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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Tfap2a
Z-value: 1.46
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Transcription factors associated with Tfap2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap2a | rn6_v1_chr17_+_24654902_24654902 | -0.07 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_169288871 Show fit | 0.51 |
ENSRNOT00000055466
|
TNF receptor superfamily member 25 |
|
| chr7_+_27174882 Show fit | 0.50 |
ENSRNOT00000051181
|
glycosyltransferase 8 domain containing 2 |
|
| chr3_+_175426752 Show fit | 0.50 |
ENSRNOT00000085718
|
SS18L1, nBAF chromatin remodeling complex subunit |
|
| chr1_+_266143818 Show fit | 0.46 |
ENSRNOT00000026987
|
SUFU negative regulator of hedgehog signaling |
|
| chr6_-_65319527 Show fit | 0.45 |
ENSRNOT00000005618
|
syntaxin binding protein 6 |
|
| chr1_-_65681440 Show fit | 0.42 |
ENSRNOT00000026305
|
zinc finger protein 128 |
|
| chr1_-_166912524 Show fit | 0.41 |
ENSRNOT00000092952
|
inositol polyphosphate phosphatase-like 1 |
|
| chr14_-_42221225 Show fit | 0.40 |
ENSRNOT00000036103
|
shisa family member 3 |
|
| chr8_+_127144903 Show fit | 0.39 |
ENSRNOT00000013530
|
eomesodermin |
|
| chr14_+_81819799 Show fit | 0.38 |
ENSRNOT00000076840
|
Max dimerization protein 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfap2a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.1 | 0.5 | GO:1904717 | regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.1 | 0.5 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
| 0.1 | 0.4 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.1 | 0.4 | GO:0061525 | hindgut development(GO:0061525) |
| 0.0 | 0.4 | GO:0032494 | response to peptidoglycan(GO:0032494) |
| 0.0 | 0.4 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.0 | 0.4 | GO:0001714 | endodermal cell fate specification(GO:0001714) |
| 0.0 | 0.4 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.0 | 0.4 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.5 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.4 | GO:0097598 | sperm cytoplasmic droplet(GO:0097598) |
| 0.1 | 0.4 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.0 | 0.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 0.3 | GO:0033557 | Slx1-Slx4 complex(GO:0033557) |
| 0.1 | 0.3 | GO:0044214 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.0 | 0.3 | GO:0034464 | BBSome(GO:0034464) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) |
| 0.0 | 0.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.5 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.5 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 0.4 | GO:0030626 | U12 snRNA binding(GO:0030626) |
| 0.1 | 0.4 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.1 | 0.4 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 0.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.4 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.4 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.5 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.4 | REACTOME PI METABOLISM | Genes involved in PI Metabolism |
| 0.0 | 0.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.4 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.3 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.3 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 0.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |