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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Spic
Z-value: 0.88
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Transcription factors associated with Spic
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spic | rn6_v1_chr7_-_29233392_29233392 | 0.41 | 5.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_5163247 Show fit | 0.29 |
ENSRNOT00000001135
|
allograft inflammatory factor 1 |
|
| chr6_+_53401109 Show fit | 0.29 |
ENSRNOT00000014763
|
twist family bHLH transcription factor 1 |
|
| chr1_-_101236065 Show fit | 0.28 |
ENSRNOT00000066834
|
CD37 molecule |
|
| chr8_+_21663325 Show fit | 0.25 |
ENSRNOT00000027749
|
ubiquitin-like 5 |
|
| chr13_-_89606326 Show fit | 0.25 |
ENSRNOT00000029179
|
Fc fragment of IgE receptor Ig |
|
| chr4_-_155923079 Show fit | 0.23 |
ENSRNOT00000013308
|
C-type lectin domain family 4, member A3 |
|
| chr13_+_89386023 Show fit | 0.23 |
ENSRNOT00000086223
|
Fc fragment of IgG receptor IIIa |
|
| chr5_-_155258392 Show fit | 0.21 |
ENSRNOT00000017065
|
complement C1q C chain |
|
| chr2_-_28799266 Show fit | 0.20 |
ENSRNOT00000089293
|
transmembrane protein 171 |
|
| chr5_-_155252003 Show fit | 0.19 |
ENSRNOT00000017060
|
complement C1q B chain |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spic
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0014739 | positive regulation of muscle hyperplasia(GO:0014739) |
| 0.1 | 0.3 | GO:0035359 | negative regulation of histone phosphorylation(GO:0033128) negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.1 | 0.3 | GO:0002434 | immune complex clearance(GO:0002434) |
| 0.1 | 0.3 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 0.1 | 0.3 | GO:2000814 | positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.0 | 0.3 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.1 | 0.2 | GO:0002554 | serotonin secretion by platelet(GO:0002554) |
| 0.1 | 0.2 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.1 | 0.2 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.1 | 0.2 | GO:0034395 | regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.3 | GO:0036194 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.2 | GO:0033557 | Slx1-Slx4 complex(GO:0033557) |
| 0.0 | 0.2 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.0 | 0.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 0.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.2 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.2 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.2 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0019767 | IgE receptor activity(GO:0019767) |
| 0.0 | 0.3 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.0 | 0.3 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 0.2 | GO:0015065 | uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553) |
| 0.0 | 0.2 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 0.2 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.0 | 0.2 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.2 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.0 | 0.2 | GO:0019864 | IgG binding(GO:0019864) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.4 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.2 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.2 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.2 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.2 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.2 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.1 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |