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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Tgif2_Tgif2lx1_Tgif2lx2
Z-value: 0.73
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Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tgif2 | rn6_v1_chr3_+_152909189_152909189 | -0.46 | 4.4e-01 | Click! |
| Tgif2lx2 | rn6_v1_chrX_+_90588124_90588124 | 0.33 | 5.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_59529785 Show fit | 1.11 |
ENSRNOT00000064840
ENSRNOT00000065181 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
|
| chrX_+_136460215 Show fit | 0.88 |
ENSRNOT00000093538
|
Rho GTPase activating protein 36 |
|
| chr2_+_204427608 Show fit | 0.74 |
ENSRNOT00000083374
|
nescient helix loop helix 2 |
|
| chr5_+_154522119 Show fit | 0.62 |
ENSRNOT00000072618
|
E2F transcription factor 2 |
|
| chr1_-_145870912 Show fit | 0.50 |
ENSRNOT00000016289
|
interleukin 16 |
|
| chr6_-_124876710 Show fit | 0.48 |
ENSRNOT00000073530
|
G protein-coupled receptor 68 |
|
| chr16_-_20888907 Show fit | 0.43 |
ENSRNOT00000027428
|
homer scaffolding protein 3 |
|
| chr8_+_116776494 Show fit | 0.41 |
ENSRNOT00000050702
|
cadherin-related family member 4 |
|
| chr4_-_130659697 Show fit | 0.37 |
ENSRNOT00000072374
|
rCG56280-like |
|
| chr10_-_59883839 Show fit | 0.33 |
ENSRNOT00000093579
|
aspartoacylase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0044705 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.1 | 0.6 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 0.1 | 0.5 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.0 | 0.5 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.1 | 0.3 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.0 | 0.3 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 0.0 | 0.3 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.1 | 0.2 | GO:1904937 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937) |
| 0.1 | 0.2 | GO:1903769 | negative regulation of cell proliferation in bone marrow(GO:1903769) |
| 0.0 | 0.2 | GO:0039534 | negative regulation of MDA-5 signaling pathway(GO:0039534) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.3 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.1 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.0 | 0.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.1 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 0.1 | GO:0030008 | TRAPP complex(GO:0030008) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.5 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 0.3 | GO:0019807 | aspartoacylase activity(GO:0019807) |
| 0.1 | 0.3 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.0 | 0.3 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.2 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.2 | GO:0019863 | IgE binding(GO:0019863) advanced glycation end-product receptor activity(GO:0050785) |
| 0.0 | 0.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.2 | GO:0031432 | titin binding(GO:0031432) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.3 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.6 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.2 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |