ISMARA results: Wrnip1_Mta3

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Wrnip1_Mta3_Rcor1

Z-value: 4.63

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Transcription factors associated with Wrnip1_Mta3_Rcor1

Gene Symbol	Gene ID	Gene Info
Wrnip1 NCBI RGD Ensembl	ENSRNOG00000017040	Werner helicase interacting protein 1
Mta3 NCBI RGD Ensembl	ENSRNOG00000004685	metastasis associated 1 family, member 3
Rcor1 NCBI RGD Ensembl	ENSRNOG00000008067	REST corepressor 1
Rcor1 NCBI RGD Ensembl	ENSRNOG00000049783	REST corepressor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Rcor1	rn6_v1_chr6_+_135513650_135513650	-0.56	3.3e-01	Click!
Mta3	rn6_v1_chr6_+_6946695_6946695	-0.28	6.5e-01	Click!
Wrnip1	rn6_v1_chr17_-_32953641_32953641	0.07	9.1e-01	Click!

Activity profile of Wrnip1_Mta3_Rcor1 motif

Sorted Z-values of Wrnip1_Mta3_Rcor1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_17186679 Show fit	7.31	ENSRNOT00000001730	Uncx NCBI RGD Ensembl Show fit	UNC homeobox
chr3_-_152382529 Show fit	7.11	ENSRNOT00000027076	Scand1 NCBI RGD Ensembl Show fit	SCAN domain-containing 1
chr7_-_123445613 Show fit	6.78	ENSRNOT00000070937	Shisa8 NCBI RGD Ensembl Show fit	shisa family member 8
chr1_+_33910912 Show fit	6.46	ENSRNOT00000044690	Irx1 NCBI RGD Ensembl Show fit	iroquois homeobox 1
chr2_-_164126783 Show fit	6.00	ENSRNOT00000016843	Shox2 NCBI RGD Ensembl Show fit	short stature homeobox 2
chr16_-_8685529 Show fit	5.70	ENSRNOT00000092751	Slc18a3 NCBI RGD Ensembl Show fit	solute carrier family 18 member A3
chr5_-_151709877 Show fit	4.76	ENSRNOT00000080602	Trnp1 NCBI RGD Ensembl Show fit	TMF1-regulated nuclear protein 1
chr15_-_34550850 Show fit	4.71	ENSRNOT00000027794 ENSRNOT00000090228	Cbln3 NCBI RGD Ensembl Show fit	cerebellin 3 precursor
chr12_-_38782010 Show fit	4.60	ENSRNOT00000001813	Wdr66 NCBI RGD Ensembl Show fit	WD repeat domain 66
chr3_-_123119460 Show fit	4.57	ENSRNOT00000028833	Avp NCBI RGD Ensembl Show fit	arginine vasopressin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Wrnip1_Mta3_Rcor1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	12.1	GO:0015671	oxygen transport(GO:0015671)
0.7	9.6	GO:1901374	acetate ester transport(GO:1901374)
2.3	9.3	GO:0072086	specification of loop of Henle identity(GO:0072086)
0.2	9.2	GO:0021762	substantia nigra development(GO:0021762)
2.2	8.8	GO:0002125	maternal aggressive behavior(GO:0002125)
0.8	7.5	GO:0071316	cellular response to nicotine(GO:0071316)
0.4	7.5	GO:0032291	central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.9	6.9	GO:0035726	common myeloid progenitor cell proliferation(GO:0035726)
1.3	6.7	GO:0010037	response to carbon dioxide(GO:0010037)
0.4	6.5	GO:0001675	acrosome assembly(GO:0001675)

Showing 1 to 10 of 1,320 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	104.5	GO:0005615	extracellular space(GO:0005615)
0.0	65.5	GO:0005576	extracellular region(GO:0005576)
0.0	53.7	GO:0016021	integral component of membrane(GO:0016021)
0.2	29.2	GO:0043209	myelin sheath(GO:0043209)
0.2	18.7	GO:0072562	blood microparticle(GO:0072562)
0.2	15.1	GO:0022626	cytosolic ribosome(GO:0022626)
0.3	14.3	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	10.4	GO:0009986	cell surface(GO:0009986)
0.2	10.1	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	8.9	GO:0005758	mitochondrial intermembrane space(GO:0005758)

Showing 1 to 10 of 397 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	36.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.8	19.6	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.1	14.8	GO:0003924	GTPase activity(GO:0003924)
0.2	13.8	GO:0005179	hormone activity(GO:0005179)
0.0	12.3	GO:0043565	sequence-specific DNA binding(GO:0043565)
0.2	9.9	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	9.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.4	8.8	GO:0048156	tau protein binding(GO:0048156)
2.7	8.0	GO:0031720	haptoglobin binding(GO:0031720)
0.1	7.8	GO:0004860	protein kinase inhibitor activity(GO:0004860)

Showing 1 to 10 of 705 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	45.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	16.5	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	13.7	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1	11.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	10.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	10.2	PID NOTCH PATHWAY	Notch signaling pathway
0.2	8.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	8.3	PID AP1 PATHWAY	AP-1 transcription factor network
0.2	7.5	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.3	7.3	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	32.8	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	19.9	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.2	19.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	15.1	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.1	13.4	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	11.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.3	10.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.4	9.9	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.5	9.7	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2	8.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Showing 1 to 10 of 195 entries

Results for Wrnip1_Mta3_Rcor1

Z-value: 4.63

Motif logo

Transcription factors associated with Wrnip1_Mta3_Rcor1

Activity-expression correlation:

Activity profile of Wrnip1_Mta3_Rcor1 motif

Sorted Z-values of Wrnip1_Mta3_Rcor1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Wrnip1_Mta3_Rcor1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: