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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Tcf21_Msc
Z-value: 0.93
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Transcription factors associated with Tcf21_Msc
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tcf21 | rn6_v1_chr1_+_23906717_23906717 | -0.72 | 1.7e-01 | Click! |
| Msc | rn6_v1_chr5_+_3955227_3955227 | -0.39 | 5.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_9226125 Show fit | 0.56 |
ENSRNOT00000088047
|
WD repeat and FYVE domain containing 3 |
|
| chr10_-_64642292 Show fit | 0.53 |
ENSRNOT00000084670
|
active BCR-related |
|
| chr14_-_92077088 Show fit | 0.48 |
ENSRNOT00000085175
|
growth factor receptor bound protein 10 |
|
| chr5_+_90800082 Show fit | 0.45 |
ENSRNOT00000093696
ENSRNOT00000093206 |
lysine demethylase 4C |
|
| chr10_+_85301875 Show fit | 0.42 |
ENSRNOT00000080935
|
suppressor of cytokine signaling 7 |
|
| chr10_+_71278650 Show fit | 0.40 |
ENSRNOT00000092020
|
synergin, gamma |
|
| chr11_+_38035450 Show fit | 0.40 |
ENSRNOT00000083067
|
MX dynamin like GTPase 2 |
|
| chr1_+_213583606 Show fit | 0.39 |
ENSRNOT00000088899
|
|
|
| chr1_+_278557792 Show fit | 0.39 |
ENSRNOT00000023414
|
attractin like 1 |
|
| chr6_-_138401621 Show fit | 0.36 |
ENSRNOT00000043210
|
integral membrane protein DGCR2/IDD-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tcf21_Msc
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.1 | 0.6 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.1 | 0.6 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.2 | 0.5 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.1 | 0.5 | GO:0045719 | negative regulation of glycogen biosynthetic process(GO:0045719) |
| 0.1 | 0.4 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.1 | 0.4 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.1 | 0.4 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.0 | 0.4 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.0 | 0.4 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 0.6 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.1 | 0.4 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 0.4 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 0.4 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.1 | 0.3 | GO:0043511 | inhibin complex(GO:0043511) |
| 0.1 | 0.3 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.1 | 0.3 | GO:0097169 | NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.3 | GO:0032437 | cuticular plate(GO:0032437) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 0.6 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.0 | 0.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 0.4 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.0 | 0.4 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.0 | 0.4 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) |
| 0.1 | 0.3 | GO:0004874 | aryl hydrocarbon receptor activity(GO:0004874) |
| 0.1 | 0.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 0.3 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 0.3 | GO:0005042 | netrin receptor activity(GO:0005042) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.5 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 0.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.3 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.2 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.1 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.3 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.3 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.3 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.3 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 0.3 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |