_120559157 8.53 ENSRNOT00000090565
ENSRNOT00000016827
ENSRNOT00000017108
phospholipase A2 group VI
chr4_+_157326727 8.50 ENSRNOT00000020493
splA/ryanodine receptor domain and SOCS box containing 2
chr9_-_20219209 8.48 ENSRNOT00000072086
SPRY domain-containing SOCS box protein 2-like
chr20_+_4967194 8.46 ENSRNOT00000070846
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr8_-_39830306 8.19 ENSRNOT00000040901
coiled-coil domain containing 15
chr2_-_123281856 7.98 ENSRNOT00000079745
cyclin A2
chr7_-_22943159 7.90 ENSRNOT00000047547
vomeronasal 2 receptor, 57
chr8_-_62893087 7.89 ENSRNOT00000058490
coiled-coil domain containing 33
chr19_+_37668693 7.88 ENSRNOT00000084970
par-6 family cell polarity regulator alpha
chr7_-_19088972 7.87 ENSRNOT00000049266
vomeronasal 2 receptor, 57
chr7_-_82687130 7.86 ENSRNOT00000006791
transmembrane protein 74
chr11_+_47200029 7.79 ENSRNOT00000079598
neurexophilin and PC-esterase domain family, member 3
chr20_-_2088389 7.75 ENSRNOT00000090910
ZNRD1 antisense RNA 1
chr1_+_72644333 7.72 ENSRNOT00000048976
ENSRNOT00000065051
family with sequence similarity 71, member E2
chr8_+_64364741 7.69 ENSRNOT00000082840
CUGBP, Elav-like family member 6
chrX_+_43293551 7.67 ENSRNOT00000084562
hypothetical protein LOC680190
chr15_+_27739251 7.55 ENSRNOT00000011840
poly (ADP-ribose) polymerase 2
chr7_-_30344426 7.50 ENSRNOT00000002638
ENSRNOT00000082016
SCY1 like pseudokinase 2
chr20_-_37700937 7.44 ENSRNOT00000001051
TBC1 domain family, member 32
chr16_+_70081035 7.41 ENSRNOT00000016098
ubiquitin carboxyl-terminal hydrolase 12-like
chr2_+_86971147 7.35 ENSRNOT00000032909
zinc finger protein 458
chr17_+_43617247 7.07 ENSRNOT00000075065
histone cluster 1, H2ao
chr1_-_163071508 7.03 ENSRNOT00000019053
myosin VIIA
chr3_-_117389456 7.03 ENSRNOT00000007103
ENSRNOT00000081533
myelin expression factor 2
chrX_-_14783792 6.95 ENSRNOT00000087609
similar to ferritin, heavy polypeptide-like 17
chr2_+_157453428 6.92 ENSRNOT00000051494
leucine, glutamate and lysine rich 1
chr4_+_88834066 6.91 ENSRNOT00000009546
ATP-binding cassette, subfamily G (WHITE), member 2
chr2_+_187302192 6.83 ENSRNOT00000015471
interferon stimulated exonuclease gene 20-like 2
chr16_-_32753278 6.83 ENSRNOT00000015759
microfibrillar-associated protein 3-like
chr20_-_10844178 6.79 ENSRNOT00000079207
heat shock transcription factor 2 binding protein
chr8_+_114867062 6.73 ENSRNOT00000074771
WD repeat domain 82
chr15_+_90364605 6.68 ENSRNOT00000020876
tripartite motif-containing 52
chr8_+_122003916 6.58 ENSRNOT00000091980
cytoplasmic linker associated protein 2
chr7_-_44121130 6.53 ENSRNOT00000005706
neurotensin
chr20_-_3299420 6.45 ENSRNOT00000090999
G protein nucleolar 1
chr18_+_62174670 6.43 ENSRNOT00000025362
phorbol-12-myristate-13-acetate-induced protein 1
chr6_-_135049728 6.26 ENSRNOT00000009556
heat shock protein 90 alpha family class A member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf1_Creb5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 28.8 GO:0043605 cellular amide catabolic process(GO:0043605)
9.3 27.8 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
8.3 33.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
6.4 25.7 GO:0098964 dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964)
6.2 18.7 GO:1901421 positive regulation of response to alcohol(GO:1901421)
5.7 17.2 GO:0046601 positive regulation of centriole replication(GO:0046601)
5.7 17.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
5.3 47.6 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
5.1 10.1 GO:0071677 positive regulation of mononuclear cell migration(GO:0071677)
4.8 28.8 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
4.7 14.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
4.6 13.7 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
4.4 17.7 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
4.4 17.6 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
4.4 13.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
4.4 13.1 GO:0006713 glucocorticoid catabolic process(GO:0006713)
4.1 70.1 GO:0006662 glycerol ether metabolic process(GO:0006662)
3.6 28.6 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
3.4 24.0 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
3.2 12.9 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
3.2 15.9 GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:0001844)
3.2 37.9 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
3.0 9.0 GO:0043060 meiotic metaphase I plate congression(GO:0043060) microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
2.6 12.9 GO:0007060 male meiosis chromosome segregation(GO:0007060)
2.5 7.6 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
2.5 7.5 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
2.4 35.3 GO:0007288 sperm axoneme assembly(GO:0007288)
2.3 6.9 GO:0019389 glucuronoside metabolic process(GO:0019389) response to 2,3,7,8-tetrachlorodibenzodioxine(GO:1904612)
2.2 8.7 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
2.0 21.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
2.0 29.4 GO:0048245 eosinophil chemotaxis(GO:0048245)
1.8 5.5 GO:0042441 eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) rhodopsin metabolic process(GO:0046154)
1.7 24.9 GO:0048733 sebaceous gland development(GO:0048733)
1.6 9.8 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
1.6 16.1 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
1.5 9.1 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
1.5 12.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
1.5 4.4 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
1.3 22.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.3 6.5 GO:0097332 response to antipsychotic drug(GO:0097332)
1.3 16.7 GO:0002371 dendritic cell cytokine production(GO:0002371)
1.3 5.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
1.3 26.3 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
1.2 20.2 GO:0034587 piRNA metabolic process(GO:0034587)
1.2 30.4 GO:0034508 centromere complex assembly(GO:0034508)
1.2 10.4 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
1.1 3.4 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
1.1 3.3 GO:0042196 chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
1.1 1.1 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244)
1.1 13.8 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
1.0 6.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
1.0 9.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.0 6.0 GO:0071918 urea transmembrane transport(GO:0071918)
0.9 3.8 GO:0052203 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.9 13.0 GO:1990314 cellular response to insulin-like growth factor stimulus(GO:1990314)
0.9 7.4 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.9 2.6 GO:0021508 floor plate formation(GO:0021508)
0.9 11.9 GO:0019985 translesion synthesis(GO:0019985)
0.8 14.3 GO:0000054 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.8 5.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.8 65.6 GO:0030317 sperm motility(GO:0030317)
0.8 3.9 GO:0044571 [2Fe-2S] cluster assembly(GO:0044571)
0.8 7.0 GO:0050957 equilibrioception(GO:0050957)
0.8 4.7 GO:0021764 amygdala development(GO:0021764)
0.7 9.7 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.7 9.9 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.7 14.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.7 4.2 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.7 2.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.7 4.8 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.7 27.9 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.7 2.7 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.7 2.6 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.7 16.3 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.6 4.4 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.6 3.7 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.6 1.8 GO:0060816 random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.6 11.5 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.6 8.8 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.6 4.0 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.6 6.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.6 10.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.6 48.9 GO:0006334 nucleosome assembly(GO:0006334)
0.6 6.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.5 2.2 GO:0060051 negative regulation of protein glycosylation(GO:0060051)
0.5 4.3 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.5 4.8 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 2.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.5 1.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.5 2.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.5 4.8 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.5 2.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 1.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.4 5.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.4 1.6 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.4 2.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 38.4 GO:0007338 single fertilization(GO:0007338)
0.4 1.2 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.4 3.0 GO:0072520 seminiferous tubule development(GO:0072520)
0.4 2.2 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.4 3.6 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.4 54.0 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.3 12.5 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.3 1.0 GO:0036451 cap mRNA methylation(GO:0036451)
0.3 3.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.3 1.3 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.3 2.3 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.3 2.9 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.3 3.8 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.3 4.7 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.3 2.0 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.3 7.4 GO:0006611 protein export from nucleus(GO:0006611)
0.3 2.8 GO:1901679 pyrimidine-containing compound transmembrane transport(GO:0072531) nucleotide transmembrane transport(GO:1901679)
0.3 4.8 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.3 9.0 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.3 0.8 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.3 4.7 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.3 3.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 2.5 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 0.8 GO:0021539 subthalamus development(GO:0021539) pulmonary vein morphogenesis(GO:0060577)
0.3 9.5 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.3 2.7 GO:0032342 aldosterone biosynthetic process(GO:0032342)
0.3 7.7 GO:0071625 vocalization behavior(GO:0071625)
0.3 1.3 GO:0030070 insulin processing(GO:0030070)
0.3 2.6 GO:0090043 tubulin deacetylation(GO:0090042) regulation of tubulin deacetylation(GO:0090043)
0.2 30.0 GO:0007286 spermatid development(GO:0007286)
0.2 0.7 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.2 0.6 GO:0030186 melatonin metabolic process(GO:0030186) negative regulation of male gonad development(GO:2000019)
0.2 3.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 1.0 GO:0090399 replicative senescence(GO:0090399)
0.2 1.6 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.2 5.6 GO:0006270 DNA replication initiation(GO:0006270)
0.2 3.2 GO:0010818 T cell chemotaxis(GO:0010818)
0.2 6.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 3.1 GO:0031424 keratinization(GO:0031424)
0.2 8.6 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.2 12.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 1.6 GO:0016926 protein desumoylation(GO:0016926) regulation of DNA endoreduplication(GO:0032875)
0.2 16.0 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.2 4.5 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.6 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.1 2.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.4 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 1.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 2.5 GO:0006152 purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.1 0.7 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1 0.4 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 2.3 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 5.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 5.5 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 5.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 1.6 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 2.1 GO:0007635 chemosensory behavior(GO:0007635)
0.1 1.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 4.4 GO:1903146 regulation of mitophagy(GO:1903146)
0.1 4.2 GO:0045429 positive regulation of nitric oxide biosynthetic process(GO:0045429)
0.1 0.8 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.1 5.7 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 6.6 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 0.7 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 1.6 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.1 2.2 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 0.2 GO:0044827 modulation by host of viral genome replication(GO:0044827) positive regulation by host of viral genome replication(GO:0044829)
0.1 2.3 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.3 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.1 15.7 GO:0007283 spermatogenesis(GO:0007283)
0.1 2.3 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.5 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.9 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.3 GO:0046836 glycolipid transport(GO:0046836)
0.0 4.0 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 3.0 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 2.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 1.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 5.2 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 1.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.1 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 2.0 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 2.5 GO:0000377 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 121.5 GO:0035686 sperm fibrous sheath(GO:0035686)
7.1 35.3 GO:1990716 axonemal central apparatus(GO:1990716)
4.3 13.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
4.3 17.1 GO:0002079 inner acrosomal membrane(GO:0002079)
3.4 17.2 GO:0098536 deuterosome(GO:0098536)
3.4 20.2 GO:0071547 piP-body(GO:0071547)
3.1 56.5 GO:0001520 outer dense fiber(GO:0001520)
2.7 13.7 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
2.6 12.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
2.5 27.8 GO:0042583 chromaffin granule(GO:0042583)
2.4 11.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
2.4 33.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
2.3 9.2 GO:0097149 centralspindlin complex(GO:0097149)
2.2 30.4 GO:0031045 dense core granule(GO:0031045)
2.0 14.2 GO:0097524 sperm plasma membrane(GO:0097524)
1.9 17.1 GO:0000813 ESCRT I complex(GO:0000813)
1.8 18.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
1.8 5.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.7 40.1 GO:0001673 male germ cell nucleus(GO:0001673)
1.6 16.3 GO:0008290 F-actin capping protein complex(GO:0008290)
1.4 12.8 GO:0000439 core TFIIH complex(GO:0000439)
1.4 4.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
1.3 3.9 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
1.2 18.2 GO:0035253 ciliary rootlet(GO:0035253)
1.2 161.0 GO:0001669 acrosomal vesicle(GO:0001669)
1.0 14.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.0 7.0 GO:0002139 stereocilia coupling link(GO:0002139)
1.0 9.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.0 3.9 GO:0097196 Shu complex(GO:0097196)
0.8 23.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.8 38.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.7 12.1 GO:0070938 contractile ring(GO:0070938)
0.7 24.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.6 4.5 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.6 11.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.6 9.0 GO:0000800 lateral element(GO:0000800)
0.6 4.8 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.5 9.8 GO:0071437 invadopodium(GO:0071437)
0.5 8.7 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.5 5.6 GO:0042555 MCM complex(GO:0042555)
0.5 12.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.5 2.3 GO:0030689 Noc complex(GO:0030689)
0.5 2.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.4 12.9 GO:0034451 centriolar satellite(GO:0034451)
0.4 4.3 GO:0000801 central element(GO:0000801)
0.4 3.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.4 1.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.4 1.1 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.3 26.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.0 GO:1990879 CST complex(GO:1990879)
0.3 5.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 2.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.3 5.5 GO:0044292 dendrite terminus(GO:0044292)
0.3 7.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 2.6 GO:0097542 ciliary tip(GO:0097542)
0.3 18.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.3 4.5 GO:0000242 pericentriolar material(GO:0000242)
0.3 1.8 GO:0000796 condensin complex(GO:0000796)
0.3 17.0 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.3 4.6 GO:0045277 respiratory chain complex IV(GO:0045277)
0.2 4.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 12.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 2.0 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2 4.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 1.6 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 1.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 1.6 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.2 4.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.2 5.7 GO:0046930 pore complex(GO:0046930)
0.2 7.0 GO:0016235 aggresome(GO:0016235)
0.2 1.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 4.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.0 GO:0005682 U5 snRNP(GO:0005682)
0.1 20.4 GO:0001650 fibrillar center(GO:0001650)
0.1 2.2 GO:0010369 chromocenter(GO:0010369)
0.1 2.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.7 GO:0000322 storage vacuole(GO:0000322)
0.1 0.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 4.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.2 GO:0030008 TRAPP complex(GO:0030008)
0.1 2.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 9.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 4.6 GO:0045095 keratin filament(GO:0045095)
0.1 2.1 GO:0031941 filamentous actin(GO:0031941)
0.1 8.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 8.8 GO:0043204 perikaryon(GO:0043204)
0.0 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 5.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.2 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
16.4 65.6 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
9.1 72.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
8.0 24.0 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
5.6 16.8 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
4.5 18.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
3.2 28.8 GO:0043515 kinetochore binding(GO:0043515)
3.0 9.0 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
2.9 8.6 GO:0097677 STAT family protein binding(GO:0097677)
2.8 13.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
2.7 24.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
2.6 25.7 GO:0034190 apolipoprotein receptor binding(GO:0034190)
2.5 9.8 GO:0070699 type II activin receptor binding(GO:0070699)
2.3 9.4 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
2.3 13.7 GO:0000150 recombinase activity(GO:0000150)
2.2 28.7 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
2.2 17.6 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
2.1 25.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
1.8 5.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
1.7 21.0 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
1.6 4.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
1.5 4.4 GO:0052723 inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
1.4 16.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
1.3 18.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
1.3 10.4 GO:0030911 TPR domain binding(GO:0030911)
1.1 3.4 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
1.1 29.4 GO:0042056 chemoattractant activity(GO:0042056)
1.1 4.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
1.0 13.6 GO:0003796 lysozyme activity(GO:0003796)
1.0 11.2 GO:0016783 sulfurtransferase activity(GO:0016783)
1.0 2.0 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.9 7.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.9 5.5 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.9 177.5 GO:0005516 calmodulin binding(GO:0005516)
0.9 9.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.9 6.3 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.9 2.7 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.9 6.0 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.8 7.6 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.8 4.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.8 6.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.8 11.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.8 12.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.8 4.5 GO:0080084 RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) 5S rDNA binding(GO:0080084)
0.7 12.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.7 32.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.7 4.0 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.7 14.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.7 12.5 GO:0015643 toxic substance binding(GO:0015643)
0.6 15.8 GO:0004623 phospholipase A2 activity(GO:0004623)
0.6 3.8 GO:0033142 progesterone receptor binding(GO:0033142)
0.6 6.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.6 3.7 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.6 14.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.5 13.0 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.5 15.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.5 1.6 GO:0019807 aspartoacylase activity(GO:0019807)
0.5 3.6 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.5 6.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.5 12.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.5 9.7 GO:0008199 ferric iron binding(GO:0008199)
0.5 11.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.4 7.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.4 12.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.4 5.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 1.6 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.4 6.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 2.6 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.4 9.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.4 16.2 GO:0042169 SH2 domain binding(GO:0042169)
0.4 2.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 12.1 GO:0008009 chemokine activity(GO:0008009)
0.3 1.0 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.3 20.9 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.3 12.9 GO:0005109 frizzled binding(GO:0005109)
0.3 16.8 GO:0005080 protein kinase C binding(GO:0005080)
0.3 22.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.3 1.6 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.3 8.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.3 8.8 GO:0030507 spectrin binding(GO:0030507)
0.3 4.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 4.7 GO:0030332 cyclin binding(GO:0030332)
0.2 3.3 GO:0016805 dipeptidase activity(GO:0016805)
0.2 12.1 GO:0019894 kinesin binding(GO:0019894)
0.2 7.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 2.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 4.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 29.1 GO:0042393 histone binding(GO:0042393)
0.2 2.5 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.2 5.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 4.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 4.8 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.1 GO:0034452 dynactin binding(GO:0034452)
0.1 51.5 GO:0003779 actin binding(GO:0003779)
0.1 2.5 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 2.7 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 2.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 6.2 GO:0051018 protein kinase A binding(GO:0051018)
0.1 4.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.2 GO:0048156 tau protein binding(GO:0048156)
0.1 1.3 GO:0048018 receptor agonist activity(GO:0048018)
0.1 9.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 11.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 2.3 GO:0001671 ATPase activator activity(GO:0001671)
0.1 2.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 0.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 2.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 4.9 GO:0002039 p53 binding(GO:0002039)
0.1 4.1 GO:0043022 ribosome binding(GO:0043022)
0.1 20.4 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.1 120.4 GO:0003677 DNA binding(GO:0003677)
0.1 15.9 GO:0003924 GTPase activity(GO:0003924)
0.1 2.4 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.6 GO:0043531 ADP binding(GO:0043531)
0.0 0.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 2.0 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 6.5 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 2.3 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.5 GO:0032451 demethylase activity(GO:0032451)
0.0 0.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.9 14.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.8 42.8 PID PLK1 PATHWAY PLK1 signaling events
0.6 52.6 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.5 18.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.3 3.8 ST JAK STAT PATHWAY Jak-STAT Pathway
0.3 7.0 ST GA12 PATHWAY G alpha 12 Pathway
0.3 6.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3 3.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 9.0 PID ATR PATHWAY ATR signaling pathway
0.2 2.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.2 11.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 7.1 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 2.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.2 8.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 4.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 6.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 0.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 ST GAQ PATHWAY G alpha q Pathway
0.0 0.8 PID CD40 PATHWAY CD40/CD40L signaling
0.0 12.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.7 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.4 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.7 PID AURORA A PATHWAY Aurora A signaling
0.0 0.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 14.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
1.4 54.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.0 43.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.9 12.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.8 13.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.8 12.8 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.8 12.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.8 28.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.8 13.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.7 17.6 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.6 9.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.5 19.0 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.5 6.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.5 26.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.5 5.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 11.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.4 5.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.4 11.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.4 6.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.3 21.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 4.8 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.3 4.8 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.3 6.2 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.3 6.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 18.8 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 12.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 5.1 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 2.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 9.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 4.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 2.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.2 2.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 17.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 5.2 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 2.7 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 4.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 4.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 3.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.9 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 3.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 2.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 0.7 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 4.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 7.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.4 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors