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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Tfdp1_Wt1_Egr2
Z-value: 3.42
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Transcription factors associated with Tfdp1_Wt1_Egr2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Wt1 | rn6_v1_chr3_+_95133713_95133713 | -0.70 | 1.8e-01 | Click! |
| Egr2 | rn6_v1_chr20_-_22459025_22459025 | 0.68 | 2.1e-01 | Click! |
| Tfdp1 | rn6_v1_chr16_+_81089292_81089308 | 0.61 | 2.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_70364813 Show fit | 4.78 |
ENSRNOT00000084012
ENSRNOT00000031230 |
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
|
| chr7_+_130474279 Show fit | 4.65 |
ENSRNOT00000092388
|
SH3 and multiple ankyrin repeat domains 3 |
|
| chr7_+_130474508 Show fit | 4.27 |
ENSRNOT00000085191
|
SH3 and multiple ankyrin repeat domains 3 |
|
| chr3_-_164095878 Show fit | 3.73 |
ENSRNOT00000079414
|
beta-1,4-galactosyltransferase 5 |
|
| chr20_+_5535432 Show fit | 2.94 |
ENSRNOT00000040859
|
synaptic Ras GTPase activating protein 1 |
|
| chr1_+_266953139 Show fit | 2.92 |
ENSRNOT00000054696
|
neuralized E3 ubiquitin protein ligase 1 |
|
| chr5_-_172623899 Show fit | 2.86 |
ENSRNOT00000080591
|
SKI proto-oncogene |
|
| chr10_+_62674561 Show fit | 2.77 |
ENSRNOT00000019946
ENSRNOT00000056110 |
ankyrin repeat domain 13B |
|
| chr1_-_125967756 Show fit | 2.74 |
ENSRNOT00000031488
|
family with sequence similarity 189, member A1 |
|
| chr16_+_19051965 Show fit | 2.66 |
ENSRNOT00000016399
|
solute carrier family 35, member E1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfdp1_Wt1_Egr2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 10.1 | GO:1904717 | regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.5 | 5.6 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.0 | 4.9 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.3 | 4.7 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.7 | 4.1 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.1 | 3.7 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.4 | 3.5 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.3 | 3.5 | GO:0032957 | inositol trisphosphate metabolic process(GO:0032957) |
| 0.3 | 3.4 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606) |
| 1.0 | 3.0 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.9 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 7.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 7.2 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.2 | 6.7 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.2 | 5.9 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 5.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 5.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 5.0 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.3 | 4.8 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 3.8 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 13.7 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 1.7 | 11.8 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.2 | 7.0 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 6.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 6.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 6.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.6 | 4.8 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.0 | 4.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 4.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 8.0 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.3 | 7.9 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 7.4 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 6.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.4 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 4.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 4.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 3.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 3.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.7 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 6.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 5.7 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 5.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 5.1 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.3 | 4.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.3 | 4.8 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.3 | 4.5 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.2 | 4.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 4.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |