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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Stat4_Stat3_Stat5b
Z-value: 0.67
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Transcription factors associated with Stat4_Stat3_Stat5b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Stat3 | rn6_v1_chr10_-_88842233_88842233 | -0.92 | 2.8e-02 | Click! |
| Stat5b | rn6_v1_chr10_-_88712309_88712309 | -0.56 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_140090922 Show fit | 0.39 |
ENSRNOT00000014456
|
lactalbumin, alpha |
|
| chr4_-_23135354 Show fit | 0.33 |
ENSRNOT00000011432
|
STEAP4 metalloreductase |
|
| chr14_+_63405408 Show fit | 0.25 |
ENSRNOT00000086658
|
|
|
| chr2_-_167607919 Show fit | 0.24 |
ENSRNOT00000089083
|
|
|
| chr20_-_3793985 Show fit | 0.23 |
ENSRNOT00000049540
ENSRNOT00000086293 |
RT1 class I, locus CE16 |
|
| chr1_-_78180216 Show fit | 0.20 |
ENSRNOT00000071576
|
complement component 5a receptor 2 |
|
| chr7_-_145174771 Show fit | 0.16 |
ENSRNOT00000055270
|
glycosylation dependent cell adhesion molecule 1 |
|
| chr15_+_43582020 Show fit | 0.15 |
ENSRNOT00000013001
|
paraneoplastic Ma antigen 2 |
|
| chrX_-_143453612 Show fit | 0.15 |
ENSRNOT00000051319
|
ATPase phospholipid transporting 11C |
|
| chr5_+_101526551 Show fit | 0.14 |
ENSRNOT00000015254
|
small nuclear RNA activating complex, polypeptide 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Stat4_Stat3_Stat5b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0046351 | disaccharide biosynthetic process(GO:0046351) |
| 0.0 | 0.3 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.0 | 0.3 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.1 | 0.2 | GO:0090024 | negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) |
| 0.0 | 0.1 | GO:2000814 | positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.0 | 0.1 | GO:0038163 | thrombopoietin-mediated signaling pathway(GO:0038163) |
| 0.0 | 0.1 | GO:0042509 | CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) |
| 0.0 | 0.1 | GO:1902211 | regulation of prolactin signaling pathway(GO:1902211) |
| 0.0 | 0.1 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.0 | 0.1 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.0 | 0.1 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.0 | 0.1 | GO:0060187 | cell pole(GO:0060187) |
| 0.0 | 0.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.1 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.1 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 0.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.0 | GO:0098982 | glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982) |
| 0.0 | 0.0 | GO:0035339 | SPOTS complex(GO:0035339) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0035250 | UDP-galactosyltransferase activity(GO:0035250) |
| 0.1 | 0.3 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 0.2 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.0 | 0.2 | GO:0048019 | receptor antagonist activity(GO:0048019) |
| 0.0 | 0.2 | GO:0043199 | sulfate binding(GO:0043199) |
| 0.0 | 0.1 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.0 | 0.1 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.0 | 0.1 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.0 | 0.1 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.0 | 0.1 | GO:0050733 | RS domain binding(GO:0050733) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |