ISMARA results: Arntl_Tfe3_Mlx_Mitf_Mlxipl

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 1.09

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Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Gene Symbol	Gene ID	Gene Info
Arntl NCBI RGD Ensembl	ENSRNOG00000014448	aryl hydrocarbon receptor nuclear translocator-like
Tfe3 NCBI RGD Ensembl	ENSRNOG00000009605	transcription factor binding to IGHM enhancer 3
Mlx NCBI RGD Ensembl	ENSRNOG00000019983	MLX, MAX dimerization protein
Mitf NCBI RGD Ensembl	ENSRNOG00000008658	melanogenesis associated transcription factor
Mlxipl NCBI RGD Ensembl	ENSRNOG00000046171	Mlxipl
Tfec NCBI RGD Ensembl	ENSRNOG00000061595	transcription factor EC

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Arntl	rn6_v1_chr1_+_178039063_178039063	-0.31	8.9e-09	Click!
Mitf	rn6_v1_chr4_+_130172727_130172727	-0.30	7.0e-08	Click!
Tfe3	rn6_v1_chrX_-_15587419_15587419	-0.29	1.4e-07	Click!
Mlx	rn6_v1_chr10_+_88997399_88997399	-0.07	2.0e-01	Click!
Tfec	rn6_v1_chr4_-_44136815_44136815	0.03	5.7e-01	Click!

Activity profile of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Sorted Z-values of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_243550627 Show fit	56.81	ENSRNOT00000085067 ENSRNOT00000083682	Adh1 NCBI RGD Ensembl Show fit	alcohol dehydrogenase 1 (class I)
chr12_+_24367199 Show fit	50.95	ENSRNOT00000001971	Fkbp6 NCBI RGD Ensembl Show fit	FK506 binding protein 6
chr13_+_105408179 Show fit	50.17	ENSRNOT00000003378	Ddx3y NCBI RGD Ensembl Show fit	DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr2_+_189106039 Show fit	47.87	ENSRNOT00000028210	Ube2q1 NCBI RGD Ensembl Show fit	ubiquitin conjugating enzyme E2 Q1
chr1_+_102849889 Show fit	47.32	ENSRNOT00000066791	Gtf2h1 NCBI RGD Ensembl Show fit	general transcription factor IIH subunit 1
chr13_+_89597138 Show fit	44.60	ENSRNOT00000004662	Apoa2 NCBI RGD Ensembl Show fit	apolipoprotein A2
chr5_+_138470069 Show fit	41.67	ENSRNOT00000076343 ENSRNOT00000064073	Zmynd12 NCBI RGD Ensembl Show fit	zinc finger, MYND-type containing 12
chr3_-_94686989 Show fit	41.12	ENSRNOT00000016677	Depdc7 NCBI RGD Ensembl Show fit	DEP domain containing 7
chr19_+_52225582 Show fit	40.15	ENSRNOT00000020917	Dnaaf1 NCBI RGD Ensembl Show fit	dynein, axonemal, assembly factor 1
chr14_-_3462629 Show fit	38.16	ENSRNOT00000061538	Brdt NCBI RGD Ensembl Show fit	bromodomain testis associated

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	107.5	GO:0030317	sperm motility(GO:0030317)
0.9	103.5	GO:0007286	spermatid development(GO:0007286)
2.3	76.2	GO:0015991	ATP hydrolysis coupled proton transport(GO:0015991)
6.8	68.3	GO:0071907	determination of digestive tract left/right asymmetry(GO:0071907)
20.6	61.8	GO:0006117	acetaldehyde metabolic process(GO:0006117)
3.5	59.5	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	56.5	GO:0007608	sensory perception of smell(GO:0007608)
10.9	54.4	GO:0006524	alanine catabolic process(GO:0006524) pyruvate family amino acid catabolic process(GO:0009080)
1.3	53.1	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.8	47.8	GO:0007129	synapsis(GO:0007129)

Showing 1 to 10 of 615 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	145.4	GO:0005759	mitochondrial matrix(GO:0005759)
1.2	102.8	GO:0031526	brush border membrane(GO:0031526)
0.8	99.6	GO:0031514	motile cilium(GO:0031514)
0.9	95.2	GO:0001669	acrosomal vesicle(GO:0001669)
1.7	76.4	GO:0000795	synaptonemal complex(GO:0000795)
1.4	74.2	GO:0005844	polysome(GO:0005844)
4.5	54.6	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4	51.9	GO:0005923	bicellular tight junction(GO:0005923)
5.6	50.8	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.7	50.4	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)

Showing 1 to 10 of 202 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	82.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
12.2	73.0	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
2.9	61.8	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
2.1	54.7	GO:0070840	dynein complex binding(GO:0070840)
1.7	54.0	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.5	53.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	52.7	GO:0004984	olfactory receptor activity(GO:0004984)
4.0	51.8	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
12.4	49.5	GO:0004027	alcohol sulfotransferase activity(GO:0004027)
1.5	47.9	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)

Showing 1 to 10 of 405 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	131.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	28.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.6	19.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.7	11.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	9.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	8.9	PID AURORA A PATHWAY	Aurora A signaling
0.1	8.9	PID P73PATHWAY	p73 transcription factor network
0.3	7.8	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.4	7.6	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	6.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta

Showing 1 to 10 of 41 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	151.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
3.5	89.9	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
1.2	69.6	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
1.0	54.2	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
3.4	50.5	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
2.2	47.5	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
2.6	44.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.5	43.5	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
2.3	43.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
3.3	42.6	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 120 entries

Results for Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 1.09

Motif logo

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Activity-expression correlation:

Activity profile of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Sorted Z-values of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: