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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Zfhx3

Z-value: 0.36

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Transcription factors associated with Zfhx3

Gene Symbol Gene ID Gene Info
ENSRNOG00000014452 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfhx3rn6_v1_chr19_-_42920344_42920344-0.711.8e-01Click!

Activity profile of Zfhx3 motif

Sorted Z-values of Zfhx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_90818736 0.18 ENSRNOT00000093480
ENSRNOT00000009083
lysine demethylase 4C
chr1_-_48891130 0.16 ENSRNOT00000083884

chr2_+_149899836 0.15 ENSRNOT00000086481
similar to hypothetical protein C130079G13
chr8_-_128754514 0.14 ENSRNOT00000025019
C-X3-C motif chemokine receptor 1
chr6_-_98666007 0.10 ENSRNOT00000082695

chr15_-_93765498 0.10 ENSRNOT00000093297
MYC binding protein 2, E3 ubiquitin protein ligase
chr6_-_50941248 0.09 ENSRNOT00000084533
dihydrouridine synthase 4-like
chrM_+_9870 0.09 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chr5_+_6373583 0.09 ENSRNOT00000084749

chr3_-_55951584 0.08 ENSRNOT00000036585
FAST kinase domains 1
chr9_+_73378057 0.07 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
microtubule-associated protein 2
chr10_-_91661558 0.07 ENSRNOT00000043156

chr2_-_177924970 0.07 ENSRNOT00000029340
Rap guanine nucleotide exchange factor 2
chr1_-_166912524 0.07 ENSRNOT00000092952
inositol polyphosphate phosphatase-like 1
chr7_+_132378273 0.06 ENSRNOT00000010990
hypothetical protein LOC690142
chr12_-_29743705 0.06 ENSRNOT00000001185
calneuron 1
chr14_+_69800156 0.05 ENSRNOT00000072746
ligand dependent nuclear receptor corepressor-like
chr16_-_10802512 0.05 ENSRNOT00000079554
bone morphogenetic protein receptor type 1A
chr2_+_113984646 0.05 ENSRNOT00000016799
TRAF2 and NCK interacting kinase
chr8_+_33239139 0.05 ENSRNOT00000011589
Rho GTPase activating protein 32
chr18_-_28017925 0.05 ENSRNOT00000075420
leucine rich repeat transmembrane neuronal 2
chr3_+_63379031 0.05 ENSRNOT00000068199
oxysterol binding protein-like 6
chr19_-_38484611 0.05 ENSRNOT00000077960
nuclear factor of activated T-cells 5
chr4_-_66955732 0.05 ENSRNOT00000084282
lysine (K)-specific demethylase 7A
chr1_-_197568165 0.05 ENSRNOT00000079044
exportin 6
chr13_-_86671515 0.05 ENSRNOT00000082869

chr5_-_48165317 0.04 ENSRNOT00000088179
ankyrin repeat domain 6
chr14_+_32257805 0.04 ENSRNOT00000039626

chr7_+_107406962 0.04 ENSRNOT00000093254
PHD finger protein 20-like protein 1
chr6_-_71199110 0.04 ENSRNOT00000081883
protein kinase D1
chr9_+_73418607 0.04 ENSRNOT00000092547
microtubule-associated protein 2
chr1_-_164977633 0.04 ENSRNOT00000029629
ring finger protein 169
chr1_-_128287151 0.04 ENSRNOT00000084946
ENSRNOT00000089723
myocyte enhancer factor 2a
chr1_-_126211439 0.03 ENSRNOT00000014988
tight junction protein 1
chr19_-_39267928 0.03 ENSRNOT00000027686
transmembrane p24 trafficking protein 6
chr17_-_76188979 0.03 ENSRNOT00000092442
UPF2 regulator of nonsense transcripts homolog (yeast)
chr2_+_123597340 0.03 ENSRNOT00000058552
similar to RIKEN cDNA D630029K19
chr5_+_116420690 0.03 ENSRNOT00000087089
nuclear factor I/A
chr13_+_98231326 0.03 ENSRNOT00000003837
CDC42 binding protein kinase alpha
chr16_+_39827749 0.03 ENSRNOT00000074885
WD repeat domain 17
chr17_-_15467320 0.03 ENSRNOT00000072490
ENSRNOT00000093561
osteoglycin
chr19_-_11669578 0.03 ENSRNOT00000026373
G protein subunit alpha o1
chr1_-_101819478 0.03 ENSRNOT00000056181
glutamate-rich WD repeat containing 1
chr6_+_48452369 0.03 ENSRNOT00000044310
myelin transcription factor 1-like
chr8_+_82043403 0.03 ENSRNOT00000091789
myosin VA
chr2_+_55747318 0.03 ENSRNOT00000050655
DAB2, clathrin adaptor protein
chr11_-_4397361 0.03 ENSRNOT00000046370
cell adhesion molecule 2
chr7_-_140291620 0.02 ENSRNOT00000088323
adenylate cyclase 6
chr17_-_76281660 0.02 ENSRNOT00000058070
UPF2 regulator of nonsense transcripts homolog (yeast)
chr9_+_77320726 0.02 ENSRNOT00000068450
sperm associated antigen 16
chr5_+_156439633 0.02 ENSRNOT00000090232
eukaryotic translation initiation factor 4 gamma, 3
chr13_-_88436789 0.02 ENSRNOT00000003901
discoidin domain receptor tyrosine kinase 2
chr3_+_104816987 0.02 ENSRNOT00000042103
ENSRNOT00000044625
formin 1
chr11_-_83300409 0.02 ENSRNOT00000029255
VPS8 CORVET complex subunit
chr7_-_15163866 0.02 ENSRNOT00000042638
zinc finger protein 870
chr2_-_88763733 0.02 ENSRNOT00000059424
similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr4_+_161720501 0.02 ENSRNOT00000008196
ENSRNOT00000055886
nuclear receptor interacting protein 2
chr1_+_88955440 0.02 ENSRNOT00000091101
proline dehydrogenase 2
chr1_+_170205591 0.02 ENSRNOT00000071063
similar to olfactory receptor 692
chr2_+_209661244 0.02 ENSRNOT00000091973

chrM_+_2740 0.02 ENSRNOT00000047550
mitochondrially encoded NADH dehydrogenase 1
chr5_+_36566783 0.02 ENSRNOT00000077650
F-box and leucine-rich repeat protein 4
chr11_-_72814850 0.01 ENSRNOT00000091575
UBX domain-containing protein 7-like
chr1_-_266428239 0.01 ENSRNOT00000027160
cytochrome P450, family 17, subfamily a, polypeptide 1
chr10_+_89285855 0.01 ENSRNOT00000028033
glucose-6-phosphatase, catalytic subunit
chr16_-_48692476 0.01 ENSRNOT00000013118
interferon regulatory factor 2
chr1_-_205030567 0.01 ENSRNOT00000023404
C-terminal binding protein 2
chr1_+_261291870 0.01 ENSRNOT00000049914
4-hydroxy-2-oxoglutarate aldolase 1
chr2_-_27287605 0.01 ENSRNOT00000034041
ankyrin repeat and death domain containing 1B
chr20_-_3605638 0.01 ENSRNOT00000074460
surfactant associated 2
chr2_-_157759819 0.01 ENSRNOT00000015763
ENSRNOT00000016016
cyclin-L1-like
chrM_+_9451 0.01 ENSRNOT00000041241
mitochondrially encoded NADH dehydrogenase 3
chrM_+_14136 0.01 ENSRNOT00000042098
mitochondrially encoded cytochrome b
chr9_+_53013413 0.01 ENSRNOT00000005313
ankyrin and armadillo repeat containing
chr16_+_8211420 0.01 ENSRNOT00000079609
oxidoreductase NAD-binding domain containing 1
chr7_-_12601674 0.01 ENSRNOT00000093489
AT-rich interaction domain 3A
chr12_+_21981755 0.01 ENSRNOT00000001871
7SK snRNA methylphosphate capping enzyme-like
chr13_-_74331214 0.01 ENSRNOT00000006018
FAM20B, glycosaminoglycan xylosylkinase
chr2_-_88660449 0.01 ENSRNOT00000051741
solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
chr2_-_184263564 0.01 ENSRNOT00000015279
F-box and WD repeat domain containing 7
chr2_+_235264219 0.01 ENSRNOT00000086245
complement factor I
chr1_-_99632845 0.01 ENSRNOT00000049123
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 pseudogene
chr17_-_54714914 0.01 ENSRNOT00000024336
zinc finger E-box binding homeobox 1
chr1_+_88955135 0.01 ENSRNOT00000083550
proline dehydrogenase 2
chr11_+_65743892 0.00 ENSRNOT00000085226

chr14_-_42560174 0.00 ENSRNOT00000003128
transmembrane protein 33
chr5_-_128730446 0.00 ENSRNOT00000089441
oxysterol binding protein-like 9
chr8_-_126390801 0.00 ENSRNOT00000089732

chr20_-_4132604 0.00 ENSRNOT00000077630
ENSRNOT00000048332
RT1 class II, locus Da
chr17_-_78499881 0.00 ENSRNOT00000079260
family with sequence similarity 107, member B
chrX_+_54390733 0.00 ENSRNOT00000004977
similar to chromosome X open reading frame 21
chr1_+_107262659 0.00 ENSRNOT00000022499
growth arrest-specific 2
chr6_-_33738825 0.00 ENSRNOT00000039492
solute carrier family 7 (cationic amino acid transporter, y+ system), member 15

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfhx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.2 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.1 GO:0048382 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) mesendoderm development(GO:0048382) regulation of cardiac ventricle development(GO:1904412)
0.0 0.1 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0 0.0 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)