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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Tbp
Z-value: 3.90
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Transcription factors associated with Tbp
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbp | rn6_v1_chr1_+_57491643_57491643 | -0.53 | 3.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_123106694 Show fit | 7.87 |
ENSRNOT00000028829
|
oxytocin/neurophysin 1 prepropeptide |
|
| chr1_+_168957460 Show fit | 4.60 |
ENSRNOT00000090745
|
hemoglobin subunit beta-2 |
|
| chr1_+_168945449 Show fit | 4.02 |
ENSRNOT00000087661
ENSRNOT00000019913 |
hemoglobin subunit beta-2-like |
|
| chr7_+_28654733 Show fit | 3.99 |
ENSRNOT00000006174
|
pro-melanin-concentrating hormone |
|
| chr3_-_123119460 Show fit | 3.91 |
ENSRNOT00000028833
|
arginine vasopressin |
|
| chr1_+_168964202 Show fit | 3.34 |
ENSRNOT00000089102
|
hemoglobin subunit beta-2-like |
|
| chr3_-_82856171 Show fit | 3.32 |
ENSRNOT00000088555
|
similar to LOC387763 protein |
|
| chr13_-_61070599 Show fit | 3.26 |
ENSRNOT00000005251
|
regulator of G-protein signaling 1 |
|
| chr4_-_80395502 Show fit | 3.19 |
ENSRNOT00000014437
|
neuropeptide VF precursor |
|
| chr12_-_23841049 Show fit | 3.05 |
ENSRNOT00000031555
|
heat shock protein family B (small) member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tbp
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.7 | GO:0015671 | oxygen transport(GO:0015671) |
| 2.9 | 11.6 | GO:0002125 | maternal aggressive behavior(GO:0002125) |
| 0.1 | 9.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 5.8 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 5.4 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.8 | 4.0 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
| 0.5 | 3.3 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.3 | 3.1 | GO:0032277 | negative regulation of gonadotropin secretion(GO:0032277) |
| 1.0 | 3.0 | GO:1903544 | cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544) |
| 0.8 | 2.5 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 19.2 | GO:0005615 | extracellular space(GO:0005615) |
| 1.9 | 15.2 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 13.5 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 10.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 6.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 4.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 4.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 3.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 3.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.7 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.6 | 15.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 9.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 9.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 8.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 8.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 4.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 4.0 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 1.3 | 3.9 | GO:0031893 | vasopressin receptor binding(GO:0031893) |
| 0.1 | 3.3 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 4.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.1 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 3.1 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 2.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 7.7 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 5.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.4 | 3.9 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 3.4 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 3.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 3.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 3.0 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.1 | 2.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 2.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |