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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Thra

Z-value: 0.22

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Transcription factors associated with Thra

Gene Symbol Gene ID Gene Info
ENSRNOG00000009066 thyroid hormone receptor alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thrarn6_v1_chr10_+_86657285_866572850.652.3e-01Click!

Activity profile of Thra motif

Sorted Z-values of Thra motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_115616766 0.10 ENSRNOT00000006143
ENSRNOT00000045870
SEL1L ERAD E3 ligase adaptor subunit
chr3_+_95715193 0.08 ENSRNOT00000089525
paired box 6
chr20_+_3827367 0.08 ENSRNOT00000079967
retinoid X receptor beta
chr1_+_82174451 0.07 ENSRNOT00000027783
transmembrane protein 145
chr10_+_14547172 0.06 ENSRNOT00000092043
unkempt family like zinc finger
chr5_+_147069616 0.05 ENSRNOT00000072908
tripartite motif-containing 62
chr8_-_61919874 0.05 ENSRNOT00000064830
similar to human chromosome 15 open reading frame 39
chr6_+_110624856 0.05 ENSRNOT00000014017
vasohibin 1
chr14_+_104250617 0.05 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chrX_-_159841072 0.05 ENSRNOT00000001158
Rac/Cdc42 guanine nucleotide exchange factor 6
chr3_+_80676820 0.05 ENSRNOT00000084809
autophagy and beclin 1 regulator 1
chr4_+_153385205 0.04 ENSRNOT00000016561
BCL2 like 13
chr7_-_12424367 0.04 ENSRNOT00000060698
midnolin
chr20_+_5008508 0.04 ENSRNOT00000001153
von Willebrand factor A domain containing 7
chr6_+_112203679 0.03 ENSRNOT00000031205
neurexin 3
chr11_+_64601029 0.03 ENSRNOT00000004138
Rho GTPase activating protein 31
chr8_-_47339343 0.03 ENSRNOT00000081007
Rho guanine nucleotide exchange factor 12
chr1_-_214414763 0.03 ENSRNOT00000025240
ENSRNOT00000077776
mitochondrial glutamate carrier 1-like
chr6_+_146784915 0.03 ENSRNOT00000008362
Sp8 transcription factor
chr8_+_116332796 0.03 ENSRNOT00000021408
hyaluronoglucosaminidase 1
chr1_+_1784078 0.03 ENSRNOT00000020098
large tumor suppressor kinase 1
chr13_-_35668968 0.03 ENSRNOT00000042862
ENSRNOT00000003428
erythrocyte membrane protein band 4.1 like 5
chr5_+_116421894 0.03 ENSRNOT00000080577
ENSRNOT00000086628
ENSRNOT00000004017
nuclear factor I/A
chr6_-_135829953 0.03 ENSRNOT00000080623
ENSRNOT00000039059
CDC42 binding protein kinase beta
chr10_+_72486152 0.03 ENSRNOT00000004193
similar to Chromodomain-helicase-DNA-binding protein 1 (CHD-1)
chr10_-_59762644 0.03 ENSRNOT00000083390
cystinosin, lysosomal cystine transporter
chr5_-_57632177 0.02 ENSRNOT00000080787
ENSRNOT00000092581
ubiquitin-associated protein 2
chr15_-_55209342 0.02 ENSRNOT00000021752
RB transcriptional corepressor 1
chr7_-_33916338 0.02 ENSRNOT00000005492
cilia and flagella associated protein 54
chr16_+_19044607 0.02 ENSRNOT00000085462
mediator complex subunit 26
chr12_+_24761210 0.02 ENSRNOT00000002003
claudin 4
chr5_+_113725717 0.02 ENSRNOT00000032248
TEK receptor tyrosine kinase
chrX_-_157095274 0.02 ENSRNOT00000084088
ATP binding cassette subfamily D member 1
chr10_+_59000397 0.02 ENSRNOT00000021134
MYB binding protein 1a
chr3_-_2727616 0.02 ENSRNOT00000061904
complement C8 gamma chain
chr1_+_88922433 0.02 ENSRNOT00000045212
NPHS1 nephrin
chr5_-_160219812 0.02 ENSRNOT00000016333
pleckstrin homology and RUN domain containing M2
chrX_+_68752597 0.02 ENSRNOT00000077039
StAR-related lipid transfer domain containing 8
chr9_+_111597037 0.02 ENSRNOT00000021758
FER tyrosine kinase
chr11_+_84745904 0.02 ENSRNOT00000002617
kelch-like family member 6
chr10_-_18443934 0.02 ENSRNOT00000059895
ENSRNOT00000080021
RAN binding protein 17
chr14_+_12218553 0.02 ENSRNOT00000003237
protein kinase, cGMP-dependent, type II
chr1_-_66212418 0.02 ENSRNOT00000026074
hypothetical protein LOC691722
chr2_+_198312428 0.02 ENSRNOT00000028758
splicing factor 3b, subunit 4
chr5_+_14415841 0.02 ENSRNOT00000010682
regulator of G-protein signaling 20
chr1_+_224824799 0.02 ENSRNOT00000024757
solute carrier family 22 member 6
chr17_+_36334147 0.02 ENSRNOT00000050261
E2F transcription factor 3
chr4_-_145948996 0.02 ENSRNOT00000043476
ATPase plasma membrane Ca2+ transporting 2
chr1_-_64446818 0.02 ENSRNOT00000081980
myeloid-associated differentiation marker
chr3_+_148510779 0.01 ENSRNOT00000012156
XK related 7
chr7_-_122926336 0.01 ENSRNOT00000000205
chondroadherin-like
chr17_+_77167740 0.01 ENSRNOT00000042881
optineurin
chr7_-_142180997 0.01 ENSRNOT00000087632
transcription factor CP2
chr6_+_29106141 0.01 ENSRNOT00000084560
ATPase family, AAA domain containing 2B
chr6_+_2216623 0.01 ENSRNOT00000008045
regulator of microtubule dynamics 2
chr10_-_85435016 0.01 ENSRNOT00000079921
RIKEN cDNA 4933428G20 gene
chr7_-_140437467 0.01 ENSRNOT00000087181
FK506 binding protein 11
chr1_-_134867001 0.01 ENSRNOT00000090149
chromodomain helicase DNA binding protein 2
chr3_+_150055749 0.01 ENSRNOT00000055335
actin-like 10
chr1_+_177048655 0.01 ENSRNOT00000081595
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr10_+_85608544 0.01 ENSRNOT00000092122
MLLT6, PHD finger domain containing
chr8_+_50559126 0.01 ENSRNOT00000024918
apolipoprotein A5
chr5_-_137238354 0.01 ENSRNOT00000039235
seizure threshold 2 homolog (mouse)
chr14_-_83219071 0.01 ENSRNOT00000085788
DEP domain containing 5
chr5_-_152473868 0.01 ENSRNOT00000022130
family with sequence similarity 110, member D
chr5_-_147691997 0.01 ENSRNOT00000011887
testis-specific serine kinase 3
chr11_+_73936750 0.01 ENSRNOT00000002350
ATPase 13A3
chr5_+_154522119 0.01 ENSRNOT00000072618
E2F transcription factor 2
chr4_+_57715946 0.01 ENSRNOT00000079059
ENSRNOT00000034429
kelch domain containing 10
chr15_+_34270648 0.01 ENSRNOT00000026333
ring finger protein 31
chr10_+_84979717 0.01 ENSRNOT00000065555
mitochondrial ribosomal protein L10
chr3_+_155297566 0.01 ENSRNOT00000021435
ENSRNOT00000084866
DEAH-box helicase 35
chr7_-_142180794 0.01 ENSRNOT00000037447
transcription factor CP2
chr5_+_14415606 0.01 ENSRNOT00000089273
regulator of G-protein signaling 20
chr11_-_4332255 0.01 ENSRNOT00000087133
cell adhesion molecule 2
chr1_+_84067938 0.01 ENSRNOT00000057213
NUMB-like, endocytic adaptor protein
chr14_+_84417320 0.01 ENSRNOT00000008788
TBC1 domain family, member 10a
chr14_-_83219464 0.01 ENSRNOT00000067694
DEP domain containing 5
chr1_-_59347472 0.01 ENSRNOT00000017718
leucyl and cystinyl aminopeptidase
chr18_+_30574627 0.01 ENSRNOT00000060484
protocadherin beta 19
chr20_+_3827086 0.01 ENSRNOT00000081588
retinoid X receptor beta
chr1_-_265798167 0.01 ENSRNOT00000079483
LIM domain binding 1
chr4_+_113948514 0.01 ENSRNOT00000011521
mannosyl-oligosaccharide glucosidase
chr1_+_72425707 0.00 ENSRNOT00000058956
SH3 domain binding kinase family, member 2
chr19_-_27535792 0.00 ENSRNOT00000024040
olfactory receptor 1666
chr9_+_88494676 0.00 ENSRNOT00000089451
mitochondrial fission factor-like
chr6_-_122721496 0.00 ENSRNOT00000079697
protein tyrosine phosphatase, non-receptor type 21
chr2_+_229196616 0.00 ENSRNOT00000012773
N-deacetylase and N-sulfotransferase 4
chr5_-_126911520 0.00 ENSRNOT00000091521
deiodinase, iodothyronine, type I
chr16_-_69242028 0.00 ENSRNOT00000019002
zinc finger protein 703
chr10_-_102423084 0.00 ENSRNOT00000065145
sidekick cell adhesion molecule 2
chrX_-_119162518 0.00 ENSRNOT00000073176
ubiquitin-conjugating enzyme E2 W
chr16_+_23553647 0.00 ENSRNOT00000041994
pleckstrin and Sec7 domain containing 3
chr12_+_51878153 0.00 ENSRNOT00000056798
HscB mitochondrial iron-sulfur cluster co-chaperone
chr15_-_86142672 0.00 ENSRNOT00000057830
COMM domain containing 6
chr3_-_13896838 0.00 ENSRNOT00000025399
F-box and WD repeat domain containing 2
chr5_-_76039760 0.00 ENSRNOT00000019959
similar to KIAA0368

Network of associatons between targets according to the STRING database.

First level regulatory network of Thra

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0021917 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.0 0.0 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.0 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.0 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.0 GO:0036117 hyaluranon cable(GO:0036117)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)