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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Tbx2
Z-value: 0.52
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Transcription factors associated with Tbx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbx2 | rn6_v1_chr10_+_73279119_73279119 | -0.99 | 1.8e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_141550633 Show fit | 0.35 |
ENSRNOT00000020047
|
mesoderm posterior bHLH transcription factor 2 |
|
| chr1_-_20155960 Show fit | 0.32 |
ENSRNOT00000061389
|
sterile alpha motif domain containing 3 |
|
| chr5_+_50381244 Show fit | 0.28 |
ENSRNOT00000012385
|
glycoprotein hormones, alpha polypeptide |
|
| chr8_+_52829085 Show fit | 0.25 |
ENSRNOT00000007754
|
similar to hypothetical protein FLJ20010 |
|
| chr20_+_6356423 Show fit | 0.24 |
ENSRNOT00000000628
|
cyclin-dependent kinase inhibitor 1A |
|
| chr2_-_45077219 Show fit | 0.21 |
ENSRNOT00000014319
|
granzyme K |
|
| chr13_-_55878094 Show fit | 0.20 |
ENSRNOT00000014218
|
LIM homeobox 9 |
|
| chr4_-_148845267 Show fit | 0.17 |
ENSRNOT00000037397
|
transmembrane protein 72 |
|
| chrX_-_111102464 Show fit | 0.15 |
ENSRNOT00000084176
|
ripply transcriptional repressor 1 |
|
| chr20_-_4677506 Show fit | 0.15 |
ENSRNOT00000061297
|
RT1 class I, locus CE6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tbx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0008078 | mesodermal cell migration(GO:0008078) |
| 0.0 | 0.3 | GO:0046884 | follicle-stimulating hormone secretion(GO:0046884) |
| 0.1 | 0.2 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 0.0 | 0.2 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.0 | 0.2 | GO:0060574 | intestinal epithelial cell maturation(GO:0060574) |
| 0.0 | 0.2 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
| 0.0 | 0.1 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.0 | 0.1 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.0 | 0.1 | GO:1902304 | positive regulation of potassium ion export(GO:1902304) |
| 0.0 | 0.1 | GO:0051464 | negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) negative regulation of interleukin-6 biosynthetic process(GO:0045409) positive regulation of cortisol secretion(GO:0051464) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.0 | 0.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.1 | GO:0089701 | U2AF(GO:0089701) |
| 0.0 | 0.1 | GO:0070765 | gamma-secretase complex(GO:0070765) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.0 | 0.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 0.1 | GO:0008265 | Mo-molybdopterin cofactor sulfurase activity(GO:0008265) |
| 0.0 | 0.1 | GO:0016608 | growth hormone-releasing hormone activity(GO:0016608) |
| 0.0 | 0.1 | GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.0 | 0.1 | GO:0070404 | NADH binding(GO:0070404) |
| 0.0 | 0.1 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.1 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.0 | 0.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 0.1 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.2 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |