ISMARA results: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41

Project

GSE49485: Hypoxia transcriptome sequencing of rat brain.

Navigation

Downloads

Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.01

Motif logo

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Gene Symbol	Gene ID	Gene Info
Tfeb NCBI RGD Ensembl	ENSRNOG00000014666	transcription factor EB
Usf1 NCBI RGD Ensembl	ENSRNOG00000004255	upstream transcription factor 1
Srebf1 NCBI RGD Ensembl	ENSRNOG00000003463	sterol regulatory element binding transcription factor 1
Usf2 NCBI RGD Ensembl	ENSRNOG00000053725	upstream transcription factor 2, c-fos interacting
Bhlhe41 NCBI RGD Ensembl	ENSRNOG00000048961	basic helix-loop-helix family, member e41
Srebf2 NCBI RGD Ensembl	ENSRNOG00000007400	sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tfeb	rn6_v1_chr9_-_15214596_15214596	-0.81	9.6e-02	Click!
Usf2	rn6_v1_chr1_-_89382463_89382463	-0.41	5.0e-01	Click!
Srebf1	rn6_v1_chr10_-_46582854_46582854	-0.25	6.9e-01	Click!
Bhlhe41	rn6_v1_chr4_-_180234804_180234804	0.21	7.4e-01	Click!
Srebf2	rn6_v1_chr7_+_123381077_123381082	0.11	8.6e-01	Click!
Usf1	rn6_v1_chr13_+_89797800_89797800	-0.01	9.8e-01	Click!

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_61531416 Show fit	0.89	ENSRNOT00000093263	Atp6v1a NCBI RGD Ensembl Show fit	ATPase H+ transporting V1 subunit A
chr10_+_71278650 Show fit	0.65	ENSRNOT00000092020	Synrg NCBI RGD Ensembl Show fit	synergin, gamma
chr1_+_154377447 Show fit	0.63	ENSRNOT00000084268 ENSRNOT00000092086 ENSRNOT00000091470 ENSRNOT00000025415	Picalm NCBI RGD Ensembl Show fit	phosphatidylinositol binding clathrin assembly protein
chr6_-_3794489 Show fit	0.61	ENSRNOT00000087891 ENSRNOT00000011000 ENSRNOT00000084499	Thumpd2 NCBI RGD Ensembl Show fit	THUMP domain containing 2
chr10_+_56610051 Show fit	0.57	ENSRNOT00000024348	Dvl2 NCBI RGD Ensembl Show fit	dishevelled segment polarity protein 2
chr5_+_90800082 Show fit	0.55	ENSRNOT00000093696 ENSRNOT00000093206	Kdm4c NCBI RGD Ensembl Show fit	lysine demethylase 4C
chr3_-_66417741 Show fit	0.54	ENSRNOT00000007662	Neurod1 NCBI RGD Ensembl Show fit	neuronal differentiation 1
chr6_-_102472926 Show fit	0.53	ENSRNOT00000079351	Zfyve26 NCBI RGD Ensembl Show fit	zinc finger FYVE-type containing 26
chr1_-_219450451 Show fit	0.53	ENSRNOT00000025317	Rad9a NCBI RGD Ensembl Show fit	RAD9 checkpoint clamp component A
chr6_-_125853461 Show fit	0.49	ENSRNOT00000007505	Atxn3 NCBI RGD Ensembl Show fit	ataxin 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:1902963	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.2	0.6	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.1	0.6	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.1	0.6	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0	0.6	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
0.1	0.5	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
0.1	0.5	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.1	0.5	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.5	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.5	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)

Showing 1 to 10 of 145 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	1.0	GO:0016235	aggresome(GO:0016235)
0.1	0.7	GO:0005879	axonemal microtubule(GO:0005879)
0.1	0.7	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1	0.6	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.6	GO:0005721	pericentric heterochromatin(GO:0005721)
0.1	0.5	GO:0030896	checkpoint clamp complex(GO:0030896)
0.1	0.5	GO:0000243	commitment complex(GO:0000243)
0.0	0.5	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.4	GO:0005869	dynactin complex(GO:0005869)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.7	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	0.7	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.1	0.6	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.6	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.6	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.6	GO:0005109	frizzled binding(GO:0005109)
0.0	0.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.2	0.5	GO:0005302	L-tyrosine transmembrane transporter activity(GO:0005302)
0.1	0.5	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)

Showing 1 to 10 of 95 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Total log-likelihood	Term	Description
1.1	PID ATM PATHWAY	ATM pathway
0.6	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Total log-likelihood	Term	Description
0.8	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.7	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.6	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.4	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex

Showing 1 to 10 of 20 entries

Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.01

Motif logo

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Activity-expression correlation:

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: