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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Zic2
Z-value: 0.87
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Transcription factors associated with Zic2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zic2 | rn6_v1_chr15_+_108908607_108908607 | -0.55 | 3.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_15577977 Show fit | 0.67 |
ENSRNOT00000052292
|
hemoglobin alpha, adult chain 3 |
|
| chr1_-_166943592 Show fit | 0.65 |
ENSRNOT00000026962
|
folate receptor 1 |
|
| chr1_+_242572533 Show fit | 0.37 |
ENSRNOT00000035123
|
transmembrane protein 252 |
|
| chr20_-_11620945 Show fit | 0.36 |
ENSRNOT00000079725
|
keratin associated protein 12-2 |
|
| chr6_-_108415093 Show fit | 0.33 |
ENSRNOT00000031650
|
synapse differentiation inducing 1-like |
|
| chr1_-_216080287 Show fit | 0.32 |
ENSRNOT00000027682
|
tyrosine hydroxylase |
|
| chr8_+_111107358 Show fit | 0.31 |
ENSRNOT00000011203
|
anaphase promoting complex subunit 13 |
|
| chrX_-_23187341 Show fit | 0.31 |
ENSRNOT00000000180
|
5'-aminolevulinate synthase 2 |
|
| chr1_-_89369960 Show fit | 0.30 |
ENSRNOT00000028545
|
hepcidin antimicrobial peptide |
|
| chr2_+_127538659 Show fit | 0.30 |
ENSRNOT00000093483
ENSRNOT00000058476 |
solute carrier family 25 member 31 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zic2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0060974 | cell migration involved in heart formation(GO:0060974) |
| 0.1 | 0.7 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.4 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.1 | 0.3 | GO:0072566 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338) |
| 0.1 | 0.3 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.1 | 0.3 | GO:0052314 | phytoalexin metabolic process(GO:0052314) |
| 0.1 | 0.3 | GO:1901423 | response to benzene(GO:1901423) |
| 0.1 | 0.3 | GO:0034760 | negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760) cellular response to bile acid(GO:1903413) |
| 0.1 | 0.3 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.0 | 0.3 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.7 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.4 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.4 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.3 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 0.2 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.0 | 0.2 | GO:1990005 | granular vesicle(GO:1990005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 0.7 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.4 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.0 | 0.4 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.0 | 0.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.3 | GO:0035473 | lipase binding(GO:0035473) |
| 0.0 | 0.3 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.1 | 0.2 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.1 | 0.2 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.0 | 0.2 | GO:0048030 | disaccharide binding(GO:0048030) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.3 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.2 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.2 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 0.2 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.1 | REACTOME AQUAPORIN MEDIATED TRANSPORT | Genes involved in Aquaporin-mediated transport |