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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Srf
Z-value: 0.61
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Transcription factors associated with Srf
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Srf | rn6_v1_chr9_+_16737642_16737642 | 0.07 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_27657628 Show fit | 1.13 |
ENSRNOT00000026303
|
early growth response 1 |
|
| chr20_-_22459025 Show fit | 0.57 |
ENSRNOT00000000792
|
early growth response 2 |
|
| chr4_-_117296082 Show fit | 0.45 |
ENSRNOT00000021097
|
early growth response 4 |
|
| chr6_+_109300433 Show fit | 0.37 |
ENSRNOT00000010712
|
FBJ osteosarcoma oncogene |
|
| chr1_-_25839198 Show fit | 0.36 |
ENSRNOT00000090388
ENSRNOT00000092757 ENSRNOT00000042072 |
triadin |
|
| chr1_-_80221710 Show fit | 0.33 |
ENSRNOT00000091687
|
FosB proto-oncogene, AP-1 transcription factor subunit |
|
| chr7_+_142912316 Show fit | 0.22 |
ENSRNOT00000010171
|
nuclear receptor subfamily 4, group A, member 1 |
|
| chr1_-_72339395 Show fit | 0.21 |
ENSRNOT00000021772
|
zinc finger protein 580 |
|
| chr1_-_47502952 Show fit | 0.18 |
ENSRNOT00000025580
|
T-cell activation RhoGTPase activating protein |
|
| chr4_+_145330457 Show fit | 0.16 |
ENSRNOT00000011937
|
actin related protein 2/3 complex, subunit 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Srf
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.1 | GO:0042222 | interleukin-1 biosynthetic process(GO:0042222) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182) |
| 0.1 | 0.6 | GO:0021593 | rhombomere morphogenesis(GO:0021593) |
| 0.1 | 0.4 | GO:0090158 | endoplasmic reticulum membrane organization(GO:0090158) |
| 0.0 | 0.4 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.0 | 0.2 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.0 | 0.1 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
| 0.0 | 0.1 | GO:1902304 | positive regulation of potassium ion export(GO:1902304) |
| 0.0 | 0.1 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 0.0 | 0.1 | GO:0006032 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.1 | GO:0007296 | vitellogenesis(GO:0007296) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 0.4 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 0.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.1 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 0.1 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.0 | GO:1990037 | Lewy body core(GO:1990037) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.1 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.0 | 0.6 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.1 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.0 | 0.1 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.0 | 0.1 | GO:0004568 | chitinase activity(GO:0004568) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |