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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Stat6

Z-value: 0.39

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Transcription factors associated with Stat6

Gene Symbol Gene ID Gene Info
ENSRNOG00000025023 signal transducer and activator of transcription 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Stat6rn6_v1_chr7_+_70946228_709462280.903.9e-02Click!

Activity profile of Stat6 motif

Sorted Z-values of Stat6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_173087648 0.17 ENSRNOT00000091079
IQ motif containing J
chr5_-_138697641 0.15 ENSRNOT00000012062
guanylate cyclase activator 2B
chr4_-_22425381 0.13 ENSRNOT00000011166
ENSRNOT00000037712
ATP binding cassette subfamily B member 1A
chr18_+_30913842 0.13 ENSRNOT00000026947
protocadherin gamma subfamily C, 3
chr3_+_110723481 0.13 ENSRNOT00000013878
bromo adjacent homology domain containing 1
chr13_-_109580271 0.12 ENSRNOT00000088326
feline leukemia virus subgroup C cellular receptor 1
chr5_-_166116516 0.12 ENSRNOT00000079919
ENSRNOT00000080888
kinesin family member 1B
chr3_-_158328881 0.12 ENSRNOT00000044466
protein tyrosine phosphatase, receptor type, T
chr9_+_111028824 0.11 ENSRNOT00000041418
ENSRNOT00000056457
peptidylglycine alpha-amidating monooxygenase
chr15_+_83703791 0.11 ENSRNOT00000090637
Kruppel-like factor 5
chr13_-_88642011 0.11 ENSRNOT00000067037
hypothetical LOC100361087
chr4_-_40036563 0.10 ENSRNOT00000084531
transmembrane protein 168
chr4_+_66090209 0.10 ENSRNOT00000031193
tetratricopeptide repeat domain 26
chr8_-_49158971 0.10 ENSRNOT00000020573
lysine methyltransferase 2A
chr14_+_39661968 0.10 ENSRNOT00000064779
gamma-aminobutyric acid type A receptor alpha2 subunit
chr7_+_97559841 0.09 ENSRNOT00000007326
zinc fingers and homeoboxes 2
chr1_+_218076116 0.09 ENSRNOT00000028374
oral cancer overexpressed 1
chr10_+_106712127 0.08 ENSRNOT00000040629
trinucleotide repeat containing 6C
chr2_+_149899836 0.08 ENSRNOT00000086481
similar to hypothetical protein C130079G13
chr2_+_189062443 0.08 ENSRNOT00000028181
adenosine deaminase, RNA-specific
chr19_-_22281778 0.08 ENSRNOT00000049624
phosphorylase kinase regulatory subunit beta
chr7_+_141666111 0.08 ENSRNOT00000083250

chr19_+_38768467 0.08 ENSRNOT00000027346
cadherin 1
chr1_-_88066101 0.08 ENSRNOT00000079473
ENSRNOT00000027893
ryanodine receptor 1
chrX_-_19386541 0.08 ENSRNOT00000072722

chr13_-_47438360 0.08 ENSRNOT00000067445
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr2_+_189629297 0.08 ENSRNOT00000049810
DENN domain containing 4B
chr4_-_88565292 0.07 ENSRNOT00000008948
LanC like 2
chr3_-_37480984 0.07 ENSRNOT00000030373
N-myc (and STAT) interactor
chrX_+_68891227 0.07 ENSRNOT00000009635
ephrin B1
chrX_-_135419704 0.07 ENSRNOT00000044435
zinc finger protein 280C
chr8_+_62317265 0.07 ENSRNOT00000083418
ENSRNOT00000091204
family with sequence similarity 219, member B
chr14_+_37113210 0.06 ENSRNOT00000089094
sarcoglycan, beta
chr12_-_35979193 0.06 ENSRNOT00000071104
transmembrane protein 132B
chr17_-_15467320 0.06 ENSRNOT00000072490
ENSRNOT00000093561
osteoglycin
chr16_+_11032531 0.06 ENSRNOT00000078390
WAPL cohesin release factor
chr15_+_4209703 0.05 ENSRNOT00000082236
protein phosphatase 3 catalytic subunit beta
chr14_-_28967980 0.05 ENSRNOT00000048175
adhesion G protein-coupled receptor L3
chr14_+_7618022 0.05 ENSRNOT00000088508
ENSRNOT00000002819
solute carrier family 10 member 6
chr15_+_45712821 0.05 ENSRNOT00000083381
ENSRNOT00000045833
family with sequence similarity 124 member A
chr13_+_36156182 0.05 ENSRNOT00000071437
hypothetical LOC288978
chr4_-_133951264 0.05 ENSRNOT00000090506
PDZ domain containing RING finger 3
chr1_-_247985497 0.05 ENSRNOT00000078998
RAN binding protein 6
chr5_-_135994848 0.05 ENSRNOT00000067675
BTB domain containing 19
chr18_+_25637588 0.05 ENSRNOT00000075283
ENSRNOT00000031530
WD repeat domain 36
chr14_-_80355420 0.05 ENSRNOT00000049798
acyl-CoA oxidase 3, pristanoyl
chr8_-_129919120 0.05 ENSRNOT00000074423
unc-51 like kinase 4
chr15_-_33725188 0.05 ENSRNOT00000083941
zinc finger homeobox 2
chr14_+_60657686 0.05 ENSRNOT00000070892
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr3_-_133122691 0.04 ENSRNOT00000083637
taspase 1
chr13_+_90184569 0.04 ENSRNOT00000082393
signaling lymphocytic activation molecule family member 1
chr1_+_171793782 0.04 ENSRNOT00000081351
olfactomedin-like 1
chr5_-_101405656 0.04 ENSRNOT00000058611
tetratricopeptide repeat domain 39B
chr5_+_116421894 0.04 ENSRNOT00000080577
ENSRNOT00000086628
ENSRNOT00000004017
nuclear factor I/A
chr1_+_88582641 0.04 ENSRNOT00000028187
zinc finger protein 382
chr3_-_21697945 0.04 ENSRNOT00000012433
zinc finger and BTB domain containing 26
chr1_+_221710670 0.04 ENSRNOT00000064798
mitogen activated protein kinase kinase kinase kinase 2
chr1_+_198199622 0.04 ENSRNOT00000026688
glycerophosphodiester phosphodiesterase domain containing 3
chr1_-_37932084 0.04 ENSRNOT00000022527
zinc finger protein 728-like
chr2_+_257633425 0.04 ENSRNOT00000071770
zinc finger, ZZ-type containing 3
chr6_+_135549137 0.04 ENSRNOT00000073989
REST corepressor 1
chr18_+_30820321 0.04 ENSRNOT00000060472
protocadherin gamma subfamily A, 3
chr20_+_3300247 0.04 ENSRNOT00000035838
proline rich 3
chr18_+_16146447 0.04 ENSRNOT00000022117
polypeptide N-acetylgalactosaminyltransferase 1
chr2_+_185590986 0.04 ENSRNOT00000088807
ENSRNOT00000088188
LPS responsive beige-like anchor protein
chr3_-_150960030 0.04 ENSRNOT00000024714
nuclear receptor coactivator 6
chr18_+_30840868 0.04 ENSRNOT00000027026
protocadherin gamma subfamily A, 5
chr4_+_78354335 0.03 ENSRNOT00000059167
GTPase, IMAP family member 7
chr7_-_70467915 0.03 ENSRNOT00000088995
solute carrier family 26, member 10
chrX_+_20423401 0.03 ENSRNOT00000093162
WNK lysine deficient protein kinase 3
chr1_-_6970040 0.03 ENSRNOT00000016273
utrophin
chr15_+_34282936 0.03 ENSRNOT00000026364
interferon regulatory factor 9
chr8_+_45797315 0.03 ENSRNOT00000059997

chr4_+_183896303 0.03 ENSRNOT00000055437
similar to hypothetical protein FLJ10652
chr4_-_148437961 0.03 ENSRNOT00000082907
arachidonate 5-lipoxygenase
chr15_-_12513931 0.03 ENSRNOT00000010103
ataxin 7
chrX_-_15504165 0.03 ENSRNOT00000006233
OTU deubiquitinase 5
chr3_+_21698032 0.03 ENSRNOT00000013378
RAB GTPase activating protein 1
chr8_-_36374673 0.03 ENSRNOT00000013763
decapping enzyme, scavenger
chr10_-_89130339 0.02 ENSRNOT00000027640
enhancer of zeste 1 polycomb repressive complex 2 subunit
chr4_-_58881045 0.02 ENSRNOT00000087241
podocalyxin-like
chr13_+_48790767 0.02 ENSRNOT00000087504
ELK4, ETS transcription factor
chr3_+_66593934 0.02 ENSRNOT00000008046
sperm specific antigen 2
chr15_+_41937880 0.02 ENSRNOT00000032514
potassium channel regulator
chrX_+_9815652 0.02 ENSRNOT00000091382
peripheral plasma membrane protein CASK-like
chr2_+_8732932 0.02 ENSRNOT00000072849
arrestin domain containing 3
chr1_+_99486253 0.02 ENSRNOT00000074820
uncharacterized LOC102546648
chr1_+_162549420 0.02 ENSRNOT00000037050
remodeling and spacing factor 1
chr11_+_7265828 0.02 ENSRNOT00000084765
1,4-alpha-glucan branching enzyme 1
chr9_-_14668297 0.02 ENSRNOT00000042404
triggering receptor expressed on myeloid cells-like 2
chr11_+_60054408 0.02 ENSRNOT00000091756
abhydrolase domain containing 10
chr7_-_60341264 0.02 ENSRNOT00000007747
lysozyme 2
chrX_+_9436707 0.02 ENSRNOT00000004187
calcium/calmodulin dependent serine protein kinase
chr8_+_70789256 0.02 ENSRNOT00000048302
caseinolytic mitochondrial matrix peptidase chaperone subunit
chr9_+_10941613 0.02 ENSRNOT00000070794
semaphorin 6B
chr1_-_165123455 0.02 ENSRNOT00000024875
DNA polymerase delta 3, accessory subunit
chr14_+_75880410 0.01 ENSRNOT00000014078
heparan sulfate-glucosamine 3-sulfotransferase 1
chr1_+_143036218 0.01 ENSRNOT00000025797
phosphodiesterase 8A
chr4_-_10329241 0.01 ENSRNOT00000017232
fibrinogen-like 2
chr10_-_56368360 0.01 ENSRNOT00000019674
solute carrier family 35, member G3
chr3_-_63568464 0.01 ENSRNOT00000068494

chr1_+_260153645 0.01 ENSRNOT00000054717
zinc finger protein 518A
chr20_+_1736377 0.01 ENSRNOT00000047035
olfactory receptor 1734
chr16_+_23447366 0.01 ENSRNOT00000068629
pleckstrin and Sec7 domain containing 3
chr10_+_63677396 0.01 ENSRNOT00000005100
solute carrier family 43 member 2
chr15_+_61826937 0.01 ENSRNOT00000084005
ENSRNOT00000079417
E74-like factor 1
chr11_-_54344615 0.01 ENSRNOT00000090307
myosin, heavy chain 15
chr1_-_124803363 0.01 ENSRNOT00000066380
Kruppel-like factor 13
chr10_+_75087892 0.01 ENSRNOT00000065910
myeloperoxidase
chr3_+_56862691 0.01 ENSRNOT00000087712
glutamate decarboxylase 1
chr8_-_53816447 0.01 ENSRNOT00000011454
tetratricopeptide repeat domain 12
chr8_-_114449956 0.01 ENSRNOT00000056414
collagen type VI alpha 6 chain
chr3_-_147479472 0.01 ENSRNOT00000074295
family with sequence similarity 110, member A
chr1_-_112947399 0.01 ENSRNOT00000093306
ENSRNOT00000093259
gamma-aminobutyric acid type A receptor alpha 5 subunit
chr5_-_135561914 0.01 ENSRNOT00000023178
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr8_+_107499262 0.01 ENSRNOT00000081029
centrosomal protein 70
chr8_+_63036976 0.01 ENSRNOT00000011383
stomatin like 1
chr1_-_217844957 0.01 ENSRNOT00000090653
anoctamin 1
chr3_+_172550258 0.01 ENSRNOT00000075148
tubulin, beta 1 class VI
chr3_-_5575136 0.01 ENSRNOT00000008034
solute carrier family 2 member 6
chr13_+_100980574 0.00 ENSRNOT00000067005
ENSRNOT00000004649
calpain 8
chr1_-_103323476 0.00 ENSRNOT00000019051
MAS related GPR family member X3
chr20_+_5057701 0.00 ENSRNOT00000001119
lymphocyte antigen 6 complex, locus G6C
chr18_-_6782757 0.00 ENSRNOT00000068150
aquaporin 4
chr1_-_143392532 0.00 ENSRNOT00000026089
fibronectin type III and SPRY domain containing 2
chr10_-_6870011 0.00 ENSRNOT00000003439
similar to CG4768-PA
chr3_-_138708332 0.00 ENSRNOT00000010678
RB binding protein 9, serine hydrolase
chr13_+_48790951 0.00 ENSRNOT00000090233
ELK4, ETS transcription factor
chr7_-_11513581 0.00 ENSRNOT00000027045
thimet oligopeptidase 1
chr20_+_2058197 0.00 ENSRNOT00000077774
ENSRNOT00000040634
RT1 class I, locus M6, gene 1
chr10_-_37130921 0.00 ENSRNOT00000006006
trafficking protein particle complex 2B
chr16_+_7103998 0.00 ENSRNOT00000016581
polybromo 1
chr4_+_62380914 0.00 ENSRNOT00000029845
transmembrane protein 140
chrX_-_118513061 0.00 ENSRNOT00000043338
interleukin 13 receptor subunit alpha 2
chr1_+_64114721 0.00 ENSRNOT00000080466
transmembrane channel-like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:2001025 positive regulation of response to drug(GO:2001025)
0.0 0.1 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.0 0.1 GO:0031179 peptide modification(GO:0031179)
0.0 0.1 GO:1900368 regulation of RNA interference(GO:1900368)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.1 GO:0019521 aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.0 0.1 GO:0060066 oviduct development(GO:0060066)
0.0 0.1 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.0 0.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.0 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.1 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.0 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) myeloid dendritic cell activation involved in immune response(GO:0002277)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0060988 lipid tube assembly(GO:0060988)
0.0 0.1 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016842 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)