ISMARA results: Tgif1

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Tgif1_Meis3

Z-value: 1.18

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Transcription factors associated with Tgif1_Meis3

Gene Symbol	Gene ID	Gene Info
Tgif1 NCBI RGD Ensembl	ENSRNOG00000015906	TGFB-induced factor homeobox 1
Meis3 NCBI RGD Ensembl	ENSRNOG00000021390	Meis homeobox 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tgif1	rn6_v1_chr9_-_119190698_119190698	0.70	1.9e-01	Click!
Meis3	rn6_v1_chr1_+_78069193_78069193	-0.13	8.3e-01	Click!

Activity profile of Tgif1_Meis3 motif

Sorted Z-values of Tgif1_Meis3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_81819799 Show fit	0.59	ENSRNOT00000076840	Mxd4 NCBI RGD Ensembl Show fit	Max dimerization protein 4
chr14_+_63095720 Show fit	0.50	ENSRNOT00000006071	Ppargc1a NCBI RGD Ensembl Show fit	PPARG coactivator 1 alpha
chr15_+_8739589 Show fit	0.50	ENSRNOT00000071751	Nr1d2 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 1, group D, member 2
chr13_-_49313940 Show fit	0.48	ENSRNOT00000012190	Cntn2 NCBI RGD Ensembl Show fit	contactin 2
chr7_-_107774397 Show fit	0.48	ENSRNOT00000093322	Ndrg1 NCBI RGD Ensembl Show fit	N-myc downstream regulated 1
chr7_-_139907640 Show fit	0.47	ENSRNOT00000045473	Zfp641 NCBI RGD Ensembl Show fit	zinc finger protein 641
chr2_+_155555840 Show fit	0.44	ENSRNOT00000080951	AABR07010944.1 NCBI RGD Ensembl Show fit
chr5_-_75319765 Show fit	0.44	ENSRNOT00000085698	Svep1 NCBI RGD Ensembl Show fit	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
chr10_-_71358190 Show fit	0.41	ENSRNOT00000078646	Ac1576 NCBI RGD Ensembl Show fit	uncharacterized LOC102552783
chr11_-_71108184 Show fit	0.40	ENSRNOT00000051989 ENSRNOT00000073865 ENSRNOT00000063883	Lrch3 NCBI RGD Ensembl Show fit	leucine rich repeats and calponin homology domain containing 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tgif1_Meis3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.2	0.6	GO:1904638	response to resveratrol(GO:1904638)
0.2	0.5	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.5	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.5	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)
0.0	0.5	GO:0099562	maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.0	0.5	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
0.1	0.4	GO:0003322	pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.1	0.4	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)
0.1	0.4	GO:0090204	protein localization to nuclear pore(GO:0090204)

Showing 1 to 10 of 297 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0098831	presynaptic active zone cytoplasmic component(GO:0098831)
0.0	0.6	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.5	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.5	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.5	GO:0016592	mediator complex(GO:0016592)
0.0	0.5	GO:0060170	ciliary membrane(GO:0060170)
0.0	0.4	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.4	GO:0042555	MCM complex(GO:0042555)
0.0	0.4	GO:0000145	exocyst(GO:0000145)

Showing 1 to 10 of 97 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.7	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	0.6	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.6	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.6	GO:0048365	Rac GTPase binding(GO:0048365)
0.1	0.5	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.5	GO:0098919	structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.0	0.5	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.5	GO:0030507	spectrin binding(GO:0030507)
0.1	0.4	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)

Showing 1 to 10 of 175 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.0	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.9	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	0.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.2	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.2	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.9	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.5	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.5	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.4	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.4	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis

Showing 1 to 10 of 42 entries

Results for Tgif1_Meis3

Z-value: 1.18

Motif logo

Transcription factors associated with Tgif1_Meis3

Activity-expression correlation:

Activity profile of Tgif1_Meis3 motif

Sorted Z-values of Tgif1_Meis3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tgif1_Meis3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: