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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Spib
Z-value: 0.61
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Transcription factors associated with Spib
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spib | rn6_v1_chr1_-_100537377_100537377 | -0.72 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_53401109 Show fit | 0.23 |
ENSRNOT00000014763
|
twist family bHLH transcription factor 1 |
|
| chr4_-_155923079 Show fit | 0.20 |
ENSRNOT00000013308
|
C-type lectin domain family 4, member A3 |
|
| chr1_-_101236065 Show fit | 0.17 |
ENSRNOT00000066834
|
CD37 molecule |
|
| chr13_-_91198036 Show fit | 0.16 |
ENSRNOT00000004204
|
low affinity immunoglobulin gamma Fc region receptor III |
|
| chr10_-_103685844 Show fit | 0.16 |
ENSRNOT00000064284
|
Cd300 molecule-like family member F |
|
| chr16_-_19791832 Show fit | 0.15 |
ENSRNOT00000040393
|
USH1 protein network component harmonin binding protein 1 |
|
| chr20_-_5163247 Show fit | 0.14 |
ENSRNOT00000001135
|
allograft inflammatory factor 1 |
|
| chr6_-_47904163 Show fit | 0.13 |
ENSRNOT00000011333
|
ribosomal protein S7 |
|
| chr7_-_122644054 Show fit | 0.12 |
ENSRNOT00000025941
|
DnaJ heat shock protein family (Hsp40) member B7 |
|
| chr2_-_198439454 Show fit | 0.12 |
ENSRNOT00000028780
|
Fc fragment of IgG receptor Ia |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spib
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0033128 | negative regulation of histone phosphorylation(GO:0033128) negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.1 | 0.2 | GO:0030886 | negative regulation of myeloid dendritic cell activation(GO:0030886) |
| 0.1 | 0.2 | GO:1902214 | regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426) |
| 0.0 | 0.2 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) |
| 0.0 | 0.1 | GO:0014739 | positive regulation of muscle hyperplasia(GO:0014739) |
| 0.0 | 0.1 | GO:0001788 | antibody-dependent cellular cytotoxicity(GO:0001788) |
| 0.0 | 0.1 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.0 | 0.1 | GO:1903972 | regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) |
| 0.0 | 0.1 | GO:0070946 | neutrophil mediated killing of gram-positive bacterium(GO:0070946) |
| 0.0 | 0.1 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.0 | 0.0 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 0.2 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
| 0.0 | 0.2 | GO:0055104 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.0 | 0.1 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.1 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.0 | 0.1 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.1 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.0 | 0.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.1 | GO:0004974 | leukotriene receptor activity(GO:0004974) |
| 0.0 | 0.0 | GO:0016823 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |