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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Tcf3

Z-value: 0.34

Motif logo

Transcription factors associated with Tcf3

Gene Symbol Gene ID Gene Info
ENSRNOG00000051499 transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tcf3rn6_v1_chr7_+_12146642_121466420.513.8e-01Click!

Activity profile of Tcf3 motif

Sorted Z-values of Tcf3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_9037942 0.25 ENSRNOT00000036770
immediate early response 5-like
chr8_-_115167486 0.18 ENSRNOT00000033018
G protein-coupled receptor 62
chr1_+_282134981 0.17 ENSRNOT00000036203
nanos C2HC-type zinc finger 1
chr3_-_147865393 0.17 ENSRNOT00000009852
SRY box 12
chr10_-_38838272 0.13 ENSRNOT00000089495
sosondowah ankyrin repeat domain family member A
chr6_-_11494459 0.12 ENSRNOT00000021570
potassium two pore domain channel subfamily K member 12
chr12_+_47193964 0.12 ENSRNOT00000001552
ENSRNOT00000039281
calcium binding protein 1
chr2_+_210381829 0.11 ENSRNOT00000024611
ALX homeobox 3
chr3_+_175144495 0.10 ENSRNOT00000082601
ENSRNOT00000088026
cadherin 4
chr17_-_13393243 0.10 ENSRNOT00000018252
growth arrest and DNA-damage-inducible, gamma
chr19_-_43911057 0.10 ENSRNOT00000026017
chymotrypsinogen B1
chr10_-_15166457 0.10 ENSRNOT00000026676
meteorin, glial cell differentiation regulator
chr9_-_82699551 0.10 ENSRNOT00000020673
obscurin-like 1
chr1_-_277768368 0.09 ENSRNOT00000023113
actin filament associated protein 1-like 2
chrX_-_111942749 0.09 ENSRNOT00000087583

chr10_-_57243435 0.09 ENSRNOT00000005050
cholinergic receptor nicotinic epsilon subunit
chr16_-_19918644 0.08 ENSRNOT00000083345
ENSRNOT00000023926
plasmalemma vesicle associated protein
chr10_-_108196217 0.08 ENSRNOT00000075440
chromobox 4
chr15_+_37806836 0.08 ENSRNOT00000076285
interleukin 17D
chr9_+_14529218 0.08 ENSRNOT00000016893
apolipoprotein B mRNA editing enzyme catalytic subunit 2
chr18_+_32594958 0.08 ENSRNOT00000018511
sprouty RTK signaling antagonist 4
chr5_-_79874671 0.08 ENSRNOT00000084563
tenascin C
chr10_-_90312386 0.08 ENSRNOT00000028445
solute carrier family 4 member 1
chr4_-_147163467 0.07 ENSRNOT00000010748
tissue inhibitor of metalloproteinase 4
chr16_-_14300951 0.07 ENSRNOT00000017038
retinal G protein coupled receptor
chr2_+_198390166 0.07 ENSRNOT00000081042
histone cluster 2, H3c2
chr4_-_160605107 0.07 ENSRNOT00000090725
tetraspanin 9
chrX_-_159841072 0.07 ENSRNOT00000001158
Rac/Cdc42 guanine nucleotide exchange factor 6
chr2_-_210782746 0.07 ENSRNOT00000025939
ENSRNOT00000081501
glutathione S-transferase, mu 7
chr17_-_44793927 0.07 ENSRNOT00000086309
histone cluster 1 H2B family member o
chr10_-_18063391 0.07 ENSRNOT00000072297
fibroblast growth factor 18
chr13_+_52662996 0.07 ENSRNOT00000047682
troponin T2, cardiac type
chr1_+_220353356 0.07 ENSRNOT00000080189
CD248 molecule
chr4_-_100099517 0.07 ENSRNOT00000014277
atonal bHLH transcription factor 8
chr1_+_238222521 0.07 ENSRNOT00000024000
aldehyde dehydrogenase 1 family, member A1
chr13_-_91020112 0.06 ENSRNOT00000030449
dual specificity phosphatase 23
chr20_+_13732198 0.06 ENSRNOT00000008608
macrophage migration inhibitory factor
chr3_+_13838304 0.06 ENSRNOT00000025067
heat shock protein family A member 5
chr1_+_222310920 0.06 ENSRNOT00000091465
MACRO domain containing 1
chr8_-_22874637 0.06 ENSRNOT00000064551
ENSRNOT00000090424
dedicator of cytokinesis 6
chr2_-_118745766 0.06 ENSRNOT00000013858
zinc finger, matrin type 3
chr1_+_220362064 0.05 ENSRNOT00000074361
endosialin
chr8_-_108261021 0.05 ENSRNOT00000040710
40S ribosomal protein S25-like
chr15_+_4554603 0.05 ENSRNOT00000075153
potassium two pore domain channel subfamily K member 5
chr5_-_48436531 0.05 ENSRNOT00000060914
peptidase M20 domain containing 2
chr15_+_33600337 0.05 ENSRNOT00000075965
CKLF-like MARVEL transmembrane domain containing 5
chr17_+_8299131 0.05 ENSRNOT00000083687
predicted gene 45623
chr5_+_156215417 0.05 ENSRNOT00000067616
ENSRNOT00000077742
endothelin converting enzyme 1
chr4_+_84854386 0.05 ENSRNOT00000013620
maturin, neural progenitor differentiation regulator homolog
chr17_+_44758460 0.05 ENSRNOT00000089436
histone cluster 1, H2an
chr17_-_43627629 0.05 ENSRNOT00000022965
histone cluster 1, H2af
chr7_+_72924799 0.05 ENSRNOT00000008969
lysosomal protein transmembrane 4 beta
chr5_+_63781801 0.05 ENSRNOT00000008302
nuclear receptor subfamily 4, group A, member 3
chr17_+_9639330 0.05 ENSRNOT00000018232
docking protein 3
chr2_-_174413236 0.05 ENSRNOT00000064588
golgi integral membrane protein 4
chr1_-_215846911 0.05 ENSRNOT00000089171
insulin-like growth factor 2
chr16_-_71319449 0.05 ENSRNOT00000029284
Fibroblast growth factor receptor 1
chr6_-_125723732 0.05 ENSRNOT00000084815
fibulin 5
chr1_-_219544328 0.05 ENSRNOT00000025847
G protein-coupled receptor kinase 2
chr18_+_25163561 0.05 ENSRNOT00000042287
ENSRNOT00000049898
ENSRNOT00000017573
bridging integrator 1
chr1_+_224938801 0.05 ENSRNOT00000073052
RIKEN cDNA 1700092M07 gene
chr7_-_140580783 0.05 ENSRNOT00000087327
desert hedgehog
chr1_-_15301998 0.05 ENSRNOT00000016400
solute carrier family 35, member D3
chr16_-_71319052 0.05 ENSRNOT00000050980
Fibroblast growth factor receptor 1
chr5_-_109651730 0.04 ENSRNOT00000093032
ELAV like RNA binding protein 2
chr12_-_38995570 0.04 ENSRNOT00000001806
ORAI calcium release-activated calcium modulator 1
chr2_+_198417619 0.04 ENSRNOT00000085945
histone cluster 2, H3c2
chr9_+_49479023 0.04 ENSRNOT00000050922
ENSRNOT00000077111
POU class 3 homeobox 3
chr5_+_21830882 0.04 ENSRNOT00000008901
chromodomain helicase DNA binding protein 7
chr14_+_12218553 0.04 ENSRNOT00000003237
protein kinase, cGMP-dependent, type II
chr1_+_220446425 0.04 ENSRNOT00000027339
endosialin-like
chr5_+_151776004 0.04 ENSRNOT00000009683
nuclear receptor subfamily 0, group B, member 2
chr3_-_80933283 0.04 ENSRNOT00000007771
cAMP responsive element binding protein 3-like 1
chr20_-_29511382 0.04 ENSRNOT00000085026
DNA-damage-inducible transcript 4
chr15_+_33600102 0.04 ENSRNOT00000022664
CKLF-like MARVEL transmembrane domain containing 5
chr4_-_77489535 0.04 ENSRNOT00000008728
protein disulfide isomerase family A, member 4
chr1_-_43884267 0.04 ENSRNOT00000024418
Cnksr family member 3
chr1_+_86938138 0.04 ENSRNOT00000075601
coiled-coil glutamate-rich protein 2
chr12_+_24761210 0.04 ENSRNOT00000002003
claudin 4
chr5_+_151436464 0.04 ENSRNOT00000012463
mitogen-activated protein kinase kinase kinase 6
chr1_-_220265772 0.04 ENSRNOT00000027119
neuronal PAS domain protein 4
chr10_+_85301875 0.04 ENSRNOT00000080935
suppressor of cytokine signaling 7
chr15_-_37383277 0.04 ENSRNOT00000011711
gap junction protein, beta 2
chr1_+_221644867 0.04 ENSRNOT00000054830
EH-domain containing 1
chr1_+_80321585 0.04 ENSRNOT00000022895
creatine kinase, M-type
chr4_+_94696965 0.04 ENSRNOT00000064696
glutamate ionotropic receptor delta type subunit 2
chrX_+_82143789 0.04 ENSRNOT00000003724
POU class 3 homeobox 4
chr19_+_54060622 0.04 ENSRNOT00000023607
Gse1 coiled-coil protein
chr5_-_144274981 0.04 ENSRNOT00000065871
MAP7 domain containing 1
chr2_-_172361779 0.04 ENSRNOT00000085876
schwannomin interacting protein 1
chr11_+_45888221 0.04 ENSRNOT00000071932
ENSRNOT00000066008
ENSRNOT00000060802
leukemia NUP98 fusion partner 1
chr9_+_10339075 0.03 ENSRNOT00000073402
vimentin-type intermediate filament associated coiled-coil protein
chr10_+_86860685 0.03 ENSRNOT00000084644
retinoic acid receptor, alpha
chr11_+_46009322 0.03 ENSRNOT00000002233
transmembrane protein 45A
chr5_-_59025631 0.03 ENSRNOT00000049000
ENSRNOT00000022801
tropomyosin 2, beta
chr6_+_6427657 0.03 ENSRNOT00000005664
protein kinase domain containing, cytoplasmic
chrX_+_105239840 0.03 ENSRNOT00000039864
dystrophin related protein 2
chr6_-_125723944 0.03 ENSRNOT00000007004
fibulin 5
chr1_+_171592797 0.03 ENSRNOT00000026607
synaptotagmin 9
chr6_+_98284170 0.03 ENSRNOT00000031979
ras homolog family member J
chr1_-_265298797 0.03 ENSRNOT00000023137
DNA polymerase lambda
chr15_+_2374582 0.03 ENSRNOT00000019644
zinc finger protein 503
chr18_-_14016713 0.03 ENSRNOT00000041125
nucleolar protein 4
chr10_-_89374516 0.03 ENSRNOT00000028084
vesicle amine transport 1
chr2_-_257376756 0.03 ENSRNOT00000065811
GIPC PDZ domain containing family, member 2
chr4_+_88328061 0.03 ENSRNOT00000084775
vomeronasal 1 receptor 87
chr13_-_89606326 0.03 ENSRNOT00000029179
Fc fragment of IgE receptor Ig
chr1_+_85213652 0.03 ENSRNOT00000092044
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr10_-_82197848 0.03 ENSRNOT00000081307
calcium voltage-gated channel subunit alpha1 G
chr1_+_82151669 0.03 ENSRNOT00000091357
capicua transcriptional repressor
chr5_+_154522119 0.03 ENSRNOT00000072618
E2F transcription factor 2
chr6_+_58467254 0.03 ENSRNOT00000065396
ets variant 1
chr7_+_130532435 0.03 ENSRNOT00000092672
ENSRNOT00000092535
SH3 and multiple ankyrin repeat domains 3
chr9_+_111028824 0.03 ENSRNOT00000041418
ENSRNOT00000056457
peptidylglycine alpha-amidating monooxygenase
chr12_+_22165486 0.03 ENSRNOT00000001890
motile sperm domain containing 3
chr13_-_111581018 0.03 ENSRNOT00000083072
ENSRNOT00000077981
SERTA domain containing 4
chr12_-_12025549 0.03 ENSRNOT00000001331
neuronal pentraxin 2
chr4_-_116278615 0.03 ENSRNOT00000020505
cytochrome P450, family 26, subfamily b, polypeptide 1
chr10_-_4910305 0.03 ENSRNOT00000033122
RecQ mediated genome instability 2
chr1_+_220416018 0.03 ENSRNOT00000027233
beta-1,4-glucuronyltransferase 1
chr6_-_104290579 0.03 ENSRNOT00000066014
enhancer of rudimentary homolog (Drosophila)
chr7_-_3342491 0.03 ENSRNOT00000081756
retinol dehydrogenase 5
chr10_+_106812739 0.03 ENSRNOT00000074225
synaptogyrin 2
chr13_-_48284408 0.03 ENSRNOT00000085967
SLIT-ROBO Rho GTPase activating protein 2
chr13_+_95589668 0.03 ENSRNOT00000005849
zinc finger protein 238
chr8_+_111495331 0.03 ENSRNOT00000091275
ENSRNOT00000012162
solute carrier organic anion transporter family, member 2a1
chr7_-_3315856 0.03 ENSRNOT00000010035
growth differentiation factor 11
chr14_-_8548310 0.02 ENSRNOT00000092436
Rho GTPase activating protein 24
chr17_-_43807540 0.02 ENSRNOT00000074763
similar to CG31613-PA
chr8_-_119012671 0.02 ENSRNOT00000028435
parathyroid hormone 1 receptor
chr6_-_102196138 0.02 ENSRNOT00000014132
transmembrane protein 229B
chr9_-_18371856 0.02 ENSRNOT00000027293
SPT3 homolog, SAGA and STAGA complex component
chr4_-_157263890 0.02 ENSRNOT00000065416
protein tyrosine phosphatase, non-receptor type 6
chr3_-_138116664 0.02 ENSRNOT00000055602
ribosome binding protein 1
chr11_+_82194657 0.02 ENSRNOT00000002445
ets variant 5
chr6_+_35314444 0.02 ENSRNOT00000005666
odd-skipped related transciption factor 1
chr3_+_11207542 0.02 ENSRNOT00000013546
proline-rich coiled-coil 2B
chr3_-_2534375 0.02 ENSRNOT00000037725
glutamate ionotropic receptor NMDA type subunit 1
chr5_-_113532878 0.02 ENSRNOT00000010173
caspase activity and apoptosis inhibitor 1
chr14_+_13192347 0.02 ENSRNOT00000000092
anthrax toxin receptor 2
chr19_-_26053762 0.02 ENSRNOT00000004646
microtubule associated serine/threonine kinase 1
chr15_+_23792931 0.02 ENSRNOT00000092091
sterile alpha motif domain containing 4A
chr12_-_25638797 0.02 ENSRNOT00000002033
GATS protein-like 2
chr1_+_170471238 0.02 ENSRNOT00000076961
ENSRNOT00000075597
ENSRNOT00000076631
ENSRNOT00000076783
translocase of inner mitochondrial membrane 10B
dynein heavy chain domain 1
chr1_-_166912524 0.02 ENSRNOT00000092952
inositol polyphosphate phosphatase-like 1
chr1_-_174350196 0.02 ENSRNOT00000055158
similar to predicted gene ICRFP703B1614Q5.5
chr9_+_84689150 0.02 ENSRNOT00000072242
potassium voltage-gated channel subfamily E regulatory subunit 4
chr12_-_36398206 0.02 ENSRNOT00000090944
ENSRNOT00000058492
transmembrane protein 132B
chr7_-_77372398 0.02 ENSRNOT00000079644
ENSRNOT00000007999
antizyme inhibitor 1
chr10_+_89339029 0.02 ENSRNOT00000031208
RUN domain containing 1
chr1_+_157646173 0.02 ENSRNOT00000013851
RAB30, member RAS oncogene family
chr9_+_82556573 0.02 ENSRNOT00000026860
desmin
chr7_+_70980422 0.02 ENSRNOT00000077912
retinol dehydrogenase 16 (all-trans)
chr1_+_101214593 0.02 ENSRNOT00000028086
TEA domain transcription factor 2
chr7_+_120153184 0.02 ENSRNOT00000013538
galectin 1
chr11_+_46714355 0.02 ENSRNOT00000073404
transmembrane protein 45A-like
chr12_+_22641104 0.02 ENSRNOT00000001916
serpin family E member 1
chr4_+_96831880 0.02 ENSRNOT00000068400
RSA-14-44 protein
chr10_+_54126486 0.02 ENSRNOT00000078820
growth arrest specific 7
chr4_-_159697207 0.02 ENSRNOT00000086440
cyclin D2
chr18_+_60392376 0.02 ENSRNOT00000023890
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr4_+_129574264 0.02 ENSRNOT00000010185
ADP-ribosylation factor like GTPase 6 interacting protein 5
chr10_+_109446444 0.02 ENSRNOT00000066736
BAH domain and coiled-coil containing 1
chrX_+_80213332 0.02 ENSRNOT00000042827
SH3 domain binding glutamate-rich protein like
chr8_-_116993193 0.02 ENSRNOT00000026327
dystroglycan 1
chr10_-_40122915 0.02 ENSRNOT00000063891
CDC42 small effector 2
chr1_-_101054851 0.02 ENSRNOT00000027849
proline rich and Gla domain 2
chr5_-_88612626 0.02 ENSRNOT00000089560
transducin like enhancer of split 1
chr17_-_9565249 0.02 ENSRNOT00000036140
transmembrane p24 trafficking protein 9
chr1_+_13595295 0.02 ENSRNOT00000079250
NHS-like 1
chr7_-_126461658 0.02 ENSRNOT00000081032
wingless-type MMTV integration site family, member 7B
chr16_-_59721227 0.02 ENSRNOT00000015166
PEAK1 related kinase activating pseudokinase 1
chr9_-_82419288 0.02 ENSRNOT00000004797
tubulin, alpha 4A
chr11_-_65209268 0.02 ENSRNOT00000077612
glycogen synthase kinase 3 beta
chr3_+_5624506 0.02 ENSRNOT00000036995
ADAMTS-like 2
chr2_-_186245163 0.02 ENSRNOT00000089339
doublecortin-like kinase 2
chr19_-_56772904 0.02 ENSRNOT00000024232
ATP binding cassette subfamily B member 10
chr1_+_198214797 0.02 ENSRNOT00000068543
T-box 6
chr10_-_15928169 0.02 ENSRNOT00000028069
neuron specific gene family member 2
chr2_-_143104412 0.02 ENSRNOT00000058116
ubiquitin-fold modifier 1
chr14_-_86395120 0.02 ENSRNOT00000006802
ENSRNOT00000078572
transmembrane p24 trafficking protein 4
chr1_+_15412603 0.02 ENSRNOT00000051496
ENSRNOT00000067070
mitogen-activated protein kinase kinase kinase 5
chr11_-_90406797 0.02 ENSRNOT00000073049
snail family transcriptional repressor 2
chr4_-_7252950 0.02 ENSRNOT00000084777
ENSRNOT00000087120
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr1_-_89007041 0.02 ENSRNOT00000032363
proline and serine rich 3
chr18_+_73256085 0.02 ENSRNOT00000080660
haloacid dehalogenase-like hydrolase domain containing 2
chr1_+_214317682 0.02 ENSRNOT00000032904
transmembrane protein 80
chr1_+_220322940 0.02 ENSRNOT00000074972
beta-1,4-glucuronyltransferase 1
chr1_+_277355619 0.02 ENSRNOT00000022788
NHL repeat containing 2
chr14_-_86739335 0.01 ENSRNOT00000078282
purine rich element binding protein B
chr4_+_8066907 0.01 ENSRNOT00000080811
SRSF protein kinase 2
chr1_-_214971929 0.01 ENSRNOT00000027195
MOB kinase activator 2
chr14_+_66598259 0.01 ENSRNOT00000049743
potassium voltage-gated channel interacting protein 4
chr3_-_172537877 0.01 ENSRNOT00000072069
cathepsin Z
chr1_-_277355075 0.01 ENSRNOT00000036321
DNA cross-link repair 1A
chr5_+_48313599 0.01 ENSRNOT00000081825
gamma-aminobutyric acid type A receptor rho 2 subunit
chr9_+_9961021 0.01 ENSRNOT00000075767
tubulin, beta 4A class IVa
chr10_+_74959285 0.01 ENSRNOT00000010296
ring finger protein 43
chr7_-_130101858 0.01 ENSRNOT00000007954
tubulin, gamma complex associated protein 6
chr9_+_82053581 0.01 ENSRNOT00000086375
wingless-type MMTV integration site family, member 10A

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0098749 cerebellar neuron development(GO:0098749)
0.0 0.2 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.0 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.1 GO:0016554 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine to uridine editing(GO:0016554) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:0032763 regulation of mast cell cytokine production(GO:0032763)
0.0 0.1 GO:0071799 bud outgrowth involved in lung branching(GO:0060447) response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.1 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 0.1 GO:0010813 neuropeptide catabolic process(GO:0010813)
0.0 0.0 GO:0060988 lipid tube assembly(GO:0060988)
0.0 0.1 GO:0010037 response to carbon dioxide(GO:0010037)
0.0 0.0 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.0 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.0 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.0 0.0 GO:0072218 ascending thin limb development(GO:0072021) metanephric ascending thin limb development(GO:0072218)
0.0 0.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.0 GO:1903334 positive regulation of protein folding(GO:1903334)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:1990393 3M complex(GO:1990393)
0.0 0.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0045098 type III intermediate filament(GO:0045098)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.1 REACTOME OPSINS Genes involved in Opsins