GSE49485: Hypoxia transcriptome sequencing of rat brain.

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Expression table
• Download the whole report

Gene Symbol	Gene ID	Gene Info
Stat1 Links NCBI RGD Ensembl	ENSRNOG00000014079	signal transducer and activator of transcription 1

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Stat1	rn6_v1_chr9_-_54484533_54484533	-0.73	1.6e-01	Click!

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_37528011 Show fit	0.27	ENSRNOT00000059628	Agrp Links NCBI RGD Ensembl Show fit	agouti related neuropeptide
chr20_-_3793985 Show fit	0.20	ENSRNOT00000049540 ENSRNOT00000086293	RT1-CE16 Links NCBI RGD Ensembl Show fit	RT1 class I, locus CE16
chr7_-_3342491 Show fit	0.17	ENSRNOT00000081756	Rdh5 Links NCBI RGD Ensembl Show fit	retinol dehydrogenase 5
chr2_+_145174876 Show fit	0.15	ENSRNOT00000040631	Mab21l1 Links NCBI RGD Ensembl Show fit	mab-21 like 1
chr9_+_15166118 Show fit	0.10	ENSRNOT00000020432	Mdfi Links NCBI RGD Ensembl Show fit	MyoD family inhibitor
chr5_+_29538380 Show fit	0.10	ENSRNOT00000010845	Calb1 Links NCBI RGD Ensembl Show fit	calbindin 1
chr10_+_84167331 Show fit	0.09	ENSRNOT00000010965	Hoxb4 Links NCBI RGD Ensembl Show fit	homeo box B4
chr7_+_72924799 Show fit	0.07	ENSRNOT00000008969	Laptm4b Links NCBI RGD Ensembl Show fit	lysosomal protein transmembrane 4 beta
chr5_+_139597731 Show fit	0.07	ENSRNOT00000072427	Cited4 Links NCBI RGD Ensembl Show fit	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr1_+_247519939 Show fit	0.07	ENSRNOT00000034421	Cd274 Links NCBI RGD Ensembl Show fit	CD274 molecule
chr2_+_114386019 Show fit	0.06	ENSRNOT00000082148	AABR07009834.1 Links NCBI RGD Ensembl Show fit
chr1_-_81152384 Show fit	0.06	ENSRNOT00000026263 ENSRNOT00000077305	Zfp94 Links NCBI RGD Ensembl Show fit	zinc finger protein 94
chr4_-_123494742 Show fit	0.05	ENSRNOT00000073268	Slc41a3 Links NCBI RGD Ensembl Show fit	solute carrier family 41, member 3
chr7_-_15163866 Show fit	0.05	ENSRNOT00000042638	Zfp870 Links NCBI RGD Ensembl Show fit	zinc finger protein 870
chr6_+_108285822 Show fit	0.05	ENSRNOT00000015889	Vsx2 Links NCBI RGD Ensembl Show fit	visual system homeobox 2
chr1_-_81412251 Show fit	0.05	ENSRNOT00000026946	Pinlyp Links NCBI RGD Ensembl Show fit	phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr7_-_94563001 Show fit	0.04	ENSRNOT00000051139 ENSRNOT00000005561	Enpp2 Links NCBI RGD Ensembl Show fit	ectonucleotide pyrophosphatase/phosphodiesterase 2
chr8_-_116349896 Show fit	0.04	ENSRNOT00000087306	Lsmem2 Links NCBI RGD Ensembl Show fit	leucine-rich single-pass membrane protein 2
chr8_-_36764422 Show fit	0.04	ENSRNOT00000017330	Hyls1 Links NCBI RGD Ensembl Show fit	HYLS1, centriolar and ciliogenesis associated
chr1_-_98493978 Show fit	0.04	ENSRNOT00000023942	Nkg7 Links NCBI RGD Ensembl Show fit	natural killer cell granule protein 7
chr3_+_95715193 Show fit	0.04	ENSRNOT00000089525	Pax6 Links NCBI RGD Ensembl Show fit	paired box 6
chr1_+_87790104 Show fit	0.04	ENSRNOT00000074580	LOC103690114 Links NCBI RGD Ensembl Show fit	zinc finger protein 383-like
chr7_-_122644054 Show fit	0.04	ENSRNOT00000025941	Dnajb7 Links NCBI RGD Ensembl Show fit	DnaJ heat shock protein family (Hsp40) member B7
chr11_+_80255790 Show fit	0.04	ENSRNOT00000002522	Bcl6 Links NCBI RGD Ensembl Show fit	B-cell CLL/lymphoma 6
chr3_-_160139947 Show fit	0.03	ENSRNOT00000014151	Ada Links NCBI RGD Ensembl Show fit	adenosine deaminase
chrX_+_13441558 Show fit	0.03	ENSRNOT00000030170	RGD1561661 Links NCBI RGD Ensembl Show fit	similar to Ferritin light chain (Ferritin L subunit)
chr7_-_140090922 Show fit	0.03	ENSRNOT00000014456	Lalba Links NCBI RGD Ensembl Show fit	lactalbumin, alpha
chr2_+_225827504 Show fit	0.03	ENSRNOT00000018343	Gclm Links NCBI RGD Ensembl Show fit	glutamate cysteine ligase, modifier subunit
chr8_-_130429132 Show fit	0.03	ENSRNOT00000026261	Hhatl Links NCBI RGD Ensembl Show fit	hedgehog acyltransferase-like
chr7_-_137856485 Show fit	0.03	ENSRNOT00000007003	LOC688906 Links NCBI RGD Ensembl Show fit	similar to splicing factor, arginine/serine-rich 2, interacting protein
chr13_-_45068077 Show fit	0.03	ENSRNOT00000004969	Mcm6 Links NCBI RGD Ensembl Show fit	minichromosome maintenance complex component 6
chr2_-_165600748 Show fit	0.03	ENSRNOT00000013216	Ift80 Links NCBI RGD Ensembl Show fit	intraflagellar transport 80
chr17_-_15467320 Show fit	0.03	ENSRNOT00000072490 ENSRNOT00000093561	Ogn Links NCBI RGD Ensembl Show fit	osteoglycin
chr7_+_2718700 Show fit	0.03	ENSRNOT00000050792	Pan2 Links NCBI RGD Ensembl Show fit	PAN2 poly(A) specific ribonuclease subunit
chr1_-_167093560 Show fit	0.03	ENSRNOT00000027301	Il18bp Links NCBI RGD Ensembl Show fit	interleukin 18 binding protein
chr14_-_86387606 Show fit	0.03	ENSRNOT00000089384 ENSRNOT00000006642	Ddx56 Links NCBI RGD Ensembl Show fit	DEAD-box helicase 56
chr3_-_112084144 Show fit	0.03	ENSRNOT00000010959	Pla2g4f Links NCBI RGD Ensembl Show fit	phospholipase A2, group IVF
chr10_+_39109522 Show fit	0.02	ENSRNOT00000010968	Irf1 Links NCBI RGD Ensembl Show fit	interferon regulatory factor 1
chr18_+_86299463 Show fit	0.02	ENSRNOT00000058152	Cd226 Links NCBI RGD Ensembl Show fit	CD226 molecule
chr17_+_18358712 Show fit	0.02	ENSRNOT00000001979	Nup153 Links NCBI RGD Ensembl Show fit	nucleoporin 153
chr1_-_78180216 Show fit	0.02	ENSRNOT00000071576	C5ar2 Links NCBI RGD Ensembl Show fit	complement component 5a receptor 2
chr19_-_43215281 Show fit	0.02	ENSRNOT00000025052	Aars Links NCBI RGD Ensembl Show fit	alanyl-tRNA synthetase
chr11_+_31806618 Show fit	0.02	ENSRNOT00000043410 ENSRNOT00000002769	Son Links NCBI RGD Ensembl Show fit	Son DNA binding protein
chr19_-_43215077 Show fit	0.02	ENSRNOT00000082151	Aars Links NCBI RGD Ensembl Show fit	alanyl-tRNA synthetase
chr1_-_189181901 Show fit	0.02	ENSRNOT00000092022	Gp2 Links NCBI RGD Ensembl Show fit	glycoprotein 2
chr2_+_30685840 Show fit	0.02	ENSRNOT00000031385	Ccdc125 Links NCBI RGD Ensembl Show fit	coiled-coil domain containing 125
chr7_-_145174771 Show fit	0.02	ENSRNOT00000055270	Glycam1 Links NCBI RGD Ensembl Show fit	glycosylation dependent cell adhesion molecule 1
chr4_+_109477920 Show fit	0.02	ENSRNOT00000008468	Reg3a Links NCBI RGD Ensembl Show fit	regenerating islet-derived 3 alpha
chrX_+_156854594 Show fit	0.02	ENSRNOT00000083442	Renbp Links NCBI RGD Ensembl Show fit	renin binding protein
chr15_+_33004133 Show fit	0.02	ENSRNOT00000013246	Oxa1l Links NCBI RGD Ensembl Show fit	OXA1L, mitochondrial inner membrane protein
chr15_+_34282936 Show fit	0.02	ENSRNOT00000026364	Irf9 Links NCBI RGD Ensembl Show fit	interferon regulatory factor 9
chr4_-_17594598 Show fit	0.02	ENSRNOT00000008936	Sema3e Links NCBI RGD Ensembl Show fit	semaphorin 3E
chr5_+_101526551 Show fit	0.02	ENSRNOT00000015254	Snapc3 Links NCBI RGD Ensembl Show fit	small nuclear RNA activating complex, polypeptide 3
chr3_-_111873974 Show fit	0.02	ENSRNOT00000077546	AABR07053509.2 Links NCBI RGD Ensembl Show fit
chr7_+_35125424 Show fit	0.02	ENSRNOT00000085978 ENSRNOT00000010117	Ndufa12 Links NCBI RGD Ensembl Show fit	NADH:ubiquinone oxidoreductase subunit A12
chrX_-_123092217 Show fit	0.02	ENSRNOT00000039710	Gm14569 Links NCBI RGD Ensembl Show fit	predicted gene 14569
chr10_+_17542374 Show fit	0.02	ENSRNOT00000064079	Fbxw11 Links NCBI RGD Ensembl Show fit	F-box and WD repeat domain containing 11
chr18_+_36829062 Show fit	0.02	ENSRNOT00000025467 ENSRNOT00000086979	Tcerg1 Links NCBI RGD Ensembl Show fit	transcription elongation regulator 1
chr4_+_118243132 Show fit	0.02	ENSRNOT00000023654	RGD1306746 Links NCBI RGD Ensembl Show fit	similar to Hypothetical protein MGC25529
chr2_+_53109684 Show fit	0.02	ENSRNOT00000086590	Selenop Links NCBI RGD Ensembl Show fit	selenoprotein P
chr17_+_47721977 Show fit	0.02	ENSRNOT00000080800	LOC100910792 Links NCBI RGD Ensembl Show fit	amphiphysin-like
chr4_+_9981958 Show fit	0.02	ENSRNOT00000015322	Napepld Links NCBI RGD Ensembl Show fit	N-acyl phosphatidylethanolamine phospholipase D
chr15_+_34452116 Show fit	0.02	ENSRNOT00000027647	Ltb4r Links NCBI RGD Ensembl Show fit	leukotriene B4 receptor
chr1_+_154131926 Show fit	0.02	ENSRNOT00000035257	LOC102549852 Links NCBI RGD Ensembl Show fit	ferritin light chain 1-like
chr1_+_214123044 Show fit	0.02	ENSRNOT00000021925	Ptdss2 Links NCBI RGD Ensembl Show fit	phosphatidylserine synthase 2
chr6_+_109939345 Show fit	0.02	ENSRNOT00000013560	Ift43 Links NCBI RGD Ensembl Show fit	intraflagellar transport 43
chr9_-_61134963 Show fit	0.01	ENSRNOT00000017967	Pgap1 Links NCBI RGD Ensembl Show fit	post-GPI attachment to proteins 1
chr10_-_56506446 Show fit	0.01	ENSRNOT00000021357	Acap1 Links NCBI RGD Ensembl Show fit	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr8_-_48850671 Show fit	0.01	ENSRNOT00000016580	Cxcr5 Links NCBI RGD Ensembl Show fit	C-X-C motif chemokine receptor 5
chr15_-_34392066 Show fit	0.01	ENSRNOT00000027315	Tgm1 Links NCBI RGD Ensembl Show fit	transglutaminase 1
chr10_-_59883839 Show fit	0.01	ENSRNOT00000093579	Aspa Links NCBI RGD Ensembl Show fit	aspartoacylase
chr1_-_164441167 Show fit	0.01	ENSRNOT00000023935	Rps3 Links NCBI RGD Ensembl Show fit	ribosomal protein S3
chrX_+_77065397 Show fit	0.01	ENSRNOT00000090007	Cox7b Links NCBI RGD Ensembl Show fit	cytochrome c oxidase subunit 7B
chr18_+_14471213 Show fit	0.01	ENSRNOT00000045224	Dtna Links NCBI RGD Ensembl Show fit	dystrobrevin, alpha
chr5_-_56567320 Show fit	0.01	ENSRNOT00000066081	Topors Links NCBI RGD Ensembl Show fit	TOP1 binding arginine/serine rich protein
chr19_+_37282018 Show fit	0.01	ENSRNOT00000021723	Tmem208 Links NCBI RGD Ensembl Show fit	transmembrane protein 208
chr7_-_83348487 Show fit	0.01	ENSRNOT00000006685	Nudcd1 Links NCBI RGD Ensembl Show fit	NudC domain containing 1
chr8_-_62332115 Show fit	0.01	ENSRNOT00000025783	Mpi Links NCBI RGD Ensembl Show fit	mannose phosphate isomerase (mapped)
chrX_-_25590048 Show fit	0.01	ENSRNOT00000004873	Mid1 Links NCBI RGD Ensembl Show fit	midline 1
chr8_+_21890319 Show fit	0.01	ENSRNOT00000027949	LOC500956 Links NCBI RGD Ensembl Show fit	hypothetical protein LOC500956
chr10_+_14240219 Show fit	0.01	ENSRNOT00000020233	Igfals Links NCBI RGD Ensembl Show fit	insulin-like growth factor binding protein, acid labile subunit
chr13_+_90184569 Show fit	0.01	ENSRNOT00000082393	Slamf1 Links NCBI RGD Ensembl Show fit	signaling lymphocytic activation molecule family member 1
chr5_-_169017295 Show fit	0.01	ENSRNOT00000067481	Camta1 Links NCBI RGD Ensembl Show fit	calmodulin binding transcription activator 1
chr5_+_164951789 Show fit	0.01	ENSRNOT00000055658 ENSRNOT00000012193	Mad2l2 Links NCBI RGD Ensembl Show fit	MAD2 mitotic arrest deficient-like 2 (yeast)
chr19_+_15294248 Show fit	0.01	ENSRNOT00000024622	Ces1f Links NCBI RGD Ensembl Show fit	carboxylesterase 1F
chr14_+_17195014 Show fit	0.01	ENSRNOT00000031667	Cxcl11 Links NCBI RGD Ensembl Show fit	C-X-C motif chemokine ligand 11
chr14_-_23604834 Show fit	0.01	ENSRNOT00000002760	Stap1 Links NCBI RGD Ensembl Show fit	signal transducing adaptor family member 1
chr1_+_226947105 Show fit	0.01	ENSRNOT00000028373	Prpf19 Links NCBI RGD Ensembl Show fit	pre-mRNA processing factor 19
chr1_-_213921208 Show fit	0.01	ENSRNOT00000044393	Ano9 Links NCBI RGD Ensembl Show fit	anoctamin 9
chr11_-_32088002 Show fit	0.01	ENSRNOT00000002732	Atp5o Links NCBI RGD Ensembl Show fit	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr7_+_83348694 Show fit	0.01	ENSRNOT00000006402	Eny2 Links NCBI RGD Ensembl Show fit	ENY2, transcription and export complex 2 subunit
chr2_+_93518806 Show fit	0.01	ENSRNOT00000050987	Snx16 Links NCBI RGD Ensembl Show fit	sorting nexin 16
chr11_+_68105369 Show fit	0.01	ENSRNOT00000046888	Parp14 Links NCBI RGD Ensembl Show fit	poly (ADP-ribose) polymerase family, member 14
chrX_-_143453612 Show fit	0.01	ENSRNOT00000051319	Atp11c Links NCBI RGD Ensembl Show fit	ATPase phospholipid transporting 11C
chr1_-_165606375 Show fit	0.01	ENSRNOT00000024290	Mrpl48 Links NCBI RGD Ensembl Show fit	mitochondrial ribosomal protein L48
chr2_-_189880743 Show fit	0.01	ENSRNOT00000018830	Snapin Links NCBI RGD Ensembl Show fit	SNAP-associated protein
chr19_-_37281933 Show fit	0.01	ENSRNOT00000059663	Lrrc29 Links NCBI RGD Ensembl Show fit	leucine rich repeat containing 29
chr18_+_57654290 Show fit	0.01	ENSRNOT00000025892	Htr4 Links NCBI RGD Ensembl Show fit	5-hydroxytryptamine receptor 4
chr3_+_176985900 Show fit	0.01	ENSRNOT00000020210	Abhd16b Links NCBI RGD Ensembl Show fit	abhydrolase domain containing 16B
chr8_-_77992621 Show fit	0.01	ENSRNOT00000085843	Myzap Links NCBI RGD Ensembl Show fit	myocardial zonula adherens protein
chr8_+_49621568 Show fit	0.01	ENSRNOT00000021949	Tmprss13 Links NCBI RGD Ensembl Show fit	transmembrane protease, serine 13
chr1_-_193700673 Show fit	0.01	ENSRNOT00000071314	Paip2l1 Links NCBI RGD Ensembl Show fit	polyadenylate-binding protein-interacting protein 2-like 1
chr14_-_42560174 Show fit	0.01	ENSRNOT00000003128	Tmem33 Links NCBI RGD Ensembl Show fit	transmembrane protein 33
chr13_-_47397890 Show fit	0.01	ENSRNOT00000005505	C4bpb Links NCBI RGD Ensembl Show fit	complement component 4 binding protein, beta
chrX_-_38468360 Show fit	0.01	ENSRNOT00000045285	Map7d2 Links NCBI RGD Ensembl Show fit	MAP7 domain containing 2
chr1_-_7480825 Show fit	0.01	ENSRNOT00000048754	Phactr2 Links NCBI RGD Ensembl Show fit	phosphatase and actin regulator 2
chr10_-_86645529 Show fit	0.01	ENSRNOT00000011947	Med24 Links NCBI RGD Ensembl Show fit	mediator complex subunit 24
chr2_+_86996497 Show fit	0.00	ENSRNOT00000042058	Zfp455 Links NCBI RGD Ensembl Show fit	zinc finger protein 455
chr12_-_30106889 Show fit	0.00	ENSRNOT00000065868 ENSRNOT00000001200	Tpst1 Links NCBI RGD Ensembl Show fit	tyrosylprotein sulfotransferase 1
chrX_+_9436707 Show fit	0.00	ENSRNOT00000004187	Cask Links NCBI RGD Ensembl Show fit	calcium/calmodulin dependent serine protein kinase
chr3_+_161519743 Show fit	0.00	ENSRNOT00000055148	Cd40 Links NCBI RGD Ensembl Show fit	CD40 molecule
chrX_+_112270986 Show fit	0.00	ENSRNOT00000091441 ENSRNOT00000082652	Vsig1 Links NCBI RGD Ensembl Show fit	V-set and immunoglobulin domain containing 1
chr11_-_82938357 Show fit	0.00	ENSRNOT00000035945	Map3k13 Links NCBI RGD Ensembl Show fit	mitogen-activated protein kinase kinase kinase 13
chr19_-_10884047 Show fit	0.00	ENSRNOT00000088196 ENSRNOT00000063791	Cpne2 Links NCBI RGD Ensembl Show fit	copine 2
chr10_-_95262024 Show fit	0.00	ENSRNOT00000066487	Bptf Links NCBI RGD Ensembl Show fit	bromodomain PHD finger transcription factor
chr7_-_2825498 Show fit	0.00	ENSRNOT00000086656 ENSRNOT00000031362	Nabp2 Links NCBI RGD Ensembl Show fit	nucleic acid binding protein 2
chr10_+_69412017 Show fit	0.00	ENSRNOT00000009448	Ccl2 Links NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 2
chr7_+_1206648 Show fit	0.00	ENSRNOT00000073689	Pros1 Links NCBI RGD Ensembl Show fit	protein S (alpha)
chr15_-_103927592 Show fit	0.00	ENSRNOT00000031036 ENSRNOT00000013366	Abcc4 Links NCBI RGD Ensembl Show fit	ATP binding cassette subfamily C member 4
chr20_+_45458558 Show fit	0.00	ENSRNOT00000000713	Cdk19 Links NCBI RGD Ensembl Show fit	cyclin-dependent kinase 19
chr1_+_157403595 Show fit	0.00	ENSRNOT00000012781	Ccdc90b Links NCBI RGD Ensembl Show fit	coiled-coil domain containing 90B
chr10_-_95431312 Show fit	0.00	ENSRNOT00000085552	AABR07030603.2 Links NCBI RGD Ensembl Show fit
chr2_+_243820661 Show fit	0.00	ENSRNOT00000090526	Eif4e Links NCBI RGD Ensembl Show fit	eukaryotic translation initiation factor 4E
chr7_-_102298522 Show fit	0.00	ENSRNOT00000006273	A1bg Links NCBI RGD Ensembl Show fit	alpha-1-B glycoprotein
chr9_+_10952374 Show fit	0.00	ENSRNOT00000074993	Lrg1 Links NCBI RGD Ensembl Show fit	leucine-rich alpha-2-glycoprotein 1
chrX_+_159703578 Show fit	0.00	ENSRNOT00000001162	Cd40lg Links NCBI RGD Ensembl Show fit	CD40 ligand
chr3_-_72171078 Show fit	0.00	ENSRNOT00000009817	Serping1 Links NCBI RGD Ensembl Show fit	serpin family G member 1
chr2_+_199162745 Show fit	0.00	ENSRNOT00000023488	Gja5 Links NCBI RGD Ensembl Show fit	gap junction protein, alpha 5

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Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:2000253	positive regulation of feeding behavior(GO:2000253)
0.0	0.1	GO:0035502	metanephric part of ureteric bud development(GO:0035502)
0.0	0.0	GO:1903165	response to polycyclic arene(GO:1903165)
0.0	0.1	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.0	0.0	GO:0003322	pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0032763	regulation of mast cell cytokine production(GO:0032763)
0.0	0.0	GO:0046103	negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) inosine biosynthetic process(GO:0046103) negative regulation of mucus secretion(GO:0070256)
0.0	0.0	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0005796	Golgi lumen(GO:0005796)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0099510	calcium ion binding involved in regulation of cytosolic calcium ion concentration(GO:0099510)
0.0	0.0	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.2	GO:0004745	retinol dehydrogenase activity(GO:0004745)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events