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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Tbx2

Z-value: 0.52

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Transcription factors associated with Tbx2

Gene Symbol Gene ID Gene Info
ENSRNOG00000003517 T-box 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx2rn6_v1_chr10_+_73279119_73279119-0.991.8e-03Click!

Activity profile of Tbx2 motif

Sorted Z-values of Tbx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_141550633 0.35 ENSRNOT00000020047
mesoderm posterior bHLH transcription factor 2
chr1_-_20155960 0.32 ENSRNOT00000061389
sterile alpha motif domain containing 3
chr5_+_50381244 0.28 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr8_+_52829085 0.25 ENSRNOT00000007754
similar to hypothetical protein FLJ20010
chr20_+_6356423 0.24 ENSRNOT00000000628
cyclin-dependent kinase inhibitor 1A
chr2_-_45077219 0.21 ENSRNOT00000014319
granzyme K
chr13_-_55878094 0.20 ENSRNOT00000014218
LIM homeobox 9
chr4_-_148845267 0.17 ENSRNOT00000037397
transmembrane protein 72
chrX_-_111102464 0.15 ENSRNOT00000084176
ripply transcriptional repressor 1
chr20_-_4677506 0.15 ENSRNOT00000061297
RT1 class I, locus CE6
chr11_-_61530567 0.14 ENSRNOT00000076277
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr14_-_21709084 0.14 ENSRNOT00000087477
submaxillary gland androgen regulated protein 3B
chr8_-_75995371 0.13 ENSRNOT00000014014
forkhead box B1
chr1_+_85485289 0.13 ENSRNOT00000026182
delta like canonical Notch ligand 3
chr1_-_124803363 0.12 ENSRNOT00000066380
Kruppel-like factor 13
chr16_-_49574314 0.11 ENSRNOT00000017568
ENSRNOT00000085535
ENSRNOT00000017054
PDZ and LIM domain 3
chr9_+_98505259 0.10 ENSRNOT00000051810
erythroferrone
chr10_+_49541051 0.10 ENSRNOT00000041606
peripheral myelin protein 22
chr3_-_164388492 0.09 ENSRNOT00000090493
transmembrane protein 189
chr2_-_210738378 0.09 ENSRNOT00000025746
glutathione S-transferase, mu 6
chr14_-_14390699 0.09 ENSRNOT00000046639
annexin A3
chr7_-_120839577 0.09 ENSRNOT00000018526
DNA meiotic recombinase 1
chr1_-_260341723 0.08 ENSRNOT00000030656
oligodendrocytic myelin paranodal and inner loop protein
chr12_+_40466495 0.08 ENSRNOT00000001816
aldehyde dehydrogenase 2 family (mitochondrial)
chr1_+_89017479 0.08 ENSRNOT00000038154
U2 small nuclear RNA auxiliary factor 1-like 4
chr1_+_185863043 0.08 ENSRNOT00000079072
SRY box 6
chr18_+_16616937 0.08 ENSRNOT00000093641
molybdenum cofactor sulfurase
chr5_+_24434872 0.08 ENSRNOT00000010696
cyclin E2
chr1_-_89017290 0.08 ENSRNOT00000028438
presenilin enhancer gamma secretase subunit
chr1_+_21525421 0.08 ENSRNOT00000017911
arginase 1
chr8_+_58431407 0.07 ENSRNOT00000011974
sarcolipin
chr2_+_198755262 0.07 ENSRNOT00000028807
RNA binding motif protein 8A
chr1_-_141533908 0.07 ENSRNOT00000020117
mesoderm posterior bHLH transcription factor 1
chr1_+_220243473 0.07 ENSRNOT00000084650
ENSRNOT00000027091
mitochondrial ribosomal protein L11
chr2_-_251532312 0.07 ENSRNOT00000019501
cysteine-rich, angiogenic inducer, 61
chr4_-_145678066 0.07 ENSRNOT00000014103
ghrelin and obestatin prepropeptide
chr3_+_170994038 0.07 ENSRNOT00000081823
SPO11, initiator of meiotic double stranded breaks
chr10_+_63884338 0.07 ENSRNOT00000007100
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
chr3_+_122720769 0.06 ENSRNOT00000009323
transmembrane channel-like 2
chrX_+_128897181 0.06 ENSRNOT00000008444
SH2 domain containing 1A
chr19_-_25288335 0.06 ENSRNOT00000050214
nanos C2HC-type zinc finger 3
chrX_+_70563570 0.05 ENSRNOT00000003772
glycerophosphodiester phosphodiesterase domain containing 2
chrX_+_135348436 0.05 ENSRNOT00000008868
RAB33A, member RAS oncogene family
chr20_-_4677034 0.05 ENSRNOT00000075244

chr1_+_22332090 0.05 ENSRNOT00000091252
trace amine-associated receptor 8c (Taar8c), mRNA
chr4_+_113887115 0.05 ENSRNOT00000010602
ancient ubiquitous protein 1
chr5_+_57845819 0.05 ENSRNOT00000017712
nudix hydrolase 2
chr1_-_89559960 0.05 ENSRNOT00000092133
sodium voltage-gated channel beta subunit 1
chr5_+_164808323 0.05 ENSRNOT00000011005
natriuretic peptide A
chr7_-_12635943 0.05 ENSRNOT00000015029
complement factor D
chr14_-_84662143 0.05 ENSRNOT00000057529
ENSRNOT00000080078
HORMA domain containing 2
chr20_-_3728844 0.05 ENSRNOT00000074958
psoriasis susceptibility 1 candidate 2
chr2_+_51672722 0.05 ENSRNOT00000016485
fibroblast growth factor 10
chr18_+_53609214 0.05 ENSRNOT00000077443
solute carrier family 27 member 6
chr19_+_12097632 0.05 ENSRNOT00000049452
carboxylesterase 5A
chr4_-_114853868 0.05 ENSRNOT00000090828
WD repeat domain 54
chr17_-_14828329 0.04 ENSRNOT00000022830
BARX homeobox 1
chr13_-_95943761 0.04 ENSRNOT00000005961
adenylosuccinate synthase
chr15_+_28295368 0.04 ENSRNOT00000013786
solute carrier family 39 member 2
chr13_-_85443976 0.04 ENSRNOT00000005213
uridine-cytidine kinase 2
chr9_+_47225585 0.04 ENSRNOT00000077303
interleukin 18 receptor accessory protein
chr1_-_22404002 0.04 ENSRNOT00000044098
trace amine-associated receptor 8a
chr4_-_113988246 0.04 ENSRNOT00000013128
WD repeat-containing protein 54
chr13_+_82429063 0.04 ENSRNOT00000076879
selectin P
chr11_+_87677966 0.04 ENSRNOT00000068711
kelch-like family member 22
chr6_+_109300433 0.04 ENSRNOT00000010712
FBJ osteosarcoma oncogene
chr6_-_103605256 0.03 ENSRNOT00000006005
DDB1 and CUL4 associated factor 5
chr1_+_277689729 0.03 ENSRNOT00000051834
von Willebrand factor A domain containing 2
chr7_-_122926336 0.03 ENSRNOT00000000205
chondroadherin-like
chr6_-_44363915 0.03 ENSRNOT00000085925
inhibitor of DNA binding 2, HLH protein
chr8_+_42511520 0.03 ENSRNOT00000042974
olfactory receptor 1259
chr13_+_49092306 0.03 ENSRNOT00000000039
NUAK family kinase 2
chr12_-_3924415 0.03 ENSRNOT00000067752

chr5_-_150704117 0.03 ENSRNOT00000067455
sestrin 2
chrX_+_104734082 0.03 ENSRNOT00000005020
sushi-repeat-containing protein, X-linked 2
chr5_-_74029238 0.03 ENSRNOT00000031432
ferric-chelate reductase 1-like
chr1_+_22364551 0.03 ENSRNOT00000043157
trace amine-associated receptor 8a
chr9_+_70310932 0.02 ENSRNOT00000088268
uncharacterized LOC103690541
chr19_+_24496569 0.02 ENSRNOT00000004982
MGAT4 family, member D
chrX_-_72370044 0.02 ENSRNOT00000004224
histone deacetylase 8
chr1_+_213686046 0.02 ENSRNOT00000019808
NACHT, LRR and PYD domains-containing protein 6-like
chr13_-_85443727 0.02 ENSRNOT00000090668
ENSRNOT00000076125
uridine-cytidine kinase 2
chr8_-_13680870 0.02 ENSRNOT00000081616
hephaestin-like 1
chr1_+_213676954 0.02 ENSRNOT00000050551
NLR family, pyrin domain containing 6
chr17_-_89163113 0.02 ENSRNOT00000050445
ribosomal protein S19-like
chr4_+_114854458 0.02 ENSRNOT00000013312
hypothetical gene supported by BC079424
chr16_+_61130755 0.02 ENSRNOT00000042609

chr19_-_31867850 0.02 ENSRNOT00000024689
anaphase promoting complex subunit 10
chr4_-_70973842 0.02 ENSRNOT00000051687
transient receptor potential cation channel, subfamily V, member 5
chr10_-_88645364 0.01 ENSRNOT00000030344
RAB5C, member RAS oncogene family
chr15_-_34322115 0.01 ENSRNOT00000026734
transmembrane 9 superfamily member 1
chr5_-_171415354 0.01 ENSRNOT00000055398
tumor protein p73
chrX_+_33599671 0.01 ENSRNOT00000006843
taxilin gamma
chr15_-_51386190 0.01 ENSRNOT00000022706
R3H domain and coiled-coil containing 1
chrX_-_142248369 0.01 ENSRNOT00000091330
fibroblast growth factor 13
chr1_+_100224401 0.01 ENSRNOT00000025846
Friend virus susceptibility 1
chr1_-_226353611 0.01 ENSRNOT00000037624
diacylglycerol lipase, alpha
chr17_+_72240802 0.01 ENSRNOT00000025993
ENSRNOT00000090453
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr7_+_143679617 0.01 ENSRNOT00000014033
eukaryotic translation initiation factor 4B
chr9_+_61738471 0.00 ENSRNOT00000090305

chr11_+_75905443 0.00 ENSRNOT00000002650
fibroblast growth factor 12
chrX_+_68713123 0.00 ENSRNOT00000076690
StAR-related lipid transfer domain containing 8
chr1_+_238843338 0.00 ENSRNOT00000024583
zinc finger AN1-type containing 5
chrX_+_134979646 0.00 ENSRNOT00000006035
SAM and SH3 domain containing 3
chr5_+_113592919 0.00 ENSRNOT00000011336
intraflagellar transport 74
chr7_-_141624972 0.00 ENSRNOT00000078785

chr1_+_85003280 0.00 ENSRNOT00000057122
Fc fragment of IgG binding protein
chr1_+_80777014 0.00 ENSRNOT00000079758
predicted gene, 19345
chr19_+_33932532 0.00 ENSRNOT00000078395
ENSRNOT00000091985
ENSRNOT00000078701
ENSRNOT00000080317
endothelin receptor type A
chr7_-_11406771 0.00 ENSRNOT00000047450
eukaryotic translation elongation factor 2
chr4_-_52350624 0.00 ENSRNOT00000060476
transmembrane protein 229A

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008078 mesodermal cell migration(GO:0008078)
0.1 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.2 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.1 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.3 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.0 0.1 GO:0051464 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) negative regulation of interleukin-6 biosynthetic process(GO:0045409) positive regulation of cortisol secretion(GO:0051464)
0.0 0.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.1 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:1902023 regulation of amino acid import(GO:0010958) L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.0 0.0 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0051177 meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.0 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.0 0.1 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.0 0.1 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
0.0 0.1 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation