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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Tbx5
Z-value: 0.52
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Transcription factors associated with Tbx5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbx5 | rn6_v1_chr12_+_42097626_42097626 | 0.34 | 5.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_15274917 Show fit | 0.26 |
ENSRNOT00000019650
|
progastricsin |
|
| chr16_-_8564379 Show fit | 0.20 |
ENSRNOT00000060975
|
hypothetical protein LOC680885 |
|
| chr5_+_164808323 Show fit | 0.20 |
ENSRNOT00000011005
|
natriuretic peptide A |
|
| chr6_+_135856218 Show fit | 0.20 |
ENSRNOT00000066715
|
similar to novel protein |
|
| chr2_-_30127269 Show fit | 0.20 |
ENSRNOT00000023869
|
CART prepropeptide |
|
| chr1_+_80777014 Show fit | 0.18 |
ENSRNOT00000079758
|
predicted gene, 19345 |
|
| chr8_+_89369417 Show fit | 0.16 |
ENSRNOT00000037530
|
meiotic double-stranded break formation protein 4 |
|
| chr7_+_41114697 Show fit | 0.15 |
ENSRNOT00000041354
|
ATPase plasma membrane Ca2+ transporting 1 |
|
| chr2_-_202816562 Show fit | 0.14 |
ENSRNOT00000020401
|
family with sequence similarity 46, member C |
|
| chr5_+_147476221 Show fit | 0.14 |
ENSRNOT00000010730
|
syncoilin, intermediate filament protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tbx5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0042374 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 0.1 | 0.3 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.0 | 0.3 | GO:0071386 | cellular response to corticosterone stimulus(GO:0071386) |
| 0.1 | 0.2 | GO:1902304 | positive regulation of potassium ion export(GO:1902304) |
| 0.1 | 0.2 | GO:2000853 | negative regulation of corticosterone secretion(GO:2000853) |
| 0.0 | 0.2 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.0 | 0.2 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) |
| 0.0 | 0.2 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.0 | 0.1 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 0.0 | 0.1 | GO:0070368 | positive regulation of hepatocyte differentiation(GO:0070368) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 0.2 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.1 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.0 | 0.1 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.0 | 0.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 0.1 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.1 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.1 | GO:1990716 | axonemal central apparatus(GO:1990716) |
| 0.0 | 0.1 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.0 | 0.1 | GO:1990357 | terminal web(GO:1990357) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.3 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.0 | 0.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
| 0.0 | 0.2 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 0.1 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
| 0.0 | 0.1 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.0 | 0.1 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.0 | 0.1 | GO:0031559 | lanosterol synthase activity(GO:0000250) oxidosqualene cyclase activity(GO:0031559) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.1 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |