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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Yy1_Yy2
Z-value: 2.04
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Transcription factors associated with Yy1_Yy2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Yy1 | rn6_v1_chr6_+_132702448_132702448 | -0.67 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_123106694 Show fit | 2.03 |
ENSRNOT00000028829
|
oxytocin/neurophysin 1 prepropeptide |
|
| chr1_-_166939541 Show fit | 1.52 |
ENSRNOT00000079675
|
folate receptor 1 |
|
| chr10_-_88670430 Show fit | 1.47 |
ENSRNOT00000025547
|
hypocretin neuropeptide precursor |
|
| chr10_-_70871066 Show fit | 1.34 |
ENSRNOT00000015139
|
C-C motif chemokine ligand 3 |
|
| chr14_+_43694183 Show fit | 1.29 |
ENSRNOT00000046342
|
similar to ribosomal protein S23 |
|
| chr3_-_123119460 Show fit | 1.17 |
ENSRNOT00000028833
|
arginine vasopressin |
|
| chr10_-_13168217 Show fit | 1.10 |
ENSRNOT00000087768
|
elongin B |
|
| chr18_-_15540177 Show fit | 1.06 |
ENSRNOT00000022113
|
transthyretin |
|
| chr5_+_64789456 Show fit | 1.02 |
ENSRNOT00000009584
|
zinc finger protein 189 |
|
| chr1_+_168964202 Show fit | 0.98 |
ENSRNOT00000089102
|
hemoglobin subunit beta-2-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of Yy1_Yy2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.3 | GO:0006412 | translation(GO:0006412) |
| 0.1 | 5.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 3.9 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.8 | 3.1 | GO:0002125 | maternal aggressive behavior(GO:0002125) |
| 0.1 | 2.9 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 2.1 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.6 | 1.7 | GO:0060974 | cell migration involved in heart formation(GO:0060974) |
| 0.1 | 1.7 | GO:0006335 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.3 | 1.4 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.0 | 1.4 | GO:0032543 | mitochondrial translation(GO:0032543) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 7.1 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 0.1 | 5.0 | GO:0005761 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.1 | 4.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.1 | 4.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 4.1 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 4.0 | GO:0030141 | secretory granule(GO:0030141) |
| 0.4 | 3.5 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 2.8 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 2.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 5.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 5.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.4 | 2.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 2.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 2.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 2.5 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.1 | 1.7 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.4 | 1.6 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 1.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.3 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.8 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 9.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 7.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.7 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 2.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 2.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 2.0 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.0 | 1.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.3 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |