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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Tlx2

Z-value: 0.28

Motif logo

Transcription factors associated with Tlx2

Gene Symbol Gene ID Gene Info
ENSRNOG00000055188 T-cell leukemia homeobox 2
ENSRNOG00000061571 T-cell leukemia homeobox 2

Activity profile of Tlx2 motif

Sorted Z-values of Tlx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_19714324 0.17 ENSRNOT00000072303
similar to cell surface receptor FDFACT
chr17_-_90315492 0.14 ENSRNOT00000070807
G protein subunit gamma 4
chr1_+_276659542 0.13 ENSRNOT00000019681
transcription factor 7 like 2
chr11_+_31389514 0.11 ENSRNOT00000000325
oligodendrocyte lineage transcription factor 2
chr5_-_17061361 0.10 ENSRNOT00000089318
proenkephalin
chr2_-_190100276 0.10 ENSRNOT00000015351
S100 calcium binding protein A9
chr3_+_147585947 0.09 ENSRNOT00000006833
scratch family transcriptional repressor 2
chr19_-_43911057 0.09 ENSRNOT00000026017
chymotrypsinogen B1
chr15_+_41069507 0.08 ENSRNOT00000018533
C1q and tumor necrosis factor related protein 9
chr5_-_34813116 0.08 ENSRNOT00000017479
Sodium/potassium transporting ATPase interacting 3
chr7_-_73216251 0.08 ENSRNOT00000057587
ribosomal protein L30-like
chr14_+_5928737 0.08 ENSRNOT00000071877
ENSRNOT00000040985
ENSRNOT00000074889
macrophage activation 2 like
chr4_+_165732643 0.08 ENSRNOT00000034403
hypothetical protein LOC690326
chr7_-_12646960 0.08 ENSRNOT00000014687
proteinase 3
chr8_-_66863476 0.08 ENSRNOT00000018820
ribosomal protein lateral stalk subunit P1
chr2_+_199199845 0.08 ENSRNOT00000020932
tubulin alpha-1C chain-like
chr13_-_80738634 0.07 ENSRNOT00000081551
flavin containing monooxygenase 1
chr5_-_136762986 0.07 ENSRNOT00000026852
artemin
chr13_-_90814119 0.07 ENSRNOT00000011208
transgelin 2
chr9_+_94928489 0.07 ENSRNOT00000087366
ENSRNOT00000085770
ENSRNOT00000024733
S-antigen visual arrestin
chr1_+_81643816 0.07 ENSRNOT00000027214
carcinoembryonic antigen-related cell adhesion molecule 1-like
chr5_+_145257714 0.07 ENSRNOT00000019214
DLG associated protein 3
chr8_-_63092009 0.07 ENSRNOT00000034300
lysyl oxidase-like 1
chr10_+_70655818 0.06 ENSRNOT00000074839
hypothetical protein LOC689039
chr2_-_260596777 0.06 ENSRNOT00000009370
LIM homeobox 8
chr10_-_40805941 0.06 ENSRNOT00000017588
antioxidant 1 copper chaperone
chr7_+_123168811 0.06 ENSRNOT00000007091
cold shock domain containing C2
chr8_+_71914867 0.06 ENSRNOT00000023372
death-associated protein kinase 2
chr15_-_41691518 0.06 ENSRNOT00000020036
emopamil binding protein-like
chr9_+_84689150 0.06 ENSRNOT00000072242
potassium voltage-gated channel subfamily E regulatory subunit 4
chr20_-_4921348 0.06 ENSRNOT00000082497
ENSRNOT00000041151
RT1 class I, locus CE4
chr7_-_121232741 0.06 ENSRNOT00000023196
platelet derived growth factor subunit B
chr12_+_19890749 0.06 ENSRNOT00000074970
similar to cell surface receptor FDFACT
chr4_+_98371184 0.06 ENSRNOT00000086911

chr9_-_101388833 0.06 ENSRNOT00000071817
coiled-coil-helix-coiled-coil-helix domain containing 2
chr4_+_168832910 0.06 ENSRNOT00000011134
G protein-coupled receptor, class C, group 5, member A
chr20_+_5351605 0.05 ENSRNOT00000089306
ENSRNOT00000041590
ENSRNOT00000081240
ENSRNOT00000082538
RT1 class Ia, locus A1
chr8_+_44847157 0.05 ENSRNOT00000080288
CXADR-like membrane protein
chr10_-_103590607 0.05 ENSRNOT00000034741
Cd300 molecule-like family member E
chr19_+_561727 0.05 ENSRNOT00000016259
ENSRNOT00000081547
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
chr3_+_13838304 0.05 ENSRNOT00000025067
heat shock protein family A member 5
chr7_-_2712723 0.05 ENSRNOT00000004363
interleukin 23 subunit alpha
chr10_-_66020682 0.05 ENSRNOT00000011019
family with sequence similarity 58, member B
chr3_+_147042944 0.05 ENSRNOT00000012608
FK506 binding protein 1a
chr2_+_187347602 0.05 ENSRNOT00000025384
nestin
chr11_+_67082193 0.05 ENSRNOT00000003129
CD86 molecule
chr1_+_88113445 0.05 ENSRNOT00000056955
gametogenetin
chr5_-_62025152 0.05 ENSRNOT00000042649
hemogen
chr8_-_83280888 0.05 ENSRNOT00000052341
GDNF family receptor alpha like
chr4_+_83391283 0.05 ENSRNOT00000031365
cAMP responsive element binding protein 5
chr5_-_128009735 0.05 ENSRNOT00000013913
glutathione peroxidase 7
chr8_+_62925357 0.05 ENSRNOT00000011074
ENSRNOT00000090588
stimulated by retinoic acid 6
chr4_+_86275717 0.05 ENSRNOT00000016414
protein phosphatase 1, regulatory subunit 17
chr1_-_224986291 0.05 ENSRNOT00000026284
TATA-box binding protein associated factor 6 like
chr2_+_190073815 0.05 ENSRNOT00000015473
S100 calcium binding protein A8
chr2_-_183128932 0.05 ENSRNOT00000031179
meiotic nuclear divisions 1
chr1_-_190596431 0.05 ENSRNOT00000079335
PDZ domain containing 9
chr18_-_55771730 0.05 ENSRNOT00000026426
small integral membrane protein 3
chr4_+_62780596 0.05 ENSRNOT00000073846
hypothetical protein LOC689574
chr10_-_37099004 0.04 ENSRNOT00000075465
Nedd4 binding protein 3
chr2_+_203768729 0.04 ENSRNOT00000018895
immunoglobulin superfamily, member 3
chr12_+_11191812 0.04 ENSRNOT00000033537
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
chr7_-_118933812 0.04 ENSRNOT00000031951
apolipoprotein L 9a
chr5_-_148577292 0.04 ENSRNOT00000017156
zinc finger CCHC-type containing 17
chr2_+_189955836 0.04 ENSRNOT00000078351
S100 calcium binding protein A3
chr1_-_80271001 0.04 ENSRNOT00000034266
CD3e molecule associated protein
chr20_-_5754773 0.04 ENSRNOT00000035977
inositol hexakisphosphate kinase 3
chr2_+_200397967 0.04 ENSRNOT00000025821
regenerating family member 4
chr1_-_153740905 0.04 ENSRNOT00000023239
protease, serine, 23
chr13_+_49003803 0.04 ENSRNOT00000080556
LEM domain containing 1
chr15_+_23553128 0.04 ENSRNOT00000012985
cyclin-dependent kinase inhibitor 3
chr10_-_35005287 0.04 ENSRNOT00000032386
nedd4 binding protein 3
chr18_-_27520295 0.04 ENSRNOT00000027544
GDNF family receptor alpha 3
chr15_-_6587367 0.04 ENSRNOT00000038449
zinc finger protein 385D
chr19_-_55967836 0.04 ENSRNOT00000051452
sulfotransferase family 5A, member 1
chr2_+_233602732 0.04 ENSRNOT00000044232
paired-like homeodomain 2
chr1_-_221087449 0.04 ENSRNOT00000016987
family with sequence similarity 89, member B
chr10_+_47490153 0.04 ENSRNOT00000003182
aldehyde dehydrogenase 3 family, member A1
chrX_-_139916883 0.04 ENSRNOT00000090442
glypican 3
chr16_+_6035926 0.04 ENSRNOT00000020284
selenoprotein K
chr15_+_31948035 0.04 ENSRNOT00000071627

chr15_+_33069382 0.04 ENSRNOT00000060193
mitochondrial ribosomal protein L52
chr7_+_122160171 0.04 ENSRNOT00000074499
CG3918-like
chr19_-_914880 0.04 ENSRNOT00000017127
chemokine-like factor
chr7_-_29233392 0.04 ENSRNOT00000064241
Spi-C transcription factor
chr4_+_66670618 0.04 ENSRNOT00000010796
thromboxane A synthase 1
chr4_+_7257752 0.03 ENSRNOT00000088357
transmembrane and ubiquitin-like domain containing 1
chr11_-_81660395 0.03 ENSRNOT00000048739
fetuin B
chr4_-_158704170 0.03 ENSRNOT00000082009
neurotrophin 3
chr4_+_130332076 0.03 ENSRNOT00000083127
melanogenesis associated transcription factor
chr19_-_25288335 0.03 ENSRNOT00000050214
nanos C2HC-type zinc finger 3
chr10_+_3227160 0.03 ENSRNOT00000088075
N-terminal asparagine amidase
chr12_+_21678580 0.03 ENSRNOT00000039797
paired immunoglobulin-like type 2 receptor alpha-like
chr3_-_170955399 0.03 ENSRNOT00000084990
bone morphogenetic protein 7
chr2_+_115678344 0.03 ENSRNOT00000036717
solute carrier family 7, member 14
chr5_-_130085838 0.03 ENSRNOT00000035252
ELAV like RNA binding protein 4
chr14_-_18733391 0.03 ENSRNOT00000003745
C-X-C motif chemokine ligand 2
chr3_-_161812243 0.03 ENSRNOT00000025238
ENSRNOT00000087646
solute carrier family 35 member C2
chr7_+_140716113 0.03 ENSRNOT00000033450
tubulin, alpha 1C
chr16_-_20592449 0.03 ENSRNOT00000026821
inositol-3-phosphate synthase 1
chr4_+_140703619 0.03 ENSRNOT00000009563
basic helix-loop-helix family, member e40
chr5_+_79179417 0.03 ENSRNOT00000010454
orosomucoid 1
chr4_+_25435873 0.03 ENSRNOT00000000018
STEAP family member 1
chr11_-_32508420 0.03 ENSRNOT00000002717
potassium voltage-gated channel subfamily E regulatory subunit 1
chr6_+_126170720 0.03 ENSRNOT00000065246
Ras and Rab interactor 3
chr10_+_14598014 0.03 ENSRNOT00000068336
TSR3, 20S rRNA accumulation
chr10_-_56850085 0.03 ENSRNOT00000025767
ribonuclease K
chr3_-_111941841 0.03 ENSRNOT00000010701
EH-domain containing 4
chr5_+_159606647 0.03 ENSRNOT00000051693
ribosomal protein S21, pseudogene 1
chr9_+_67763897 0.03 ENSRNOT00000071226
inducible T-cell co-stimulator
chr15_+_31533675 0.03 ENSRNOT00000084141

chr8_-_40137390 0.03 ENSRNOT00000042717
pannexin 3
chr5_-_57896475 0.03 ENSRNOT00000017903
similar to testes development-related NYD-SP22 isoform 1
chr9_+_43331155 0.03 ENSRNOT00000023036
zeta chain of T cell receptor associated protein kinase 70
chr2_+_239415046 0.03 ENSRNOT00000072196
CXXC finger protein 4
chr9_+_24066303 0.03 ENSRNOT00000018163
cysteine-rich secretory protein 3
chr6_+_126170911 0.03 ENSRNOT00000077477
Ras and Rab interactor 3
chr3_-_9738752 0.03 ENSRNOT00000045993
prostaglandin E synthase
chr10_+_106800142 0.03 ENSRNOT00000074899
hypothetical protein LOC688282
chr10_-_103972668 0.03 ENSRNOT00000004836
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
chr12_-_9988618 0.03 ENSRNOT00000087449
RAS-like family 11 member A
chr10_-_64202380 0.03 ENSRNOT00000008982
refilin B
chr10_-_71383378 0.03 ENSRNOT00000077025
dual specificity phosphatase 14
chr8_+_116857684 0.03 ENSRNOT00000026711
macrophage stimulating 1
chr1_-_88112683 0.03 ENSRNOT00000090615
sprouty-related, EVH1 domain containing 3
chr10_+_37215937 0.03 ENSRNOT00000006567
secretion associated, Ras related GTPase 1B
chrX_+_122808605 0.03 ENSRNOT00000017567
zinc finger CCHC-type containing 12
chr17_+_76079720 0.03 ENSRNOT00000073933
proline and serine rich 2
chr2_+_119139717 0.03 ENSRNOT00000016051
NADH:ubiquinone oxidoreductase subunit B5
chr15_-_28517335 0.03 ENSRNOT00000060514
ENSRNOT00000090378
heterogeneous nuclear ribonucleoproteins C1/C2-like
chr2_-_88113029 0.03 ENSRNOT00000013354
carbonic anhydrase 2
chr9_-_82699551 0.03 ENSRNOT00000020673
obscurin-like 1
chr1_-_87155118 0.03 ENSRNOT00000072441

chr1_-_90208036 0.03 ENSRNOT00000076255
ENSRNOT00000076967
LSM14A mRNA processing body assembly factor
chr11_+_46009322 0.03 ENSRNOT00000002233
transmembrane protein 45A
chrX_+_113948654 0.03 ENSRNOT00000068431
transmembrane protein 164
chr4_-_97784842 0.03 ENSRNOT00000007698
growth arrest and DNA-damage-inducible, alpha
chr1_-_52544450 0.03 ENSRNOT00000043474
phosphodiesterase 10A
chr5_+_139038134 0.03 ENSRNOT00000078155
human immunodeficiency virus type I enhancer binding protein 3
chr9_-_94250809 0.03 ENSRNOT00000026387
endothelin converting enzyme-like 1
chr11_+_67451549 0.03 ENSRNOT00000042777
stefin A2-like 2
chr13_-_112099336 0.03 ENSRNOT00000009158
ENSRNOT00000044161
calcium/calmodulin-dependent protein kinase IG
chr11_+_46714355 0.03 ENSRNOT00000073404
transmembrane protein 45A-like
chr12_-_9998779 0.03 ENSRNOT00000001265
ribosomal protein L21
chr1_-_101054851 0.03 ENSRNOT00000027849
proline rich and Gla domain 2
chr4_-_147742114 0.03 ENSRNOT00000041464
EF-hand calcium binding domain 12
chr6_-_108488330 0.03 ENSRNOT00000016076
NPC intracellular cholesterol transporter 2
chr6_+_108488678 0.03 ENSRNOT00000016089
iron-sulfur cluster assembly 2
chr5_-_154394328 0.03 ENSRNOT00000030043
ribosomal protein L11
chr2_-_123193130 0.03 ENSRNOT00000019554
annexin A5
chr19_-_15570611 0.02 ENSRNOT00000022679
matrix metallopeptidase 2
chr3_-_176465162 0.02 ENSRNOT00000048807
Sodium/potassium transporting ATPase interacting 4
chr15_+_33596301 0.02 ENSRNOT00000022563
interleukin 25
chr2_+_187282000 0.02 ENSRNOT00000065211
hepatoma-derived growth factor
chr14_-_2032593 0.02 ENSRNOT00000000037
fibroblast growth factor receptor-like 1
chr19_-_10653800 0.02 ENSRNOT00000022128
C-X3-C motif chemokine ligand 1
chr6_+_22302069 0.02 ENSRNOT00000039132
dpy-30 histone methyltransferase complex regulatory subunit
chr1_-_64021321 0.02 ENSRNOT00000090819
ribosomal protein S9
chr7_+_14589520 0.02 ENSRNOT00000060210
cytochrome P450, family 4, subfamily f, polypeptide 37
chr4_+_8166082 0.02 ENSRNOT00000076429
SRSF protein kinase 2
chr20_+_12917111 0.02 ENSRNOT00000038953
ybeY metallopeptidase
chr3_-_114307250 0.02 ENSRNOT00000064592
Src homology 2 domain containing F
chr1_+_264827739 0.02 ENSRNOT00000021553
Kazal-type serine peptidase inhibitor domain 1
chr20_-_5110191 0.02 ENSRNOT00000076597
casein kinase 2 beta
chr1_-_89017290 0.02 ENSRNOT00000028438
presenilin enhancer gamma secretase subunit
chr1_+_198120099 0.02 ENSRNOT00000073652
bolA family member 2
chr8_+_94686938 0.02 ENSRNOT00000013285
ripply transcriptional repressor 2
chr20_+_44521279 0.02 ENSRNOT00000085987
FYN proto-oncogene, Src family tyrosine kinase
chr13_-_53870428 0.02 ENSRNOT00000000812
nuclear receptor subfamily 5, group A, member 2
chr3_+_170252901 0.02 ENSRNOT00000005871
melanocortin 3 receptor
chr11_+_45751812 0.02 ENSRNOT00000079336
similar to Dermal papilla derived protein 7
chr10_+_89352835 0.02 ENSRNOT00000028060
ribosomal protein L27
chr4_+_61850348 0.02 ENSRNOT00000013423
aldo-keto reductase family 1, member B7
chr8_+_48443767 0.02 ENSRNOT00000010127
C1q and tumor necrosis factor related protein 5
chr1_+_198655742 0.02 ENSRNOT00000023944
myosin light chain, phosphorylatable, fast skeletal muscle
chr2_+_248398917 0.02 ENSRNOT00000045855
guanylate binding protein 1
chr7_+_74047814 0.02 ENSRNOT00000014879
odd-skipped related transciption factor 2
chr3_+_148150698 0.02 ENSRNOT00000087075
ENSRNOT00000010251
histocompatibility minor 13
chr7_+_70349863 0.02 ENSRNOT00000031796
cyclin-dependent kinase 4
chr7_-_107963073 0.02 ENSRNOT00000093353
ENSRNOT00000010980
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr7_-_18180705 0.02 ENSRNOT00000065954
zinc finger protein 494
chr4_+_149908375 0.02 ENSRNOT00000019504
uncharacterized LOC100909657
chr2_-_149347796 0.02 ENSRNOT00000091020
purinergic receptor P2Y14
chr1_-_187766670 0.02 ENSRNOT00000092513
ENSRNOT00000092282
ribosomal protein S15a
chr5_-_154394023 0.02 ENSRNOT00000079823
ribosomal protein L11
chr6_+_34030620 0.02 ENSRNOT00000091651
lysosomal protein transmembrane 4 alpha
chr1_-_86923575 0.02 ENSRNOT00000027029
mitochondrial ribosomal protein S12
chr8_-_39266959 0.02 ENSRNOT00000046590
EI24, autophagy associated transmembrane protein
chr19_-_41029206 0.02 ENSRNOT00000023383
Vac14, PIKFYVE complex component
chr15_+_42522108 0.02 ENSRNOT00000021621
coiled-coil domain containing 25
chrX_-_112328642 0.02 ENSRNOT00000083150
proteasome 26S subunit, non-ATPase 10
chr17_-_18828929 0.02 ENSRNOT00000051732
stathmin domain-containing protein 1-like
chr10_+_43871613 0.02 ENSRNOT00000080540
ENSRNOT00000003797
RoBo-1
chr7_+_116632506 0.02 ENSRNOT00000009811
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr10_+_62303662 0.02 ENSRNOT00000056355
TLC domain containing 2
chr8_-_14156656 0.02 ENSRNOT00000089364
deuterosome assembly protein 1
chr4_+_129574264 0.02 ENSRNOT00000010185
ADP-ribosylation factor like GTPase 6 interacting protein 5
chr10_+_86860685 0.02 ENSRNOT00000084644
retinoic acid receptor, alpha
chr11_+_58624198 0.02 ENSRNOT00000002091
growth associated protein 43
chr1_+_89017479 0.02 ENSRNOT00000038154
U2 small nuclear RNA auxiliary factor 1-like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Tlx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) embryonic hindgut morphogenesis(GO:0048619)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:0051867 general adaptation syndrome, behavioral process(GO:0051867)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 0.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.1 GO:0072254 metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254)
0.0 0.1 GO:1904401 cellular response to Thyroid stimulating hormone(GO:1904401)
0.0 0.1 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
0.0 0.1 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 0.1 GO:0051140 positive regulation of memory T cell differentiation(GO:0043382) regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142) regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.0 0.0 GO:2000422 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
0.0 0.0 GO:0046865 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.1 GO:0045105 intermediate filament polymerization or depolymerization(GO:0045105)
0.0 0.0 GO:0021539 pulmonary myocardium development(GO:0003350) subthalamus development(GO:0021539) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577)
0.0 0.1 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.0 0.0 GO:0072011 glomerular endothelium development(GO:0072011)
0.0 0.0 GO:0007403 glial cell fate determination(GO:0007403)
0.0 0.0 GO:0072134 nephrogenic mesenchyme morphogenesis(GO:0072134)
0.0 0.0 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.0 GO:0036023 embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0 0.0 GO:0043366 beta selection(GO:0043366)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0032280 symmetric synapse(GO:0032280)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0002046 opsin binding(GO:0002046)
0.0 0.0 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)