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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Tfap2d

Z-value: 0.39

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Transcription factors associated with Tfap2d

Gene Symbol Gene ID Gene Info
ENSRNOG00000011642 transcription factor AP-2 delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap2drn6_v1_chr9_+_25304876_253048760.197.6e-01Click!

Activity profile of Tfap2d motif

Sorted Z-values of Tfap2d motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_226501920 0.13 ENSRNOT00000050716
leucine rich repeat containing 10B
chr8_+_53678777 0.12 ENSRNOT00000045944
dopamine receptor D2
chr1_-_79930263 0.08 ENSRNOT00000019219
forkhead box A3
chr10_-_56403188 0.08 ENSRNOT00000019947
cholinergic receptor nicotinic beta 1 subunit
chr10_-_85049331 0.08 ENSRNOT00000012538
T-box 21
chr9_+_99998275 0.06 ENSRNOT00000074395
glypican 1
chr4_-_113610243 0.06 ENSRNOT00000008813
hexokinase 2
chr14_-_81725181 0.06 ENSRNOT00000078252
cilia and flagella associated protein 99
chr13_+_51795867 0.05 ENSRNOT00000006747
ubiquitin-conjugating enzyme E2T
chr3_-_171342646 0.05 ENSRNOT00000071853
prostate transmembrane protein, androgen induced 1
chr6_+_107485249 0.05 ENSRNOT00000080859
acyl-CoA thioesterase 1
chr3_+_13838304 0.05 ENSRNOT00000025067
heat shock protein family A member 5
chr3_-_15433252 0.05 ENSRNOT00000008817
LIM homeobox 6
chr11_+_87549059 0.04 ENSRNOT00000002567
coiled-coil domain containing 74A
chr2_+_165486910 0.04 ENSRNOT00000012982
hypothetical protein LOC100362176
chr6_+_137243185 0.04 ENSRNOT00000030879
zinc finger and BTB domain containing 42
chr5_-_61077627 0.04 ENSRNOT00000015338
SH2 domain containing adaptor protein B
chr7_+_116745061 0.04 ENSRNOT00000076174
rhophilin, Rho GTPase binding protein 1
chr1_-_270472866 0.04 ENSRNOT00000015979
sortilin-related VPS10 domain containing receptor 1
chr1_+_198690794 0.03 ENSRNOT00000023999
zinc finger protein 771
chr10_+_89181180 0.03 ENSRNOT00000078931
ENSRNOT00000027770
WNK lysine deficient protein kinase 4
chr2_-_186245342 0.03 ENSRNOT00000057062
ENSRNOT00000022292
doublecortin-like kinase 2
chr1_-_254671778 0.03 ENSRNOT00000025493
5-hydroxytryptamine receptor 7
chr1_-_141349881 0.03 ENSRNOT00000021109
Rh family, C glycoprotein
chr4_-_153028129 0.03 ENSRNOT00000074558
cat eye syndrome chromosome region, candidate 6
chr14_+_11198896 0.03 ENSRNOT00000079767
heterogeneous nuclear ribonucleoprotein D-like
chr1_-_92069160 0.02 ENSRNOT00000039115
dpy-19-like 3 (C. elegans)
chr8_-_63092009 0.02 ENSRNOT00000034300
lysyl oxidase-like 1
chr5_+_148193710 0.02 ENSRNOT00000088568
adhesion G protein-coupled receptor B2
chr3_-_79390956 0.02 ENSRNOT00000077943
protein tyrosine phosphatase, receptor type, J
chr18_+_25163561 0.02 ENSRNOT00000042287
ENSRNOT00000049898
ENSRNOT00000017573
bridging integrator 1
chr6_+_28571351 0.02 ENSRNOT00000005389
adenylate cyclase 3
chr3_+_111545007 0.02 ENSRNOT00000007247
inositol-trisphosphate 3-kinase A
chr1_+_46378807 0.02 ENSRNOT00000043521
zinc finger, DHHC-type containing 14
chr12_-_17358617 0.02 ENSRNOT00000001733
G protein-coupled receptor 146
chr14_-_11198194 0.02 ENSRNOT00000003083
enolase-phosphatase 1
chr4_+_145580799 0.02 ENSRNOT00000013727
von Hippel-Lindau tumor suppressor
chr10_-_11174861 0.02 ENSRNOT00000006680
GLIS family zinc finger 2
chr2_-_183031214 0.02 ENSRNOT00000013260
similar to RIKEN cDNA D930015E06
chr3_+_114747410 0.02 ENSRNOT00000043414
spermatogenesis associated 5-like 1
chr8_+_116311078 0.02 ENSRNOT00000037363
Ras association domain family member 1
chr1_+_154377247 0.02 ENSRNOT00000092945
phosphatidylinositol binding clathrin assembly protein
chrX_-_114232939 0.02 ENSRNOT00000042639
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr3_+_164822111 0.02 ENSRNOT00000014568
par-6 family cell polarity regulator beta
chr3_+_159421671 0.02 ENSRNOT00000010343
myeloblastosis oncogene-like 2
chr1_+_84470829 0.02 ENSRNOT00000025472
tetratricopeptide repeat domain 9B
chr1_-_146289465 0.02 ENSRNOT00000017362
abhydrolase domain containing 17C
chr1_+_72580424 0.02 ENSRNOT00000022977
ubiquitin-conjugating enzyme E2S
chrX_+_127562660 0.02 ENSRNOT00000029031
ENSRNOT00000010367
glutamate ionotropic receptor AMPA type subunit 3
chr1_-_179010257 0.02 ENSRNOT00000017199
related RAS viral (r-ras) oncogene homolog 2
chr1_-_254671596 0.02 ENSRNOT00000025450
5-hydroxytryptamine receptor 7
chr2_-_31826867 0.02 ENSRNOT00000025687
phosphoinositide-3-kinase regulatory subunit 1
chr8_+_128087345 0.02 ENSRNOT00000019777
activin A receptor type 2B
chr4_-_145147397 0.02 ENSRNOT00000010347
lipoma HMGIC fusion partner-like 4
chr1_+_261389804 0.02 ENSRNOT00000064160
MARVEL domain containing 1
chr12_+_31934343 0.02 ENSRNOT00000011181
transmembrane protein 132D
chr1_-_80515694 0.01 ENSRNOT00000075144
CLK4-associating serine/arginine rich protein
chr1_+_82480195 0.01 ENSRNOT00000028051
transforming growth factor, beta 1
chr8_+_115069095 0.01 ENSRNOT00000014770
dual specificity phosphatase 7
chr19_+_24747178 0.01 ENSRNOT00000038879
ENSRNOT00000079106
DnaJ heat shock protein family (Hsp40) member B1
chr16_+_62483761 0.01 ENSRNOT00000058805
Werner syndrome RecQ like helicase
chr8_-_116391158 0.01 ENSRNOT00000078720
ENSRNOT00000022550
G protein subunit alpha i2
chr3_+_2591331 0.01 ENSRNOT00000017466
suppressor APC domain containing 2
chr14_+_39661968 0.01 ENSRNOT00000064779
gamma-aminobutyric acid type A receptor alpha2 subunit
chrX_+_156963870 0.01 ENSRNOT00000077109
PDZ domain containing 4
chr5_-_156689415 0.01 ENSRNOT00000083474
PTEN induced putative kinase 1
chr12_-_17972737 0.01 ENSRNOT00000001783
FAM20C, golgi associated secretory pathway kinase
chr11_-_61530567 0.01 ENSRNOT00000076277
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr19_+_21372163 0.01 ENSRNOT00000020329
siah E3 ubiquitin protein ligase 1
chr1_+_267359830 0.01 ENSRNOT00000015495
STE20-like kinase
chr4_-_58250798 0.01 ENSRNOT00000048436
Kruppel-like factor 14
chr2_-_186245163 0.01 ENSRNOT00000089339
doublecortin-like kinase 2
chr10_-_85222861 0.01 ENSRNOT00000031045
aminopeptidase puromycin sensitive
chr19_+_52032886 0.01 ENSRNOT00000019923
malonyl-CoA decarboxylase
chr8_+_61659445 0.01 ENSRNOT00000023831
protein tyrosine phosphatase, non-receptor type 9
chrX_-_32355296 0.01 ENSRNOT00000081652
ENSRNOT00000065075
adaptor-related protein complex 1, sigma 2 subunit
chr4_+_157511642 0.01 ENSRNOT00000065846
PILR alpha associated neural protein
chr2_+_151685251 0.01 ENSRNOT00000019340
RAP2B, member of RAS oncogene family
chr18_-_18079560 0.01 ENSRNOT00000072093

chr1_-_125967756 0.01 ENSRNOT00000031488
family with sequence similarity 189, member A1
chr1_+_80056755 0.01 ENSRNOT00000021221
small nuclear ribonucleoprotein D2 polypeptide
chr17_+_11953552 0.01 ENSRNOT00000090782
receptor tyrosine kinase-like orphan receptor 2
chr11_+_64601029 0.01 ENSRNOT00000004138
Rho GTPase activating protein 31
chrX_-_33665821 0.01 ENSRNOT00000066676
RB binding protein 7, chromatin remodeling factor
chr6_+_93740586 0.01 ENSRNOT00000011466
dishevelled-binding antagonist of beta-catenin 1
chr11_-_34598275 0.01 ENSRNOT00000077233
phosphatidylinositol glycan anchor biosynthesis, class P
chr8_+_115179893 0.01 ENSRNOT00000017469
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
chr19_-_11669578 0.01 ENSRNOT00000026373
G protein subunit alpha o1
chr12_+_15890170 0.01 ENSRNOT00000001654
G protein subunit alpha 12
chr7_+_130474508 0.01 ENSRNOT00000085191
SH3 and multiple ankyrin repeat domains 3
chr3_-_11747113 0.01 ENSRNOT00000032893
cyclin-dependent kinase 9
chrX_+_63343546 0.01 ENSRNOT00000076315
kelch-like family member 15
chr19_+_37830917 0.01 ENSRNOT00000025608
nuclear transport factor 2
chr3_+_152933771 0.01 ENSRNOT00000027539
similar to RIKEN cDNA 1110008F13
chr6_-_96442682 0.01 ENSRNOT00000010923
transmembrane protein 30B
chr5_+_147714163 0.01 ENSRNOT00000012663
MARCKS-like 1
chr19_-_55300403 0.01 ENSRNOT00000018591
ring finger protein 166
chr19_+_34139997 0.01 ENSRNOT00000017867
Rho GTPase activating protein 10
chr10_+_45659143 0.01 ENSRNOT00000058327
wingless-type MMTV integration site family, member 9A
chr19_+_53635688 0.01 ENSRNOT00000067141
microtubule-associated protein 1 light chain 3 beta
chr7_-_70498992 0.01 ENSRNOT00000067774
ENSRNOT00000079327
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr6_-_137733026 0.01 ENSRNOT00000019213
jagged 2
chr8_+_116154913 0.01 ENSRNOT00000081242
calcium voltage-gated channel auxiliary subunit alpha2delta 2
chr3_+_79678201 0.01 ENSRNOT00000087604
ENSRNOT00000079709
mitochondrial carrier 2
chr13_+_97702097 0.01 ENSRNOT00000057787
saccharopine dehydrogenase-like oxidoreductase
chr9_-_82214440 0.01 ENSRNOT00000024419
Indian hedgehog
chr16_+_83824430 0.01 ENSRNOT00000032918
insulin receptor substrate 2
chr1_+_101554642 0.01 ENSRNOT00000028474
branched chain amino acid transaminase 2
chr20_-_6960481 0.01 ENSRNOT00000093172
mitochondrial carrier 1
chr8_+_116154736 0.01 ENSRNOT00000021218
calcium voltage-gated channel auxiliary subunit alpha2delta 2
chr5_+_8666200 0.01 ENSRNOT00000007766
ADP ribosylation factor guanine nucleotide exchange factor 1
chr6_+_137824213 0.01 ENSRNOT00000056880
phosphofurin acidic cluster sorting protein 2
chr4_+_70903253 0.01 ENSRNOT00000019720
Eph receptor B6
chr11_-_34598102 0.01 ENSRNOT00000068743
phosphatidylinositol glycan anchor biosynthesis, class P
chr19_-_25801526 0.01 ENSRNOT00000003884
nucleus accumbens associated 1
chr16_-_21274688 0.01 ENSRNOT00000027953
testis-specific serine kinase 6
chr10_+_86711240 0.01 ENSRNOT00000012812
male specific lethal 1 homolog
chr10_+_85744568 0.01 ENSRNOT00000005522
LIM and SH3 protein 1
chr16_+_4469468 0.01 ENSRNOT00000021164
wingless-type MMTV integration site family, member 5A
chr6_+_107596782 0.00 ENSRNOT00000076882
dynein, axonemal, light chain 1
chrX_+_54734385 0.00 ENSRNOT00000005023
nuclear receptor subfamily 0, group B, member 1
chr10_-_59360661 0.00 ENSRNOT00000036942
cytochrome b5 domain containing 2
chr5_-_151117042 0.00 ENSRNOT00000066549
family with sequence similarity 76, member A
chr2_+_3400977 0.00 ENSRNOT00000093593
multiple C2 and transmembrane domain containing 1
chr16_+_61954590 0.00 ENSRNOT00000017883
RNA binding protein with multiple splicing
chr11_-_44292884 0.00 ENSRNOT00000084060
discoidin, CUB and LCCL domain containing 2
chr4_-_66624912 0.00 ENSRNOT00000064891
homeodomain interacting protein kinase 2
chr2_+_24449485 0.00 ENSRNOT00000073688
tubulin folding cofactor A
chr1_+_143036218 0.00 ENSRNOT00000025797
phosphodiesterase 8A
chr3_+_147772165 0.00 ENSRNOT00000008713
TBC1 domain family, member 20
chr3_-_148706972 0.00 ENSRNOT00000036956
testis specific protein, Y-linked 26
chr16_-_71237118 0.00 ENSRNOT00000066974
nuclear receptor binding SET domain protein 3
chr3_+_175408629 0.00 ENSRNOT00000081344
LSM family member 14B
chr1_+_200037749 0.00 ENSRNOT00000027630
inositol polyphosphate-5-phosphatase F
chr3_+_6211789 0.00 ENSRNOT00000012892
retinoid X receptor alpha
chr9_+_10846596 0.00 ENSRNOT00000075386
dipeptidyl peptidase 9
chr1_-_220480132 0.00 ENSRNOT00000027421
cornichon family AMPA receptor auxiliary protein 2
chr20_-_4698718 0.00 ENSRNOT00000047527
RT1 class I, locus CE7
chr9_+_66716969 0.00 ENSRNOT00000031261
family with sequence similarity 117, member B
chr1_+_214317682 0.00 ENSRNOT00000032904
transmembrane protein 80
chr2_-_43999107 0.00 ENSRNOT00000065473
mitogen-activated protein kinase kinase kinase 1-like
chr8_+_50310405 0.00 ENSRNOT00000073507
SIK family kinase 3
chr17_+_36334589 0.00 ENSRNOT00000081368
E2F transcription factor 3
chr3_+_11317183 0.00 ENSRNOT00000091171
ENSRNOT00000016341
golgin A2
chr7_-_139394166 0.00 ENSRNOT00000082429
vitamin D (1,25- dihydroxyvitamin D3) receptor
chr1_+_79911516 0.00 ENSRNOT00000019075
interferon regulatory factor 2 binding protein 1
chr2_+_95320283 0.00 ENSRNOT00000015537
hes-related family bHLH transcription factor with YRPW motif 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2d

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0051944 glial cell-derived neurotrophic factor secretion(GO:0044467) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) negative regulation of dopamine receptor signaling pathway(GO:0060160) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.0 GO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994)
0.0 0.1 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
0.0 0.1 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.0 0.0 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 0.1 GO:1904925 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.0 GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)