ISMARA results: Aire

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Aire

Z-value: 0.96

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Transcription factors associated with Aire

Gene Symbol	Gene ID	Gene Info
Aire NCBI RGD Ensembl	ENSRNOG00000001213	autoimmune regulator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Aire	rn6_v1_chr20_+_11365697_11365697	-0.26	2.1e-06	Click!

Activity profile of Aire motif

Sorted Z-values of Aire motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_200762206 Show fit	35.99	ENSRNOT00000068511 ENSRNOT00000086835	Hsd3b2 NCBI RGD Ensembl Show fit	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chrM_-_14061 Show fit	31.46	ENSRNOT00000051268	Mt-nd6 NCBI RGD Ensembl Show fit	mitochondrially encoded NADH dehydrogenase 6
chrM_+_14136 Show fit	27.24	ENSRNOT00000042098	Mt-cyb NCBI RGD Ensembl Show fit	mitochondrially encoded cytochrome b
chr2_-_200762492 Show fit	26.29	ENSRNOT00000056172	Hsd3b2 NCBI RGD Ensembl Show fit	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr3_+_128155069 Show fit	24.88	ENSRNOT00000051184 ENSRNOT00000006389	Plcb1 NCBI RGD Ensembl Show fit	phospholipase C beta 1
chr16_-_79671719 Show fit	24.74	ENSRNOT00000015908	Myom2 NCBI RGD Ensembl Show fit	myomesin 2
chrM_+_7006 Show fit	24.55	ENSRNOT00000043693	Mt-co2 NCBI RGD Ensembl Show fit	mitochondrially encoded cytochrome c oxidase II
chr7_+_48867664 Show fit	21.85	ENSRNOT00000005862	Ppfia2 NCBI RGD Ensembl Show fit	PTPRF interacting protein alpha 2
chr1_+_101884019 Show fit	18.41	ENSRNOT00000028650	Tmem143 NCBI RGD Ensembl Show fit	transmembrane protein 143
chr11_-_31772984 Show fit	17.51	ENSRNOT00000002771	Dnajc28 NCBI RGD Ensembl Show fit	DnaJ heat shock protein family (Hsp40) member C28

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Aire

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	90.1	GO:0007606	sensory perception of chemical stimulus(GO:0007606)
10.4	62.3	GO:0034757	negative regulation of iron ion transport(GO:0034757)
0.6	37.6	GO:0042773	ATP synthesis coupled electron transport(GO:0042773)
0.4	31.5	GO:0042220	response to cocaine(GO:0042220)
0.1	28.8	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
2.8	28.3	GO:0046684	response to pyrethroid(GO:0046684)
3.4	27.2	GO:0033590	response to cobalamin(GO:0033590)
8.3	24.9	GO:0035722	interleukin-12-mediated signaling pathway(GO:0035722) interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-12(GO:0071349) cellular response to interleukin-15(GO:0071350)
3.5	24.7	GO:0002074	extraocular skeletal muscle development(GO:0002074)
5.5	16.4	GO:0051867	general adaptation syndrome, behavioral process(GO:0051867)

Showing 1 to 10 of 75 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	93.5	GO:0005739	mitochondrion(GO:0005739)
0.1	75.0	GO:0031966	mitochondrial membrane(GO:0031966)
0.9	61.4	GO:0070469	respiratory chain(GO:0070469)
0.0	31.8	GO:0005887	integral component of plasma membrane(GO:0005887)
1.4	28.3	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
2.3	27.2	GO:0045275	respiratory chain complex III(GO:0045275)
0.1	25.2	GO:0043209	myelin sheath(GO:0043209)
2.1	24.7	GO:0005859	muscle myosin complex(GO:0005859)
1.5	24.6	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	19.4	GO:0045202	synapse(GO:0045202)

Showing 1 to 10 of 49 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
20.8	62.3	GO:0004769	steroid delta-isomerase activity(GO:0004769)
2.3	61.4	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	60.4	GO:0004984	olfactory receptor activity(GO:0004984)
0.3	29.6	GO:0016503	pheromone receptor activity(GO:0016503)
3.4	27.2	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.1	24.9	GO:0005521	phosphatidylinositol phospholipase C activity(GO:0004435) lamin binding(GO:0005521)
1.9	24.7	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.8	24.6	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3	16.8	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
2.7	16.4	GO:0001515	opioid peptide activity(GO:0001515)

Showing 1 to 10 of 75 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	24.9	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.4	14.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.4	12.6	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.4	10.5	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	8.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	7.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	6.9	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.1	6.0	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	5.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.5	5.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.8	57.5	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
2.5	24.9	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.6	14.9	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.8	14.8	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.4	14.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.3	11.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.4	11.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.7	11.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.7	10.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	10.3	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels

Showing 1 to 10 of 32 entries

Results for Aire

Z-value: 0.96

Motif logo

Transcription factors associated with Aire

Activity-expression correlation:

Activity profile of Aire motif

Sorted Z-values of Aire motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Aire

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: