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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Aire

Z-value: 0.96

Motif logo

Transcription factors associated with Aire

Gene Symbol Gene ID Gene Info
ENSRNOG00000001213 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Airern6_v1_chr20_+_11365697_11365697-0.262.1e-06Click!

Activity profile of Aire motif

Sorted Z-values of Aire motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_200762206 35.99 ENSRNOT00000068511
ENSRNOT00000086835
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chrM_-_14061 31.46 ENSRNOT00000051268
mitochondrially encoded NADH dehydrogenase 6
chrM_+_14136 27.24 ENSRNOT00000042098
mitochondrially encoded cytochrome b
chr2_-_200762492 26.29 ENSRNOT00000056172
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr3_+_128155069 24.88 ENSRNOT00000051184
ENSRNOT00000006389
phospholipase C beta 1
chr16_-_79671719 24.74 ENSRNOT00000015908
myomesin 2
chrM_+_7006 24.55 ENSRNOT00000043693
mitochondrially encoded cytochrome c oxidase II
chr7_+_48867664 21.85 ENSRNOT00000005862
PTPRF interacting protein alpha 2
chr1_+_101884019 18.41 ENSRNOT00000028650
transmembrane protein 143
chr11_-_31772984 17.51 ENSRNOT00000002771
DnaJ heat shock protein family (Hsp40) member C28
chr9_+_12475006 17.11 ENSRNOT00000079703
uncharacterized LOC100912293
chrM_+_9451 16.96 ENSRNOT00000041241
mitochondrially encoded NADH dehydrogenase 3
chr4_+_88695590 16.79 ENSRNOT00000087835
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr5_-_17061837 16.39 ENSRNOT00000011892
proenkephalin
chrM_+_7758 15.21 ENSRNOT00000046201
mitochondrially encoded ATP synthase 8
chr20_-_4823475 14.89 ENSRNOT00000082536
ENSRNOT00000001114
ATPase H+ transporting V1 subunit G2
chr2_-_179704629 14.79 ENSRNOT00000083361
ENSRNOT00000077941
glutamate ionotropic receptor AMPA type subunit 2
chr2_+_83393282 14.73 ENSRNOT00000044871
catenin delta 2
chr8_+_49418965 14.72 ENSRNOT00000021819
sodium voltage-gated channel beta subunit 2
chr3_-_51612397 13.63 ENSRNOT00000081401
sodium voltage-gated channel alpha subunit 3
chrM_+_8599 13.22 ENSRNOT00000049683
mitochondrially encoded cytochrome C oxidase III
chrM_+_11736 13.01 ENSRNOT00000048767
mitochondrially encoded NADH dehydrogenase 5
chr4_-_120559078 12.95 ENSRNOT00000085730
ENSRNOT00000079575
kelch repeat and BTB domain containing 12
chr3_+_151335292 12.68 ENSRNOT00000073642
matrix metallopeptidase 24
chr20_+_34633157 12.59 ENSRNOT00000000469
phospholamban
chr1_+_228142778 12.01 ENSRNOT00000028517
mitochondrial ribosomal protein L16
chr7_-_138483612 11.76 ENSRNOT00000085620
solute carrier family 38, member 4
chr11_-_4332255 11.69 ENSRNOT00000087133
cell adhesion molecule 2
chr1_+_101884276 11.56 ENSRNOT00000082917
transmembrane protein 143
chr12_+_40417944 11.19 ENSRNOT00000073125
acyl-CoA dehydrogenase family, member 10
chr10_-_27862868 11.07 ENSRNOT00000004877
gamma-aminobutyric acid type A receptor alpha 6 subunit
chr1_+_59156251 10.97 ENSRNOT00000017442
limb and CNS expressed 1
chr2_+_182006242 10.54 ENSRNOT00000064091
fibrinogen alpha chain
chr3_-_48831417 10.34 ENSRNOT00000009920
ENSRNOT00000085246
potassium voltage-gated channel subfamily H member 7
chr17_+_68477446 10.19 ENSRNOT00000086236
ENSRNOT00000068174
pitrilysin metallopeptidase 1
chr7_+_123482255 9.91 ENSRNOT00000064487
hypothetical protein LOC688613
chr1_-_154165524 9.22 ENSRNOT00000023468
Hikeshi, heat shock protein nuclear import factor
chr4_-_23135354 9.18 ENSRNOT00000011432
STEAP4 metalloreductase
chr9_-_105693357 9.14 ENSRNOT00000066968
nudix hydrolase 12
chr1_+_266482858 9.10 ENSRNOT00000027223
arsenite methyltransferase
chr5_+_60528997 9.09 ENSRNOT00000051445
glyoxylate and hydroxypyruvate reductase
chr2_-_210282352 8.76 ENSRNOT00000075653
solute carrier family 6 member 17
chr7_-_123655896 8.58 ENSRNOT00000012413
cytochrome P450, family 2, subfamily d, polypeptide 2
chr4_-_179339795 8.32 ENSRNOT00000080410
branched chain amino acid transaminase 1
chr17_-_84614228 8.30 ENSRNOT00000043042

chrX_+_26294066 8.07 ENSRNOT00000037862
holocytochrome c synthase
chr4_+_155709613 7.97 ENSRNOT00000013272
NECAP endocytosis associated 1
chr1_-_146556171 7.80 ENSRNOT00000017636
aryl hydrocarbon receptor nuclear translocator 2
chr2_-_41785792 7.65 ENSRNOT00000015871
RAB3C, member RAS oncogene family
chr16_-_64716224 7.52 ENSRNOT00000071166
fucosyltransferase 10
chr4_-_7582207 7.46 ENSRNOT00000013932
kelch-like family member 7
chr3_+_77152425 7.24 ENSRNOT00000092045
ENSRNOT00000082255
olfactory receptor 653
chr1_-_72509431 6.94 ENSRNOT00000071971
similar to isochorismatase domain containing 2
chr5_-_124403195 6.94 ENSRNOT00000067850
complement C8 alpha chain
chr10_+_37594578 6.92 ENSRNOT00000007676
S-phase kinase-associated protein 1
chr6_-_142385773 6.82 ENSRNOT00000071555

chr1_+_94793195 6.40 ENSRNOT00000079174

chr7_-_9711928 6.31 ENSRNOT00000011167
neuronal differentiation 4
chr1_+_71844368 6.12 ENSRNOT00000044754
vomeronasal 1 receptor 32
chr11_+_64790801 5.99 ENSRNOT00000004023
translocase of inner mitochondrial membrane domain containing 1
chrX_-_10218583 5.72 ENSRNOT00000013382
nyctalopin
chr4_+_88423412 5.70 ENSRNOT00000040163
vomeronasal 1 receptor 88
chr3_-_113312127 5.65 ENSRNOT00000065285
microfibrillar-associated protein 1A
chr3_+_95233874 5.63 ENSRNOT00000079743
hypothetical protein LOC691083
chr10_-_52290657 5.54 ENSRNOT00000005293
mitogen activated protein kinase kinase 4
chr3_-_153042395 5.50 ENSRNOT00000055232
NDRG family member 3
chr2_-_21931720 5.15 ENSRNOT00000018449
mutS homolog 3
chr7_+_44009069 5.04 ENSRNOT00000005523
MGAT4 family, member C
chr20_+_22728208 4.98 ENSRNOT00000000794
nuclear receptor-binding factor 2-like
chr4_+_88184956 4.96 ENSRNOT00000077129
vomeronasal 1 receptor 83
chr3_-_103460529 4.87 ENSRNOT00000047274
olfactory receptor 4F6-like
chr1_-_66212418 4.77 ENSRNOT00000026074
hypothetical protein LOC691722
chr2_+_227080924 4.74 ENSRNOT00000029871
fatty acid binding protein 2
chr5_-_58484900 4.73 ENSRNOT00000012386
family with sequence similarity 214, member B
chr1_+_62964901 4.61 ENSRNOT00000075013
vomeronasal 2 receptor, 22-like
chrX_-_1704033 4.49 ENSRNOT00000051956
ubiquitin specific peptidase 11
chr1_-_162713610 4.38 ENSRNOT00000018091
aquaporin 11
chr19_+_15081590 4.31 ENSRNOT00000024187
carboxylesterase 1F
chr3_+_75465399 4.12 ENSRNOT00000057479
olfactory receptor 562
chrX_+_110014252 4.06 ENSRNOT00000093611
Nik related kinase
chr7_-_98804499 4.06 ENSRNOT00000070909
TatD DNase domain containing 1
chr1_+_72230038 3.95 ENSRNOT00000058997
vomeronasal 1 receptor 38
chr3_-_77661863 3.91 ENSRNOT00000080807
olfactory receptor 668
chr3_-_148493225 3.81 ENSRNOT00000012141
p53 and DNA damage regulated 1
chr9_+_7643533 3.79 ENSRNOT00000074923
vomeronasal 2 receptor, 76
chr18_+_61377051 3.77 ENSRNOT00000066659
O-acyltransferase like
chr3_+_78876609 3.73 ENSRNOT00000049936
olfactory receptor 726
chr9_+_93086012 3.57 ENSRNOT00000089470
proteasome 26S subunit, non-ATPase 1
chr3_-_103217528 3.52 ENSRNOT00000074456
olfactory receptor 784
chr7_-_57679795 3.46 ENSRNOT00000007461
thyrotropin-releasing hormone degrading enzyme
chr1_-_172076138 3.44 ENSRNOT00000051241
olfactory receptor 239
chrX_+_83926513 3.36 ENSRNOT00000035274
similar to RIKEN cDNA 2010106E10
chr7_-_13425311 3.27 ENSRNOT00000060455
olfactory receptor 1076
chr1_-_172215730 3.14 ENSRNOT00000055175
olfactory receptor 244
chr20_-_5927070 2.98 ENSRNOT00000059264
solute carrier family 26 member 8
chr4_+_118160147 2.87 ENSRNOT00000022014
family with sequence similarity 136, member A
chr9_+_84410972 2.86 ENSRNOT00000019724
monoacylglycerol O-acyltransferase 1
chr3_+_153398130 2.85 ENSRNOT00000068135
ribophorin II
chr12_+_4248808 2.85 ENSRNOT00000042410

chr1_+_169616178 2.82 ENSRNOT00000023170
olfactory receptor 157
chrX_-_915953 2.69 ENSRNOT00000075264
sperm acrosome associated 5
chr10_-_44082313 2.58 ENSRNOT00000051126
olfactory receptor 1421
chr1_+_169919411 2.51 ENSRNOT00000050034
olfactory receptor 186
chr5_-_104920906 2.41 ENSRNOT00000071318
family with sequence similarity 154, member A
chr2_+_196608496 2.39 ENSRNOT00000091681
aryl hydrocarbon receptor nuclear translocator
chr11_-_33760100 2.36 ENSRNOT00000065810
RGD1562683
chrX_-_45284341 2.35 ENSRNOT00000045436
odorant binding protein I f
chr7_-_143738237 2.34 ENSRNOT00000055320
SPRY domain containing 3
chr3_-_78725950 2.33 ENSRNOT00000008690
olfactory receptor 721
chr4_+_87312766 2.26 ENSRNOT00000052126
vomeronasal 1 receptor 71
chr7_-_69104950 2.26 ENSRNOT00000049063
hypothetical protein LOC500846
chr2_-_127781003 2.25 ENSRNOT00000050764
major facilitator superfamily domain containing 8
chr1_-_168725656 2.20 ENSRNOT00000040224
olfactory receptor 115
chr1_-_168819946 2.18 ENSRNOT00000048499
olfactory receptor 121
chr1_+_66663965 2.17 ENSRNOT00000040738
vomeronasal type-1 receptor 2-like
chr2_-_100249811 2.16 ENSRNOT00000086760
hepatocyte nuclear factor 4, gamma
chr3_-_102432479 2.15 ENSRNOT00000047270
olfactory receptor 747
chr4_-_117575154 2.09 ENSRNOT00000075813
probable N-acetyltransferase CML2-like
chr11_+_83986230 2.05 ENSRNOT00000002331
ENSRNOT00000073703
ALG3, alpha-1,3- mannosyltransferase
chr3_+_79729739 2.05 ENSRNOT00000084833
kelch repeat and BTB domain containing 4
chr1_-_99135977 2.05 ENSRNOT00000056515
vomeronasal 2 receptor, 38
chr1_-_88558387 2.02 ENSRNOT00000074174

chr13_-_98529040 2.01 ENSRNOT00000091715
presenilin 2
chr14_+_107178838 2.01 ENSRNOT00000091331

chr3_-_78942535 1.98 ENSRNOT00000008924
olfactory receptor 731
chr1_+_150492239 1.94 ENSRNOT00000047771
ENSRNOT00000048404

chr8_-_58253688 1.94 ENSRNOT00000010956
cullin 5
chr13_-_82129989 1.90 ENSRNOT00000078963

chr4_-_165774126 1.89 ENSRNOT00000007453
taste receptor, type 2, member 107
chr10_+_7279920 1.84 ENSRNOT00000003749
transmembrane protein 114
chr4_-_97567844 1.83 ENSRNOT00000042169
vomeronasal 1 receptor 89
chr8_+_52751854 1.79 ENSRNOT00000072518
neurexophilin and PC-esterase domain family, member 1
chr2_-_210874304 1.77 ENSRNOT00000088657
adenosine monophosphate deaminase 2
chr8_+_4405227 1.75 ENSRNOT00000040595
vomeronasal type-2 receptor 26-like
chr7_-_4183525 1.74 ENSRNOT00000047673
olfactory receptor 889
chr18_-_36322320 1.74 ENSRNOT00000060260
glutaredoxin and cysteine rich domain containing 2
chr11_+_45462345 1.74 ENSRNOT00000029420
nitrilase family, member 2
chr1_+_116869957 1.72 ENSRNOT00000075203
vomeronasal 2 receptor, 25
chr2_+_4820016 1.69 ENSRNOT00000047222
ENSRNOT00000093226
olfactory receptor 205
chr17_-_44948432 1.65 ENSRNOT00000092195
putative olfactory receptor 2W6
chr1_+_150130084 1.65 ENSRNOT00000041243
olfactory receptor 25
chr11_-_45616429 1.63 ENSRNOT00000046587
olfactory receptor 1533
chr8_+_41987849 1.57 ENSRNOT00000073800
olfactory receptor 143-like
chr2_-_168260536 1.55 ENSRNOT00000072551
vomeronasal 1 receptor 55
chr2_+_168228099 1.53 ENSRNOT00000074681
vomeronasal 1 receptor 56
chr7_-_11754508 1.53 ENSRNOT00000026341
ornithine decarboxylase antizyme 1
chr5_+_153845094 1.49 ENSRNOT00000041600
sperm-tail PG-rich repeat containing 1
chr3_+_73988945 1.44 ENSRNOT00000050404
olfactory receptor 515
chr10_+_61160125 1.44 ENSRNOT00000074715
olfactory receptor 1519
chr4_-_123161985 1.41 ENSRNOT00000011490
XPC complex subunit, DNA damage recognition and repair factor
chr3_-_158985814 1.35 ENSRNOT00000071070
olfactory receptor 150-like
chr3_+_102630019 1.33 ENSRNOT00000041799
olfactory receptor 757
chr8_-_19386384 1.29 ENSRNOT00000051572
olfactory receptor 1145
chr3_+_76052230 1.28 ENSRNOT00000039963
olfactory receptor 5W2-like
chr4_-_165828814 1.27 ENSRNOT00000007481
taste receptor, type 2, member 105
chr11_+_43521054 1.17 ENSRNOT00000041679
olfactory receptor 1551
chr1_+_61132818 1.16 ENSRNOT00000041434
vomeronasal 1 receptor 20
chr1_+_142951094 1.13 ENSRNOT00000077441
solute carrier family 28 member 1
chr1_-_149529350 1.11 ENSRNOT00000052226
vomeronasal 2 receptor, 43
chr13_+_52147555 1.09 ENSRNOT00000084766
leiomodin 1
chr10_-_91117889 1.07 ENSRNOT00000031498
dephospho-CoA kinase domain containing
chr16_-_52127591 1.05 ENSRNOT00000033652
tripartite motif family-like 2
chr10_+_60728160 1.05 ENSRNOT00000041085
olfactory receptor 1501
chr12_+_52356832 0.98 ENSRNOT00000050252
fibrosin-like 1
chr15_+_61879184 0.96 ENSRNOT00000042606
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr3_-_79051103 0.95 ENSRNOT00000088256
olfactory receptor 737
chrX_-_29825439 0.91 ENSRNOT00000048155
gem (nuclear organelle) associated protein 8
chr3_-_73561623 0.91 ENSRNOT00000052306
olfactory receptor 486
chr9_-_80295446 0.89 ENSRNOT00000023769
transition protein 1
chr1_-_172465446 0.89 ENSRNOT00000088386
olfactory receptor 484-like
chr8_-_21224737 0.86 ENSRNOT00000067321
olfactory receptor, family 7, subfamily E, member 24
chr4_-_1752548 0.85 ENSRNOT00000071677
olfactory receptor 150-like
chr1_-_220096319 0.83 ENSRNOT00000091787
ENSRNOT00000073983
copper chaperone for superoxide dismutase
chr17_+_25228437 0.83 ENSRNOT00000072904

chr3_+_78748001 0.79 ENSRNOT00000008715
olfactory receptor 722
chr6_+_44225233 0.76 ENSRNOT00000066593
kinase D-interacting substrate 220
chr3_-_78193481 0.73 ENSRNOT00000008419
olfactory receptor 696
chr3_-_74014795 0.60 ENSRNOT00000073426
olfactory receptor 516
chr3_+_139894331 0.60 ENSRNOT00000064695
Ras and Rab interactor 2
chr16_-_75120417 0.59 ENSRNOT00000044094
defensin beta 12
chr8_-_23282989 0.58 ENSRNOT00000019204
zinc finger protein 717
chr1_-_88558696 0.58 ENSRNOT00000038642

chr7_+_16958034 0.57 ENSRNOT00000034654
vomeronasal 2 receptor, 54
chr16_-_10603850 0.55 ENSRNOT00000087737
family with sequence similarity 35, member A
chr9_+_24170858 0.53 ENSRNOT00000081915

chr4_+_1513759 0.53 ENSRNOT00000073972
olfactory receptor 1239
chr18_-_19275273 0.52 ENSRNOT00000041707
lateral signaling target protein 2 homolog
chr10_+_73868943 0.51 ENSRNOT00000081012
tubulin, delta 1
chr1_+_230450529 0.50 ENSRNOT00000045383
olfactory receptor 371
chr3_-_77618518 0.42 ENSRNOT00000044273
olfactory receptor 666
chr13_-_42885440 0.42 ENSRNOT00000038020
NCK-associated protein 5
chr1_-_168587241 0.41 ENSRNOT00000021254
olfactory receptor 104
chr10_-_46172166 0.40 ENSRNOT00000091052
ENSRNOT00000004412
folliculin
chr1_+_65409829 0.37 ENSRNOT00000046796
vomeronasal 2 receptor, 19
chr8_-_121973125 0.35 ENSRNOT00000012114
programmed cell death 6 interacting protein
chr20_+_1861272 0.35 ENSRNOT00000044570
olfactory receptor 1744
chr3_+_75771589 0.31 ENSRNOT00000007665
olfactory receptor 598
chr7_-_130151880 0.24 ENSRNOT00000088623
plexin B2
chr5_+_146656049 0.20 ENSRNOT00000036029
CUB and Sushi multiple domains 2
chr16_+_68633720 0.11 ENSRNOT00000081838
sperm motility kinase-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Aire

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.4 62.3 GO:0034757 negative regulation of iron ion transport(GO:0034757)
8.3 24.9 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-12(GO:0071349) cellular response to interleukin-15(GO:0071350)
5.5 16.4 GO:0051867 general adaptation syndrome, behavioral process(GO:0051867)
3.5 24.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
3.4 27.2 GO:0033590 response to cobalamin(GO:0033590)
3.0 9.1 GO:0006742 NADP catabolic process(GO:0006742) NAD catabolic process(GO:0019677)
2.9 8.8 GO:0015820 leucine transport(GO:0015820)
2.8 28.3 GO:0046684 response to pyrethroid(GO:0046684)
2.8 8.3 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
2.1 10.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.8 12.6 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
1.4 5.5 GO:0072709 cellular response to sorbitol(GO:0072709)
1.1 9.2 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
1.0 5.1 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
1.0 2.9 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.9 12.7 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.9 4.4 GO:0015793 glycerol transport(GO:0015793)
0.7 15.8 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.7 4.1 GO:0060721 regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.6 14.8 GO:0060992 response to fungicide(GO:0060992)
0.6 37.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.6 9.1 GO:0009404 toxin metabolic process(GO:0009404)
0.6 15.2 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 7.5 GO:0036065 fucosylation(GO:0036065)
0.5 6.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.5 1.5 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.5 1.4 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.5 6.9 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.4 6.6 GO:0009642 response to light intensity(GO:0009642)
0.4 31.5 GO:0042220 response to cocaine(GO:0042220)
0.4 8.1 GO:0017004 cytochrome complex assembly(GO:0017004)
0.3 11.0 GO:0097352 autophagosome maturation(GO:0097352)
0.3 11.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 5.7 GO:0006020 inositol metabolic process(GO:0006020)
0.3 1.8 GO:0032264 IMP salvage(GO:0032264)
0.3 1.7 GO:0006528 asparagine metabolic process(GO:0006528)
0.3 1.1 GO:1904823 purine nucleobase transmembrane transport(GO:1904823)
0.2 12.0 GO:0032543 mitochondrial translation(GO:0032543)
0.2 1.0 GO:0052422 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.2 6.9 GO:0019835 cytolysis(GO:0019835)
0.2 1.9 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.2 14.7 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.2 2.0 GO:0007220 Notch receptor processing(GO:0007220)
0.2 2.4 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.2 0.4 GO:1901856 negative regulation of cellular respiration(GO:1901856)
0.2 14.9 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.2 3.0 GO:0019532 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.2 9.1 GO:0007588 excretion(GO:0007588)
0.2 4.1 GO:0006308 DNA catabolic process(GO:0006308)
0.1 11.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 28.8 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 8.6 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.1 9.2 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 5.7 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.4 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 4.7 GO:0050892 intestinal absorption(GO:0050892)
0.1 0.9 GO:0000012 single strand break repair(GO:0000012)
0.1 3.5 GO:0043171 peptide catabolic process(GO:0043171)
0.1 3.2 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.1 11.7 GO:0008037 cell recognition(GO:0008037)
0.1 7.6 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 2.1 GO:0097502 mannosylation(GO:0097502)
0.1 90.1 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.1 1.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.8 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.1 8.5 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 0.8 GO:0019430 removal of superoxide radicals(GO:0019430)
0.0 2.2 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 2.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 7.8 GO:0032355 response to estradiol(GO:0032355)
0.0 3.8 GO:0006457 protein folding(GO:0006457)
0.0 8.0 GO:0006897 endocytosis(GO:0006897)
0.0 2.1 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 1.7 GO:0007605 sensory perception of sound(GO:0007605)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.6 GO:0090534 calcium ion-transporting ATPase complex(GO:0090534)
2.7 16.4 GO:0032280 symmetric synapse(GO:0032280)
2.3 27.2 GO:0045275 respiratory chain complex III(GO:0045275)
2.1 24.7 GO:0005859 muscle myosin complex(GO:0005859)
1.5 24.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
1.4 28.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.3 10.5 GO:0005577 fibrinogen complex(GO:0005577)
1.3 17.5 GO:0017119 Golgi transport complex(GO:0017119)
1.2 14.8 GO:0098839 postsynaptic density membrane(GO:0098839)
1.2 15.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.2 6.9 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
1.0 6.9 GO:0005579 membrane attack complex(GO:0005579)
0.9 61.4 GO:0070469 respiratory chain(GO:0070469)
0.9 14.9 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.5 5.1 GO:0032300 mismatch repair complex(GO:0032300)
0.5 5.7 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.5 11.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.5 3.8 GO:0016272 prefoldin complex(GO:0016272)
0.5 4.7 GO:0045179 apical cortex(GO:0045179)
0.5 1.4 GO:0071942 XPC complex(GO:0071942)
0.5 12.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 8.0 GO:0030125 clathrin vesicle coat(GO:0030125)
0.3 1.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 7.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 12.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 5.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 2.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 3.6 GO:0022624 proteasome accessory complex(GO:0022624)
0.1 75.0 GO:0031966 mitochondrial membrane(GO:0031966)
0.1 25.2 GO:0043209 myelin sheath(GO:0043209)
0.1 8.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 7.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 9.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 7.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 7.6 GO:0008021 synaptic vesicle(GO:0008021)
0.1 93.5 GO:0005739 mitochondrion(GO:0005739)
0.1 0.9 GO:0032797 SMN complex(GO:0032797)
0.1 4.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 7.3 GO:0043204 perikaryon(GO:0043204)
0.0 0.9 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 2.0 GO:0019866 organelle inner membrane(GO:0019866)
0.0 19.4 GO:0045202 synapse(GO:0045202)
0.0 1.7 GO:0005902 microvillus(GO:0005902)
0.0 31.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.4 GO:0030425 dendrite(GO:0030425)
0.0 6.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 1.1 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
20.8 62.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
3.4 27.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
3.0 14.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.8 8.3 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
2.7 16.4 GO:0001515 opioid peptide activity(GO:0001515)
2.3 9.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
2.3 61.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
2.2 11.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
1.9 24.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
1.9 5.7 GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827)
1.8 14.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.8 12.6 GO:0042030 ATPase inhibitor activity(GO:0042030)
1.7 5.1 GO:0032142 dinucleotide insertion or deletion binding(GO:0032139) single guanine insertion binding(GO:0032142)
1.7 14.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.5 9.2 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
1.3 7.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
1.1 24.9 GO:0005521 phosphatidylinositol phospholipase C activity(GO:0004435) lamin binding(GO:0005521)
0.8 10.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.8 24.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.8 4.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.7 11.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.7 2.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.7 8.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.6 13.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.5 1.5 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.5 9.1 GO:0070402 NADPH binding(GO:0070402)
0.5 2.9 GO:0004144 2-acylglycerol O-acyltransferase activity(GO:0003846) diacylglycerol O-acyltransferase activity(GO:0004144)
0.5 5.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.4 10.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.4 1.8 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.4 6.9 GO:0097602 cullin family protein binding(GO:0097602)
0.4 1.1 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.4 4.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.4 6.9 GO:0001848 complement binding(GO:0001848)
0.3 7.6 GO:0031489 myosin V binding(GO:0031489)
0.3 8.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.3 4.4 GO:0015250 water channel activity(GO:0015250)
0.3 29.6 GO:0016503 pheromone receptor activity(GO:0016503)
0.3 16.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 1.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.2 8.6 GO:0070330 aromatase activity(GO:0070330)
0.2 2.7 GO:0003796 lysozyme activity(GO:0003796)
0.2 2.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 3.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 15.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.2 2.4 GO:0005549 odorant binding(GO:0005549)
0.2 9.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 0.4 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.2 1.9 GO:0005000 vasopressin receptor activity(GO:0005000)
0.2 0.8 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 3.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 14.7 GO:0008013 beta-catenin binding(GO:0008013)
0.1 11.8 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 1.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 8.0 GO:0019843 rRNA binding(GO:0019843)
0.1 1.3 GO:0008527 taste receptor activity(GO:0008527)
0.1 2.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 10.1 GO:0030674 protein binding, bridging(GO:0030674)
0.1 6.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 1.1 GO:0005523 tropomyosin binding(GO:0005523)
0.1 5.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 7.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 5.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 4.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 60.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 4.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 2.2 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 4.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 10.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 1.4 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 4.1 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups(GO:0016747)
0.0 2.3 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 24.9 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.5 5.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 12.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4 10.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.4 14.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.3 6.9 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 5.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 8.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 6.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.5 PID AURORA A PATHWAY Aurora A signaling
0.0 2.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 7.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 57.5 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
2.5 24.9 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.8 14.8 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.7 10.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.7 11.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.6 14.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.5 8.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.4 14.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 11.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.3 6.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.3 11.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.3 5.0 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 1.5 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.2 10.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 6.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 2.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 8.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 4.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.6 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 5.5 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 2.4 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 2.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 9.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 1.4 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 2.8 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 8.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules