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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Zic4
Z-value: 0.54
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Transcription factors associated with Zic4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zic4 | rn6_v1_chr8_+_98745310_98745310 | 0.79 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_20607507 Show fit | 0.50 |
ENSRNOT00000000011
|
cerebellin 1 precursor |
|
| chr17_-_9695292 Show fit | 0.47 |
ENSRNOT00000036162
|
proline rich 7 (synaptic) |
|
| chr10_-_40953651 Show fit | 0.42 |
ENSRNOT00000063889
|
glycine receptor, alpha 1 |
|
| chr6_+_33885495 Show fit | 0.42 |
ENSRNOT00000086633
|
syndecan 1 |
|
| chr10_-_40953467 Show fit | 0.28 |
ENSRNOT00000092189
|
glycine receptor, alpha 1 |
|
| chr1_-_67390141 Show fit | 0.27 |
ENSRNOT00000025808
|
SH3 domain binding kinase 1 |
|
| chr16_-_20890949 Show fit | 0.26 |
ENSRNOT00000081977
|
homer scaffolding protein 3 |
|
| chr1_-_209641123 Show fit | 0.26 |
ENSRNOT00000021702
|
early B-cell factor 3 |
|
| chr8_-_68038533 Show fit | 0.26 |
ENSRNOT00000018756
|
SKI family transcriptional corepressor 1 |
|
| chr3_+_147585947 Show fit | 0.24 |
ENSRNOT00000006833
|
scratch family transcriptional repressor 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zic4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:2000344 | negative regulation of transmission of nerve impulse(GO:0051970) positive regulation of acrosome reaction(GO:2000344) |
| 0.0 | 0.5 | GO:0021707 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.1 | 0.4 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.1 | 0.2 | GO:0021586 | pons maturation(GO:0021586) |
| 0.0 | 0.2 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 0.1 | GO:0097117 | guanylate kinase-associated protein clustering(GO:0097117) |
| 0.0 | 0.1 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.0 | 0.1 | GO:0032242 | regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) negative regulation of long term synaptic depression(GO:1900453) |
| 0.0 | 0.1 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 0.0 | 0.1 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 0.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 0.1 | GO:0005915 | zonula adherens(GO:0005915) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0030977 | taurine binding(GO:0030977) |
| 0.0 | 0.1 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 0.1 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.0 | 0.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.1 | GO:0051766 | inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 0.0 | GO:0044378 | non-sequence-specific DNA binding, bending(GO:0044378) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |