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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Taf1
Z-value: 2.84
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Transcription factors associated with Taf1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_12673659 Show fit | 2.15 |
ENSRNOT00000091650
ENSRNOT00000041277 ENSRNOT00000044865 |
polypyrimidine tract binding protein 1 |
|
| chrX_+_156812064 Show fit | 1.28 |
ENSRNOT00000077142
|
host cell factor C1 |
|
| chr2_+_196594303 Show fit | 1.22 |
ENSRNOT00000064442
ENSRNOT00000044738 |
aryl hydrocarbon receptor nuclear translocator |
|
| chr13_+_50196042 Show fit | 1.19 |
ENSRNOT00000090858
|
zinc finger CCCH-type containing 11A |
|
| chr8_-_116531784 Show fit | 1.17 |
ENSRNOT00000024529
|
RNA binding motif protein 5 |
|
| chr8_+_48925604 Show fit | 1.11 |
ENSRNOT00000077445
|
DEAD-box helicase 6 |
|
| chr14_-_17616170 Show fit | 1.10 |
ENSRNOT00000090938
|
THAP domain containing 6 |
|
| chr4_+_594882 Show fit | 1.09 |
ENSRNOT00000033377
|
RNA binding motif protein 33 |
|
| chr4_-_8255379 Show fit | 1.06 |
ENSRNOT00000076583
ENSRNOT00000076950 ENSRNOT00000076633 |
lysine methyltransferase 2E |
|
| chr6_-_111477090 Show fit | 1.00 |
ENSRNOT00000016389
|
alkB homolog 1, histone H2A dioxygenase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Taf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.1 | 3.2 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.1 | 2.5 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.2 | 2.1 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.2 | 2.0 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 1.5 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.1 | 1.4 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 1.4 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.0 | 1.4 | GO:0001510 | RNA methylation(GO:0001510) |
| 0.3 | 1.3 | GO:0019046 | viral latency(GO:0019042) release from viral latency(GO:0019046) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.6 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.1 | 2.4 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 2.4 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.1 | 1.9 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.2 | 1.6 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.2 | 1.5 | GO:0090576 | RNA polymerase III transcription factor complex(GO:0090576) |
| 0.0 | 1.5 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 1.4 | GO:0000791 | euchromatin(GO:0000791) |
| 0.3 | 1.3 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 2.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 2.0 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 2.0 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) |
| 0.2 | 1.9 | GO:0046972 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 1.9 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.1 | 1.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 1.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 1.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 2.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.6 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 1.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.2 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 1.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 0.8 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.0 | 2.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 1.5 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 1.3 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 1.3 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 1.0 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.0 | 1.0 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 1.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.0 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.9 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |