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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Stat5a
Z-value: 1.52
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Transcription factors associated with Stat5a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Stat5a | rn6_v1_chr10_+_88764732_88764732 | -0.87 | 5.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_91581262 Show fit | 0.69 |
ENSRNOT00000034507
|
|
|
| chr5_+_10125070 Show fit | 0.67 |
ENSRNOT00000085321
|
|
|
| chr1_+_80777014 Show fit | 0.59 |
ENSRNOT00000079758
|
predicted gene, 19345 |
|
| chr18_+_25613831 Show fit | 0.52 |
ENSRNOT00000091040
|
thymic stromal lymphopoietin |
|
| chr9_+_81535483 Show fit | 0.44 |
ENSRNOT00000077285
|
actin related protein 2/3 complex, subunit 2 |
|
| chr20_-_11644166 Show fit | 0.44 |
ENSRNOT00000073009
|
keratin associated protein 12-1-like |
|
| chr20_+_3979035 Show fit | 0.40 |
ENSRNOT00000000529
|
transporter 1, ATP binding cassette subfamily B member |
|
| chr2_+_251534535 Show fit | 0.39 |
ENSRNOT00000080311
|
|
|
| chr2_-_167607919 Show fit | 0.39 |
ENSRNOT00000089083
|
|
|
| chr7_-_140090922 Show fit | 0.39 |
ENSRNOT00000014456
|
lactalbumin, alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of Stat5a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.1 | 0.7 | GO:0052697 | xenobiotic glucuronidation(GO:0052697) |
| 0.0 | 0.7 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 0.1 | 0.6 | GO:2000814 | positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.1 | 0.6 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.1 | 0.6 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion(GO:0034116) |
| 0.0 | 0.6 | GO:0038094 | Fc-gamma receptor signaling pathway(GO:0038094) |
| 0.1 | 0.5 | GO:0046351 | disaccharide biosynthetic process(GO:0046351) |
| 0.1 | 0.5 | GO:0032815 | negative regulation of natural killer cell activation(GO:0032815) |
| 0.1 | 0.5 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.6 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.0 | 0.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 0.5 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 0.5 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.2 | 1.0 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.0 | 0.6 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.0 | 0.6 | GO:0005549 | odorant binding(GO:0005549) |
| 0.0 | 0.6 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.0 | 0.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 0.5 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 0.5 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.0 | 0.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 1.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.0 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.5 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |