ISMARA results: Ascl2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Ascl2

Z-value: 1.17

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Transcription factors associated with Ascl2

Gene Symbol	Gene ID	Gene Info
Ascl2 NCBI RGD Ensembl	ENSRNOG00000020434	achaete-scute family bHLH transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Ascl2	rn6_v1_chr1_-_216156409_216156409	-0.15	8.0e-03	Click!

Activity profile of Ascl2 motif

Sorted Z-values of Ascl2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_87774552 Show fit	71.68	ENSRNOT00000044342	Krtap9-1 NCBI RGD Ensembl Show fit	keratin associated protein 9-1
chr1_+_100199057 Show fit	61.16	ENSRNOT00000025831	Klk1 NCBI RGD Ensembl Show fit	kallikrein 1
chr10_+_87759769 Show fit	50.05	ENSRNOT00000017378 ENSRNOT00000046526	Krtap9-1 NCBI RGD Ensembl Show fit	keratin associated protein 9-1
chr10_+_87782376 Show fit	42.04	ENSRNOT00000017415	LOC680396 NCBI RGD Ensembl Show fit	hypothetical protein LOC680396
chr12_+_24761210 Show fit	40.28	ENSRNOT00000002003	Cldn4 NCBI RGD Ensembl Show fit	claudin 4
chr3_+_119015412 Show fit	38.49	ENSRNOT00000013605	Slc27a2 NCBI RGD Ensembl Show fit	solute carrier family 27 member 2
chr19_-_43911057 Show fit	32.32	ENSRNOT00000026017	Ctrb1 NCBI RGD Ensembl Show fit	chymotrypsinogen B1
chr5_-_151459037 Show fit	32.23	ENSRNOT00000064472 ENSRNOT00000087836	Sytl1 NCBI RGD Ensembl Show fit	synaptotagmin-like 1
chr10_+_87788458 Show fit	31.54	ENSRNOT00000042020	LOC100910814 NCBI RGD Ensembl Show fit	keratin-associated protein 9-1-like
chr3_+_119014620 Show fit	31.20	ENSRNOT00000067700	Slc27a2 NCBI RGD Ensembl Show fit	solute carrier family 27 member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Ascl2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
23.2	69.7	GO:0097089	methyl-branched fatty acid metabolic process(GO:0097089)
1.8	62.9	GO:0002675	positive regulation of acute inflammatory response(GO:0002675)
8.5	50.7	GO:0010957	negative regulation of vitamin D biosynthetic process(GO:0010957)
2.0	49.0	GO:0061436	establishment of skin barrier(GO:0061436)
11.6	46.6	GO:0033277	abortive mitotic cell cycle(GO:0033277)
14.5	43.5	GO:0001905	activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
4.5	36.0	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
3.2	34.8	GO:0015747	urate transport(GO:0015747)
2.6	31.1	GO:1902993	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.4	27.4	GO:0032094	response to food(GO:0032094)

Showing 1 to 10 of 256 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	107.0	GO:0045177	apical part of cell(GO:0045177)
1.4	103.2	GO:0045095	keratin filament(GO:0045095)
0.6	72.5	GO:0072562	blood microparticle(GO:0072562)
3.7	69.7	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
2.6	62.9	GO:0016327	apicolateral plasma membrane(GO:0016327)
5.8	46.6	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.5	44.4	GO:0030863	cortical cytoskeleton(GO:0030863)
0.1	44.4	GO:0000323	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1	38.0	GO:0016607	nuclear speck(GO:0016607)
0.5	36.5	GO:0031526	brush border membrane(GO:0031526)

Showing 1 to 10 of 117 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	166.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
7.7	76.9	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.4	57.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
5.2	46.6	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.7	41.3	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	40.6	GO:0045296	cadherin binding(GO:0045296)
3.0	36.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
2.3	32.2	GO:0042043	neurexin family protein binding(GO:0042043)
8.8	26.5	GO:0031714	C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
2.8	25.5	GO:0019534	toxin transporter activity(GO:0019534)

Showing 1 to 10 of 183 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	91.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.4	81.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	31.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.7	29.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.6	28.1	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.4	25.1	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.5	18.7	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
1.6	17.6	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.4	17.2	PID FGF PATHWAY	FGF signaling pathway
0.5	16.8	PID EPHB FWD PATHWAY	EPHB forward signaling

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	73.2	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
5.8	69.7	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
3.6	58.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
1.2	34.2	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.4	32.0	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.6	27.6	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
1.3	27.0	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.9	26.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.0	24.6	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
1.4	23.5	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI

Showing 1 to 10 of 95 entries

Results for Ascl2

Z-value: 1.17

Motif logo

Transcription factors associated with Ascl2

Activity-expression correlation:

Activity profile of Ascl2 motif

Sorted Z-values of Ascl2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ascl2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: