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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Arnt

Z-value: 0.41

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Transcription factors associated with Arnt

Gene Symbol Gene ID Gene Info
ENSRNOG00000031174 aryl hydrocarbon receptor nuclear translocator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Arntrn6_v1_chr2_+_196594303_196594303-0.202.9e-04Click!

Activity profile of Arnt motif

Sorted Z-values of Arnt motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_197991198 15.18 ENSRNOT00000056322
circadian associated repressor of transcription
chr2_-_197991574 14.51 ENSRNOT00000085632
circadian associated repressor of transcription
chr7_+_38945836 12.47 ENSRNOT00000006455
coiled-coil glutamate-rich protein 1
chr1_+_261229347 8.18 ENSRNOT00000018485
ubiquitin domain containing 1
chr2_-_44504354 7.38 ENSRNOT00000013035
DEAD-box helicase 4
chr19_+_37226186 7.26 ENSRNOT00000075933
ENSRNOT00000065013
heat shock transcription factor 4
chr3_+_72238981 6.92 ENSRNOT00000011006
solute carrier family 43 member 1
chr4_-_180234804 6.57 ENSRNOT00000070957
basic helix-loop-helix family, member e41
chr10_+_16542882 5.62 ENSRNOT00000028146
stanniocalcin 2
chr5_-_139227196 5.46 ENSRNOT00000050941
forkhead box O6
chr9_-_113331319 3.84 ENSRNOT00000020681
VAMP associated protein A
chr3_+_113415774 3.68 ENSRNOT00000056151
small EDRK-rich factor 2
chr3_-_159802952 3.44 ENSRNOT00000011610
oxidative stress responsive serine-rich 1
chr1_-_93949187 3.41 ENSRNOT00000018956
zinc finger protein 536
chr2_+_189400696 3.41 ENSRNOT00000046919
ENSRNOT00000089801
similar to NICE-3
chr4_+_95498003 3.29 ENSRNOT00000008358
atonal bHLH transcription factor 1
chr7_+_123043503 3.24 ENSRNOT00000026258
ENSRNOT00000086355
TEF, PAR bZIP transcription factor
chr1_+_102849889 3.09 ENSRNOT00000066791
general transcription factor IIH subunit 1
chr2_-_34185682 3.07 ENSRNOT00000066925
ENSRNOT00000082755
neurolysin
chr17_+_86199623 2.98 ENSRNOT00000022727
pancreas specific transcription factor, 1a
chr2_+_115337439 2.98 ENSRNOT00000015779
eukaryotic translation initiation factor 5A2
chr8_-_36760742 2.97 ENSRNOT00000017307
DEAD-box helicase 25
chr4_-_157679962 2.76 ENSRNOT00000050443
glyceraldehyde-3-phosphate dehydrogenase
chr20_-_3401273 2.53 ENSRNOT00000089257
ENSRNOT00000078451
ENSRNOT00000001085
nurim (nuclear envelope membrane protein)
chr20_-_5533448 2.49 ENSRNOT00000000568
cutA divalent cation tolerance homolog
chr4_-_98593664 2.41 ENSRNOT00000007927
ribose 5-phosphate isomerase A
chr20_-_5533600 2.37 ENSRNOT00000072319
cutA divalent cation tolerance homolog
chr2_+_34186091 2.34 ENSRNOT00000016129
small glutamine rich tetratricopeptide repeat containing beta
chr14_-_35652709 2.32 ENSRNOT00000003080
GS homeobox 2
chr9_+_81783349 2.26 ENSRNOT00000021548
CCR4-NOT transcription complex subunit 9
chr1_-_86948845 2.17 ENSRNOT00000027212
NFKB inhibitor beta
chr7_-_75422268 1.98 ENSRNOT00000080218
poly(A) binding protein, cytoplasmic 1
chr2_-_189400323 1.93 ENSRNOT00000024364
ubiquitin associated protein 2-like
chr8_+_22402890 1.86 ENSRNOT00000079230
interleukin enhancer binding factor 3
chr1_-_234670113 1.68 ENSRNOT00000017133
similar to hypothetical protein D030056L22
chr3_+_79678201 1.61 ENSRNOT00000087604
ENSRNOT00000079709
mitochondrial carrier 2
chr8_-_67869019 1.55 ENSRNOT00000066009
protein inhibitor of activated STAT, 1
chr17_+_27496353 1.53 ENSRNOT00000077994
ENSRNOT00000019040
ENSRNOT00000089736
signal sequence receptor subunit 1
chr15_-_34314345 1.48 ENSRNOT00000026552
importin 4
chr7_-_18634079 1.47 ENSRNOT00000010031
angiopoietin-like 4
chr4_-_82160240 1.45 ENSRNOT00000038775
ENSRNOT00000058985
homeo box A4
chr1_-_94404211 1.42 ENSRNOT00000019463
URI1, prefoldin-like chaperone
chr7_+_139762614 1.40 ENSRNOT00000031157
coiled-coil domain containing 184
chr7_-_58219790 1.35 ENSRNOT00000067907
TBC1 domain family, member 15
chr5_+_169506138 1.27 ENSRNOT00000014904
ribosomal protein L22
chr3_+_164248731 1.26 ENSRNOT00000086459
ring finger protein 114
chr1_+_77994203 1.25 ENSRNOT00000002044
NSF attachment protein alpha
chr3_-_173953684 1.23 ENSRNOT00000090468
protein phosphatase 1, regulatory subunit 3D
chr15_-_27855999 1.13 ENSRNOT00000013225
transmembrane protein 55B
chr4_-_82127051 1.06 ENSRNOT00000083658
ENSRNOT00000007807
homeo box A1
chr10_+_89236256 0.97 ENSRNOT00000027957
proteasome activator subunit 3
chr5_+_143500441 0.94 ENSRNOT00000045513
glutamate ionotropic receptor kainate type subunit 3
chr5_-_50362344 0.88 ENSRNOT00000035808
zinc finger protein 292
chr1_+_220114228 0.79 ENSRNOT00000026718
cathepsin F
chr5_+_141572536 0.72 ENSRNOT00000023514
Ras-related GTP binding C
chr12_+_21981755 0.71 ENSRNOT00000001871
7SK snRNA methylphosphate capping enzyme-like
chr10_+_61746082 0.69 ENSRNOT00000003992
TSR1, ribosome maturation factor
chr11_-_60613718 0.62 ENSRNOT00000002906
autophagy related 3
chr1_+_12823363 0.54 ENSRNOT00000086790
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr1_-_129780356 0.51 ENSRNOT00000077479
arrestin domain containing 4
chr1_-_102849430 0.45 ENSRNOT00000086856
serum amyloid A4
chr19_-_55367353 0.38 ENSRNOT00000091139
piezo-type mechanosensitive ion channel component 1
chr4_+_117235023 0.27 ENSRNOT00000021030
chaperonin containing TCP1 subunit 7
chr13_-_51183269 0.26 ENSRNOT00000039540
PTPRF interacting protein alpha 4
chr16_+_7103998 0.26 ENSRNOT00000016581
polybromo 1
chr6_-_125853461 0.26 ENSRNOT00000007505
ataxin 3
chr20_+_5455974 0.25 ENSRNOT00000000553
ENSRNOT00000092676
prefoldin subunit 6
chr8_+_50310405 0.22 ENSRNOT00000073507
SIK family kinase 3
chr4_-_82194927 0.07 ENSRNOT00000072302
homeobox protein Hox-A9
chr1_+_154377247 0.07 ENSRNOT00000092945
phosphatidylinositol binding clathrin assembly protein
chr10_+_69737328 0.02 ENSRNOT00000055999
ENSRNOT00000076773
transmembrane protein 132E
chr9_-_10734073 0.01 ENSRNOT00000071199
lysine demethylase 4B

Network of associatons between targets according to the STRING database.

First level regulatory network of Arnt

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 29.7 GO:0045475 locomotor rhythm(GO:0045475)
1.0 3.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.9 2.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.6 2.4 GO:0006014 D-ribose metabolic process(GO:0006014)
0.6 6.2 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.5 3.5 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.5 3.0 GO:0006449 regulation of translational termination(GO:0006449) positive regulation of translational elongation(GO:0045901)
0.5 3.8 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.5 1.4 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.5 2.3 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.4 7.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.4 3.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 3.0 GO:0061074 regulation of neural retina development(GO:0061074)
0.4 2.0 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.4 1.1 GO:0021570 rhombomere 3 development(GO:0021569) rhombomere 4 development(GO:0021570)
0.4 5.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.3 7.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.3 1.3 GO:0035494 SNARE complex disassembly(GO:0035494)
0.3 1.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.3 2.3 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.2 2.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 6.9 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.2 3.1 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 1.6 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.5 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 1.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 1.5 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 0.9 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 3.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 5.5 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 0.4 GO:0033625 positive regulation of integrin activation(GO:0033625) positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 1.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.6 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 1.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.7 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.0 0.3 GO:1903405 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0 0.7 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.0 0.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 3.4 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.1 GO:1902961 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.0 1.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 1.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.5 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 1.4 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.0 3.7 GO:0051260 protein homooligomerization(GO:0051260)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.4 GO:0071547 piP-body(GO:0071547)
0.5 2.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 2.8 GO:0097452 GAIT complex(GO:0097452)
0.3 3.1 GO:0000439 core TFIIH complex(GO:0000439)
0.3 1.0 GO:0008537 proteasome activator complex(GO:0008537)
0.2 2.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 1.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.2 3.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 3.0 GO:0033391 chromatoid body(GO:0033391)
0.1 1.2 GO:0042587 glycogen granule(GO:0042587)
0.1 1.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 2.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.7 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 2.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.6 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.1 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.5 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0090544 BAF-type complex(GO:0090544)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0070012 oligopeptidase activity(GO:0070012)
1.0 3.8 GO:0033149 FFAT motif binding(GO:0033149)
0.9 6.6 GO:0043426 MRF binding(GO:0043426)
0.7 2.8 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.6 30.2 GO:0070888 E-box binding(GO:0070888)
0.4 3.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 1.3 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.4 1.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.2 2.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 1.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.2 6.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 0.6 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 3.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 2.0 GO:0008143 poly(A) binding(GO:0008143)
0.1 10.4 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 1.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 2.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.7 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 8.2 GO:0043130 ubiquitin binding(GO:0043130)
0.1 4.9 GO:0005507 copper ion binding(GO:0005507)
0.1 0.5 GO:0050693 LBD domain binding(GO:0050693)
0.1 2.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 2.3 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 7.3 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 5.6 GO:0005179 hormone activity(GO:0005179)
0.0 1.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 3.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 3.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.7 GO:0019003 GDP binding(GO:0019003)
0.0 4.5 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.3 GO:0044183 protein binding involved in protein folding(GO:0044183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 7.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 2.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 6.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 3.1 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 3.0 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 2.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 3.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.1 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.5 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation