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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Zbtb3

Z-value: 0.58

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Transcription factors associated with Zbtb3

Gene Symbol Gene ID Gene Info
Zbtb3
ENSRNOG00000019461 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zbtb3rn6_v1_chr1_+_224998172_2249981720.856.9e-02Click!

Activity profile of Zbtb3 motif

Sorted Z-values of Zbtb3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_71210301 0.39 ENSRNOT00000006504
Fam171b
family with sequence similarity 171, member B
chr16_-_84939323 0.35 ENSRNOT00000022742
Myo16
myosin XVI
chr1_+_226435979 0.34 ENSRNOT00000048704
ENSRNOT00000036232
ENSRNOT00000035576
ENSRNOT00000036180
ENSRNOT00000036168
ENSRNOT00000047964
ENSRNOT00000036283
ENSRNOT00000007429
Syt7
synaptotagmin 7
chr1_-_261446570 0.23 ENSRNOT00000020182
Sfrp5
secreted frizzled-related protein 5
chr7_-_113937941 0.20 ENSRNOT00000012408
Kcnk9
potassium two pore domain channel subfamily K member 9
chr3_+_161433410 0.20 ENSRNOT00000024657
Slc12a5
solute carrier family 12 member 5
chrX_+_65040934 0.20 ENSRNOT00000044006
Zc3h12b
zinc finger CCCH-type containing 12B
chr1_-_65597899 0.19 ENSRNOT00000046708
Zfp446
zinc finger protein 446
chr11_+_69739384 0.19 ENSRNOT00000016340
Kalrn
kalirin, RhoGEF kinase
chr14_+_86652365 0.18 ENSRNOT00000077428
Zmiz2
zinc finger, MIZ-type containing 2
chrX_+_31140960 0.17 ENSRNOT00000084395
ENSRNOT00000004494
Mospd2
motile sperm domain containing 2
chr3_+_142739781 0.17 ENSRNOT00000006181
Sstr4
somatostatin receptor 4
chr17_+_43632397 0.17 ENSRNOT00000013790
Hist1h2ah
histone cluster 1, H2ah
chr9_+_100885051 0.17 ENSRNOT00000082987
AC109427.1

chr12_-_15996958 0.16 ENSRNOT00000039726
Amz1
archaelysin family metallopeptidase 1
chr7_+_143749221 0.15 ENSRNOT00000014807
Igfbp6
insulin-like growth factor binding protein 6
chr18_+_30435119 0.14 ENSRNOT00000027190
Pcdhb8
protocadherin beta 8
chr13_-_52266100 0.14 ENSRNOT00000087532
AC096239.3

chr7_-_12598183 0.13 ENSRNOT00000089009
Arid3a
AT-rich interaction domain 3A
chr7_-_12598370 0.13 ENSRNOT00000026708
Arid3a
AT-rich interaction domain 3A
chr20_+_28572242 0.13 ENSRNOT00000072485
Sh3rf3
SH3 domain containing ring finger 3
chr4_-_176026133 0.13 ENSRNOT00000043374
ENSRNOT00000046598
Slco1a4
solute carrier organic anion transporter family, member 1a4
chr2_-_210943620 0.13 ENSRNOT00000026750
Gpr61
G protein-coupled receptor 61
chr10_+_14547172 0.12 ENSRNOT00000092043
Unkl
unkempt family like zinc finger
chr7_+_18510354 0.12 ENSRNOT00000060002
Pram1
PML-RARA regulated adaptor molecule 1
chr6_+_119519714 0.12 ENSRNOT00000004955
Flrt2
fibronectin leucine rich transmembrane protein 2
chr10_-_103685844 0.11 ENSRNOT00000064284
Cd300lf
Cd300 molecule-like family member F
chr20_+_13067242 0.11 ENSRNOT00000083878
Dip2a
disco-interacting protein 2 homolog A
chr13_+_49850189 0.11 ENSRNOT00000042125
Pik3c2b
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chrX_+_75792931 0.11 ENSRNOT00000037575
Magee2
MAGE family member E2
chr11_-_81444375 0.11 ENSRNOT00000058479
ENSRNOT00000078131
ENSRNOT00000080949
ENSRNOT00000080562
ENSRNOT00000084867
Kng1
kininogen 1
chr10_+_35343189 0.10 ENSRNOT00000083688
Mapk9
mitogen-activated protein kinase 9
chr4_-_100303047 0.10 ENSRNOT00000018170
ENSRNOT00000084782
Mat2a
methionine adenosyltransferase 2A
chr2_+_186980793 0.10 ENSRNOT00000091336
Arhgef11
Rho guanine nucleotide exchange factor 11
chr4_+_113247795 0.09 ENSRNOT00000007984
Tacr1
tachykinin receptor 1
chr5_+_139963002 0.09 ENSRNOT00000048506
Col9a2
collagen type IX alpha 2 chain
chr3_+_48082935 0.09 ENSRNOT00000087711
ENSRNOT00000067545
Slc4a10
solute carrier family 4 member 10
chr10_+_13915214 0.09 ENSRNOT00000015092
Pkd1
polycystin 1, transient receptor potential channel interacting
chr18_+_87580424 0.09 ENSRNOT00000070984
Tmx3
thioredoxin-related transmembrane protein 3
chr7_+_139762614 0.09 ENSRNOT00000031157
Ccdc184
coiled-coil domain containing 184
chr3_-_94418711 0.09 ENSRNOT00000089554
Hipk3
homeodomain interacting protein kinase 3
chr3_-_29996865 0.09 ENSRNOT00000080382
Zeb2
zinc finger E-box binding homeobox 2
chr2_-_86475096 0.09 ENSRNOT00000075247
ENSRNOT00000075062
LOC100909688
zinc finger protein 43-like
chr10_-_65502936 0.08 ENSRNOT00000089615
Supt6h
SPT6 homolog, histone chaperone
chr19_-_22632071 0.08 ENSRNOT00000077275
Gpt2
glutamic--pyruvic transaminase 2
chr16_+_82184387 0.08 ENSRNOT00000089329
ENSRNOT00000068416
Tubgcp3
tubulin, gamma complex associated protein 3
chr8_-_73194837 0.08 ENSRNOT00000024885
ENSRNOT00000081450
ENSRNOT00000064613
Tln2
talin 2
chr6_+_1410507 0.08 ENSRNOT00000034919
Gpatch11
G patch domain containing 11
chr15_+_41448064 0.08 ENSRNOT00000019551
Sacs
sacsin molecular chaperone
chr11_-_67702955 0.08 ENSRNOT00000084540
ENSRNOT00000078285
Kpna1
karyopherin subunit alpha 1
chr20_+_29897594 0.08 ENSRNOT00000057752
Vsir
V-set immunoregulatory receptor
chr9_+_16702460 0.07 ENSRNOT00000061432
Ptk7
protein tyrosine kinase 7
chr18_+_60639860 0.07 ENSRNOT00000083363
Nedd4l
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr2_+_220298245 0.07 ENSRNOT00000022625
Plppr4
phospholipid phosphatase related 4
chr7_+_122979021 0.07 ENSRNOT00000085707
Zc3h7b
zinc finger CCCH-type containing 7B
chr17_+_15966234 0.06 ENSRNOT00000084304
Wnk2
WNK lysine deficient protein kinase 2
chr1_+_48077033 0.06 ENSRNOT00000020100
Mas1
MAS1 proto-oncogene, G protein-coupled receptor
chr1_-_124038966 0.06 ENSRNOT00000082487
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
chr11_-_71128299 0.06 ENSRNOT00000080568
Fyttd1
forty-two-three domain containing 1
chr5_-_166430254 0.06 ENSRNOT00000048914
Nmnat1
nicotinamide nucleotide adenylyltransferase 1
chr1_+_67340809 0.06 ENSRNOT00000045266
LOC100362054
mCG114696-like
chr20_-_5927070 0.06 ENSRNOT00000059264
Slc26a8
solute carrier family 26 member 8
chr3_-_44522930 0.06 ENSRNOT00000006963
Acvr1
activin A receptor type 1
chr3_+_172692452 0.05 ENSRNOT00000077193
Zfp831
zinc finger protein 831
chr15_-_3773340 0.05 ENSRNOT00000063831
LOC103689945
zinc finger SWIM domain-containing protein 8-like
chr5_-_62683964 0.05 ENSRNOT00000060005
Anks6
ankyrin repeat and sterile alpha motif domain containing 6
chr15_+_5306459 0.05 ENSRNOT00000092079
LOC108348081
CD99 antigen-like protein 2
chr10_+_40438356 0.05 ENSRNOT00000078910
Gm2a
GM2 ganglioside activator
chr6_-_79306443 0.05 ENSRNOT00000030706
Clec14a
C-type lectin domain family 14, member A
chr10_+_103934797 0.05 ENSRNOT00000035865
Cdr2l
cerebellar degeneration-related protein 2-like
chr7_+_18409147 0.05 ENSRNOT00000086336
ENSRNOT00000011849
Adamts10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr2_+_180012414 0.05 ENSRNOT00000082273
Pdgfc
platelet derived growth factor C
chr1_-_204817080 0.05 ENSRNOT00000077956
Fam53b
family with sequence similarity 53, member B
chr7_-_122963299 0.05 ENSRNOT00000090208
Rangap1
RAN GTPase activating protein 1
chr10_-_35005287 0.04 ENSRNOT00000032386
LOC103689949
nedd4 binding protein 3
chr8_+_44990014 0.04 ENSRNOT00000044608
Hspa8
heat shock protein family A (Hsp70) member 8
chr9_-_88086488 0.04 ENSRNOT00000019579
Irs1
insulin receptor substrate 1
chr20_+_3155652 0.04 ENSRNOT00000042882
RT1-S2
RT1 class Ib, locus S2
chr10_+_45322248 0.04 ENSRNOT00000047268
Trim11
tripartite motif-containing 11
chr1_-_124039196 0.04 ENSRNOT00000051883
Chrna7
cholinergic receptor nicotinic alpha 7 subunit
chr1_-_188713270 0.04 ENSRNOT00000082192
ENSRNOT00000065892
Gprc5b
G protein-coupled receptor, class C, group 5, member B
chr1_+_79931156 0.04 ENSRNOT00000019814
ENSRNOT00000084985
Sympk
symplekin
chr1_+_201256910 0.04 ENSRNOT00000090143
Tacc2
transforming, acidic coiled-coil containing protein 2
chr8_-_132911193 0.04 ENSRNOT00000087799
Fyco1
FYVE and coiled-coil domain containing 1
chr4_+_70903253 0.04 ENSRNOT00000019720
Ephb6
Eph receptor B6
chr3_+_67849966 0.04 ENSRNOT00000057826
Dusp19
dual specificity phosphatase 19
chr5_-_160282810 0.03 ENSRNOT00000076160
ENSRNOT00000016352
Ddi2
DNA-damage inducible protein 2
chr2_+_72006099 0.03 ENSRNOT00000034044
Cdh12
cadherin 12
chr9_-_20195566 0.03 ENSRNOT00000015223
Adgrf5
adhesion G protein-coupled receptor F5
chrX_-_75566481 0.03 ENSRNOT00000003714
Zdhhc15
zinc finger, DHHC-type containing 15
chr14_+_79540235 0.03 ENSRNOT00000089334
Sorcs2
sortilin-related VPS10 domain containing receptor 2
chr17_+_30670171 0.03 ENSRNOT00000022369
Fam217a
family with sequence similarity 217, member A
chr1_+_214664537 0.03 ENSRNOT00000075002
AABR07006030.1

chr15_+_43582020 0.03 ENSRNOT00000013001
Pnma2
paraneoplastic Ma antigen 2
chr3_-_176666282 0.03 ENSRNOT00000016947
Eef1a2
eukaryotic translation elongation factor 1 alpha 2
chr5_+_128215711 0.03 ENSRNOT00000011670
Cc2d1b
coiled-coil and C2 domain containing 1B
chr2_+_18392142 0.02 ENSRNOT00000043196
Hapln1
hyaluronan and proteoglycan link protein 1
chr13_-_50761306 0.02 ENSRNOT00000076610
ENSRNOT00000004241
Prelp
proline and arginine rich end leucine rich repeat protein
chr19_-_10358695 0.02 ENSRNOT00000019770
Katnb1
katanin regulatory subunit B1
chr8_+_31497639 0.02 ENSRNOT00000020041
Snx19
sorting nexin 19
chr2_+_198231291 0.02 ENSRNOT00000078288
ENSRNOT00000046739
Otud7b
OTU deubiquitinase 7B
chr10_-_37099004 0.02 ENSRNOT00000075465
N4bp3
Nedd4 binding protein 3
chr1_+_197128411 0.02 ENSRNOT00000083248
LOC361646
similar to K04F10.2
chr8_-_122402127 0.02 ENSRNOT00000074238
ENSRNOT00000076548
Crtapl1
cartilage associated protein-like 1
chr18_-_16543992 0.02 ENSRNOT00000036306
Slc39a6
solute carrier family 39 member 6
chr9_+_93799278 0.02 ENSRNOT00000084590
Dis3l2
DIS3-like 3'-5' exoribonuclease 2
chr8_-_128622314 0.02 ENSRNOT00000084950
ENSRNOT00000024408
Gorasp1
golgi reassembly stacking protein 1
chr5_-_173339890 0.02 ENSRNOT00000067704
ENSRNOT00000078453
Pusl1
pseudouridylate synthase-like 1
chr1_+_265904566 0.02 ENSRNOT00000086041
ENSRNOT00000036156
Gbf1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr16_+_50016857 0.02 ENSRNOT00000035781
Tlr3
toll-like receptor 3
chr4_+_2711385 0.02 ENSRNOT00000035996
Dnajb6
DnaJ heat shock protein family (Hsp40) member B6
chr15_+_39945095 0.01 ENSRNOT00000016826
Shisa2
shisa family member 2
chr8_-_22929294 0.01 ENSRNOT00000015609
Rab3d
RAB3D, member RAS oncogene family
chr20_+_31313018 0.01 ENSRNOT00000036719
Tysnd1
trypsin domain containing 1
chr16_-_7588841 0.01 ENSRNOT00000084645
Mettl6
methyltransferase like 6
chr2_-_30458542 0.01 ENSRNOT00000072926
Naip6
NLR family, apoptosis inhibitory protein 6
chr20_-_45053640 0.01 ENSRNOT00000072256
RGD1561777
similar to Na+ dependent glucose transporter 1
chr1_+_273854248 0.01 ENSRNOT00000044827
ENSRNOT00000017600
ENSRNOT00000086496
Add3
adducin 3
chr6_-_1410339 0.01 ENSRNOT00000035905
Heatr5b
HEAT repeat containing 5B
chr2_-_27364906 0.01 ENSRNOT00000078639
Polk
DNA polymerase kappa
chr1_-_133503194 0.01 ENSRNOT00000077049
Mctp2
multiple C2 and transmembrane domain containing 2
chr1_+_201055644 0.01 ENSRNOT00000054937
ENSRNOT00000047161
Tacc2
transforming, acidic coiled-coil containing protein 2
chr1_+_100830064 0.01 ENSRNOT00000027320
Il4i1
interleukin 4 induced 1
chr10_-_91448477 0.01 ENSRNOT00000038836
Arhgap27
Rho GTPase activating protein 27
chr8_-_39723927 0.00 ENSRNOT00000089662
Slc37a2
solute carrier family 37 member 2
chr7_-_11783849 0.00 ENSRNOT00000026202
Sf3a2
splicing factor 3a, subunit 2
chr4_-_77706994 0.00 ENSRNOT00000038517
Zfp777
zinc finger protein 777
chr6_+_64252020 0.00 ENSRNOT00000047296
ENSRNOT00000082105
Pnpla8
patatin-like phospholipase domain containing 8
chr2_+_218951141 0.00 ENSRNOT00000091001
Extl2
exostosin-like glycosyltransferase 2
chr2_+_44096061 0.00 ENSRNOT00000018438
Ankrd55
ankyrin repeat domain 55
chr1_-_219853329 0.00 ENSRNOT00000026169
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 0.2 GO:2000040 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.2 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.0 0.1 GO:1902214 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426)
0.0 0.2 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.1 GO:0001982 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.0 0.1 GO:0072156 distal tubule morphogenesis(GO:0072156) metanephric proximal tubule development(GO:0072237)
0.0 0.2 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.1 GO:0042851 L-alanine metabolic process(GO:0042851)
0.0 0.1 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.0 GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740) regulation of lysosomal membrane permeability(GO:0097213) positive regulation of lysosomal membrane permeability(GO:0097214)
0.0 0.1 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0070827 chromatin maintenance(GO:0070827)
0.0 0.1 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.1 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.0 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.3 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0097441 basilar dendrite(GO:0097441)
0.0 0.0 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.0 0.0 GO:1990836 lysosomal matrix(GO:1990836)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.0 0.1 GO:0047635 L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635)
0.0 0.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.0 0.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.0 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels