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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Tcf21_Msc

Z-value: 0.93

Motif logo

Transcription factors associated with Tcf21_Msc

Gene Symbol Gene ID Gene Info
ENSRNOG00000016700 transcription factor 21
ENSRNOG00000007540 musculin

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tcf21rn6_v1_chr1_+_23906717_23906717-0.721.7e-01Click!
Mscrn6_v1_chr5_+_3955227_3955227-0.395.2e-01Click!

Activity profile of Tcf21_Msc motif

Sorted Z-values of Tcf21_Msc motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_9226125 0.56 ENSRNOT00000088047
WD repeat and FYVE domain containing 3
chr10_-_64642292 0.53 ENSRNOT00000084670
active BCR-related
chr14_-_92077088 0.48 ENSRNOT00000085175
growth factor receptor bound protein 10
chr5_+_90800082 0.45 ENSRNOT00000093696
ENSRNOT00000093206
lysine demethylase 4C
chr10_+_85301875 0.42 ENSRNOT00000080935
suppressor of cytokine signaling 7
chr10_+_71278650 0.40 ENSRNOT00000092020
synergin, gamma
chr11_+_38035450 0.40 ENSRNOT00000083067
MX dynamin like GTPase 2
chr1_+_213583606 0.39 ENSRNOT00000088899

chr1_+_278557792 0.39 ENSRNOT00000023414
attractin like 1
chr6_-_138401621 0.36 ENSRNOT00000043210
integral membrane protein DGCR2/IDD-like
chr1_-_166912524 0.36 ENSRNOT00000092952
inositol polyphosphate phosphatase-like 1
chr2_-_178521038 0.35 ENSRNOT00000033107
relaxin/insulin-like family peptide receptor 1
chr17_-_51912496 0.32 ENSRNOT00000019272
inhibin beta A subunit
chr5_-_168734296 0.32 ENSRNOT00000066120
calmodulin binding transcription activator 1
chr2_+_196594303 0.31 ENSRNOT00000064442
ENSRNOT00000044738
aryl hydrocarbon receptor nuclear translocator
chr17_-_10208360 0.31 ENSRNOT00000087397
unc-5 netrin receptor A
chr20_+_3351303 0.30 ENSRNOT00000080419
ENSRNOT00000001065
ENSRNOT00000086503
alpha tubulin acetyltransferase 1
chr3_+_72329967 0.30 ENSRNOT00000090256
solute carrier family 43, member 3
chr9_+_94425252 0.28 ENSRNOT00000064965
ENSRNOT00000076099
GRB10 interacting GYF protein 2
chr1_-_199439210 0.27 ENSRNOT00000026699
PYD and CARD domain containing
chr13_+_50196042 0.27 ENSRNOT00000090858
zinc finger CCCH-type containing 11A
chr5_+_167141875 0.27 ENSRNOT00000089314
solute carrier family 2 member 5
chr7_-_145450233 0.25 ENSRNOT00000092974
ENSRNOT00000021523
calcium binding and coiled coil domain 1
chr11_-_90406797 0.25 ENSRNOT00000073049
snail family transcriptional repressor 2
chr12_-_25638797 0.25 ENSRNOT00000002033
GATS protein-like 2
chr1_-_212622537 0.25 ENSRNOT00000025609
shadow of prion protein homolog (zebrafish)
chr18_-_55891710 0.25 ENSRNOT00000064686
synaptopodin
chrX_-_26376467 0.25 ENSRNOT00000051655
ENSRNOT00000036502
Rho GTPase activating protein 6
chr6_+_26537707 0.24 ENSRNOT00000050102
zinc finger protein 513
chrX_-_39956841 0.24 ENSRNOT00000050708
kelch-like family member 34
chr4_+_157538303 0.24 ENSRNOT00000086418
zinc finger protein 384
chr12_-_47987255 0.23 ENSRNOT00000074000
ubiquitin protein ligase E3B
chr5_-_154363329 0.23 ENSRNOT00000064596
elongin A
chr9_-_80166807 0.23 ENSRNOT00000079493
insulin-like growth factor binding protein 5
chr1_-_167911961 0.23 ENSRNOT00000025097
olfactory receptor 59
chr4_+_157126935 0.23 ENSRNOT00000056051
complement C1r
chr1_+_192233910 0.23 ENSRNOT00000016418
ENSRNOT00000016442
protein kinase C, beta
chr3_-_112876773 0.22 ENSRNOT00000015086
ubiquitin protein ligase E3 component n-recognin 1
chr20_+_14101659 0.22 ENSRNOT00000072696
guanylyl cyclase domain containing 1
chr8_+_116343096 0.22 ENSRNOT00000022092
interferon-related developmental regulator 2
chr4_-_145147397 0.22 ENSRNOT00000010347
lipoma HMGIC fusion partner-like 4
chr2_-_261402880 0.21 ENSRNOT00000052396
ENSRNOT00000077839
ENSRNOT00000088561
fucose-1-phosphate guanylyltransferase
chr8_+_53295222 0.21 ENSRNOT00000009724
ENSRNOT00000067420
ubiquitin specific peptidase 28
chr11_+_38035611 0.21 ENSRNOT00000087603
ENSRNOT00000002695
MX dynamin like GTPase 2
chr9_+_111028824 0.21 ENSRNOT00000041418
ENSRNOT00000056457
peptidylglycine alpha-amidating monooxygenase
chr7_-_130128589 0.21 ENSRNOT00000079777
ENSRNOT00000009325
mitogen-activated protein kinase 11
chr7_+_73588163 0.21 ENSRNOT00000015707
potassium voltage-gated channel, modifier subfamily S, member 2
chr10_+_75055020 0.21 ENSRNOT00000010755
TSPO associated protein 1
chr12_+_660011 0.21 ENSRNOT00000040830
PDS5 cohesin associated factor B
chr1_-_215846911 0.20 ENSRNOT00000089171
insulin-like growth factor 2
chr14_-_78377825 0.20 ENSRNOT00000068104

chr19_-_34752695 0.20 ENSRNOT00000052018
nuclear receptor subfamily 3, group C, member 2
chr5_+_5616483 0.19 ENSRNOT00000011026
nuclear receptor coactivator 2
chr5_+_122390522 0.19 ENSRNOT00000064567
SH3-domain GRB2-like (endophilin) interacting protein 1
chr20_+_3827367 0.19 ENSRNOT00000079967
retinoid X receptor beta
chr11_+_84745904 0.19 ENSRNOT00000002617
kelch-like family member 6
chr14_-_114649173 0.19 ENSRNOT00000083528
spectrin, beta, non-erythrocytic 1
chr7_-_142300382 0.19 ENSRNOT00000048262
bridging integrator 2
chr7_+_12146642 0.19 ENSRNOT00000085899
transcription factor 3
chr8_+_62925357 0.18 ENSRNOT00000011074
ENSRNOT00000090588
stimulated by retinoic acid 6
chr12_+_36734372 0.18 ENSRNOT00000001301
scavenger receptor class B, member 1
chr11_-_82664554 0.18 ENSRNOT00000002425
ENSRNOT00000087105
Sumo1/sentrin/SMT3 specific peptidase 2
chr14_+_12218553 0.17 ENSRNOT00000003237
protein kinase, cGMP-dependent, type II
chr17_-_78910671 0.17 ENSRNOT00000064609
acyl-CoA binding domain containing 7
chr5_-_153790157 0.17 ENSRNOT00000025051
RCAN family member 3
chr5_+_63781801 0.17 ENSRNOT00000008302
nuclear receptor subfamily 4, group A, member 3
chr18_+_56180089 0.17 ENSRNOT00000030966
arylsulfatase family, member I
chr11_-_43022565 0.16 ENSRNOT00000002285
ribosomal oxygenase 2
chr2_+_243840134 0.16 ENSRNOT00000093355
eukaryotic translation initiation factor 4E
chr10_-_51669297 0.16 ENSRNOT00000071595
Rho GTPase activating protein 44
chr14_-_84106997 0.16 ENSRNOT00000065501
oxysterol binding protein 2
chr1_-_191651628 0.16 ENSRNOT00000055048
ubiquitin specific peptidase 31
chr2_-_88135410 0.16 ENSRNOT00000014180
carbonic anhydrase 3
chr12_-_37185548 0.16 ENSRNOT00000001338
uncharacterized LOC102556092
chr7_-_117712213 0.16 ENSRNOT00000092930
cysteine and histidine rich 1
chr1_+_266380973 0.15 ENSRNOT00000080509
WW domain binding protein 1-like
chr3_-_61494778 0.15 ENSRNOT00000068018
lunapark, ER junction formation factor
chr2_-_118989127 0.15 ENSRNOT00000014871
G protein subunit beta 4
chr5_-_137014375 0.15 ENSRNOT00000066165
ENSRNOT00000091866
lysine demethylase 4A
chr5_+_145138697 0.15 ENSRNOT00000019135
zinc finger MYM-type containing 6
chr7_-_11777503 0.14 ENSRNOT00000026220
anti-Mullerian hormone
chr6_-_127248372 0.14 ENSRNOT00000085517
ankyrin repeat and SOCS box-containing 2
chr5_-_158439078 0.14 ENSRNOT00000025517
kelch domain containing 7A
chr4_+_21872856 0.14 ENSRNOT00000044810
cyclin D binding myb-like transcription factor 1
chr1_-_277768368 0.14 ENSRNOT00000023113
actin filament associated protein 1-like 2
chr13_+_50434702 0.14 ENSRNOT00000032244
SRY box 13
chr1_+_13595295 0.14 ENSRNOT00000079250
NHS-like 1
chr5_-_58469399 0.14 ENSRNOT00000013213
phosphatidylinositol glycan anchor biosynthesis, class O
chr8_+_58120179 0.14 ENSRNOT00000049076
ENSRNOT00000090114
nuclear protein, co-activator of histone transcription
chr3_-_7422738 0.14 ENSRNOT00000088339
general transcription factor IIIC subunit 4
chr2_-_45518502 0.14 ENSRNOT00000014627
heat shock protein family B (small) member 3
chr20_+_28572242 0.14 ENSRNOT00000072485
SH3 domain containing ring finger 3
chr3_+_172856733 0.14 ENSRNOT00000009826
endothelin 3
chr9_-_65307995 0.13 ENSRNOT00000030934
CDC-like kinase 1
chr19_+_45938915 0.13 ENSRNOT00000065508
MON1 homolog B, secretory trafficking associated
chr3_-_12007570 0.13 ENSRNOT00000060186
leucine rich repeat and sterile alpha motif containing 1
chr16_-_79973735 0.13 ENSRNOT00000057845
ENSRNOT00000086896
DLG associated protein 2
chr5_-_136965191 0.13 ENSRNOT00000056842
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
chr15_+_4554603 0.13 ENSRNOT00000075153
potassium two pore domain channel subfamily K member 5
chr8_+_68526093 0.13 ENSRNOT00000011385
alpha- and gamma-adaptin binding protein
chr3_-_110324084 0.13 ENSRNOT00000010381
Bcl2 modifying factor
chr1_-_278042312 0.13 ENSRNOT00000018693
actin-binding LIM protein 1
chr2_+_210381829 0.13 ENSRNOT00000024611
ALX homeobox 3
chr15_-_37383277 0.13 ENSRNOT00000011711
gap junction protein, beta 2
chr15_-_33725188 0.13 ENSRNOT00000083941
zinc finger homeobox 2
chr5_+_48274477 0.13 ENSRNOT00000075992
ENSRNOT00000041271
ubiquitin-conjugating enzyme E2, J1
chr16_-_14348046 0.13 ENSRNOT00000018630
cadherin-related family member 1
chr3_-_171286413 0.13 ENSRNOT00000008365
ENSRNOT00000081036
Z-DNA binding protein 1
chr8_-_58119623 0.13 ENSRNOT00000050555
ATM serine/threonine kinase
chr18_+_14471213 0.12 ENSRNOT00000045224
dystrobrevin, alpha
chr10_-_74679858 0.12 ENSRNOT00000003859
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr13_+_89805962 0.12 ENSRNOT00000074035
thiosulfate sulfurtransferase like domain containing 1
chr15_-_42898150 0.12 ENSRNOT00000030036
protein tyrosine kinase 2 beta
chr13_-_48284408 0.12 ENSRNOT00000085967
SLIT-ROBO Rho GTPase activating protein 2
chr15_-_106678918 0.12 ENSRNOT00000034723
serine/threonine kinase 24
chr4_+_25538497 0.12 ENSRNOT00000009264
cilia and flagella associated protein 69
chr12_-_22126350 0.12 ENSRNOT00000076328
Sin3A-associated protein 25
chr1_+_80321585 0.12 ENSRNOT00000022895
creatine kinase, M-type
chr15_-_55209342 0.12 ENSRNOT00000021752
RB transcriptional corepressor 1
chrX_+_71528988 0.12 ENSRNOT00000075963
O-linked N-acetylglucosamine (GlcNAc) transferase
chr3_+_110723481 0.12 ENSRNOT00000013878
bromo adjacent homology domain containing 1
chr12_+_48577905 0.12 ENSRNOT00000000888
selectin P ligand
chr18_+_44737154 0.12 ENSRNOT00000021972
TNF alpha induced protein 8
chr14_+_81488008 0.12 ENSRNOT00000018477
TNFAIP3 interacting protein 2
chr17_+_77195247 0.12 ENSRNOT00000081940
optineurin
chr8_-_116531784 0.12 ENSRNOT00000024529
RNA binding motif protein 5
chr10_+_62191656 0.11 ENSRNOT00000029866
SET and MYND domain containing 4
chr4_-_22425381 0.11 ENSRNOT00000011166
ENSRNOT00000037712
ATP binding cassette subfamily B member 1A
chr7_-_12275609 0.11 ENSRNOT00000086061
APC2, WNT signaling pathway regulator
chr17_+_9596957 0.11 ENSRNOT00000017349
family with sequence similarity 193, member B
chr6_+_79254339 0.11 ENSRNOT00000073970
somatostatin receptor 1
chr18_+_30387937 0.11 ENSRNOT00000027210
protocadherin beta 4
chr4_+_68011932 0.11 ENSRNOT00000073638
transmembrane protein 178B
chr4_+_168599331 0.11 ENSRNOT00000086719
cAMP responsive element binding protein-like 2
chr14_+_69800156 0.11 ENSRNOT00000072746
ligand dependent nuclear receptor corepressor-like
chr12_-_41993957 0.11 ENSRNOT00000001891
RNA binding motif protein 19
chr2_-_40386669 0.11 ENSRNOT00000014074
ELOVL fatty acid elongase 7
chr14_+_86652365 0.11 ENSRNOT00000077428
zinc finger, MIZ-type containing 2
chr19_+_755460 0.11 ENSRNOT00000076560
dynein, cytoplasmic 1 light intermediate chain 2
chr8_-_114013623 0.11 ENSRNOT00000018175
ATPase secretory pathway Ca2+ transporting 1
chr14_-_28856214 0.11 ENSRNOT00000044659
adhesion G protein-coupled receptor L3
chr7_-_140600818 0.11 ENSRNOT00000082375
limb development membrane protein 1-like
chr9_+_65331290 0.11 ENSRNOT00000058667
ENSRNOT00000018014
NGG1 interacting factor 3 like 1
chr14_-_45797887 0.11 ENSRNOT00000029209
TBC1 domain family member 1
chr9_+_47281961 0.11 ENSRNOT00000065234
solute carrier family 9 member A4
chr3_+_5555807 0.11 ENSRNOT00000007677
calcium channel flower domain containing 1
chr10_+_54156649 0.11 ENSRNOT00000074718
growth arrest specific 7
chr7_-_97977135 0.10 ENSRNOT00000008785
WDYHV motif containing 1
chr2_+_77868412 0.10 ENSRNOT00000065897
ENSRNOT00000014022
myosin X
chr2_+_197720259 0.10 ENSRNOT00000070919
golgi phosphoprotein 3-like
chr7_+_137155481 0.10 ENSRNOT00000089895
anoctamin 6
chr1_+_85112834 0.10 ENSRNOT00000026107
dual specificity tyrosine phosphorylation regulated kinase 1B
chr10_-_43512287 0.10 ENSRNOT00000036481
fatty acid hydroxylase domain containing 2
chr1_-_214971929 0.10 ENSRNOT00000027195
MOB kinase activator 2
chr12_-_22127021 0.10 ENSRNOT00000076261
Sin3A-associated protein 25
chr19_-_41433346 0.10 ENSRNOT00000022952
cap methyltransferase 2
chr18_+_27424328 0.10 ENSRNOT00000033784
kinesin family member 20A
chrX_+_156812064 0.10 ENSRNOT00000077142
host cell factor C1
chr1_+_80000165 0.10 ENSRNOT00000084912
SIX homeobox 5
chr4_+_110699557 0.10 ENSRNOT00000030588
ENSRNOT00000092261
leucine rich repeat transmembrane neuronal 4
chr4_-_159697207 0.10 ENSRNOT00000086440
cyclin D2
chr8_-_96132634 0.10 ENSRNOT00000041655
synaptotagmin binding, cytoplasmic RNA interacting protein
chr6_-_15191660 0.10 ENSRNOT00000092654
neurexin 1
chr13_+_50873605 0.10 ENSRNOT00000004382
fibromodulin
chr1_-_222272285 0.10 ENSRNOT00000028737
fermitin family member 3
chr2_-_210943620 0.10 ENSRNOT00000026750
G protein-coupled receptor 61
chr1_-_252808380 0.10 ENSRNOT00000025856
cholesterol 25-hydroxylase
chr20_+_3363737 0.10 ENSRNOT00000079654
alpha tubulin acetyltransferase 1
chr13_-_73558912 0.10 ENSRNOT00000093655
centrosomal protein 350
chr3_+_8547349 0.10 ENSRNOT00000079108
ENSRNOT00000091697
spectrin, alpha, non-erythrocytic 1
chr7_-_120882392 0.10 ENSRNOT00000056179
ENSRNOT00000056178
family with sequence similarity 227, member A
chr7_-_140580783 0.09 ENSRNOT00000087327
desert hedgehog
chr2_-_120316357 0.09 ENSRNOT00000065469
coiled-coil domain containing 39
chr18_+_17043903 0.09 ENSRNOT00000068139
formin homology 2 domain containing 3
chr3_+_7237192 0.09 ENSRNOT00000016904
tuberous sclerosis 1
chr3_-_110556808 0.09 ENSRNOT00000092158
ENSRNOT00000045362
similar to hypothetical protein
chr4_-_125929002 0.09 ENSRNOT00000083271
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr10_+_83231238 0.09 ENSRNOT00000077625
speckle type BTB/POZ protein
chr1_-_90956544 0.09 ENSRNOT00000051422
nesprin-4
chr1_+_124625985 0.09 ENSRNOT00000021068
OTU deubiquitinase 7A
chr1_+_104635989 0.09 ENSRNOT00000078477
neuron navigator 2
chr11_-_83926524 0.09 ENSRNOT00000041777
ENSRNOT00000040029
eukaryotic translation initiation factor 4 gamma, 1
chr17_+_27496353 0.09 ENSRNOT00000077994
ENSRNOT00000019040
ENSRNOT00000089736
signal sequence receptor subunit 1
chr1_+_220353356 0.09 ENSRNOT00000080189
CD248 molecule
chr14_+_85250042 0.09 ENSRNOT00000057407
adaptor-related protein complex 1, beta 1 subunit
chr4_+_127164453 0.09 ENSRNOT00000017889
kelch repeat and BTB domain containing 8
chr8_+_77107536 0.09 ENSRNOT00000083255
ADAM metallopeptidase domain 10
chr3_+_176818437 0.09 ENSRNOT00000087279
regulator of telomere elongation helicase 1
chr10_-_47724499 0.09 ENSRNOT00000085011
ring finger protein 112
chr16_-_19643236 0.09 ENSRNOT00000087597
zinc finger protein 709
chr4_-_67301102 0.09 ENSRNOT00000034549
DENN domain containing 2A
chr12_-_38504774 0.09 ENSRNOT00000011286
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr13_+_44812567 0.08 ENSRNOT00000005372
R3H domain containing 1
chr10_-_67285617 0.08 ENSRNOT00000019044
UTP6 small subunit processome component
chr9_-_10659357 0.08 ENSRNOT00000091450
lysine demethylase 4B
chr9_+_82571269 0.08 ENSRNOT00000026941
SPEG complex locus
chr2_+_185343883 0.08 ENSRNOT00000093640
SH3 domain containing 19
chr1_+_220362064 0.08 ENSRNOT00000074361
endosialin
chr15_-_62200837 0.08 ENSRNOT00000017599
protocadherin 8
chr3_-_64554953 0.08 ENSRNOT00000067452
serine/arginine repetitive matrix protein 1-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf21_Msc

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.1 0.4 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 0.6 GO:0035973 aggrephagy(GO:0035973)
0.1 0.4 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 0.3 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585)
0.1 0.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.3 GO:0060279 positive regulation of ovulation(GO:0060279)
0.1 0.2 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
0.1 0.7 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.1 0.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 0.5 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.1 0.6 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 0.2 GO:0019086 late viral transcription(GO:0019086)
0.1 0.2 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959)
0.1 0.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.2 GO:0046864 isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.1 0.2 GO:0032497 lipopolysaccharide transport(GO:0015920) detection of lipopolysaccharide(GO:0032497)
0.1 0.2 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.2 GO:0031179 peptide modification(GO:0031179)
0.1 0.3 GO:0015755 fructose transport(GO:0015755)
0.1 0.2 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 0.2 GO:0072434 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.0 0.4 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.1 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.2 GO:0071233 cellular response to leucine(GO:0071233)
0.0 0.2 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.1 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.0 0.1 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.0 0.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.2 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.0 0.1 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.1 GO:0006407 rRNA export from nucleus(GO:0006407)
0.0 0.2 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.2 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.2 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.1 GO:1905230 carbohydrate export(GO:0033231) daunorubicin transport(GO:0043215) response to borneol(GO:1905230) cellular response to borneol(GO:1905231) response to codeine(GO:1905233) response to quercetin(GO:1905235) drug transport across blood-brain barrier(GO:1990962) establishment of blood-retinal barrier(GO:1990963)
0.0 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.1 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0019046 viral latency(GO:0019042) release from viral latency(GO:0019046)
0.0 0.3 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0071283 cellular response to iron(III) ion(GO:0071283)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.1 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.1 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772) thiamine diphosphate metabolic process(GO:0042357) thiamine-containing compound metabolic process(GO:0042723)
0.0 0.1 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.0 0.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.0 0.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.0 GO:0034635 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.0 0.1 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.1 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 0.1 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
0.0 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.1 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.4 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0060383 regulation of DNA strand elongation(GO:0060382) positive regulation of DNA strand elongation(GO:0060383)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.0 GO:0072054 renal outer medulla development(GO:0072054)
0.0 0.1 GO:0023035 CD40 signaling pathway(GO:0023035)
0.0 0.1 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.0 0.1 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 0.1 GO:0060558 regulation of calcidiol 1-monooxygenase activity(GO:0060558)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.0 GO:1904404 traversing start control point of mitotic cell cycle(GO:0007089) response to formaldehyde(GO:1904404)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.3 GO:0061157 mRNA destabilization(GO:0061157)
0.0 0.1 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.2 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.1 GO:0046710 GDP metabolic process(GO:0046710)
0.0 0.3 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.0 GO:0048861 oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.1 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.1 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.0 0.0 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.0 0.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.0 GO:0006533 aspartate catabolic process(GO:0006533) D-amino acid metabolic process(GO:0046416)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.3 GO:0043511 inhibin complex(GO:0043511)
0.1 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.3 GO:0097444 spine apparatus(GO:0097444)
0.1 0.3 GO:0097169 NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
0.0 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.2 GO:0070449 elongin complex(GO:0070449)
0.0 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.1 GO:0031308 intrinsic component of nuclear outer membrane(GO:0031308) integral component of nuclear outer membrane(GO:0031309)
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.0 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.3 GO:0000346 transcription export complex(GO:0000346)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.3 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 0.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 0.2 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.2 GO:0016842 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) amidine-lyase activity(GO:0016842)
0.1 0.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.1 0.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.4 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.2 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.3 GO:0070061 fructose binding(GO:0070061)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.1 GO:0001155 TFIIIA-class transcription factor binding(GO:0001155)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.2 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.0 0.0 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.0 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.7 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.0 0.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.5 PID IGF1 PATHWAY IGF1 pathway
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.1 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane